The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Host-Bacterial Mutualism in the Human Intestine
Abstract
The distal human intestine represents an anaerobic bioreactor programmed with an enormous population of bacteria, dominated by relatively few divisions that are highly diverse at the strain/subspecies level. This microbiota and its collective genomes (microbiome) provide us with genetic and metabolic attributes we have not been required to evolve on our own, including the ability to harvest otherwise inaccessible nutrients. New studies are revealing how the gut microbiota has coevolved with us and how it manipulates and complements our biology in ways that are mutually beneficial. We are also starting to understand how certain keystone members of the microbiota operate to maintain the stability and functional adaptability of this microbial organ.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increased gut permeability is thought to facilitate the movement of inflammatory mediators from the gut into the circulation, promoting systemic insulin resistance [134,136].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [136]
In the citing paper
“Most of the animal and human studies have reported that obesity and insulin resistance are associated with an altered ratio of Firmicutes and Bacteroidetes [8,9].”
From Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study (2019) · cites this paper as [9]
In the citing paper
“It is now understood that the gut microbiota coevolved with the human host over thousands of years and are integral to overall human physiology, playing a pivotal role in metabolism, immune system function and maintenance of gut homeostasis.1, 2”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [1]
In the citing paper
“This number is likely an underestimate given the lack of any systematic analyses of the gut microbial metabolism of drugs and the vast genetic diversity within the microbiome34.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [34]
In the citing paper
“A major function of the gut microbiota is to aid in host food digestion, harvesting key nutrients that the host is incapable of metabolizing without the help of microbes (Backhed et al., 2005).”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Backhed et al., 2005
In the citing paper
“Under healthy conditions, the microbiota influences numerous physiological processes within the host, such as protection against pathogens, nutrient digestion and absorption, development, and education of multiple host organs and the immune system (3–6).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [4]
Citations
Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Self-citationProkaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871
Energy conservation in chemotrophic anaerobic bacteria
Thauer, R. K., Jungermann, K., & Decker, K. (1977) · Bacteriological Reviews · doi:10.1128/br.41.1.100-180.1977 · Cited by 4,146
The diversity–stability debate
McCann, K. S. (2000) · Nature · doi:10.1038/35012234 · Cited by 3,220
Biodiversity and ecosystem productivity in a fluctuating environment: The insurance hypothesis
Yachi, S., & Loreau, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1463 · Cited by 3,211
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity
Hugenholtz, P., Goebel, B. M., & Pace, N. R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.18.4765-4774.1998 · Cited by 2,429
Marine viruses and their biogeochemical and ecological effects
Fuhrman, J. A. (1999) · Nature · doi:10.1038/21119 · Cited by 2,288
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360
A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- E. G. Zoetendal et al., Microb. Ecol. Health Dis.13, 129 (2001).
Cited by
Sorted by citations
Items 901–1,000 of 1,068
Sex-specific association between gut microbiome and fat distribution
Min, Y., Ma, X., Sankaran, K., Ru, Y., Chen, L., Baiocchi, M., & Zhu, S. (2019) · Nature Communications · doi:10.1038/s41467-019-10440-5 · Cited by 133
Koropatkin, N. M., & Smith, T. J. (2010) · Structure · doi:10.1016/j.str.2009.12.010 · Cited by 133
Fusobacterium and Enterobacteriaceae: Important players for CRC?
Allen‐Vercoe, E., & Jobin, C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.05.014 · Cited by 137
Aidy, S. E., Merrifield, C. A., Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Levenez, F., Dore, J. M., Dekker, J. P., Holmes, E. C., Claus, S. P., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301955 · Cited by 141
Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper
Fiocchi, A. G., Burks, W. A., Bahna, S. L., Bielory, L., Boyle, R. J., Cocco, R. R., Dreborg, S. K. G., Goodman, R. E., Kuitunen, M., Haahtela, T., et al. (2012) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3182784ee0 · Cited by 132
Oligosaccharides: a boon from nature’s desk
Belorkar, S. A., & Gupta, A. (2016) · AMB Express · doi:10.1186/s13568-016-0253-5 · Cited by 133
Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut
Crook, N., Ferreiro, A. L., Gasparrini, A. J., Pesesky, M. W., Gibson, M. K., Wang, B., Sun, X., Condiotte, Z. J., Dobrowolski, S., Peterson, D. A., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.005 · Cited by 134
Self-citationThe primate vaginal microbiome: Comparative context and implications for human health and disease
Stumpf, R. M., Wilson, B. A., Rivera, A. J., Yıldırım, S., Yeoman, C. J., Polk, J. D., White, B. A., & Leigh, S. R. (2013) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22395 · Cited by 134
MetaHIT: The European Union Project on Metagenomics of the Human Intestinal Tract
Ehrlich, S. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7089-3_15 · Cited by 132
Probiotics in the critically ill
Petrof, E. O., Dhaliwal, R., Manzanares, W., Johnstone, J., Cook, D., & Heyland, D. K. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318260cc33 · Cited by 137
Knecht, L. D., O'Connor, G., Mittal, R., Liu, X. Z., Daftarian, P., Deo, S. K., & Daunert, S. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.05.037 · Cited by 132
The human microbiome: A hot spot of microbial horizontal gene transfer
Liu, L., Chen, X., Skogerbø, G., Zhang, P., Chen, R., He, S., & Huang, D.-W. (2012) · Genomics · doi:10.1016/j.ygeno.2012.07.012 · Cited by 131
Kumar, R., Sood, U., Gupta, V., Singh, M., Scaria, J., & Lal, R. (2019) · Indian Journal of Microbiology · doi:10.1007/s12088-019-00808-y · Cited by 139
Notting, F., Pirovano, W., Sybesma, W., & Kort, R. (2023) · Gut Microbiome · doi:10.1017/gmb.2023.14 · Cited by 135
Reigstad, C. S., Östergren‐Lundén, G., Felin, J., & Bäckhed, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005842 · Cited by 131
Wang, Y., Devkota, S., Musch, M. W., Jabrì, B., Nagler‐Anderson, C., Antonopoulos, D. A., Chervonsky, A. V., & Chang, E. B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013607 · Cited by 129
Rendueles, O., Ferrières, L., Frétaud, M., Bégaud, É., Herbomel, P., Levraud, J., & Ghigo, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002815 · Cited by 134
Zhang, X., Yang, Y., Wu, Z., & Weng, P. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b00586 · Cited by 130
Nakata, K., Sugi, Y., Narabayashi, H., Kobayakawa, T., Nakanishi, Y., Tsuda, M., Hosono, A., Kaminogawa, S., Hanazawa, S., & Takahashi, K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.788596 · Cited by 137
The potter’s wheel: the host’s role in sculpting its microbiota
Bevins, C. L., & Salzman, N. H. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0830-3 · Cited by 134
Influence of Oral and Gut Microbiota in the Health of Menopausal Women
Vieira, A. T., Castelo, P. M., Ribeiro, D. A., & Ferreira, C. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01884 · Cited by 131
Mao, B., Gu, J., Li, D., Cui, S., Zhao, J., Zhang, H., & Chen, W. (2018) · Nutrients · doi:10.3390/nu10081105 · Cited by 129
Brugman, S., Ikeda‐Ohtsubo, W., Braber, S., Folkerts, G., Pieterse, C. M. J., & Bakker, P. A. H. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00080 · Cited by 134
Precision nutrition: A review of current approaches and future endeavors
Livingstone, K. M., Ramos-López, O., Përusse, L., Kato, H., Ordovás, J. M., & Martínez, J. A. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.08.017 · Cited by 140
Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes
Chen, X., & Devaraj, S. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1104-3 · Cited by 132
Fecal Microbiota Transplantation
Borody, T. J., & Campbell, J. (2012) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2012.08.008 · Cited by 143
Bifidobacterial Dialogue With Its Human Host and Consequent Modulation of the Immune System
Alessandri, G., Ossiprandi, M. C., MacSharry, J. A., van Sinderen, D., & Ventura, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02348 · Cited by 133
Microbiota Effects on Carcinogenesis: Initiation, Promotion, and Progression
Lopez, L. R., Bleich, R. M., & Arthur, J. C. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-080719-091604 · Cited by 136
Gut microbiota controlling radiation-induced enteritis and intestinal regeneration
Moraitis, I., Guiu, J., & Rubert, J. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.05.006 · Cited by 131
Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species
Kastman, E. K., Kamelamela, N., Norville, J. W., Cosetta, C. M., Dutton, R. J., & Wolfe, B. E. (2016) · mBio · doi:10.1128/mbio.01157-16 · Cited by 127
Effects of chlorpyrifos on the gut microbiome and urine metabolome in mouse (Mus musculus)
Zhao, Y., Zhang, Y., Wang, G., Han, R., & Xie, X. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.03.055 · Cited by 127
Microbial Metabolism Modulates Antibiotic Susceptibility within the Murine Gut Microbiome
Cabral, D. J., Penumutchu, S., Reinhart, E. M., Zhang, C., Korry, B. J., Wurster, J. I., Nilson, R., Guang, A., Sano, W. H., Rowan-Nash, A. D., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.020 · Cited by 132
Ecological rules for the assembly of microbiome communities
Coyte, K. Z., Rao, C., Rakoff-Nahoum, S., & Foster, K. R. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001116 · Cited by 124
The role of colonic metabolism in lactose intolerance
He, T., Venema, K., Priebe, M. G., Welling, G. W., Brummer, R. J., & Vonk, R. J. (2008) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.01966.x · Cited by 128
Early life events influence whole-of-life metabolic health via gut microflora and gut permeability
Kerr, C. A., Grice, D. M., Tran, C. D., Bauer, D. C., Li, D., Hendry, P. L., & Hannan, G. N. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2013.837863 · Cited by 129
Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome
Cox, M. J., Huang, Y. J., Fujimura, K. E., Liu, J. T., McKean, M., Boushey, H. A., Segal, M. R., Brodie, E., Cabana, M. D., & Lynch, S. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008745 · Cited by 129
Manipulation of the Gut Microbiota Reveals Role in Colon Tumorigenesis
Zackular, J. P., Baxter, N. T., Chen, G., & Schloss, P. D. (2015) · mSphere · doi:10.1128/msphere.00001-15 · Cited by 125
Staudacher, H. M., & Whelan, K. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000021 · Cited by 133
Treating Obesity and Metabolic Syndrome with Fecal Microbiota Transplantation.
Marotz, C. A., & Zarrinpar, A. (2016) · PubMed · Cited by 128
Stewart, C. J., Auchtung, T. A., Ajami, N. J., Velasquez, K. M., Smith, D. P., Garza, R. D. L., Salas, R., & Petrosino, J. F. (2018) · PeerJ · doi:10.7717/peerj.4693 · Cited by 124
Microbiome and diabetes: Where are we now?
Vallianou, N. G., Stratigou, T., & Tsagarakis, S. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.10.008 · Cited by 126
McKean, J., Naug, H., Nikbakht, E., Amiet, B., & Colson, N. (2017) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2016.0023 · Cited by 125
Endotoxemia, nutrition, and cardiometabolic disorders
Kallio, K. A. E., Hätönen, K. A., Lehto, M., Salomaa, V., Männistö, S., & Pussinen, P. J. (2015) · Acta Diabetologica · doi:10.1007/s00592-014-0662-3 · Cited by 125
Manderino, L., Carroll, I., Azcarate-Peril, M. A., Rochette, A., Heinberg, L., Peat, C., Steffen, K., Mitchell, J., & Gunstad, J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000492 · Cited by 125
Impact of stressor exposure on the interplay between commensal microbiota and host inflammation
Galley, J. D., & Bailey, M. T. (2014) · Gut Microbes · doi:10.4161/gmic.28683 · Cited by 125
Eguchi, S., Takatsuki, M., Hidaka, M., Soyama, A., Ichikawa, T., & Kanematsu, T. (2010) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2010.02.013 · Cited by 123
Association of gut microbiota with post-operative clinical course in Crohn’s disease
Dey, N., Soergel, D. A. W., Repo, S., & Brenner, S. E. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-131 · Cited by 125
Murine Models of Candida Gastrointestinal Colonization and Dissemination
Koh, A. Y. (2013) · Eukaryotic Cell · doi:10.1128/ec.00196-13 · Cited by 130
Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases
Dolan, K. T., & Chang, E. B. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600129 · Cited by 136
Bletz, M. C., Archer, H. M., Harris, R. N., McKenzie, V. J., Rabemananjara, F. C. E., Rakotoarison, A., & Vences, M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01530 · Cited by 129
Cheng, L., Qi, C., Zhuang, H., Fu, T., & Zhang, X. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa511 · Cited by 125
Maternal gut microbes shape the early-life assembly of gut microbiota in passerine chicks via nests
Chen, C.-Y., Chen, C.-K., Chen, Y.-Y., Fang, A., Shaw, G. T.-W., Hung, C., & Wang, D. (2020) · Microbiome · doi:10.1186/s40168-020-00896-9 · Cited by 127
Probiotics, prebiotics, and the host microbiome: the science of translation
Petschow, B., Doré, J., Hibberd, P., Dinan, T., Reid, G., Blaser, M., Cani, P. D., Degnan, F. H., Foster, J., Gibson, G., et al. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12303 · Cited by 124
Self-citationThe Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
Aydin, Ö., Nieuwdorp, M., & Gerdes, V. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1020-6 · Cited by 124
Metagenome and metabolism: the tissue microbiota hypothesis
Burcelin, R., Sérino, M., Chabo, C., Garidou, L., Pomié, C., Courtney, M., Amar, J., & Bouloumié, A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12157 · Cited by 130
Liu, Z., Li, C. L., Huang, M., Tong, C., Zhang, X., Wang, L., Peng, H., Lan, P., Zhang, P., Huang, N., et al. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0260-z · Cited by 124
The putative role of the intestinal microbiota in the irritable bowel syndrome.
Collins, S., Denou, E., Verdú, E., & Bercik, P. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.023 · Cited by 130
Prince, T., McBain, A. J., & O’Neill, C. A. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00595-12 · Cited by 133
Lyons, P. P., Turnbull, J. F., Dawson, K. A., & Crumlish, M. (2016) · Aquaculture Research · doi:10.1111/are.13080 · Cited by 124
New insights into therapeutic strategies for gut microbiota modulation in inflammatory diseases
Vieira, A. T., Fukumori, C., & Ferreira, C. M. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.38 · Cited by 125
A Review on Role of Microbiome in Obesity and Antiobesity Properties of Probiotic Supplements
Sivamaruthi, B. S., Kesika, P., Suganthy, N., & Chaiyasut, C. (2019) · BioMed Research International · doi:10.1155/2019/3291367 · Cited by 128
Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension
Zubcevic, J. A., Richards, E. M., Yang, T., Kim, S., Sumners, C., Pepine, C. J., & Raizada, M. K. (2019) · Circulation Research · doi:10.1161/circresaha.119.313965 · Cited by 126
Dietary protein and the intestinal microbiota: An understudied relationship
Bartlett, A., & Kleiner, M. (2022) · iScience · doi:10.1016/j.isci.2022.105313 · Cited by 134
Intestinal methane production in obese individuals is associated with a higher body mass index.
Basseri, R. J., Basseri, B., Pimentel, M., Chong, K., Youdim, A., Low, K., Hwang, L. J., Soffer, E., Chang, C. C.-C., & Mathur, R. (2012) · PubMed Central · Cited by 123
Response of Intestinal Microbiota to Antibiotic Growth Promoters in Chickens
Lin, J., Hunkapiller, A. A., Layton, A. C., Chang, Y., & Robbins, K. R. (2013) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2012.1348 · Cited by 131
Gut microbiome and anticancer immune response: really hot Sh*t!
Viaud, S., Daillère, R., Boneca, I. G., Lepage, P., Langella, P., Chamaillard, M., Pittet, M. J., Ghiringhelli, F., Trinchieri, G., Goldszmid, R., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.56 · Cited by 123
Reis, D. J., Ilardi, S. S., & Punt, S. E. W. (2018) · PLOS ONE · doi:10.1371/journal.pone.0199041 · Cited by 123
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology
Xie, J., Bruggeman, A., De Nolf, C., Vandendriessche, C., Van Imschoot, G., Van Wonterghem, E., Vereecke, L., & Vandenbroucke, R. E. (2023) · The EMBO Journal · doi:10.15252/embj.2022111515 · Cited by 125
Park, H. ‐., Lee, S. E., Kim, H. ‐., Isaacson, R. E., Seo, K., & Song, K.-H. (2014) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12455 · Cited by 134
Impact of enteric bacterial infections at and beyond the epithelial barrier
Rogers, A. P., Mileto, S. J., & Lyras, D. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00794-x · Cited by 132
The role of the gut microbiota in health and cardiovascular diseases
Wang, L., Wang, S., Zhang, Q., He, C., Fu, C., & Wei, Q. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00091-2 · Cited by 132
Structure and functions of exopolysaccharide produced by gut commensal Lactobacillus reuteri 100-23
Sims, I. M., Frese, S. A., Walter, J., Loach, D. M., Wilson, M., Appleyard, K., Eason, J. R., Livingston, M. K., Baird, M. A., Cook, G. M., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.201 · Cited by 126
Mucosal immune dysfunction in AIDS pathogenesis.
Paiardini, M., Frank, I., Pandrea, I., Apetrei, C., & Silvestri, G. (2008) · PubMed · Cited by 122
van Zanten, G. C., Knudsen, A. S., Röytiö, H., Forssten, S. D., Lawther, M., Blennow, A., Lahtinen, S. J., Jakobsen, M., Svensson, B., & Jespersen, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047212 · Cited by 125
Infection, inflammation, and chronic diseases: consequences of a modern lifestyle
Ehlers, S., & Kaufmann, S. H. E. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.02.003 · Cited by 124
Ng, S. C., Benjamin, J. L., McCarthy, N. E., Hedin, C. R. H., Koutsoumpas, A. L., Plamondon, S., Price, C. L., Hart, A. L., Kamm, M. A., Forbes, A., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21590 · Cited by 131
Sabico, S., Al-Mashharawi, A., Al‐Daghri, N. M., Yakout, S. M., Alnaami, A. M., Alokail, M. S., & McTernan, P. G. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1354-x · Cited by 122
Systems biology in hepatology: approaches and applications
Mardinoğlu, A., Borén, J., Smith, U., Uhlén, M., & Nielsen, J. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0007-8 · Cited by 127
Ríos-Covián, D., Arboleya, S., Hernández‐Barranco, A. M., Álvarez-Buylla, J. R., Ruas‐Madiedo, P., Gueimonde, M., & Reyes‐Gavilán, C. G. D. L. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.02545-13 · Cited by 122
I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life
Lorenzo‐Zúñiga, V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8709 · Cited by 120
Hakim, J. A., Koo, H., Kumar, R., Lefkowitz, E. J., Morrow, C. D., Powell, M. L., Watts, S. A., & Bej, A. K. (2016) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw146 · Cited by 121
Eukaryotic protein glycosylation: a primer for histochemists and cell biologists
Corfield, A. P. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1526-4 · Cited by 123
Frost, F., Storck, L. J., Kacprowski, T., Gärtner, S., Rühlemann, M. C., Bang, C., Franke, A., Völker, U., Aghdassi, A. A., Steveling, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219489 · Cited by 125
Ribeiro, C. F. A., Silveira, G. G. D. O. S., Cândido, E. D. S., Cardoso, M. H. E. S., Carvalho, C. M. E., & Franco, O. L. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00036 · Cited by 126
Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome
Gao, A., Su, J., Liu, R., Zhao, S., Wen, L., Xu, X., Li, D., Shi, J., Gu, B., Zhang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27187-7 · Cited by 123
Isolation of flagellated bacteria implicated in Crohnʼs disease
Duck, W. L., Walter, M. R., Novák, J., Kelly, D., Tomasi, M., Cong, Y., & Elson, C. O. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20237 · Cited by 121
Russell, G., Kaplan, J., Ferraro, M., & Michelow, I. C. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3363 · Cited by 120
Masse, K. E., & Lu, V. B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1169624 · Cited by 120
“In earlier studies, obesity and insulin resistance were associated with an increased abundance of Bacillota and concomitant decrease of Bacteroidota in both animal (7, 168), and human studies (6, 167, 169).”
BackgroundMetagenomics and biological ontology
Dupré, J., & O’Malley, M. A. (2007) · Studies in History and Philosophy of Science Part C Studies in History and Philosophy of Biological and Biomedical Sciences · doi:10.1016/j.shpsc.2007.09.001 · Cited by 121
Gut Microbiota, Inflammation, and Probiotics on Neural Development in Autism Spectrum Disorder
Doenyas, C. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.060 · Cited by 123
Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus
Ma, Y., Xu, X., Li, M., Cai, J., Wei, Q., & Niu, H. (2019) · Molecular Medicine · doi:10.1186/s10020-019-0102-5 · Cited by 120
Lactobacillus acidophilus Membrane Vesicles as a Vehicle of Bacteriocin Delivery
Dean, S. N., Rimmer, M. A., Turner, K. B., Phillips, D. A., Caruana, J. C., Hervey, W. J., Leary, D. H., & Walper, S. A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00710 · Cited by 122
Hajjar, R., González, E., Fragoso, G., Oliero, M., Alaoui, A. A., Calvé, A., Rendos, H. V., Djediai, S., Cuisiniere, T., Laplante, P., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-328389 · Cited by 127
Wu, R., Xiong, R., Li, Y., Chen, J., & Yan, R. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103062 · Cited by 124
Correlation of intestinal microbiota with overweight and obesity in Kazakh school children
Xu, P., Li, M., Zhang, J., & Zhang, T. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-283 · Cited by 120
Gut microbiota of mice putatively modifies amino acid metabolism in the host brain
Kawase, T., Nagasawa, M., Ikeda, H., Yasuo, S., Koga, Y., & Furuse, M. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517000678 · Cited by 119
Johansson, M., & Hansson, G. C. (2013) · Digestive Diseases · doi:10.1159/000354683 · Cited by 119
Takeshita, K., & Kikuchi, Y. (2016) · Research in Microbiology · doi:10.1016/j.resmic.2016.11.005 · Cited by 119
Dynamic and Asymmetric Changes of the Microbial Communities after Cohousing in Laboratory Mice
Caruso, R., Ono, M., Bunker, M. E., Núñez, G., & Inohara, N. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.042 · Cited by 120
Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects
Malaguarnera, L. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106112 · Cited by 120
Metadata
- Authors
- Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I.
- Affiliations
- Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.
- Washington University in St. Louis (US)
- Corresponding author
- Ley, Ruth E.
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2005-03-25
- Volume
- 307
- Issue
- 5717
- Pages
- 1915-1920
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980914602
- Cited by
- 5,277
- References
- 37
- Citations by year
- 2026: 143 · 2025: 225 · 2024: 281 · 2023: 322 · 2022: 363 · 2021: 389 · 2020: 359 · 2019: 344 · 2018: 276 · 2017: 277 · 2016: 313 · 2015: 257 · 2014: 288 · 2013: 243 · 2012: 227
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- gut microbiota, human intestine, microbiome, coevolution, microbial diversity, strain-level diversity, nutrient acquisition, microbiological stability, keystone species, anaerobic bioreactor
- MeSH terms
- Anaerobiosis, Bacteria, Bacteroides, Energy Intake, Energy Metabolism, Biological Evolution, Humans, Intestines, Obesity, Selection, Genetic, Genome, Bacterial, Ecosystem, Bacterial Physiological Phenomena, Gastrointestinal Tract, Biodiversity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
