Cited by 1,184Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyGastrointestinal motility and disorders

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Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

Sonnenburg, Justin L., Xu, Jian, Leip, Douglas D., Chen, Chien-Huan, Westover, Benjamin P., Weatherford, Jeremy, Buhler, Jeremy D., Gordon, Jeffrey I.·2005·Science

DOI 10.1126/science.1109051

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Abstract

Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.

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We thank D. O'Donnell M. Karlsson S. Wagoner L. Gaynon J. Dant and the University of California San Diego Glycotechnology Core Facility for invaluable assistance and our colleagues R. Ley F. Backhed and E. Sonnenburg for many helpful comments. Supported by NIH grants DK30292 and DK052574. All GeneChip data sets have been deposited in Gene Expression Omnibus under accession number GSE2231 (www.ncbi.nlm.nih.gov/geo).

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Authors: Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Gordon, Jeffrey I.
ORCID: Sonnenburg, Justin L.
Xu, Jian
Chen, Chien-Huan
Buhler, Jeremy D.
Gordon, Jeffrey I.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-03-25
Volume: 307
Issue: 5717
Pages: 1955-1959
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1109051
OpenAlex: W2044977356
Semantic Scholar: 5770f825e573c00badca438062410bc63cf95bdc
Cited by: 1,184
References: 17
Citations by year: 2026: 39 · 2025: 40 · 2024: 74 · 2023: 69 · 2022: 79 · 2021: 85 · 2020: 78 · 2019: 52 · 2018: 65 · 2017: 69 · 2016: 76 · 2015: 58 · 2014: 78 · 2013: 53 · 2012: 43
FWCI: 12.55
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK‐052574, DK-30292, P30DK052574)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Bacteroides thetaiotaomicron, host-microbe interactions, polysaccharide utilization, glycoside hydrolases, germ-free mice, diet, gut microbiota
MeSH terms: Adaptation, Physiological, Animals, Bacterial Proteins, Bacteroides, Cecum, Diet, Dietary Carbohydrates, Germ-Free Life, Glycoside Hydrolases, Hexoses, Intestines, Male, Mucus, Operon, Polysaccharide-Lyases, Polysaccharides, Symbiosis, Transcription, Genetic, Up-Regulation, Gene Expression Regulation, Bacterial, Cluster Analysis, Ecosystem, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice

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Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

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