The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Host-Bacterial Mutualism in the Human Intestine
Abstract
The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that are highly diverse at the strain/subspecies level. This microbiota and its collective genomes (microbiome) provide us with genetic and metabolic attributes we have not been required to evolve on our own, including the ability to harvest otherwise inaccessible nutrients. New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements our biology in ways that are mutually beneficial. We are also starting to understand how certain keystone members of the microbiota operate to maintain the stability and functional adaptability of this microbial organ.
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In the citing paper
“Increased gut permeability is thought to facilitate the movement of inflammatory mediators from the gut into the circulation, promoting systemic insulin resistance [134,136].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [136]
In the citing paper
“Most of the animal and human studies have reported that obesity and insulin resistance are associated with an altered ratio of Firmicutes and Bacteroidetes [8,9].”
From Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study (2019) · cites this paper as [9]
In the citing paper
“It is now understood that the gut microbiota coevolved with the human host over thousands of years and are integral to overall human physiology, playing a pivotal role in metabolism, immune system function and maintenance of gut homeostasis.1, 2”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [1]
In the citing paper
“This number is likely an underestimate given the lack of any systematic analyses of the gut microbial metabolism of drugs and the vast genetic diversity within the microbiome34.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [34]
In the citing paper
“A major function of the gut microbiota is to aid in host food digestion, harvesting key nutrients that the host is incapable of metabolizing without the help of microbes (Backhed et al., 2005).”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Backhed et al., 2005
In the citing paper
“Under healthy conditions, the microbiota influences numerous physiological processes within the host, such as protection against pathogens, nutrient digestion and absorption, development, and education of multiple host organs and the immune system (3–6).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [4]
Citations
Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Self-citationProkaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871
Energy conservation in chemotrophic anaerobic bacteria
Thauer, R. K., Jungermann, K., & Decker, K. (1977) · Bacteriological Reviews · doi:10.1128/br.41.1.100-180.1977 · Cited by 4,146
The diversity–stability debate
McCann, K. S. (2000) · Nature · doi:10.1038/35012234 · Cited by 3,220
Biodiversity and ecosystem productivity in a fluctuating environment: The insurance hypothesis
Yachi, S., & Loreau, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1463 · Cited by 3,211
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity
Hugenholtz, P., Goebel, B. M., & Pace, N. R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.18.4765-4774.1998 · Cited by 2,429
Marine viruses and their biogeochemical and ecological effects
Fuhrman, J. A. (1999) · Nature · doi:10.1038/21119 · Cited by 2,288
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360
A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353
Self-citation
Research works printed but not linked: 1
- E. G. Zoetendal et al., Microb. Ecol. Health Dis.13, 129 (2001).
Cited by
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Items 701–800 of 1,068
Underwood, M. A., Salzman, N. H., Bennett, S. H., Barman, M., Mills, D. A., Marcobal, A. M., Tancredi, D. J., Bevins, C. L., & Sherman, M. P. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31818de195 · Cited by 169
Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel
Cremer, J., Šegota, I., Chih-Yu, Y., Arnoldini, M., Sauls, J. T., Zhang, Z., Gutierrez, E., Groisman, A., & Hwa, T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601306113 · Cited by 166
Stereotypes About Enterotype: The Old and New Ideas
Cheng, M., & Ning, K. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.02.004 · Cited by 178
Salazar, N., Ruas-Madiedo, P., Kolida, S., Collins, M., Rastall, R., Gibson, G., & de los Reyes-Gavilán, C. G. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.08.017 · Cited by 168
Yun, Y., Srinivas, G., Kuenzel, S., Linnenbrink, M., Alnahas, S., Bruce, K. D., Steinhoff, U., Baines, J. F., & Schaible, U. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113466 · Cited by 168
Shanks, O. C., Newton, R. J., Kelty, C. A., Huse, S. M., Sogin, M. L., & McLellan, S. L. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03448-12 · Cited by 170
Identification and quantitation of cobalamin and cobalamin analogues in human feces
Allen, R. H., & Stabler, S. P. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1324 · Cited by 168
Cremer, J., Arnoldini, M., & Hwa, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619598114 · Cited by 165
Lopetuso, L. R., Petito, V., Graziani, C., Schiavoni, E., Sterbini, F. P., Poscia, A., Gaetani, E., Franceschi, F., Cammarota, G., Sanguinetti, M., et al. (2017) · Digestive Diseases · doi:10.1159/000477205 · Cited by 168
Cremon, C., Barbaro, M. R., Ventura, M., & Barbara, G. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.08.010 · Cited by 179
Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases
Liu, M., Yang, J.-Y., Yan, Z.-H., Hu, S., Li, J.-Q., Xu, Z., & Jian, Y. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.08.029 · Cited by 176
Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine
An, D., Na, C., Bielawski, J., Hannun, Y. A., & Kasper, D. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001501107 · Cited by 167
Cevenini, E., Caruso, C., Candore, G., Capri, M., Nuzzo, D., Duro, G., Rizzo, C., Colonna‐Romano, G., Lio, D., Carlo, D., et al. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883840 · Cited by 168
Wier, A. M., Nyholm, S. V., Mandel, M. J., Massengo-Tiassé, R. P., Schaefer, A. L., Koroleva, I., BonDurant, S. S., Brown, B. J., Manzella, L., Snir, E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909712107 · Cited by 164
Identification of a Core Bacterial Community within the Large Intestine of the Horse
Dougal, K., de la Fuente, G., Harris, P. A., Girdwood, S. E., Pinloche, E., & Newbold, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077660 · Cited by 165
Propheter, D. C., Chara, A. L., Harris-Tryon, T. A., Ruhn, K. A., & Hooper, L. V. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711395114 · Cited by 167
Harsch, I. A., & Konturek, P. C. (2018) · Medical Sciences · doi:10.3390/medsci6020032 · Cited by 173
Gut Microbiota: From Microorganisms to Metabolic Organ Influencing Obesity
Stephens, R. W., Arhire, L. I., & Covașă, M. (2018) · Obesity · doi:10.1002/oby.22179 · Cited by 170
Role of gut microbiota in intestinal wound healing and barrier function
Alam, A., & Neish, A. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1539595 · Cited by 166
Review article: the role of bacteria in onset and perpetuation of inflammatory bowel disease
Seksik, P., Sokol, H., Lepage, P., Vasquez, N., Manichanh, C., Mangin, I., Pochart, P., Dore, J. M., & Marteau, P. R. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03053.x · Cited by 166
Fåk, F., & Bäckhed, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046837 · Cited by 166
Rajoka, M. S. R., Shi, J., Mehwish, H. M., Zhu, J., Li, Q., Shao, D., Huang, Q., & Yang, H. (2017) · Food Science and Human Wellness · doi:10.1016/j.fshw.2017.07.003 · Cited by 174
Interactions between host and gut microbiota in domestic pigs: a review
Patil, Y. D., Gooneratne, R., & Ju, X. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1690363 · Cited by 163
Influence of Maternal Milk on the Neonatal Intestinal Microbiome
Gopalakrishna, K. P., & Hand, T. W. (2020) · Nutrients · doi:10.3390/nu12030823 · Cited by 170
Zhang, X., Zou, Q., Zhao, B., Zhang, J., Zhao, W., Li, Y., Liu, R., Liu, X., & Liu, Z. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101535 · Cited by 166
Gut microbiota: A new insight into lung diseases
Ma, P.-J., Wang, M., & Wang, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113810 · Cited by 171
Payne, A. N., Chassard, C., Zimmermann, M. B., Müller, P., Stinca, S., & Lacroix, C. (2011) · Nutrition and Diabetes · doi:10.1038/nutd.2011.8 · Cited by 168
The microbiome and obesity: Is obesity linked to our gut flora?
Tsai, F., & Coyle, W. (2009) · Current Gastroenterology Reports · doi:10.1007/s11894-009-0045-z · Cited by 166
Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans
Portal‐Celhay, C., Bradley, E., & Blaser, M. J. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-49 · Cited by 166
Metagenomic Approaches for Understanding New Concepts in Microbial Science
Alves, L. D. F., Westmann, C. A., Lovate, G. L., de Siqueira, G. M. V., Borelli, T. C., & Guazzaroni, M. (2018) · International Journal of Genomics · doi:10.1155/2018/2312987 · Cited by 167
Tandon, D., Haque, M. M., Gote, M., Jain, M., Bhaduri, A., Dubey, A. K., & Mande, S. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-41837-3 · Cited by 176
The infant gut microbiome as a microbial organ influencing host well-being
Turroni, F., Milani, C., Duranti, S., Lugli, G. A., Bernasconi, S., Margollés, A., Pierro, F. D., van Sinderen, D., & Ventura, M. (2020) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-020-0781-0 · Cited by 176
Vaughan, E. E., Heilig, H. G. H. J., BENAMOR, K., & DEVOS, W. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.04.009 · Cited by 191
Xia, H. H. X., & Talley, N. J. (1997) · PubMed · Cited by 161
Cresci, G., Thangaraju, M., Mellinger, J. D., Liu, K., & Ganapathy, V. (2009) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-009-1045-x · Cited by 164
Organisms or biological individuals? Combining physiological and evolutionary individuality
Pradeu, T. (2016) · Biology & Philosophy · doi:10.1007/s10539-016-9551-1 · Cited by 171
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Nakayama, J., Yamamoto, A., Conde, L. A., Higashi, K., Sonomoto, K., Tan, J. D., & Lee, Y. K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00197 · Cited by 171
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Nagpal, R., Shively, C. A., Register, T. C., Craft, S., & Yadav, H. (2019) · F1000Research · doi:10.12688/f1000research.18992.1 · Cited by 168
Yu, Y., Chang, Y. E., Wu, Y., Liu, H., Liu, Q., Kang, Z., Wu, M., Yin, H. Z., & Duan, J. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.209 · Cited by 165
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Manson, J. M., Rauch, M., & Gilmore, M. S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09550-9_2 · Cited by 161
Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk
Miele, L., Giorgio, V., Alberelli, M. A., Candia, E. D., Gasbarrini, A., & Grieco, A. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0671-z · Cited by 168
Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction
Orešič, M. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.04.018 · Cited by 165
A Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing
Ismail, A. S., Valastyan, J. S., & Bassler, B. L. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.02.020 · Cited by 160
The Impact of Gut Microbiota Disorders on the Blood–Brain Barrier
Wei, T., Zhu, H., Feng, Y., Guo, R., & Wan, D. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s254403 · Cited by 171
Sonnenburg, E. D., Sonnenburg, J. L., Manchester, J. K., Hansen, E. E., Chiang, H. C., & Gordon, J. I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603249103 · Cited by 163
Self-citationEvidence for a bacterial mechanism for group-specific social odors among hyenas
Theis, K. R., Schmidt, T. M., & Holekamp, K. E. (2012) · Scientific Reports · doi:10.1038/srep00615 · Cited by 164
Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation
Laugerette, F., Vors, C., Peretti, N., & Michalski, M. (2010) · Biochimie · doi:10.1016/j.biochi.2010.04.016 · Cited by 170
Integrating nutrition and immunology: A new frontier
Ponton, F., Wilson, K. L., Holmes, A. J., Cotter, S. C., Raubenheimer, D., & Simpson, S. J. (2012) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2012.10.011 · Cited by 166
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Clayton, J. B., Gomez, A. M., Amato, K. R., Knights, D., Travis, D. A., Blekhman, R., Knight, R. D., Leigh, S. R., Stumpf, R. M., Wolf, T. M., et al. (2018) · American Journal of Primatology · doi:10.1002/ajp.22867 · Cited by 168
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Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 191
Wang, S., Charbonnier, L.-M., Noval Rivas, M., Georgiev, P., Li, N., Gerber, G., Bry, L., & Chatila, T. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.014 · Cited by 161
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Tranah, T. H., Edwards, L. A., Schnabl, B., & Shawcross, D. L. (2020) · Gut · doi:10.1136/gutjnl-2020-320786 · Cited by 168
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Romano, K. A., Nemet, I., Saha, P. P., Haghikia, A., Li, X. S., Mohan, M. L., Lovano, B. S., Castel, L., Witkowski, M., Buffa, J. A., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.122.009972 · Cited by 168
Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160
Development of gut microbiota in infants not exposed to medical interventions
Eggesbø, M. Å., Moen, B., Peddada, S. D., Baird, D. D., Rugtveit, J., Midtvedt, T., Bushel, P. R., Sekelja, M., & Rudi, K. (2010) · Apmis · doi:10.1111/j.1600-0463.2010.02688.x · Cited by 163
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Wagner, J., Maksimovic, J., Farries, G., Sim, W. H., Bishop, R. F., Cameron, D. J. S., Catto‐Smith, A. G., & Kirkwood, C. D. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e318292477c · Cited by 169
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Mathur, R., & Barlow, G. M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1051029 · Cited by 162
Zhang, M., Chekan, J. R., Dodd, D., Hong, P., Radlinski, L. C., Revindran, V., Nair, S. K., Mackie, R. I., & Cann, I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406156111 · Cited by 162
Palau‐Rodriguez, M., Tulipani, S., Queipo‐Ortuño, M. I., Urpí-Sardà, M., Tinahones, F. J., & Andrés‐Lacueva, C. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01151 · Cited by 163
Wei, X., Yan, X., Zou, D., Yang, Z., Wang, X., Liu, W., Wang, S., Li, X., Han, J., Huang, L., et al. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-175 · Cited by 160
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Shu, S.-A., Yuen, A. W. T., Woo, E., Chu, K. H., Kwan, H. S., Yang, G., Yang, Y., & Leung, P. S. C. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8723-y · Cited by 160
Islam, M. R., Rauf, A., Akash, S., Trisha, S. I., Nasim, A. H., Akter, M., Dhar, P. S., Ogaly, H. A., Hemeg, H. A., Wilairatana, P., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116034 · Cited by 174
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Kane, A. V., Dinh, D. M., & Ward, H. (2014) · Pediatric Research · doi:10.1038/pr.2014.179 · Cited by 163
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Preter, V. D., Hamer, H. M., Windey, K., & Verbeke, K. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000451 · Cited by 157
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Frese, S. A., MacKenzie, D. A., Peterson, D. A., Schmaltz, R. J., Fangman, T., Zhou, Y., Zhang, C. H., Benson, A. K., Cody, L. A., Mulholland, F., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1004057 · Cited by 156
Self-citationChen, Q., Liu, M., Zhang, P., Fan, S., Huang, J., Yu, S., Zhang, C., & Li, H. (2019) · Nutrition · doi:10.1016/j.nut.2019.03.001 · Cited by 157
Antimicrobial prophylaxis for colorectal surgery
Nelson, R. L., Glenny, A., & Song, F. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001181.pub3 · Cited by 156
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Surana, N. K., & Kasper, D. L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01075.x · Cited by 160
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Reese, A. T., Pereira, F. C., Schintlmeister, A., Berry, D., Wagner, M., Hale, L. P., Wu, A., Jiang, S., Durand, H. K., Zhou, X., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0267-7 · Cited by 152
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Jeraldo, P., Sipos, M., Chia, N., Brulc, J. M., Dhillon, A. S., Konkel, M. E., Larson, C. L., Nelson, K. E., Qu, A., Schook, L. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206721109 · Cited by 149
Ducatelle, R., Eeckhaut, V., Haesebrouck, F., & Immerseel, F. V. (2014) · animal · doi:10.1017/s1751731114002584 · Cited by 154
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Engelhardt, K. R., & Grimbacher, B. (2014) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-43492-5_1 · Cited by 156
Elucidation of complexity and prediction of interactions in microbial communities
Zúñiga, C., Zaramela, L. S., & Zengler, K. (2017) · Microbial Biotechnology · doi:10.1111/1751-7915.12855 · Cited by 159
Bo, T., Zhang, X., Wen, J., Deng, K., Qin, X.-W., & Wang, D. (2019) · The ISME Journal · doi:10.1038/s41396-019-0492-y · Cited by 159
Chen, J., & Li, H. (2011) · Cited by 154
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Metadata
- Authors
- Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I.
- Affiliations
- Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.
- Washington University in St. Louis (US)
- Corresponding author
- Ley, Ruth E.
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2005-03-25
- Volume
- 307
- Issue
- 5717
- Pages
- 1915-1920
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980914602
- Cited by
- 5,277
- References
- 37
- Citations by year
- 2026: 143 · 2025: 225 · 2024: 281 · 2023: 322 · 2022: 363 · 2021: 389 · 2020: 359 · 2019: 344 · 2018: 276 · 2017: 277 · 2016: 313 · 2015: 257 · 2014: 288 · 2013: 243 · 2012: 227
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- gut microbiota, human intestine, microbiome, coevolution, microbial diversity, strain-level diversity, nutrient acquisition, microbiological stability, keystone species, anaerobic bioreactor
- MeSH terms
- Anaerobiosis, Bacteria, Bacteroides, Energy Intake, Energy Metabolism, Biological Evolution, Humans, Intestines, Obesity, Selection, Genetic, Genome, Bacterial, Ecosystem, Bacterial Physiological Phenomena, Gastrointestinal Tract, Biodiversity
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