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Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice
Abstract
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.
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Citations
Cites
Finding genes that underlie complex traits.
Glazier, A. M., Nadeau, J. H., & Aitman, T. J. (2002) · Science · doi:10.1126/science.1076641 · Cited by 855
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Cited by
Mouse genomic variation and its effect on phenotypes and gene regulation.
Keane, T. M., Goodstadt, L., Danecek, P., White, M. A., Wong, K., Yalcin, B., Heger, A., Agam, A., Slater, G., Goodson, M., et al. (2011) · Nature · doi:10.1038/nature10413 · Cited by 1,580
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119
Ho, M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh212 · Cited by 201
Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men
Kas, M. J. H., Fernandes, C., Schalkwyk, L. C., & Collier, D. A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001979 · Cited by 122
Metadata
- Authors
- Singer, J. B., Hill, A. E., Burrage, L. C., Olszens, K. R., Song, J., Justice, M., O'Brien, W. E., Conti, D. V., Witte, J. S., Lander, E. S., & Nadeau, J. H.
- Venue
- Science
- Published
- 2004-04-16
- Volume
- 304
- Issue
- 5669
- Pages
- 445-448
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2102126633
- Cited by
- 348
- References
- 1
- FWCI
- 17.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Singer, J. B., Hill, A. E., Burrage, L. C., Olszens, K. R., Song, J., Justice, M., O'Brien, W. E., Conti, D. V., Witte, J. S., Lander, E. S., & Nadeau, J. H. (2004). Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice. Science. https://doi.org/10.1126/science.1093139
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