The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Host-Bacterial Mutualism in the Human Intestine
Abstract
The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that are highly diverse at the strain/subspecies level. This microbiota and its collective genomes (microbiome) provide us with genetic and metabolic attributes we have not been required to evolve on our own, including the ability to harvest otherwise inaccessible nutrients. New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements our biology in ways that are mutually beneficial. We are also starting to understand how certain keystone members of the microbiota operate to maintain the stability and functional adaptability of this microbial organ.
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“Increased gut permeability is thought to facilitate the movement of inflammatory mediators from the gut into the circulation, promoting systemic insulin resistance [134,136].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [136]
In the citing paper
“Most of the animal and human studies have reported that obesity and insulin resistance are associated with an altered ratio of Firmicutes and Bacteroidetes [8,9].”
From Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study (2019) · cites this paper as [9]
In the citing paper
“It is now understood that the gut microbiota coevolved with the human host over thousands of years and are integral to overall human physiology, playing a pivotal role in metabolism, immune system function and maintenance of gut homeostasis.1, 2”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [1]
In the citing paper
“This number is likely an underestimate given the lack of any systematic analyses of the gut microbial metabolism of drugs and the vast genetic diversity within the microbiome34.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [34]
In the citing paper
“A major function of the gut microbiota is to aid in host food digestion, harvesting key nutrients that the host is incapable of metabolizing without the help of microbes (Backhed et al., 2005).”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Backhed et al., 2005
In the citing paper
“Under healthy conditions, the microbiota influences numerous physiological processes within the host, such as protection against pathogens, nutrient digestion and absorption, development, and education of multiple host organs and the immune system (3–6).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [4]
Citations
Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Self-citationProkaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871
Energy conservation in chemotrophic anaerobic bacteria
Thauer, R. K., Jungermann, K., & Decker, K. (1977) · Bacteriological Reviews · doi:10.1128/br.41.1.100-180.1977 · Cited by 4,146
The diversity–stability debate
McCann, K. S. (2000) · Nature · doi:10.1038/35012234 · Cited by 3,220
Biodiversity and ecosystem productivity in a fluctuating environment: The insurance hypothesis
Yachi, S., & Loreau, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1463 · Cited by 3,211
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity
Hugenholtz, P., Goebel, B. M., & Pace, N. R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.18.4765-4774.1998 · Cited by 2,429
Marine viruses and their biogeochemical and ecological effects
Fuhrman, J. A. (1999) · Nature · doi:10.1038/21119 · Cited by 2,288
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360
A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353
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Research works printed but not linked: 1
- E. G. Zoetendal et al., Microb. Ecol. Health Dis.13, 129 (2001).
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Items 501–600 of 1,068
Interaction Between Atypical Antipsychotics and the Gut Microbiome in a Bipolar Disease Cohort
Flowers, S. A., Evans, S. J., Ward, K. M., McInnis, M. G., & Ellingrod, V. L. (2017) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1890 · Cited by 235
Mucin Dynamics in Intestinal Bacterial Infection
Lindén, S. K., Florin, T. H., & McGuckin, M. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003952 · Cited by 242
Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model
Lin, H., An, Y., Tang, H., & Wang, Y. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00249 · Cited by 240
The Evolution of Mutualism in Gut Microbiota Via Host Epithelial Selection
Schlüter, J., & Foster, K. R. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001424 · Cited by 237
Dumonceaux, T., Hill, J. E., Hemmingsen, S. M., & Kessel, A. G. V. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.4.2815-2823.2006 · Cited by 234
Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses
Nyholm, S. V., & Graf, J. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2894 · Cited by 241
Evolution of microbial markets
Werner, G. D. A., Strassmann, J. E., Ivens, A. B. F., Engelmoer, D. J. P., Verbruggen, E., Queller, D. C., Noë, R., Johnson, N. C., Hammerstein, P., & Kiers, E. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315980111 · Cited by 236
Staley, C. M., Kaiser, T., Beura, L. K., Hamilton, M. J., Weingarden, A. R., Bobr, A., Kang, J., Masopust, D., Sadowsky, M. J., & Khoruts, A. (2017) · Microbiome · doi:10.1186/s40168-017-0306-2 · Cited by 241
Obesity and cancer pathogenesis
Berger, N. A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12416 · Cited by 241
Comparative Analysis of Korean Human Gut Microbiota by Barcoded Pyrosequencing
Nam, Y., Jung, M., Roh, S. W., Kim, M., & Bae, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022109 · Cited by 242
Amor, K. B., Heilig, H. G. H. J., Smidt, H., Vaughan, E. E., Abee, T., & de Vos, W. M. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.8.4679-4689.2005 · Cited by 232
Impact of gut microbiota on diabetes mellitus
Blandino, G., Inturri, R., Lazzara, F., Rosa, M. D., & Malaguarnera, L. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.04.004 · Cited by 235
The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions
Ellis, S. R., Nguyen, M., Vaughn, A. R., Notay, M., Burney, W. A., Sandhu, S., & Sivamani, R. K. (2019) · Microorganisms · doi:10.3390/microorganisms7110550 · Cited by 242
Ringel-Kulka, T., Cheng, J., Ringel, Y., Salojärvi, J., Carroll, I., Palva, A., de Vos, W. M., & Satokari, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064315 · Cited by 230
Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii
Benson, A., Pifer, R., Behrendt, C. L., Hooper, L. V., & Yarovinsky, F. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.06.005 · Cited by 235
Zinkernagel, M. S., Zysset-Burri, D. C., Keller, I., Berger, L. E., Leichtle, A. B., Largiadèr, C. R., Fiedler, G. M., & Wolf, S. (2017) · Scientific Reports · doi:10.1038/srep40826 · Cited by 229
LoCascio, R. G., Desai, P., Sela, D. A., Weimer, B., & Mills, D. A. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00675-10 · Cited by 229
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Lasserre, J. F., Brecx, M., & Toma, S. (2018) · Materials · doi:10.3390/ma11101802 · Cited by 232
Hasain, Z., Mokhtar, N. M., Kamaruddin, N. A., Ismail, N. A. M., Razalli, N. H., Gnanou, J. V., & Ali, R. A. R. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00188 · Cited by 242
Garrido, D., Dallas, D. C., & Mills, D. A. (2013) · Microbiology · doi:10.1099/mic.0.064113-0 · Cited by 228
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Ouwerkerk, J. P., de Vos, W. M., & Belzer, C. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.001 · Cited by 245
Brusca, S. B., Abramson, S. B., & Scher, J. U. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000008 · Cited by 231
Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study
Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Sawaki, E., Koga, Y., & Benno, Y. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00009 · Cited by 227
The gut microbiota of Colombians differs from that of Americans, Europeans and Asians
Escobar, J. S., Klotz, B., Valdés-Duque, B. E., & Agudelo, G. M. (2014) · BMC Microbiology · doi:10.1186/s12866-014-0311-6 · Cited by 232
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Goodacre, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.259s · Cited by 282
Alterations of intestinal barrier and microbiota in chronic kidney disease
Sabatino, A., Regolisti, G., Brusasco, I., Cabassi, A., Morabito, S., & Fiaccadori, E. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu287 · Cited by 227
Structural basis for nutrient acquisition by dominant members of the human gut microbiota
Glenwright, A. J., Pothula, K. R., Bhamidimarri, S. P., Chorev, D. S., Baslé, A., Firbank, S. J., Zheng, H., Robinson, C. V., Winterhalter, M., Kleinekathöfer, U., et al. (2017) · Nature · doi:10.1038/nature20828 · Cited by 223
Damman, C. J., Miller, S. I., Surawicz, C. M., & Zisman, T. L. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.93 · Cited by 229
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Jones, R. M., Mercante, J. W., & Neish, A. S. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799828283 · Cited by 232
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Arike, L., & Hansson, G. C. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.02.010 · Cited by 233
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Presti, A. L., Zorzi, F., CHIERICO, F. D., Altomare, A., Cocca, S., Avola, A., Biasio, F. D., Russo, A., Cella, E., Reddel, S., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01655 · Cited by 228
Tilg, H., Moschen, A. R., & Kaser, A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.030 · Cited by 233
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Kwon, Y. H., Wang, H., Denou, E., Ghia, J., Rossi, L., Fontes, M. E., Bernier, S. P., Shajib, M. S., Banskota, S., Collins, S. M., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.01.004 · Cited by 228
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Su, C., Lei, L., Duan, Y.-Q., Zhang, K., & Yang, J. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3800-7 · Cited by 236
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Yetukuri, L., Ekroos, K., Vidal‐Puig, A., & Orešič, M. (2007) · Molecular BioSystems · doi:10.1039/b715468b · Cited by 227
Kukkonen, A. K., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., & Kuitunen, M. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1192 · Cited by 220
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Barr, J. J., Auro, R., Sam-Soon, N., Kassegne, S., Peters, G., Bonilla, N., Hatay, M., Mourtada, S., Bailey, B., Youle, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508355112 · Cited by 219
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Liu, Z., Huang, M., Zhang, X., Wang, L., Huang, N., Peng, H., Lan, P., Peng, J., Yang, Z., Yang, X., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.040949 · Cited by 222
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Clavel, T., Henderson, G., Engst, W., Dore, J. M., & Blaut, M. (2006) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2005.00057.x · Cited by 209
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Domingo, J. W. S., Bambic, D. G., Edge, T. A., & Wuertz, S. (2007) · Water Research · doi:10.1016/j.watres.2007.06.001 · Cited by 209
Jang, H.-M., Lee, K.-E., & Kim, D.-H. (2019) · Nutrients · doi:10.3390/nu11040819 · Cited by 208
Wernimont, S. M., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D. V., MacLeay, J. M., Jewell, D. E., & Suchodolski, J. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 244
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Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 229
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Metadata
- Authors
- Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I.
- Affiliations
- Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.
- Washington University in St. Louis (US)
- Corresponding author
- Ley, Ruth E.
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2005-03-25
- Volume
- 307
- Issue
- 5717
- Pages
- 1915-1920
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980914602
- Cited by
- 5,277
- References
- 37
- Citations by year
- 2026: 143 · 2025: 225 · 2024: 281 · 2023: 322 · 2022: 363 · 2021: 389 · 2020: 359 · 2019: 344 · 2018: 276 · 2017: 277 · 2016: 313 · 2015: 257 · 2014: 288 · 2013: 243 · 2012: 227
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- gut microbiota, human intestine, microbiome, coevolution, microbial diversity, strain-level diversity, nutrient acquisition, microbiological stability, keystone species, anaerobic bioreactor
- MeSH terms
- Anaerobiosis, Bacteria, Bacteroides, Energy Intake, Energy Metabolism, Biological Evolution, Humans, Intestines, Obesity, Selection, Genetic, Genome, Bacterial, Ecosystem, Bacterial Physiological Phenomena, Gastrointestinal Tract, Biodiversity
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