Cited by 1,184Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyGastrointestinal motility and disorders

The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.

Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

Sonnenburg, Justin L., Xu, Jian, Leip, Douglas D., Chen, Chien-Huan, Westover, Benjamin P., Weatherford, Jeremy, Buhler, Jeremy D., Gordon, Jeffrey I.·2005·Science

DOI 10.1126/science.1109051

Open this paper in CoChat — free account

Abstract

Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.

Integrity signals

Registry

Crossref · 10.1126/science.1109051

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Self-citation
Biodiversity and ecosystem productivity in a fluctuating environment: The insurance hypothesis
Yachi, S., & Loreau, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1463 · Cited by 3,211
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Self-citation
H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE
Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623
Self-citation
A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353
Self-citation
Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians
Moore, W. E. C., & Holdeman, L. V. (1974) · Applied Microbiology · doi:10.1128/am.27.5.961-979.1974 · Cited by 1,144
Honor thy symbionts
Xu, J., & Gordon, J. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734063100 · Cited by 890
Self-citation
A Model of Host-Microbial Interactions in an Open Mammalian Ecosystem
Bry, L., Falk, P. G., Midtvedt, T., & Gordon, J. I. (1996) · Science · doi:10.1126/science.273.5280.1380 · Cited by 607
Self-citation
Carbon nutrition of Escherichia coli in the mouse intestine
Chang, D., Smalley, D. J., Tucker, D. L., Leatham, M. P., Norris, W. E., Stevenson, S. J., Anderson, A. B., Grissom, J. E., Laux, D. C., Cohen, P. S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307888101 · Cited by 513

Flagged first, then by citations

Show all 17 references

1 of the 17 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

We thank D. O'Donnell M. Karlsson S. Wagoner L. Gaynon J. Dant and the University of California San Diego Glycotechnology Core Facility for invaluable assistance and our colleagues R. Ley F. Backhed and E. Sonnenburg for many helpful comments. Supported by NIH grants DK30292 and DK052574. All GeneChip data sets have been deposited in Gene Expression Omnibus under accession number GSE2231 (www.ncbi.nlm.nih.gov/geo).

Sorted by citations

Items 201–300 of 998

Sphingolipids in host–microbial interactions
Heaver, S. L., Johnson, E. L., & Ley, R. E. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.12.011 · Cited by 221
The immune system bridges the gut microbiota with systemic energy homeostasis: focus on TLRs, mucosal barrier, and SCFAs
Spiljar, M., Merkler, D., & Trajkovski, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01353 · Cited by 219
Biomass Utilization by Gut Microbiomes
White, B. A., Lamed, R., Bayer, E. A., & Flint, H. J. (2014) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155618 · Cited by 217
Human symbionts inject and neutralize antibacterial toxins to persist in the gut
Wexler, A. G., Bao, Y., Whitney, J. C. C., Bobay, L., Xavier, J. B., Schofield, W. B., Barry, N. A., Russell, A. B., Tran, B. Q., Goo, Y. A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525637113 · Cited by 220
The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications
Goldsmith, J. R., & Sartor, R. B. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-0953-z · Cited by 224
The Uptake, Trafficking, and Biodistribution of Bacteroides thetaiotaomicron Generated Outer Membrane Vesicles
Jones, E. J., Booth, C., Fonseca, S., Parker, A., Cross, K. L., Miquel-Clopés, A., Hautefort, I., Mayer, U., Wileman, T. E., Stentz, R., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00057 · Cited by 219
Bacterial Flagella: Twist and Stick, or Dodge across the Kingdoms
Rossez, Y., Wolfson, E. B., Holmes, A., Gally, D. L., & Holden, N. J. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004483 · Cited by 216
Investigations of Bacteroides spp. towards next-generation probiotics
Tan, H., Zhai, Q., & Chen, W. (2018) · Food Research International · doi:10.1016/j.foodres.2018.08.088 · Cited by 228
Metabolic Model-Based Integration of Microbiome Taxonomic and Metabolomic Profiles Elucidates Mechanistic Links between Ecological and Metabolic Variation
Noecker, C. A., Eng, A., Srinivasan, S., Theriot, C. M., Young, V. B., Jansson, J. K., Fredricks, D. N., & Borenstein, E. (2016) · mSystems · doi:10.1128/msystems.00013-15 · Cited by 217
The Impact of Mushroom Polysaccharides on Gut Microbiota and Its Beneficial Effects to Host: A Review
Yin, C., Noratto, G. D., Fan, X., Chen, Z., Yao, F., Shi, D., & Gao, H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116942 · Cited by 217
Host sialoglycans and bacterial sialidases: a mucosal perspective
Lewis, A. L., & Lewis, W. G. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01807.x · Cited by 210
A single regulatory gene is sufficient to alter bacterial host range
Mandel, M. J., Wollenberg, M. S., Stabb, E. V., Visick, K. L., & Ruby, E. G. (2009) · Nature · doi:10.1038/nature07660 · Cited by 206
Defects in mucosal immunity leading to Crohn's disease
Cobrin, G. M., & Abreu, M. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00293.x · Cited by 214
Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism
Tong, M., McHardy, I. H., Ruegger, P. M., Goudarzi, M., Kashyap, P., Haritunians, T., Li, X., Graeber, T. G., Schwager, E., Huttenhower, C., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.64 · Cited by 213
Self-citation
Salmonella versus the Microbiome
Rogers, A. W. L., Tsolis, R. M., & Bäumler, A. J. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-19 · Cited by 207
The gastrointestinal microbiota and colorectal cancer
Keku, T. O., Dulal, S., Deveaux, A. E., Jovov, B., & Han, X. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2012 · Cited by 207
Evolution of Bacterial Pathogens Within the Human Host
Bliven, K. A., & Maurelli, A. T. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0017-2015 · Cited by 212
Role of gut microbiota in cardiovascular diseases
Novaković, M., Rout, A., Kingsley, T. C., Kirchoff, R. W., Singh, A., Verma, V. K., Kant, R., & Chaudhary, R. (2020) · World Journal of Cardiology · doi:10.4330/wjc.v12.i4.110 · Cited by 213
Motility allows S. Typhimurium to benefit from the mucosal defence
Stecher, B., Barthel, M., Schlumberger, M. C., Haeberli, L., Rabsch, W., Kremer, M., & Hardt, W. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01118.x · Cited by 198
Inter-individual differences in the gene content of human gut bacterial species
Zhu, A., Sunagawa, S., Mende, D. R., & Bork, P. (2015) · Genome biology · doi:10.1186/s13059-015-0646-9 · Cited by 205
Gut Bacteriophage: Current Understanding and Challenges
Sutton, T., & Hill, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00784 · Cited by 199
Genomics and ecological overview of the genus Bifidobacterium
Turroni, F., van Sinderen, D., & Ventura, M. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.12.010 · Cited by 201
Effects of dietary components on intestinal permeability in health and disease
Khoshbin, K., & Camilleri, M. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00245.2020 · Cited by 206
Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity
Dennis, R. J., Taylor, E. J., Macauley, M. S., Stubbs, K. A., Turkenburg, J. P., Hart, S., Black, G. N., Vocadlo, D. J., & Davies, G. J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1079 · Cited by 195
Interspecies cross-feeding orchestrates carbon degradation in the rumen ecosystem
Solden, L., Naas, A. E., Roux, S., Daly, R. A., Collins, W., Nicora, C., Purvine, S. O., Hoyt, D. W., Schückel, J., Jørgensen, B., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0225-4 · Cited by 195
Bacteroides thetaiotaomicron Ameliorates Colon Inflammation in Preclinical Models of Crohn’s Disease
Delday, M., Mulder, I., Logan, E. T., & Grant, G. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy281 · Cited by 193
Gut Microbial Succession Follows Acute Secretory Diarrhea in Humans
David, L. A., Weil, A. A., Ryan, E. T., Calderwood, S. B., Harris, J. B., Chowdhury, F., Begum, Y. A., Qadri, F., LaRocque, R. C., & Turnbaugh, P. J. (2015) · mBio · doi:10.1128/mbio.00381-15 · Cited by 187
Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium
Egan, M., Motherway, M. O., Kilcoyne, M., Kane, M., Joshi, L., Ventura, M., & van Sinderen, D. (2014) · BMC Microbiology · doi:10.1186/s12866-014-0282-7 · Cited by 193
Molecular link between dietary fibre, gut microbiota and health
Kumar, J., Rani, K., & Datt, C. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05611-3 · Cited by 211
The Gut Microbiota and Liver Disease
Llorente, C., & Schnabl, B. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.04.003 · Cited by 195
Comparative analysis of proteins with a mucus-binding domain found exclusively in lactic acid bacteria
Boekhorst, J., Helmer, Q., Kleerebezem, M., & Siezen, R. J. (2005) · Microbiology · doi:10.1099/mic.0.28415-0 · Cited by 201
Dietary Arginine Supplementation of Mice Alters the Microbial Population and Activates Intestinal Innate Immunity
Ren, W., Chen, S., Yin, J., Duan, J., Li, T., Liu, G., Feng, Z., Tan, B., Yin, Y., & Wu, G. (2014) · Journal of Nutrition · doi:10.3945/jn.114.192120 · Cited by 190
Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice
Bergstrom, K., Fu, J., Johansson, M., Liu, X., Gao, N., Wu, Q., Song, J., McDaniel, J. M., McGee, S., Chen, W., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.45 · Cited by 188
Host Selection of Microbiota via Differential Adhesion
McLoughlin, K. G., Schlüter, J., Rakoff-Nahoum, S., Smith, A. L., & Foster, K. R. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.02.021 · Cited by 185
Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia
Lanis, J. M., Alexeev, E. E., Curtis, V. F., Kitzenberg, D., Kao, D. J., Battista, K. D., Gerich, M. E., Glover, L. E., Kominsky, D., & Colgan, S. P. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.133 · Cited by 193
Exopolysaccharides Produced by Lactic Acid Bacteria and Bifidobacteria as Fermentable Substrates by the Intestinal Microbiota
Salazar, N., Gueimonde, M., de los Reyes-Gavilán, C. G., & Ruas-Madiedo, P. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.770728 · Cited by 188
Large-Scale Survey of Gut Microbiota Associated With MHE Via 16S rRNA-Based Pyrosequencing
Zhang, Z., Zhai, H., Geng, J., Yu, R., Ren, H.-Q., Fan, H., & Shi, P. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.221 · Cited by 186
Modulation of immune homeostasis by commensal bacteria
Ivanov, I. I., & Littman, D. R. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.12.003 · Cited by 188
Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans
Pudlo, N. A., Urs, K., Kumar, S. S., German, J. B., Mills, D. A., & Martens, E. C. (2015) · mBio · doi:10.1128/mbio.01282-15 · Cited by 187
Microbial Biogeography and Core Microbiota of the Rat Digestive Tract
Li, D., Chen, H., Mao, B., Yang, Q., Zhao, J., Gu, Z., Zhang, H., Chen, Y. Q., & Chen, W. (2017) · Scientific Reports · doi:10.1038/srep45840 · Cited by 191
Beneficial Effect of Intestinal Fermentation of Natural Polysaccharides
Zhang, T., Yang, Y., Liang, Y., Jiao, X., & Zhao, C. (2018) · Nutrients · doi:10.3390/nu10081055 · Cited by 190
Integrative Physiology of Fasting
Secor, S. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150013 · Cited by 183
Coordinate Regulation of Glycan Degradation and Polysaccharide Capsule Biosynthesis by a Prominent Human Gut Symbiont
Martens, E. C., Roth, R. A., Heuser, J. E., & Gordon, J. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008094 · Cited by 190
Self-citation
Impact of mycotoxins on the intestine: are mucus and microbiota new targets?
Robert, H., Payros, D., Pinton, P., Théodorou, V., Mercier‐Bonin, M., & Oswald, I. P. (2017) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2017.1326071 · Cited by 193
Patterns of Early-Life Gut Microbial Colonization during Human Immune Development: An Ecological Perspective
Laforest‐Lapointe, I., & Arrieta, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00788 · Cited by 195
The interplay between host immune cells and gut microbiota in chronic inflammatory diseases
Kim, D.-H., Zeng, M. Y., & Núñez, G. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.24 · Cited by 191
Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial
Corbin, K. D., Carnero, E. Á., Dirks, B., IGUDESMAN, D. A., Yi, F., Marcus, A. K., Davis, T. L., Pratley, R. E., Rittmann, B. E., Krajmalnik‐Brown, R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38778-x · Cited by 193
Intestinal Fucose as a Mediator of Host–Microbe Symbiosis
Pickard, J. M., & Chervonsky, A. V. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500395 · Cited by 184
High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction
Rastmanesh, R. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.10.002 · Cited by 180
Genetics and Environmental Interactions Shape the Intestinal Microbiome to Promote Inflammatory Bowel Disease Versus Mucosal Homeostasis
Sartor, R. B. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.036 · Cited by 164
A refined palate: Bacterial consumption of host glycans in the gut
Marcobal, A. M., Southwick, A. M., Earle, K. A., & Sonnenburg, J. L. (2013) · Glycobiology · doi:10.1093/glycob/cwt040 · Cited by 178
Self-citation
Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth
Goffredo, M., Maas, K. R., Parks, E. J., Wagner, D. A., McClure, E. A., Graf, J., Savoye, M., Pierpont, B. M., Cline, G. W., & Santoro, N. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1797 · Cited by 188
Shigella Diversity and Changing Landscape: Insights for the Twenty-First Century
Anderson, M. C., Sansonetti, P. J., & Marteyn, B. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00045 · Cited by 184
Sulfatases and a Radical S-Adenosyl-l-methionine (AdoMet) Enzyme Are Key for Mucosal Foraging and Fitness of the Prominent Human Gut Symbiont, Bacteroides thetaiotaomicron
Benjdia, A., Martens, E. C., Gordon, J. I., & Berteau, O. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228841 · Cited by 173
Self-citation
Directed Culturing of Microorganisms Using Metatranscriptomics
Bomar, L., Maltz, M. A., Colston, S. M., & Graf, J. (2011) · mBio · doi:10.1128/mbio.00012-11 · Cited by 170
Signaling in Host-Associated Microbial Communities
Fischbach, M. A., & Segre, J. A. (2016) · Cell · doi:10.1016/j.cell.2016.02.037 · Cited by 180
Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere
Baquero, F., Lanza, V. F., Baquero, M.-R., del Campo, R., & Bravo-Vázquez, D. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02261 · Cited by 174
Ecology and metabolism of the beneficial intestinal commensal bacteriumFaecalibacterium prausnitzii
Miquel, S., Martín, R., Bridonneau, C., Robert, V., Sokol, H., Bermúdez‐Humarán, L. G., Thomas, M., & Langella, P. (2014) · Gut Microbes · doi:10.4161/gmic.27651 · Cited by 177
Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions
Feng, J., Qian, Y., Zhou, Z., Sarah, E., Vivas, E. I., Lan, F., Hamilton, J. J., Rey, F. E., Anantharaman, K., & Venturelli, O. S. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2021.12.006 · Cited by 173
Oligosaccharides Released from Milk Glycoproteins Are Selective Growth Substrates for Infant-Associated Bifidobacteria
Karav, S., Parc, A. L., Bell, J. M. L. N. D. M., Frese, S. A., Kirmiz, N., Block, D. E., Barile, D., & Mills, D. A. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.00547-16 · Cited by 176
The Battle Within: Interactions of Bacteriophages and Bacteria in the Gastrointestinal Tract
Sordi, L. D., Lourenço, M., & Debarbieux, L. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.018 · Cited by 168
Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine
An, D., Na, C., Bielawski, J., Hannun, Y. A., & Kasper, D. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001501107 · Cited by 167
Links between environment, diet, and the hunter-gatherer microbiome
Fragiadakis, G. K., Smits, S. A., Sonnenburg, E. D., Treuren, W. V., Reid, G., Knight, R. D., Manjurano, A. M., Changalucha, J. M., Domínguez-Bello, M. G., Leach, J. D., et al. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1494103 · Cited by 168
Self-citation
Diversity, vitality and activities of intestinal lactic acid bacteria and bifidobacteria assessed by molecular approaches
Vaughan, E. E., Heilig, H. G. H. J., BENAMOR, K., & DEVOS, W. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.04.009 · Cited by 191
Cross-Domain and Viral Interactions in the Microbiome
Rowan-Nash, A. D., Korry, B. J., Mylonakis, E. E., & Belenky, P. A. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00044-18 · Cited by 173
Resistant starch, microbiome, and precision modulation
Dobranowski, P., & Stintzi, A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1926842 · Cited by 168
Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer
Kuugbee, E. D., Shang, X., Gamallat, Y., Bamba, D., Awadasseid, A., Suliman, M. A., Zang, S., Ma, Y., Chiwala, G., Xin, Y., et al. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4238-7 · Cited by 165
A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism
Sonnenburg, E. D., Sonnenburg, J. L., Manchester, J. K., Hansen, E. E., Chiang, H. C., & Gordon, J. I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603249103 · Cited by 163
Self-citation
Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments
Liu, H., Shiver, A. L., Price, M. N., Carlson, H. K., Trotter, V. V., Chen, Y., Escalante, V., Ray, J., Hern, K. E., Petzold, C. J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108789 · Cited by 157
Vibrio fischeri and its host: it takes two to tango
Visick, K. L., & Ruby, E. G. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.10.001 · Cited by 160
Human microbiome signatures of differential colorectal cancer drug metabolism
Guthrie, L., Gupta, S., Daily, J. P., & Kelly, L. (2017) · npj Biofilms and Microbiomes · doi:10.1038/s41522-017-0034-1 · Cited by 169
Phase-variable capsular polysaccharides and lipoproteins modify bacteriophage susceptibility in Bacteroides thetaiotaomicron
Porter, N. T., Hryckowian, A. J., Merrill, B. D., Fuentes, J. J., Gardner, J. O., Glowacki, R. W. P., Singh, S., Crawford, R., Snitkin, E. S., Sonnenburg, J. L., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0746-5 · Cited by 166
Self-citation
In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut
Rawls, J. F., Mahowald, M. A., Goodman, A. L., Trent, C. M., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702386104 · Cited by 159
Self-citation
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway
Xiong, T., Zheng, X., Zhang, K., Wu, H.-S., Dong, Y., Zhou, F.-C., Cheng, B., Li, L.-Z., Xu, W., Su, J., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115001 · Cited by 168
Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection
Wlodarska, M., Willing, B. P., Bravo, D. M., & Finlay, B. B. (2015) · Scientific Reports · doi:10.1038/srep09253 · Cited by 160
Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?
Berry, D., & Reinisch, W. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.005 · Cited by 154
Selective Utilization of the Human Milk Oligosaccharides 2′-Fucosyllactose, 3-Fucosyllactose, and Difucosyllactose by Various Probiotic and Pathogenic Bacteria
Salli, K. M., Hirvonen, J., Siitonen, J., Ahonen, I., Anglenius, H., & Maukonen, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06041 · Cited by 160
Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors
Simpson, R. C., Shanahan, E. R., Scolyer, R. A., & Long, G. V. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00803-9 · Cited by 153
Functional Genomic Studies of Uropathogenic Escherichia coli and Host Urothelial Cells when Intracellular Bacterial Communities Are Assembled
Reigstad, C. S., Hultgren, S. J., & Gordon, J. I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611502200 · Cited by 152
Self-citation
Mechanisms of weight loss and improved metabolism following bariatric surgery
Mulla, C. M., Middelbeek, R. J. W., & Patti, M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13409 · Cited by 161
Modifications of Glycans: Biological Significance and Therapeutic Opportunities
Muthana, S. M., Campbell, C. T., & Gildersleeve, J. C. (2011) · ACS Chemical Biology · doi:10.1021/cb2004466 · Cited by 151
The human microbiome and bile acid metabolism: Dysbiosis, dysmetabolism, disease and intervention
Jones, M. L., Martoni, C. J., Ganopolsky, J. G., Labbé, A., & Prakash, S. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.880420 · Cited by 150
Characterization of the Gut Microbiota in Six Geographical Populations of Chinese Rhesus Macaques (Macaca mulatta), Implying an Adaptation to High-Altitude Environment
Zhao, J., Yao, Y., Li, D., Xu, H., Wu, J., Wen, A., Xie, M., Ni, Q., Zhang, M., Peng, G., et al. (2018) · Microbial Ecology · doi:10.1007/s00248-018-1146-8 · Cited by 148
Mucus Layers in Inflammatory Bowel Disease
Johansson, M. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000117 · Cited by 150
Inflammatory bowel disease, past, present and future: lessons from animal models
Mizoguchi, A., & Mizoguchi, E. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-007-2111-3 · Cited by 147
Characterization of the Primary Starch Utilization Operon in the Obligate Anaerobe Bacteroides fragilis : Regulation by Carbon Source and Oxygen
Spence, C., Wells, W. G., & Smith, C. J. (2006) · Journal of Bacteriology · doi:10.1128/jb.00125-06 · Cited by 147
NAD precursors cycle between host tissues and the gut microbiome
Chellappa, K., McReynolds, M. R., Lu, W., Zeng, X., Makarov, M., Hayat, F., Mukherjee, S., Bhat, Y. R., Lingala, S. R., Shima, R. T., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.004 · Cited by 146
Multi-layered regulation of intestinal antimicrobial defense
Mukherjee, S., Vaishnava, S., & Hooper, L. V. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8182-3 · Cited by 154
Modulation of Intestinal Goblet Cell Function during Infection by an Attaching and Effacing Bacterial Pathogen
Bergstrom, K., Guttman, J. A., Rumi, M. A. K., Ma, C., Bouzari, S., Khan, M. A., Gibson, D. L., Vogl, A. W., & Vallance, B. A. (2007) · Infection and Immunity · doi:10.1128/iai.00093-07 · Cited by 141
Bacterial Metabolism Shapes the Host–Pathogen Interface
Passalacqua, K. D., Charbonneau, M., & O’Riordan, M. X. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0027-2015 · Cited by 149
Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview
Daïen, C., Pinget, G. V., Tan, J. K., & Macia, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00548 · Cited by 147
TLR4 signalling in the intestine in health and disease
Fukata, M., & Abreu, M. T. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351473 · Cited by 142
Bifidobacterium longum subsp. infantis uses two different β-galactosidases for selectively degrading type-1 and type-2 human milk oligosaccharides
Yoshida, E., Sakurama, H., Kiyohara, M., Nakajima, M., Kitaoka, M., Ashida, H., Hirose, J., Katayama, T., Yamamoto, K., & Kumagai, H. (2011) · Glycobiology · doi:10.1093/glycob/cwr116 · Cited by 140
Salmonella Typhimurium Diarrhea Reveals Basic Principles of Enteropathogen Infection and Disease-Promoted DNA Exchange
Wotzka, S. Y., Nguyen, B. D., & Hardt, W. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.009 · Cited by 141
Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes
Poole, A. C., Goodrich, J. K., Youngblut, N. D., Luque, G. G., Ruaud, A., Sutter, J. L., Waters, J. L., Shi, Q., El-Hadidi, M. S., Johnson, L. M., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.03.001 · Cited by 143
Good Gone Bad: One Toxin Away From Disease for Bacteroides fragilis
Valguarnera, E., & Wardenburg, J. B. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.003 · Cited by 141
Bacteroides thetaiotaomicron
Porter, N. T., Luis, A. S., & Martens, E. C. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.08.005 · Cited by 139
The convergence of carbohydrate active gene repertoires in human gut microbes
Lozupone, C. A., Hamady, M., Cantarel, B. L., Coutinho, P. M., Henrissat, B., Gordon, J. I., & Knight, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807339105 · Cited by 139
Self-citation
Bacteroides thetaiotaomicron in the gut: Molecular aspects of their interaction
Zocco, M. A., Ainora, M. E., Gasbarrini, A., & Gasbarrini, A. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.04.003 · Cited by 138
Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health
Ha, C. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16498 · Cited by 137

Authors: Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Gordon, Jeffrey I.
ORCID: Sonnenburg, Justin L.
Xu, Jian
Chen, Chien-Huan
Buhler, Jeremy D.
Gordon, Jeffrey I.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-03-25
Volume: 307
Issue: 5717
Pages: 1955-1959
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1109051
OpenAlex: W2044977356
Semantic Scholar: 5770f825e573c00badca438062410bc63cf95bdc
Cited by: 1,184
References: 17
Citations by year: 2026: 39 · 2025: 40 · 2024: 74 · 2023: 69 · 2022: 79 · 2021: 85 · 2020: 78 · 2019: 52 · 2018: 65 · 2017: 69 · 2016: 76 · 2015: 58 · 2014: 78 · 2013: 53 · 2012: 43
FWCI: 12.55
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK‐052574, DK-30292, P30DK052574)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Bacteroides thetaiotaomicron, host-microbe interactions, polysaccharide utilization, glycoside hydrolases, germ-free mice, diet, gut microbiota
MeSH terms: Adaptation, Physiological, Animals, Bacterial Proteins, Bacteroides, Cecum, Diet, Dietary Carbohydrates, Germ-Free Life, Glycoside Hydrolases, Hexoses, Intestines, Male, Mucus, Operon, Polysaccharide-Lyases, Polysaccharides, Symbiosis, Transcription, Genetic, Up-Regulation, Gene Expression Regulation, Bacterial, Cluster Analysis, Ecosystem, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks