The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium
Abstract
Several described growth factors influence the proliferation and regeneration of the intestinal epithelium. Using a transgenic mouse model, we identified a human gene, R-spondin1 , with potent and specific proliferative effects on intestinal crypt cells. Human R-spondin1 (hRSpo1) is a thrombospondin domain-containing protein expressed in enteroendocrine cells as well as in epithelial cells in various tissues. Upon injection into mice, the protein induced rapid onset of crypt cell proliferation involving β-catenin stabilization, possibly by a process that is distinct from the canonical Wnt-mediated signaling pathway. The protein also displayed efficacy in a model of chemotherapy-induced intestinal mucositis and may have therapeutic application in gastrointestinal diseases.
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Cites
R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis
Kazanskaya, O., Glinka, A., del Barco Barrantes, I., Stannek, P., Niehrs, C., & Wu, W. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.019 · Cited by 431
Modulation of specific intestinal epithelial progenitors by enteric neurons
Bjerknes, M., & Cheng, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211278098 · Cited by 325
Cited by
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Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
Metadata
- Authors
- Kim, K.-A., Kakitani, M., Zhao, J., Oshima, T., Tang, T., Binnerts, M., Liu, Y., Boyle, B., Park, E., Emtage, P., Funk, W. D., & Tomizuka, K.
- Venue
- Science
- Published
- 2005-08-19
- Volume
- 309
- Issue
- 5738
- Pages
- 1256-1259
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2138224451
- Cited by
- 586
- References
- 2
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, K.-A., Kakitani, M., Zhao, J., Oshima, T., Tang, T., Binnerts, M., Liu, Y., Boyle, B., Park, E., Emtage, P., Funk, W. D., & Tomizuka, K. (2005). Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium. Science. https://doi.org/10.1126/science.1112521
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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