Cited by 319Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Selective D2 Receptor Actions on the Functional Circuitry of Working Memory

Wang, Min, Vijayraghavan, Susheel, Goldman-Rakic, Patricia S.·2004·Science

DOI 10.1126/science.1091162

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Abstract

Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no effect on the persistent mnemonic-related activity, which is instead modulated by D1 receptors. This associates the D2 receptor with a specific component of working memory circuitry and fractionates the modulatory effects of D1 and D2 receptors on the neural machinery of a cognitive process.

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Authors: Wang, M., Vijayraghavan, S., & Goldman-Rakic, P. S.
Affiliations: Yale University (US)
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Corresponding author: Wang, Min
ORCID: Wang, Min
Vijayraghavan, Susheel
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2004-02-06
Volume: 303
Issue: 5659
Pages: 853-856
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1091162
OpenAlex: W2002132239
Cited by: 319
References: 29
Citations by year: 2026: 6 · 2025: 3 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 18 · 2014: 15 · 2013: 19 · 2012: 20
FWCI: 9.39
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (P50 MH44866, P50MH068789, P50MH044866)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine D2 receptor, dopamine D1 receptor, working memory, memory-guided saccades, prefrontal cortex, receptor selectivity
MeSH terms: Animals, Benzazepines, Cues, Dose-Response Relationship, Drug, Electrophysiology, Macaca mulatta, Male, Memory, Neurons, Psychomotor Performance, Reward, Saccades, Salicylamides, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Quinpirole, Raclopride, Dopamine D2 Receptor Antagonists

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Selective D2 Receptor Actions on the Functional Circuitry of Working Memory

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