The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Natural Antibiotic Function of a Human Gastric Mucin Against Helicobacter pylori Infection
Abstract
Helicobacter pylori infects the stomachs of nearly a half the human population, yet most infected individuals remain asymptomatic, which suggests that there is a host defense against this bacterium. Because H. pylori is rarely found in deeper portions of the gastric mucosa, where O -glycans are expressed that have terminal α1,4-linked N -acetylglucosamine, we tested whether these O -glycans might affect H. pylori growth. Here, we report that these O -glycans have antimicrobial activity against H. pylori , inhibiting its biosynthesis of cholesteryl-α-D-glucopyranoside, a major cell wall component. Thus, the unique O -glycans in gastric mucin appeared to function as a natural antibiotic, protecting the host from H. pylori infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
Helicobacter pylori and gastrointestinal tract adenocarcinomas
Peek, R. M., & Blaser, M. J. (2002) · Nature Reviews Cancer · doi:10.1038/nrc703 · Cited by 1,813
Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
Ilver, D., Arnqvist, A., Ögren, J., Frick, I.-M., Kersulyte, D., Incecik, E. T., Berg, D. E., Covacci, A., Engstrand, L., & Borén, T. (1998) · Science · doi:10.1126/science.279.5349.373 · Cited by 1,224
Apoptosis of T cells mediated by galectin-1
Perillo, N. L., Pace, K. E., Seilhamer, J. J., & Baum, L. G. (1995) · Nature · doi:10.1038/378736a0 · Cited by 1,074
SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein
Higashi, H., Tsutsumi, R., Muto, S., Sugiyama, T., Azuma, T., Asaka, M., & Hatakeyama, M. (2002) · Science · doi:10.1126/science.1067147 · Cited by 1,029
Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation
Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., Ångström, J., Larsson, T., Teneberg, S., Karlsson, K.-A., et al. (2002) · Science · doi:10.1126/science.1069076 · Cited by 932
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
Demetriou, M., Granovsky, M., Quaggin, S., & Dennis, J. W. (2001) · Nature · doi:10.1038/35055582 · Cited by 901
Fringe is a glycosyltransferase that modifies Notch
Moloney, D. J., Panin, V. M., Johnston, S. H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K. D., Haltiwanger, R. S., et al. (2000) · Nature · doi:10.1038/35019000 · Cited by 852
Yeh, J.-C., Hiraoka, N., Petryniak, B., Nakayama, J., Ellies, L. G., Rabuka, D., Hindsgaul, O., Marth, J. D., Lowe, J. B., & Fukuda, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00394-4 · Cited by 346
Self-citationGlycosylation, Immunity, and Autoimmunity
Lowe, J. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00277-x · Cited by 303
Cited by
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
Muc5b is required for airway defence
Roy, M. G., Livraghi-Butrico, A., Fletcher, A. A., McElwee, M. M., Evans, S. E., Boerner, R. M., Alexander, S. N., Bellinghausen, L. K., Song, A. S., Petrova, Y. M., et al. (2014) · Nature · doi:10.1038/nature12807 · Cited by 764
Morgan, E., Arnold, M., Camargo, M. C., Gini, A., Kunzmann, A. T., Matsuda, T., Meheus, F., Verhoeven, R. H. A., Vignat, J., Laversanne, M., et al. (2022) · eClinicalMedicine · doi:10.1016/j.eclinm.2022.101404 · Cited by 773
Intestinal barrier dysfunction in inflammatory bowel diseases
McGuckin, M. A., Eri, R., Simms, L. A., Florin, T. H. J., & Radford-Smith, G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20539 · Cited by 627
THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES
Atherton, J. C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100125 · Cited by 567
Metadata
- Authors
- Kawakubo, M., Ito, Y., Okimura, Y., Kobayashi, M., Sakura, K., Kasama, S., Fukuda, M. N., Fukuda, M., Katsuyama, T., & Nakayama, J.
- Venue
- Science
- Published
- 2004-08-13
- Volume
- 305
- Issue
- 5686
- Pages
- 1003-1006
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017020122
- Cited by
- 332
- References
- 21
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Natural Antibiotic Function of a Human Gastric Mucin Against Helicobacter pylori Infection. https://app.cochat.ai/papers/10.1126/science.1099250
- The paper
- Kawakubo, M., Ito, Y., Okimura, Y., Kobayashi, M., Sakura, K., Kasama, S., Fukuda, M. N., Fukuda, M., Katsuyama, T., & Nakayama, J. (2004). Natural Antibiotic Function of a Human Gastric Mucin Against Helicobacter pylori Infection. Science. https://doi.org/10.1126/science.1099250
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
