The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice
Abstract
Apoptotic cells expose phosphatidylserine and are swiftly engulfed by macrophages. Milk fat globule epidermal growth factor (EGF) factor 8 (MFG-E8) is a protein that binds to apoptotic cells by recognizing phosphatidylserine and that enhances the engulfment of apoptotic cells by macrophages. We report that tingible body macrophages in the germinal centers of the spleen and lymph nodes strongly express MFG-E8. Many apoptotic lymphocytes were found on the MFG-E8 –/– tingible body macrophages, but they were not efficiently engulfed. The MFG-E8 –/– mice developed splenomegaly, with the formation of numerous germinal centers, and suffered from glomerulonephritis as a result of autoantibody production. These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The best characterized of these are the soluble protein MFG-E8 87,121 and the glycolipid-anchored protein Tim-4 88.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [88]
Citations
Cites
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
A blast from the past: clearance of apoptotic cells regulates immune responses
Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574
Corpse clearance defines the meaning of cell death
Savill, J., & Fadok, V. A. (2000) · Nature · doi:10.1038/35037722 · Cited by 1,572
Identification of a factor that links apoptotic cells to phagocytes
Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401
Self-citationPhagocytosis and clearance of apoptotic cells is mediated by MER
Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K. (2001) · Nature · doi:10.1038/35075603 · Cited by 1,215
T-cell apoptosis detected in situ during positive and negative selection in the thymus
Surh, C. D., & Sprent, J. (1994) · Nature · doi:10.1038/372100a0 · Cited by 1,082
Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production
Mevorach, D., Zhou, J. L., Song, X., & Elkon, K. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.387 · Cited by 567
Hoffmann, P. R., deCathelineau, A. M., Ogden, C. A., Leverrier, Y., Bratton, D. L., Daleke, D. L., Ridley, A. J., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108080 · Cited by 541
Stubbs, J. D., Lekutis, C., Singer, K. L., Bui, A., Yuzuki, D., Srinivasan, U., & Parry, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8417 · Cited by 313
Life and Death in Germinal Centers (Redux)
Kelsoe, G. H. (1996) · Immunity · doi:10.1016/s1074-7613(00)80675-5 · Cited by 312
Rabinowitz, S. S., & Gordon, S. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.4.827 · Cited by 233
Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation
Kawane, K., Fukuyama, H., Yoshida, H., Nagase, H., Ohsawa, Y., Uchiyama, Y., Okada, K., Iida, T., & Nagata, S. (2003) · Nature Immunology · doi:10.1038/ni881 · Cited by 230
Self-citationMarginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.
Kraal, G., & Janse, M. (1986) · PubMed Central · Cited by 222
Hengartner, M. O. (2001) · Cell · doi:10.1016/s0092-8674(01)00219-7 · Cited by 181
Hanayama, R., Tanaka, M., Miwa, K., & Nagata, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3876 · Cited by 142
Self-citationMiyasaka, K., Hanayama, R., Tanaka, M., & Nagata, S. (2004) · European Journal of Immunology · doi:10.1002/eji.200424930 · Cited by 117
Self-citationApoptotic Thymocyte Clearance in Scavenger Receptor Class A-Deficient Mice Is Apparently Normal
Platt, N., Suzuki, H., Kodama, T., & Gordon, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4861 · Cited by 94
Membrane Molecules as Differentiation Antigens of Murine Macrophages
McKnight, A. J., & Gordon, S. (1998) · Advances in immunology · doi:10.1016/s0065-2776(08)60562-3 · Cited by 81
Effect of thioglycolate on phagocytic and microbicidal activities of peritoneal macrophages
Leijh, P. C. J., van Zwet, T. L., ter Kuile, M. N., & van Furth, R. (1984) · Infection and Immunity · doi:10.1128/iai.46.2.448-452.1984 · Cited by 81
Oshima, K., Aoki, N., Negi, M., Kishi, M., Kitajima, K., & Matsuda, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.0107 · Cited by 81
Smith, J. P., Lister, A. M., Tew, J. G., & Szakal, A. K. (1991) · The Anatomical Record · doi:10.1002/ar.1092290412 · Cited by 41
Circulating immune complexes in renal injury.
Gauthier, V., & Abrass, C. K. (1992) · PubMed · Cited by 13
Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus
Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5
Flagged first, then by citations
Research works printed but not linked: 3
- G. Kraal, M. Janse, Immunology58, 665 (1986).
- V. J. Gauthier, C. K. Abrass, Semin. Nephrol.12, 379 (1992).
- G. Kelsoe, Immunity4, 107 (1996).
Cited by
Sorted by citations
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Metadata
- Authors
- Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., & Nagata, S.
- Affiliations
- RIKEN (JP)
- Corresponding author
- Nagata, Shigekazu
- Venue
- Science
- Published
- 2004-05-21
- Volume
- 304
- Issue
- 5674
- Pages
- 1147-1150
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037393136
- Cited by
- 992
- References
- 24
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 32 · 2023: 37 · 2022: 34 · 2021: 48 · 2020: 36 · 2019: 36 · 2018: 41 · 2017: 46 · 2016: 32 · 2015: 42 · 2014: 51 · 2013: 64 · 2012: 59
- FWCI
- 21.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- MFG-E8, efferocytosis, phosphatidylserine, macrophages, tingible body macrophages, germinal center, splenomegaly, glomerulonephritis, autoantibodies, autoimmune disease, B cell apoptosis
- MeSH terms
- CD68 Molecule, Animals, Antigens, Surface, Antibodies, Antinuclear, Autoantibodies, Autoimmune Diseases, B-Lymphocytes, Female, Glomerulonephritis, Macrophage Activation, Macrophages, Membrane Glycoproteins, Milk Proteins, Phagocytosis, Phosphatidylserines, Protein Binding, Spleen, Splenomegaly, T-Lymphocytes, Blotting, Northern, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Apoptosis, Macrophages, Peritoneal, Gene Targeting, Germinal Center, In Situ Nick-End Labeling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
