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Cited by 754

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Inflammatory Exposure and Historical Changes in Human Life-Spans

Finch, Caleb E., Crimmins, Eileen M.·2004·Science

Abstract

Most explanations of the increase in life expectancy at older ages over history emphasize the importance of medical and public health factors of a particular historical period. We propose that the reduction in lifetime exposure to infectious diseases and other sources of inflammation—a cohort mechanism—has also made an important contribution to the historical decline in old-age mortality. Analysis of birth cohorts across the life-span since 1751 in Sweden reveals strong associations between early-age mortality and subsequent mortality in the same cohorts. We propose that a “cohort morbidity phenotype” represents inflammatory processes that persist from early age into adult life.

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Research works printed but not linked: 27

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Metadata

Authors
Finch, C. E., & Crimmins, E. M.
Venue
Science
Published
2004-09-17
Volume
305
Issue
5691
Pages
1736-1739
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2056709367
Cited by
754
References
1
FWCI
137.06
Type
journal article
Language
en
Open access
closed

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Finch, C. E., & Crimmins, E. M. (2004). Inflammatory Exposure and Historical Changes in Human Life-Spans. Science. https://doi.org/10.1126/science.1092556

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