Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells
Open accessAbstract
Epidermis is one of the best-studied tissues in mammals that contain types of stem cells. Outstanding works in recent years have shed great light on behaviors of different epidermal stem cell populations in the homeostasis and regeneration of the epidermis as well as hair follicles. Also, the molecular mechanisms governing these stem cells are being elucidated, from genetic to epigenetic levels. Compared with the explicit knowledge about adult skin, embryonic development of the epidermis, especially the early period, still needs exploration. Furthermore, stem cells in the embryonic epidermis are largely unstudied or ambiguously depicted. In this review, we will summarize and discuss the process of embryonic epidermal development, with focuses on some key molecular regulators and the role of the sub-epidermal mesenchyme. We will also try to trace adult epidermal stem cell populations back to embryonic development. In addition, we will comment on in vitro derivation of epidermal lineages from ES cells and iPS cells.
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Mouse embryonic skin mesenchymal and epithelial cells are composed of heterogeneous cell populations.
“Because both mesenchymal and epithelial cells from mouse embryonic skin are composed of heterogeneous cell populations (52, 53)”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [53]
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works
Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276 · see citing works
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,224 · see citing works
p63 is a p53 homologue required for limb and epidermal morphogenesis
Mills, A. A., Zheng, B., Wang, X., Vogel, H. S., Roop, D. R., & Bradley, A. (1999) · Nature · doi:10.1038/19531 · Cited by 1,974 · see citing works
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
Woltjen, K., Michael, I. P., Mohseni, P., Desai, R., Mileikovsky, M., Hämäläinen, R. H., Cowling, R. A., Wang, W., Liu, P., Gertsenstein, M., et al. (2009) · Nature · doi:10.1038/nature07863 · Cited by 1,810 · see citing works
Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins
Zhou, H., Wu, S., Joo, J. Y., Zhu, S., Han, D. W., Lin, T., Trauger, S., Bien, G., Yao, S., Zhu, Y., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.005 · Cited by 1,788 · see citing works
Isolation of multipotent adult stem cells from the dermis of mammalian skin
Toma, J. G., Akhavan, M., Fernandes, K. J. L., Barnabé‐Heider, F., Sadikot, A. F., Kaplan, D. R., & Miller, F. D. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-778 · Cited by 1,593 · see citing works
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428 · see citing works
Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370 · see citing works
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352 · see citing works
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317 · see citing works
Three clonal types of keratinocyte with different capacities for multiplication.
Barrandon, Y., & Green, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2302 · Cited by 1,293 · see citing works
Capturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283 · see citing works
Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity
Kawasaki, H., Mizuseki, K., Nishikawa, S., Kaneko, S., Kuwana, Y., Nakanishi, S., Nishikawa, S., & Sasai, Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00083-0 · Cited by 1,277 · see citing works
Jones, P. H., & Watt, F. M. (1993) · Cell · doi:10.1016/0092-8674(93)90251-k · Cited by 1,100 · see citing works
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089 · see citing works
van Genderen, C., Okamura, R., Fariñas, I., Quo, R. G., Parslow, T., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 1,031 · see citing works
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998 · see citing works
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995 · see citing works
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967 · see citing works
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966 · see citing works
Overview of retinoid metabolism and function
Blomhoff, R., & Blomhoff, H. K. (2006) · Journal of Neurobiology · doi:10.1002/neu.20242 · Cited by 948 · see citing works
The secret life of the hair follicle
Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931 · see citing works
Scratching the surface of skin development
Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930 · see citing works
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
Senoo, M., Pinto, F., Crum, C. P., & McKeon, F. (2007) · Cell · doi:10.1016/j.cell.2007.02.045 · Cited by 881 · cited 2× · see citing works
“Nonetheless, it is generally agreed that DNp63 is preferentially expressed in basal cells and is pivotal for keeping their proliferative properties [7,16,88].”
BackgroundNotch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C., Krishna, S., METZGER, D., Chambon, P., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3427 · Cited by 867 · see citing works
A single type of progenitor cell maintains normal epidermis
Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H. (2007) · Nature · doi:10.1038/nature05574 · Cited by 853 · see citing works
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800 · see citing works
Klf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C., & Fuchs, E. V. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 793 · see citing works
Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs
Miyoshi, N., Ishii, H., Nagano, H., Haraguchi, N., Dewi, D. L., Kano, Y., Nishikawa, S., Tanemura, M., Mimori, K., Tanaka, F., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.05.001 · Cited by 756 · see citing works
<i>Lgr6</i> Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., et al. (2010) · Science · doi:10.1126/science.1184733 · Cited by 751 · see citing works
Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.009 · Cited by 741 · see citing works
p63 is the molecular switch for initiation of an epithelial stratification programPreprint
Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., & Roop, D. R. (2004) · Genes & Development · doi:10.1101/gad.1165104 · Cited by 622 · see citing works
WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism
Sick, S., Reinker, S., Timmer, J., & Schlake, T. (2006) · Science · doi:10.1126/science.1130088 · Cited by 612 · see citing works
Modeling familial Alzheimer's disease with induced pluripotent stem cells
Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H., & Suzuki, N. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr394 · Cited by 599 · see citing works
Distinct contribution of stem and progenitor cells to epidermal maintenance
Mascré, G., Dekoninck, S., Drogat, B., Youssef, K. K., Brohée, S., Sotiropoulou, P. A., Simons, B. D., & Blanpain, C. (2012) · Nature · doi:10.1038/nature11393 · Cited by 567 · see citing works
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skinPreprint
Merrill, B. J., Gat, U., DasGupta, R., & Fuchs, E. V. (2001) · Genes & Development · doi:10.1101/gad.891401 · Cited by 559 · see citing works
Hair follicle stem cells are specified and function in early skin morphogenesis
Nowak, J. A., Polak, L., Pasolli, H. A., & Fuchs, E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.05.009 · Cited by 554 · see citing works
van der Veen, C., Handjiski, B., Paus, R., Müller-Röver, S., Maurer, M., Eichmüller, S., Ling, G., Hofmann, U., Foitzik, K., & Mecklenburg, L. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00740.x · Cited by 553 · see citing works
Wnt signaling maintains the hair-inducing activity of the dermal papillaPreprint
Kishimoto, J., Burgeson, R. E., & Morgan, B. A. (2000) · Genes & Development · doi:10.1101/gad.14.10.1181 · Cited by 535 · see citing works
Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis
Jensen, K. B., Collins, C. A., Nascimento, E. M., Tan, D. W., Frye, M., Itami, S., & Watt, F. M. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.014 · Cited by 523 · see citing works
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489 · see citing works
Programming gene expression in developing epidermis
Byrne, C. R., Tainsky, M. A., & Fuchs, E. V. (1994) · Development · doi:10.1242/dev.120.9.2369 · Cited by 487 · see citing works
p63 regulates proliferation and differentiation of developmentally mature keratinocytesPreprint
Truong, A. B., Kretz, M., Ridky, T. W., Kimmel, R. A., & Khavari, P. A. (2006) · Genes & Development · doi:10.1101/gad.1463206 · Cited by 480 · see citing works
THE EPIDERMAL PROLIFERATIVE UNIT: THE POSSIBLE ROLE OF THE CENTRAL BASAL CELL
Potten, C. S. (1974) · Cell Proliferation · doi:10.1111/j.1365-2184.1974.tb00401.x · Cited by 454 · see citing works
Brownell, I., Guevara, E., Bai, C. B., Loomis, C. A., & Joyner, A. L. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.021 · Cited by 453 · see citing works
Canonical notch signaling functions as a commitment switch in the epidermal lineagePreprint
Blanpain, C., Lowry, W. E., Pasolli, H. A., & Fuchs, E. V. (2006) · Genes & Development · doi:10.1101/gad.1477606 · Cited by 431 · see citing works
Skin stem cells: rising to the surface
Fuchs, E. V. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708185 · Cited by 431 · see citing works
Vidal, V., Chaboissier, M., Lützkendorf, S., Cotsarelis, G., Mill, P., Hui, C., Ortonne, N., Ortonne, J. P., & Schedl, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.064 · Cited by 427 · see citing works
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.06.048 · Cited by 426 · see citing works
BMP signaling in dermal papilla cells is required for their hair follicle-inductive propertiesPreprint
Rendl, M., Polak, L., & Fuchs, E. V. (2008) · Genes & Development · doi:10.1101/gad.1614408 · Cited by 423 · see citing works
Neural induction: old problem, new findings, yet more questions
Stern, C. D. (2005) · Development · doi:10.1242/dev.01794 · Cited by 421 · cited 2× · see citing works
“Without Wnt signals, the ectodermal cells respond to FGF signals which could inhibit BMP signaling activity and thus develop towards a neural fate [12].”
BackgroundDistinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis
Levy, V., Lindon, C., Harfe, B. D., & Morgan, B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.11.003 · Cited by 419 · see citing works
Noggin is a mesenchymally derived stimulator of hair-follicle induction
Botchkarev, V. A., Botchkareva, N. V., Roth, W., Nakamura, M., Chen, L.-H., Herzog, W., Lindner, G., McMahon, J. A., Peters, C., Lauster, R., et al. (1999) · Nature Cell Biology · doi:10.1038/11078 · Cited by 414 · see citing works
β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
Enshell‐Seijffers, D., Lindon, C., Kashiwagi, M., & Morgan, B. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.016 · Cited by 408 · see citing works
Identification of the cell lineage at the origin of basal cell carcinoma
Youssef, K. K., Keymeulen, A. V., Lapouge, G., Beck, B., Michaux, C., Achouri, Y., Sotiropoulou, P. A., & Blanpain, C. (2010) · Nature Cell Biology · doi:10.1038/ncb2031 · Cited by 400 · see citing works
Oshimori, N., & Fuchs, E. V. (2012) · Cell stem cell · doi:10.1016/j.stem.2011.11.005 · Cited by 397 · see citing works
Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
Sennett, R., & Rendl, M. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.011 · Cited by 387 · see citing works
Epidermal stem cells arise from the hair follicle after wounding
Levy, V., Lindon, C., Zheng, Y., Harfe, B. D., & Morgan, B. A. (2007) · The FASEB Journal · doi:10.1096/fj.06-6926com · Cited by 386 · see citing works
Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.011 · Cited by 363 · see citing works
Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin
Haegebarth, A., & Clevers, H. C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080758 · Cited by 360 · see citing works
Ingraham, C. R., Kinoshita, A., Kondo, S., Yang, B., Sajan, S. A., Trout, K. J., Malik, M., Dunnwald, M., Goudy, S. L., Lovett, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1903 · Cited by 356 · see citing works
Lavker, R. M., & Sun, T. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12540880 · Cited by 347 · see citing works
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
Richardson, R. J., Dixon, J., Malhotra, S., Hardman, M. J., Knowles, L., Boot-Handford, R., Shore, P., Whitmarsh, A. J., & Dixon, M. J. (2006) · Nature Genetics · doi:10.1038/ng1894 · Cited by 325 · see citing works
Mechanisms Regulating Epithelial Stratification
Koster, M. I., & Roop, D. R. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123357 · Cited by 324 · see citing works
Franke, W. W., Gründ, C., Jackson, B. W., & Illmensee, K. (1983) · PubMed · Cited by 318 · see citing works
Yan, M., Wang, L.-C., Hymowitz, S. G., Schilbach, S., Lee, J., Goddard, A. D., de Vos, A. M., Gao, W., & Dixit, V. M. (2000) · Science · doi:10.1126/science.290.5491.523 · Cited by 312 · see citing works
Perp Is a p63-Regulated Gene Essential for Epithelial Integrity
Ihrie, R. A., Marques, M. R., Nguyen, B., Horner, J. S., Papazoglu, C., Bronson, R. T., Mills, A. A., & Attardi, L. D. (2005) · Cell · doi:10.1016/j.cell.2005.01.008 · Cited by 311 · see citing works
Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
Kulessa, H., Turk, G., & Hogan, B. L. M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6664 · Cited by 303 · see citing works
Lu, C. P., Polak, L., Rocha, A. S., Pasolli, H. A., Chen, S.-C., Sharma, N., Blanpain, C., & Fuchs, E. (2012) · Cell · doi:10.1016/j.cell.2012.04.045 · Cited by 301 · cited 2× · see citing works
“On the other hand, the glandular myoepithelial stem cells and the luminal stem cells only contribute to their own lineages, respectively [120].”
BackgroundStratification and terminal differentiation of cultured epidermal cells
Watt, F. M., & Green, H. (1982) · Nature · doi:10.1038/295434a0 · Cited by 301 · see citing works
Itoh, M., Kiuru, M., Cairo, M. S., & Christiano, A. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100332108 · Cited by 282 · see citing works
Candi, E., Rufini, A., Terrinoni, A., Dinsdale, D. D., Ranalli, M., Paradisi, A., Laurenzi, V. D., Spagnoli, L. G., Catani, M. V., Ramadan, S. M., et al. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401926 · Cited by 266 · see citing works
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
Kobielak, K., Pasolli, H. A., Alonso, L. C., Polak, L., & Fuchs, E. V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200309042 · Cited by 261 · see citing works
Guenou, H., Nissan, X., Larcher, F., Feteira, J., Lemaitre, G., Saidani, M., Del Rio, M., Barrault, C. C., Bernard, F.-X., Peschanski, M., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61496-3 · Cited by 261 · see citing works
Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260 · see citing works
Feijen, A., Goumans, M., van den, A. J. M., & van Raaij, E. J. (1994) · Development · doi:10.1242/dev.120.12.3621 · Cited by 252 · see citing works
p63 induces key target genes required for epidermal morphogenesis
Koster, M. I., Dai, D., Marinari, B., Sano, Y., Costanzo, A., Karin, M., & Roop, D. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611376104 · Cited by 234 · see citing works
Moll, R., Moll, I., & Wiest, W. (1982) · Differentiation · doi:10.1111/j.1432-0436.1982.tb01280.x · Cited by 229 · see citing works
The Ordered Architecture of Murine Ear Epidermis Is Maintained by Progenitor Cells with Random Fate
Doupé, D. P., Klein, A. M., Simons, B. D., & Jones, P. H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.016 · Cited by 224 · see citing works
Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle
Karlsson, L., Bondjers, C., & Betsholtz, C. (1999) · Development · doi:10.1242/dev.126.12.2611 · Cited by 222 · see citing works
Formation of cytoskeletal elements during mouse embryogenesis
Franke, W. W., Gründ, C., Jackson, B. W., & Illmensee, K. (1984) · Differentiation · doi:10.1111/j.1432-0436.1984.tb01348.x · Cited by 218 · see citing works
Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices
Schmidt-Ullrich, R., Aebischer, T., Hülsken, J., Birchmeier, W., Klemm, U., & Scheidereit, C. (2001) · Development · doi:10.1242/dev.128.19.3843 · Cited by 216 · see citing works
BMP signaling in the control of skin development and hair follicle growth
Botchkarev, V. A., & Sharov, A. A. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07209005.x · Cited by 213 · see citing works
Nijhof, J. G. W., Braun, K. M., Giangreco, A., van Pelt, C., Kawamoto, H., Boyd, R. L., Willemze, R., Mullenders, L. H. F., Watt, F. M., de Gruijl, F. R., et al. (2006) · Development · doi:10.1242/dev.02443 · Cited by 211 · see citing works
BMPs mediate lateral inhibition at successive stages in feather tract development
Noramly, S., & Morgan, B. A. (1998) · Development · doi:10.1242/dev.125.19.3775 · Cited by 208 · see citing works
Generation of the primary hair follicle pattern.
Mou, C., Jackson, B., Schneider, P., Overbeek, P. A., & Headon, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600825103 · Cited by 206 · see citing works
Embryonic development and pattern formation
Morriss‐Kay, G. M., & Sokolova, N. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801178 · Cited by 203 · see citing works
Formation of Cytoskeletal Elements During Mouse Embryogenesis
Jackson, B. W., Gründ, C., Winter, S., Franke, W. W., & Illmensee, K. (1981) · Differentiation · doi:10.1111/j.1432-0436.1981.tb01177.x · Cited by 202 · see citing works
A dermal HOX transcriptional program regulates site-specific epidermal fatePreprint
Rinn, J. L., Wang, J. K., Allen, N., Brugmann, S. A., Mikels, A. J., Liu, H., Ridky, T. W., Stadler, H. S., Nusse, R., Helms, J. A., et al. (2008) · Genes & Development · doi:10.1101/gad.1610508 · Cited by 201 · see citing works
p63 and the epithelial stem cell: more than status quo?Preprint
McKeon, F. (2004) · Genes & Development · doi:10.1101/gad.1190504 · Cited by 197 · see citing works
Dickkopf genes are co-ordinately expressed in mesodermal lineages
Monaghan, A. P., Kioschis, P., Wu, W., Zúñiga, A., Bock, D., Poustka, A., Delius, H., & Niehrs, C. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00138-0 · Cited by 192 · see citing works
Okuyama, R., Nguyen, B.-C., Talora, C., Ogawa, E., di Vignano, A. T., Lioumi, M., Chiorino, G., Tagami, H., Woo, M., & Dotto, G. P. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00098-x · Cited by 185 · see citing works
Kandyba, E. E., Leung, Y., Chen, Y., Widelitz, R. B., Chuong, C., & Kobielak, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121312110 · Cited by 185 · see citing works
Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loopPreprint
Woo, W., Zhen, H. H., & Oro, A. E. (2012) · Genes & Development · doi:10.1101/gad.187401.112 · Cited by 183 · see citing works
Kumar, A., Eby, M. T., Sinha, S. K., Jasmin, A., & Chaudhary, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008356200 · Cited by 178 · see citing works
Yu, Z., Lin, K., Bhandari, A., Spencer, J. A., Xu, X., Wang, N., Lu, Z., Gill, G. N., Roop, D. R., Wertz, P. W., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.015 · Cited by 173 · see citing works
The TGF-β2 Isoform Is Both a Required and Sufficient Inducer of Murine Hair Follicle Morphogenesis
Foitzik, K., Paus, R., Doetschman, T. C., & Dotto, G. P. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9325 · Cited by 170 · see citing works
Pummila, M., Fliniaux, I., Jaatinen, R., James, M. J., Laurikkala, J., Schneider, P., Thesleff, I., & Mikkola, M. L. (2006) · Development · doi:10.1242/dev.02708 · Cited by 167 · see citing works
Metallo, C. M., Lin, J., de Pablo, J. J., & Palecek, S. P. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0501 · Cited by 167 · see citing works
The hair follicle—a stem cell zoo
Jaks, V., Kasper, M., & Toftgård, R. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.03.014 · Cited by 156 · see citing works
Induced Pluripotent Stem Cells from Individuals with Recessive Dystrophic Epidermolysis Bullosa
Tolar, J., Xia, L., Riddle, M. J., Lees, C. J., Eide, C. R., McElmurry, R. T., Titeux, M., Osborn, M. J., Lund, T. C., Hovnanian, A., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.346 · Cited by 155 · see citing works
Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA
Warren, L., Ni, Y., Wang, J., & Guo, X. (2012) · Scientific Reports · doi:10.1038/srep00657 · Cited by 154 · see citing works
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin
Collins, C. A., Kretzschmar, K., & Watt, F. M. (2011) · Development · doi:10.1242/dev.064592 · Cited by 152 · see citing works
Development and homeostasis of the sebaceous gland
Niemann, C., & Horsley, V. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.08.010 · Cited by 151 · see citing works
Reconstituted skin from murine embryonic stem cells
Coraux, C., Hilmi, C., Rouleau, M., Spadafora, A., Hinnrasky, J., Ortonne, J.-P., Dani, C., & Aberdam, D. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00296-3 · Cited by 149 · see citing works
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE
Vooijs, M., Ong, C., Hadland, B., Huppert, S. S., Liu, Z., Korving, J., van den Born, M., Stappenbeck, T. S., Wu, Y., Clevers, H. C., et al. (2007) · Development · doi:10.1242/dev.02733 · Cited by 146 · see citing works
A Signaling Pathway Involving TGF-β2 and Snail in Hair Follicle Morphogenesis
Jamora, C., Lee, P., Kocieniewski, P., Azhar, M., Hosokawa, R., Chai, Y., & Fuchs, E. V. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0030011 · Cited by 145 · see citing works
Mackenzie, I. C. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12336255 · Cited by 138 · see citing works
EDA Signaling and Skin Appendage Development
Cui, C., & Schlessinger, D. (2006) · Cell Cycle · doi:10.4161/cc.5.21.3403 · Cited by 135 · see citing works
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
Shalom‐Feuerstein, R., Lena, A. M., Zhou, H., Divonne, S. B.-D. L. F., van Bokhoven, H., Candi, E., Melino, G., & Aberdam, D. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.159 · Cited by 131 · see citing works
Nair, M., Teng, A., Bilanchone, V., Agrawal, A., Li, B., & Dai, X. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508196 · Cited by 125 · see citing works
Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage
Bilousova, G., Chen, J., & Roop, D. R. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.364 · Cited by 123 · see citing works
Fliniaux, I., Mikkola, M. L., Lefebvre, S., & Thesleff, I. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.023 · Cited by 117 · see citing works
VARIATION IN THE PLANE OF CELL CLEAVAGE DURING THE PROCESS OF STRATIFICATION IN THE MOUSE EPIDERMIS
Smart, I. H. M. (1970) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1970.tb12437.x · Cited by 117 · see citing works
Distinct functions of BMP4 during different stages of mouse ES cell neural commitment
Zhang, K., Li, L., Huang, C., Shen, C., Tan, F., Xia, C., Liu, P., Rossant, J., & Jing, N. (2010) · Development · doi:10.1242/dev.049494 · Cited by 109 · see citing works
Stem cell dynamics in sebaceous gland morphogenesis in mouse skin
Frances, D., & Niemann, C. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.12.028 · Cited by 103 · see citing works
A Functional Enhancer of Keratin14 Is a Direct Transcriptional Target of ΔNp63
Romano, R., Birkaya, B. G., & Sinha, S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700652 · Cited by 99 · see citing works
Bazzi, H., Fantauzzo, K. A., Richardson, G. D., Jahoda, C. A. B., & Christiano, A. M. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.035 · Cited by 98 · see citing works
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice
Yuhki, M., Yamada, M., Kawano, M., Iwasato, T., Itohara, S., Yoshida, H., Ogawa, M., & Mishina, Y. M. (2004) · Development · doi:10.1242/dev.01079 · Cited by 97 · see citing works
Gambaro, K., Aberdam, É., Virolle, T., Aberdam, D., & Rouleau, M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401799 · Cited by 94 · see citing works
Liu, S., Liu, S., Wang, X., Zhou, J., Cao, Y., Wang, F., & Duan, E. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00704.x · Cited by 92 · see citing works
Self-citationSignaling and subcellular localization of the TNF receptor Edar.
Koppinen, P., Pispa, J., Laurikkala, J., Thesleff, I., & Mikkola, M. L. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5331 · Cited by 78 · see citing works
Zhao, G., & Skeath, J. B. (2002) · Development · doi:10.1242/dev.129.5.1165 · Cited by 76 · see citing works
Walcher, T., Xie, Q. M., Sun, J., Irmler, M., Beckers, J., Öztürk, T., Niessing, D., Stoykova, A., Cvekl, A., Ninkovic, J., et al. (2013) · Development · doi:10.1242/dev.082875 · Cited by 72 · see citing works
A Pure Population of Ectodermal Cells Derived from Human Embryonic Stem Cells
Aberdam, É., Barak, E., Rouleau, M., de LaForest, S., Berrih‐Aknin, S., Suter, D. M., Krause, K., Amit, M., Itskovitz‐Eldor, J., & Aberdam, D. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0588 · Cited by 70 · see citing works
A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice
Herron, B. J., Liddell, R. A., Parker, A., Grant, S., Kinne, J., Fisher, J. K., & Siracusa, L. D. (2005) · Nature Genetics · doi:10.1038/ng1652 · Cited by 68 · see citing works
Identification of 14-3-3σ mutation causing cutaneous abnormality in repeated-epilation mutant mouse
Li, Q., Lu, Q., Estepa, G., & Verma, I. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508310102 · Cited by 66 · see citing works
Hu, H., Zhang, S.-B., Lei, X., Deng, Z., Guo, W.-X., Qiu, Z.-F., Liu, S., Wang, X., Zhang, H., & Duan, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040124 · Cited by 64 · see citing works
Self-citationTAp63α induces AP-2γ as an early event in epidermal morphogenesis
Koster, M. I., Kim, S., Huang, J. J., Williams, T., & Roop, D. R. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.041 · Cited by 61 · see citing works
Bamberger, C., Schmale, H., & Pollet, D. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01649.x · Cited by 60 · see citing works
Commitment of embryonic stem cells to an epidermal cell fate and differentiation in vitro
Troy, T., & Turksen, K. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20223 · Cited by 59 · see citing works
TGF‐β2 is specifically expressed in human dermal papilla cells and modulates hair folliculogenesis
Inoue, K., D, N. A. M., Yamauchi, Y., Sato, T., D, H. S. M., D, H. E. M., D, H. K. M., Tabata, Y., & Yoshimura, K. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00739.x · Cited by 56 · see citing works
In Vivo Function of Desmosomes
Cheng, X., & Koch, P. J. (2004) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2004.tb00654.x · Cited by 54 · see citing works
Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia
Uyttendaele, H., Panteleyev, A. A., de Berker, D., Tobin, D. J., & Christiano, A. M. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07208006.x · Cited by 54 · see citing works
Bagutti, C., Hutter, C., Chiquet‐Ehrismann, R., Fässler, R., & Watt, F. M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0149 · Cited by 53 · see citing works
Zhou, J., Jia, L., Liu, W., Miao, C., Liu, S., Cao, Y., & Duan, E. (2006) · Human Reproduction · doi:10.1093/humrep/del086 · Cited by 51 · see citing works
Self-citationTsukushi controls the hair cycle by regulating TGF-β1 signaling
Niimori, D., Kawano, R., Felemban Athary Abdulhaleem, M., Niimori‐Kita, K., Tanaka, H., Ihn, H., & Ohta, K. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.08.030 · Cited by 50 · see citing works
Generation and Differentiation of Human Embryonic Stem Cell-Derived Keratinocyte Precursors
Lin, J., Allen‐Hoffmann, B. L., de Pablo, J. J., & Palecek, S. P. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.665 · Cited by 50 · see citing works
The Epidermis of Grhl3-Null Mice Displays Altered Lipid Processing and Cellular Hyperproliferation
Ting, S. B., Caddy, J., Wilanowski, T., Auden, A., Cunningham, J. M., Elias, P. M., Holleran, W. M., & Jane, S. M. (2005) · Organogenesis · doi:10.4161/org.2.2.2167 · Cited by 48 · see citing works
Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells
Yang, L., Wang, L., & Yang, X. Y. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-07-0731 · Cited by 47 · see citing works
Li, J., Miao, C., Guo, W., Jia, L., Zhou, J., Ma, B., Peng, S., Liu, S., Cao, Y., & Duan, E. (2007) · Cell Research · doi:10.1038/cr.2007.103 · Cited by 46 · see citing works
Self-citationRequirement for Shh and Fox family genes at different stages in sweat gland development
Kunisada, M., Cui, C., Piao, Y., Ko, M. S. H., & Schlessinger, D. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp089 · Cited by 41 · see citing works
Qiao, Y., Zhu, Y., Sheng, N., Chen, J., Tao, R., Zhu, Q., Zhang, T., Qian, C., & Jing, N. (2012) · Cell Research · doi:10.1038/cr.2012.122 · Cited by 35 · see citing works
Ohyama, A., Saito, F., Ohuchi, H., & Noji, S. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00525-6 · Cited by 35 · see citing works
Fu, X., Li, J., Sun, X., Sun, T., & Sheng, Z. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130113.x · Cited by 34 · see citing works
İnanç, B., Elçin, A. E., & Elçin, Y. M. (2008) · Tissue Engineering Part A · doi:10.1089/tea.2007.0213 · Cited by 33 · see citing works
Re-Assessing K15 as an Epidermal Stem Cell Marker
Troy, T., Arabzadeh, A., & Turksen, K. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9243-9 · Cited by 33 · see citing works
İnanç, B., Elçin, A. E., & Elçin, Y. M. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0213 · Cited by 31 · see citing works
Effects of Wnt3a on proliferation and differentiation of human epidermal stem cells
Jia, L., Zhou, J., Peng, S., Li, J., Cao, Y., & Duan, E. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.097 · Cited by 31 · see citing works
Self-citationZhang, S., Hu, H., Zhang, H., Liu, S., Liu, S., Zhang, Y., Lei, X., Ning, L., Cao, Y., & Duan, E. (2012) · Cell Transplantation · doi:10.3727/096368912x640538 · Cited by 25 · see citing works
Self-citationEnrichment and identification of human 'fetal' epidermal stem cells
Zhou, J. (2004) · Human Reproduction · doi:10.1093/humrep/deh166 · Cited by 23 · see citing works
In vitro differentiation of murine embryonic stem cells into keratinocyte-like cells
Haase, I., Knaup, R., Wartenberg, M., Sauer, H., Hescheler, J., & Mahrle, G. (2007) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2007.07.001 · Cited by 17 · see citing works
Yun, U. J., Kim, S. Y., Liu, J., Adler, P. N., Bae, E., Kim, J., & Park, W. J. (1999) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1999)25:4 · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [10]Sato K. Biology of the eccrine sweat gland Dermatol. Gen. Med. N. Y. McGraw-Hill 1993 1 221 241
- [131]Zhao G. Skeath J.B. The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm Development 2002 129 1165 1174 11874912
- [135]Haselbeck R.J. Hoffmann I. Duester G. Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways Dev. Genet 1999 25 353 364 10570467 PMC4342002
Cited by
Sorted by citations
Panich, U., Sittithumcharee, G., Rathviboon, N., & Jirawatnotai, S. (2016) · Stem Cells International · doi:10.1155/2016/7370642 · Cited by 374 · see citing works
Bioprinting: From Tissue and Organ Development to in Vitro Models
Mota, C., Camarero‐Espinosa, S., Baker, M., Wieringa, P., & Moroni, L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00789 · Cited by 308 · see citing works
Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
Veltri, A., Lang, C. M. R., & Lien, W. (2017) · Stem Cells · doi:10.1002/stem.2723 · Cited by 147 · see citing works
Embryonic skin development and repair
Hu, M. S.-M., Borrelli, M. R., Hong, W. X., Malhotra, S., Cheung, A. T. M., Ransom, R. C., Rennert, R. C., Morrison, S. D., Lorenz, H. P., & Longaker, M. T. (2018) · Organogenesis · doi:10.1080/15476278.2017.1421882 · Cited by 96 · see citing works
Skin equivalents: skin from reconstructions as models to study skin development and diseases
Ali, N., Hosseini, M., Vainio, S. J., Taı̈eb, A., Cario, M., & Rezvani, H. R. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13886 · Cited by 90 · see citing works
The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review
Aleemardani, M., Trikić, M. Z., Green, N. H., & Claeyssens, F. (2021) · Bioengineering · doi:10.3390/bioengineering8110148 · Cited by 83 · see citing works
Jenkins, B. A., & Lumpkin, E. A. (2017) · Development · doi:10.1242/dev.120402 · Cited by 79 · see citing works
Bioengineered skin organoids: from development to applications
Hong, Z.-X., Zhu, S.-T., Li, H., Luo, J.-Z., Yang, Y., An, Y., Wang, X., & Wang, K. (2023) · Military Medical Research · doi:10.1186/s40779-023-00475-7 · Cited by 77 · see citing works
Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction
Kageyama, T., Shimizu, A., Anakama, R., Nakajima, R., Suzuki, K., Okubo, Y., & Fukuda, J. (2022) · Science Advances · doi:10.1126/sciadv.add4603 · Cited by 73 · see citing works
Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology
Sevilla, L. M., & Pérez, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071906 · Cited by 72 · see citing works
Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium
Xiao, Y., Thoresen, D. T., Williams, J. S., Wang, C., Perna, J., Petrova, R., & Brownell, I. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504177112 · Cited by 71 · see citing works
Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., & Wen, Z. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.028 · Cited by 61 · see citing works
Bigas, J., Sevilla, L. M., Carceller, E., Boix, J., & Pérez, P. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0673-z · Cited by 59 · see citing works
Ahmed, N. S., Ghatak, S., Masry, M. S. E., Gnyawali, S. C., Roy, S., Amer, M., Everts, H. B., Sen, C. K., & Khanna, S. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.07.010 · Cited by 57 · see citing works
Yadav, K., Singh, D., & Singh, M. R. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.021 · Cited by 56 · see citing works
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Patthey, C., & Gunhaga, L. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.08.002 · Cited by 54 · see citing works
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Kao, W. W. ‐. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108206 · Cited by 51 · see citing works
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van Soldt, B. J., & Cardoso, W. V. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.371 · Cited by 50 · see citing works
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Wnt Signaling Pathways in Keratinocyte Carcinomas
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Kishi, K., Hayashi, M., Onuma, T. A., & Nishida, H. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.06.008 · Cited by 33 · see citing works
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Panicker, N., Coutman, M., Lawlor-O’Neill, C., Kahl, R. G. S., Roselli, S., & Verrills, N. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00358 · Cited by 27 · see citing works
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He, N., Su, R., Wang, Z., Zhang, Y., & Li, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231376 · Cited by 28 · see citing works
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Xie, J., Yao, B., Han, Y., Huang, S., & Fu, X. (2016) · Burns & Trauma · doi:10.1186/s41038-016-0064-6 · Cited by 25 · see citing works
Skin Development and Disease: A Molecular Perspective
Dermitzakis, I., Chatzi, D., Kyriakoudi, S. A., Evangelidis, N., Vakirlis, E., Meditskou, S., Theotokis, P., & Μanthou, M. E. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080487 · Cited by 27 · see citing works
Oceguera-Yañez, F., Ávila-Robinson, A., & Woltjen, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1030339 · Cited by 24 · see citing works
Application of Organoids in Regenerative Medicine
Wu, Y., Ye, W., Gao, Y., Yi, Z., Chen, Z., Qu, C., Huang, J., Liu, F., & Liu, Z. (2023) · Stem Cells · doi:10.1093/stmcls/sxad072 · Cited by 23 · see citing works
Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate
Mammadova, A., Zhou, H., Carels, C. E. L., & den Hoff, J. W. V. (2016) · Differentiation · doi:10.1016/j.diff.2016.05.001 · Cited by 23 · see citing works
Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27KIP1/p15INK4b signaling
Liu, S., Wang, X., Zhao, Q., Liu, S., Zhang, H., Shi, J., Li, N., Lei, X., Zhao, H., Deng, Z., et al. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1877-3 · Cited by 23 · see citing works
Self-citationCellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis
Wang, J., He, J., Zhu, M., Han, Y. Y., Yang, R., Liu, H., Xu, X., & Chen, X. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10295-8 · Cited by 22 · see citing works
Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization
Perevedentseva, E. V., Ali, N., Karmenyan, A., Skovorodkin, I., Prunskaite‐Hyyryläinen, R., Vainio, S. J., Cheng, C., & Kinnunen, M. T. (2019) · Materials · doi:10.3390/ma12223762 · Cited by 21 · see citing works
Granzyme B in epithelial barrier dysfunction and related skin diseases
Jung, K., Pawluk, M. A., Lane, M. D., Nabai, L., & Granville, D. J. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00052.2022 · Cited by 21 · see citing works
IRF6 and AP2A Interaction Regulates Epidermal Development
Kousa, Y. A., Fuller, E. J., & Schutte, B. C. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.05.030 · Cited by 19 · see citing works
Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin
Zhang, H., Zhang, S., Zhao, H., Qiao, J., Liu, S., Deng, Z., Lei, X., Ning, L., Cao, Y., Zhao, Y. X., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160817779 · Cited by 18 · see citing works
Self-citationAdvances in engineered organoid models of skin for biomedical research
Zeng, D., Li, S., Du, F., Xia, Y., Zhang, J., Yu, S., & Qin, J. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf016 · Cited by 20 · see citing works
Fathi, A., Eisa-Beygi, S., & Baharvand, H. (2017) · PubMed Central · doi:10.22074/cellj.2016.3915 · Cited by 17 · see citing works
Idiopathic facial aseptic granuloma: case report and literature review
Satta, R. R., Montesu, M. A., Biondi, G., & Lissia, A. (2016) · International Journal of Dermatology · doi:10.1111/ijd.13161 · Cited by 16 · see citing works
Conditional knockout in mice reveals the critical roles of Ppp2ca in epidermis development
Fang, C., Li, L., & Li, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050756 · Cited by 15 · see citing works
He, N., Dong, Z., Tai, D., Liang, H., Guo, X., Cang, M., & Liu, D. (2018) · Cytotechnology · doi:10.1007/s10616-018-0206-8 · Cited by 14 · see citing works
Genetic analysis of Ras genes in epidermal development and tumorigenesis
Drosten, M., Lechuga, C. G., & Barbacid, M. (2013) · Small GTPases · doi:10.4161/sgtp.26905 · Cited by 12 · see citing works
Walters, B. W., Tan, T. J., Tan, C. T., Dube, C. T., Lee, K. T., Koh, J., Ong, Y. H. B., Tan, V., Jahan, F. R. S., Lim, X. N., et al. (2023) · Journal of Cell Science · doi:10.1242/jcs.260723 · Cited by 12 · see citing works
Cytokeratin Expression at Different Stages in Sweat Gland Development of C57BL/6J Mice
Xie, J., Yao, B., Han, Y., Shang, T., Gao, D., Yang, S., Ma, K., Huang, S., & Fu, X. (2015) · The International Journal of Lower Extremity Wounds · doi:10.1177/1534734615611563 · Cited by 12 · see citing works
Role of Actin Cytoskeleton in the Regulation of Epithelial Cutaneous Stem Cells
Yang, G. N., Kopecki, Z., & Cowin, A. J. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0051 · Cited by 12 · see citing works
Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis
Sahu, A., Karmakar, S., Halder, S., Ghosh, G., Acharjee, S., Dasgupta, P., Ghosh, R., Deshpande, G., & Prasad, M. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009685 · Cited by 11 · see citing works
Zhang, H., Zhao, H., Qiao, J., Zhang, S., Liu, S., Li, N., Lei, X., Ning, L., Cao, Y., & Duan, E. (2016) · Cell Transplantation · doi:10.3727/096368916x691989 · Cited by 10 · see citing works
Self-citationXenopus: An in vivo model for studying skin response to ultraviolet B irradiation
Mir, J. E., Fédou, S., Thézé, N., Morice‐Picard, F., Cario, M., Fayyad‐Kazan, H., Thiébaud, P., & Rezvani, H. R. (2023) · Development Growth & Differentiation · doi:10.1111/dgd.12848 · Cited by 10 · see citing works
Shue, Y. T., Lee, K. T., Walters, B. W., Ong, Y. H. B., Silvaraju, S., Lam, W. J., & Lim, C. Y. (2020) · Epigenetics · doi:10.1080/15592294.2020.1738028 · Cited by 11 · see citing works
Spatiotemporal Expression of p63 in Mouse Epidermal Commitment
Zhao, Q., Liu, S., Zhang, H., Li, N., Wang, X., Cao, Y., Ning, L., Duan, E., & Xia, G. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226185 · Cited by 9 · see citing works
Self-citationEpithelial dynamics shed light on mechanisms underlying ear canal defects
Fons, J. M., Mozaffari, M., Malik, D., Marshall, A. R., Connor, S. E. J., Greene, N. D. E., & Tucker, A. S. (2020) · Development · doi:10.1242/dev.194654 · Cited by 9 · see citing works
Au nanostar nanoparticle as a bio-imaging agent and its detection and visualization in biosystems
Perevedentseva, E. V., Ali, N., Lin, Y.-C., Karmenyan, A., Chang, C.-C., Bibikova, O., Skovorodkin, I., Prunskaite‐Hyyryläinen, R., Vainio, S. J., Kinnunen, M. T., et al. (2020) · Biomedical Optics Express · doi:10.1364/boe.401462 · Cited by 9 · see citing works
Ontogeny of Skin Stem Cells and Molecular Underpinnings
Dermitzakis, I., Kampitsi, D. D., Μanthou, M. E., Evangelidis, P., Vakirlis, E., Meditskou, S., & Theotokis, P. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080481 · Cited by 8 · see citing works
Novel Approaches for the Application of Herbs for Skin Care
Gautam, R. K., Kamal, M. A., Chopra, H., Tsagkaris, C., & Matthews, L. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023666220411110358 · Cited by 7 · see citing works
Wüstner, L.-S., Klingenstein, M., Frey, K. G., Nikbin, M. R., Milazzo, A., Kleger, A., Liebau, S., & Klingenstein, S. (2022) · Cells · doi:10.3390/cells11121955 · Cited by 7 · see citing works
Xenopus as a model system for studying pigmentation and pigmentary disorders
Mir, J. E., Nasrallah, A., Thézé, N., Cario, M., Fayyad‐Kazan, H., Thiébaud, P., & Rezvani, H. R. (2024) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13178 · Cited by 7 · see citing works
N-Acetylcysteine modulates the effects of composites on human gingival keratinocytes
Siemer, K., Husari, A., Vach, K., Tomakidi, P., Hellwig, E., Schulz, S., & Polydorou, O. (2021) · Dental Materials · doi:10.1016/j.dental.2021.01.011 · Cited by 6 · see citing works
Wang, J., Xiao, B., Kimura, E., Mongan, M., & Xia, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-15760-z · Cited by 6 · see citing works
Hubka, K. M., Wu, D., Harrington, D. A., Langer, J., Pocard, T., Jammayrac, O., Farach‐Carson, M. C., & Pradhan-Bhatt, S. (2015) · Applied In Vitro Toxicology · doi:10.1089/aivt.2015.0013 · Cited by 6 · see citing works
Getting out of a mammalian egg: the egg tooth and caruncle of the echidna
Fenelon, J. C., Bennetts, A., Anthwal, N., Pyne, M. J., Johnston, S. D., Evans, A. R., Tucker, A. S., & Renfree, M. B. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.12.005 · Cited by 5 · see citing works
Dafinger, C., Benzing, T. R., Dötsch, J., Schermer, B., & Liebau, M. C. (2021) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-021-00111-1 · Cited by 5 · see citing works
Toward Understanding Wound Immunology for High-Fidelity Skin RegenerationPreprint
Xue, Y., Reddy, S., & Garza, L. A. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041241 · Cited by 5 · see citing works
Xu, H., Lan, S., Lin, S., Wang, A., Luo, Y., Wang, J., & Yang, Z. (2025) · Antioxidants · doi:10.3390/antiox14010118 · Cited by 4 · see citing works
Dai, C., Chen, H., Jiao, M., Zhang, N., Tang, X., Fan, A., Liu, S., Qian, Z., Wang, C., Xu, Y. X., et al. (2023) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s403075 · Cited by 4 · see citing works
Self-citationGlucocorticoid Receptor Signaling in Skin Barrier Function
Sevilla, L. M., & Pérez, P. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.79458 · Cited by 4 · see citing works
Alkhafaji, R. S., Khalfa, H. M., & AL-Msaid, H. L. F. (2022) · PubMed Central · doi:10.22092/ari.2022.357103.1974 · Cited by 4 · see citing works
Nikzad, S., Same, S., Safiri, S., Dolati, S., Zineh, B. R., Meshgi, S., Roshangar, L., & Şahi̇n, F. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad2a3e · Cited by 3 · see citing works
Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis
Deng, Q., Cai, P., Luo, Y., Zhang, Z., Ma, W., Huang, Z., Chen, X., Hao, S., Ma, W., Xu, J., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03652-0 · Cited by 3 · see citing works
Mesfin, S., Afework, M., Yami, D. B., Tessema, A., & Sento, M. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s387720 · Cited by 3 · see citing works
Anatomie et physiologie du cheveu humain
Pélissier‐Alicot, A. (2023) · Annales de Toxicologie Analytique · doi:10.1016/j.toxac.2023.07.002 · Cited by 3 · see citing works
Kinetics of the maintenance of the epidermis
Zhdanov, V. P., & Cho, N. (2013) · Open Physics · doi:10.2478/s11534-013-0292-3 · Cited by 3 · see citing works
Anatomy and Biology of Hair at Different Ages
Pélissier‐Alicot, A. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837671946-00001 · Cited by 2 · see citing works
Boukani, L. M., Ezzati, M., Khosroshahi, A. F., & Kheirjou, R. (2024) · Cell and Tissue Banking · doi:10.1007/s10561-024-10143-2 · Cited by 2 · see citing works
Generation of iPS-Derived Model Cells for Analyses of Hair Shaft Differentiation
Kido, T., Horigome, T., Uda, M., Adachi, N., & Hirai, Y. (2017) · BioTechniques · doi:10.2144/000114589 · Cited by 2 · see citing works
DNA repair during embryonic epidermal stratification
Meguro, F., Kawasaki, K., Kakihara, Y., Kawasaki, M., Fukushima, M., Sari, F. T., Utama, V., Kesuma, A., Nihara, J., Kudo, T., et al. (2025) · Developmental Dynamics · doi:10.1002/dvdy.70046 · Cited by 1 · see citing works
Protein targets & therapeutics in psoriasis: toward personalization
Shaikh, M. A., Haque, Z., Haque, A., Kumar, S., & Taleuzzaman, M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115331 · Cited by 1 · see citing works
Wnt‐Signalwege bei kutaner Homöostase und Pathologie
Augustin, I. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12620_suppl · Cited by 1 · see citing works
Skin Organogenesis and Dysmorphogenetic Factors in Skin Diseases (Review)
Yaglova, N. V., Obernikhin, S. S., Tsomartova, D. A., Ivanova, M. J., Kartashkina, N. L., & Васильевна, Ч. Е. (2018) · Современные технологии в медицине · doi:10.17691/stm2018.10.4.23 · Cited by 1 · see citing works
FOXO4-SP6 axis controls surface epithelium commitment by mediating epigenomic remodeling
Liu, J., Huang, H., An, F., Wu, S., Guo, H., Wang, B., Han, Z., Tan, J., Lin, Z., Fang, Y., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102445 · Cited by 1 · see citing works
Khalfa, H. M., AL-Msaid, H. L. F., Abood, A. H., Naji, M. A., & Hussein, S. K. (2020) · AIP conference proceedings · doi:10.1063/5.0027389 · Cited by 1 · see citing works
Liu, Y.-F., Huang, S., Yao, B., Zhao, L., Li, X., Fu, X., & Xu, W. (2017) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2017.06.08
Genetic and Environmental Factors that Control Merkel Cell Development and Survival
Logan-Graf, G. (2017) · D-Scholarship@Pitt (University of Pittsburgh)
Environmental Influences on the Development of Epidermal Progenitors
Kogut, I., & Bilousova, G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65469-7
Chan, C. C. M., Kamiguchi, H., & Shimogori, T. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12603
An Engrailed1 enhancer underlies human thermoregulatory evolutionPreprint
Aldea, D., Atsuta, Y., Kokalari, B., Schaffner, S. F., Warder, B. N., & Kamberov, Y. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.22.262659
Ellenbogen, E. (2021) · Springer eBooks · doi:10.1007/978-3-030-54779-0_1
Liu, Y., & Ng, M. K. (2022) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-022-00362-6
IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE
Dosh, R. H., Khalfa, H. M., Al-Rehemi, S. M., AL-Msaid, H. L. F., & Hadi, N. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202211203
- Authors
- Liu, S., Zhang, H., & Duan, E.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Duan, Enkui
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-05-24
- Volume
- 14
- Issue
- 6
- Pages
- 10869-10895
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3709707
- OpenAlex
- W2154963888
- Cited by
- 110
- References
- 155
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 1 · 2013: 3
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31201099)
- Chinese Academy of Sciences
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- epidermal development, embryonic epidermis, epidermal stem cells, epidermal homeostasis, epidermal regeneration, hair follicle development, epigenetic regulation, embryonic stem cells, induced pluripotent stem cells, molecular regulators
- MeSH terms
- Animals, Epidermis, Homeostasis, Mammals, Stem Cells, Signal Transduction, Cell Lineage
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