The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Selective D2 Receptor Actions on the Functional Circuitry of Working Memory
Abstract
Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no effect on the persistent mnemonic-related activity, which is instead modulated by D1 receptors. This associates the D2 receptor with a specific component of working memory circuitry and fractionates the modulatory effects of D1 and D2 receptors on the neural machinery of a cognitive process.
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In the citing paper
“D2-receptors in the PFC are concentrated in layer V neurons where they also increase response-related firing (Wang et al., 2004).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Wang et al., 2004
In the citing paper
“excessive D2 receptor stimulation impairs PFC working memory function in animals69 and humans70 and is associated with increased response-related firing in monkeys71 and increased response-related blood oxygen level-dependent signals in human imaging studies70.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [71]
In the citing paper
“Iontophoresis of D2 drugs onto PFC neurons has no effect on delay cell firing during the delay period in a working memory task but has marked effects on response cell firing in relationship to the eye movement response (124).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [124]
In the citing paper
“In contrast to delay cells, which reduce firing with high levels of dopamine D1R stimulation, layer V sensory-motor response cells in dlPFC show increased firing with high levels of dopamine D2 receptor stimulation63.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [63]
Citations
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Cousens, G. A., & Muir, G. M. (2006) · Europe PMC (PubMed Central)
Yuan, N. (2006) · OhioLink ETD Center (Ohio Library and Information Network)
Sokolenko, E. (2019) · Minerva Access (University of Melbourne)
Serotonin and Dopamine Modulate Maternal Behavior
卿, 若. (2020) · Advances in Psychology · doi:10.12677/ap.2020.102019
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Timing-dependent modulation of working memory by VTA dopamine release in medial prefrontal cortexPreprint
Ge, C., Chen, Z., Sun, F., Hou, R., Fan, H., Li, Y., & Li, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.01.555676
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Working memory circuits and rhythms in cognition in Parkinson's disease
Spicer, M. M., Yeager, B. E., Kim, Y.-C., & Narayanan, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00043-2
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Dopaminergic fronto-striatal connectivity underlies schema-dependent learning
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Cognitive impairment: quantification and possibilities for pharmacological treatment
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Iodine and Cognition in Young Adults: A Randomised, Placebo-Controlled Trial
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Metadata
- Authors
- Wang, M., Vijayraghavan, S., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
- Corresponding author
- Wang, Min
- Venue
- Science
- Published
- 2004-02-06
- Volume
- 303
- Issue
- 5659
- Pages
- 853-856
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002132239
- Cited by
- 319
- References
- 29
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 18 · 2014: 15 · 2013: 19 · 2012: 20
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (P50 MH44866, P50MH068789, P50MH044866)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D2 receptor, dopamine D1 receptor, working memory, memory-guided saccades, prefrontal cortex, receptor selectivity
- MeSH terms
- Animals, Benzazepines, Cues, Dose-Response Relationship, Drug, Electrophysiology, Macaca mulatta, Male, Memory, Neurons, Psychomotor Performance, Reward, Saccades, Salicylamides, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Quinpirole, Raclopride, Dopamine D2 Receptor Antagonists
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