The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
RNA Polymerase II Is Required for RNAi-Dependent Heterochromatin Assembly
Abstract
In Schizosaccharomyces pombe , the RNA interference (RNAi) machinery converts pericentromeric transcripts into small interfering RNAs (siRNAs) and is required for the assembly of pericentromeric heterochromatin. Here we describe a mutation in the second largest subunit of RNA polymerase II (RNAPII). Both wild-type and mutant RNAPII localized to the pericentromere. However, the mutation resulted in the loss of heterochromatic histone modifications and in the accumulation of pericentromeric transcripts, accompanied by the loss of siRNAs. This phenotype resembles mutants in RNAi and suggests that RNAPII couples pericentromeric transcription with siRNA processing and heterochromatin assembly.
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Cites
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,373
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
Volpe, T. A., Kidner, C., Hall, I. M., Teng, G., Grewal, S. I. S., & Martienssen, R. A. (2002) · Science · doi:10.1126/science.1074973 · Cited by 2,055
Self-citationRole of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
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Role of transposable elements in heterochromatin and epigenetic control
Lippman, Z., Gendrel, A.-V., Black, M., Vaughn, M. W., Dedhia, N., Richard McCombie, W., Lavine, K., Mittal, V., May, B., Kasschau, K. D., et al. (2004) · Nature · doi:10.1038/nature02651 · Cited by 1,065
Self-citationRNA Polymerase IV Directs Silencing of Endogenous DNA
Herr, A. J., Jensen, M. B., Dalmay, T., & Baulcombe, D. C. (2005) · Science · doi:10.1126/science.1106910 · Cited by 717
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Requirement of Heterochromatin for Cohesion at Centromeres
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Two RNAi Complexes, RITS and RDRC, Physically Interact and Localize to Noncoding Centromeric RNAs
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Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast
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Cited by
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
Global Transcription in Pluripotent Embryonic Stem Cells
Efroni, S., Duttagupta, R., Cheng, J., Dehghani, H., Hoeppner, D. J., Dash, C., Bazett-Jones, D. P., Le Grice, S., McKay, R. D. G., Buetow, K. H., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.03.021 · Cited by 698
H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes
Becker, J. S., Nicetto, D., & Zaret, K. S. (2016) · Trends in Genetics · doi:10.1016/j.tig.2015.11.001 · Cited by 485
Role of H3K9me3 heterochromatin in cell identity establishment and maintenance
Nicetto, D., & Zaret, K. S. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.04.013 · Cited by 312
WEINBERG, M. S., VILLENEUVE, L. M., EHSANI, A., AMARZGUIOUI, M., AAGAARD, L., CHEN, Z.-X., RIGGS, A. D., ROSSI, J. J., & MORRIS, K. V. (2006) · RNA · doi:10.1261/rna.2235106 · Cited by 275
Metadata
- Authors
- Kato, H., Goto, D. B., Martienssen, R. A., Urano, T., Furukawa, K., & Murakami, Y.
- Venue
- Science
- Published
- 2005-07-15
- Volume
- 309
- Issue
- 5733
- Pages
- 467-469
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992506108
- Cited by
- 274
- References
- 16
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- closed
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