Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

Willem, Michael, Garratt, Alistair N., Novak, Bozidar, Citron, Martin, Kaufmann, Steve, Rittger, Andrea, DeStrooper, Bart, Saftig, Paul, Birchmeier, Carmen, Haass, Christian·2006·Science
DOI 10.1126/science.1132341

Cited by (726)

Items 601–700 of 726

  1. Verubecestat
    Andrew W. Stamford, Jared N. Cumming, Jack D. Scott, Corey O. Strickland · 2017 · Elsevier eBooks
  2. Memapsin 2
    Jordan Tang, Gerald Koelsch · 2012 · Elsevier eBooks
  3. The Nerve to Give BACE Inhibitors a Second Chance?
    Robert H. Baloh · 2020 · Neurotherapeutics
  4. Amyloid-β Effects on Peripheral Nerve: A New Model System
    Mark M. Stecker, Ankita Srivastava, Allison Bethanne Reiss · 2023 · International Journal of Molecular Sciences
  5. Modulation of BACE1 Activity as a Potential Therapeutic Strategy for Treating Alzheimer’s Disease
    David William Klaver, Giuseppina Tesco · 2014 · Elsevier eBooks
  6. Targets and Strategies Toward the Development of Alzheimer Therapeutics
    Michael S. Wolfe · 2016 · Topics in medicinal chemistry
  7. Discovery and Chemical Development of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer’s Disease
    David A. Thaisrivongs, William J. Morris, Jack D. Scott · 2018 · ACS symposium series
  8. Peptidomimetic Modulators of BACE1
    John Paul Juliano, David Henry Small, Marie‐Isabel Aguilar · 2020 · Australian Journal of Chemistry
  9. The future of dementia prevention and treatment strategies
    里 直行 · 2020 · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics
  10. Preparation and Implementation of a High Throughput Virtual Screening Protocol on a Shared Memory GPU Supercomputer
    Hortênsia Gomes Leal, Michelle A. Arya, Richard Anderson, Kimberly A. Stieglitz · 2021 · Engineering materials
  11. Structural Study of Membrane Glycoprotein-Precursor of β-Amyloid and Proteins Involved in Its Proteolysis
    Anatoly S. Urban, Yaroslav V. Bershatsky, Konstantin V. Pavlov, Eduard Valeryevich Bocharov · 2021 · Crystallography Reports
  12. Identification and Functional Characterization of Genetic Risk Factors in Alzheimer´s Disease
    Kerstin Eckart · 2009 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
  13. Current and Future Therapies for Alzheimer Disease
    Paramita Chakrabarty, Pritam Das, Todd Eliot Golde · 2010 · Wiley eBooks
  14. Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics
    Donald L. Price, Alena V. Savonenko, Tong Li, Michael K. Lee, Philip C. Wong · 2010 · Wiley eBooks
  15. Future Strategies for Development of Novel BACE Inhibitors: Anti‐APP β‐Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease
    Beka Solomon, Michal Arbel‐Ornath, Clare A. Peters-Libeu, Varghese John · 2010 · Wiley eBooks
  16. BACE: A (Almost) Perfect Target for Staving off Alzheimer's Disease
    S. Sinha · 2011 · Methods and principles in medicinal chemistry
  17. Identification of BACE as a Target in Alzheimer's Disease
    Robert L. Heinrikson, Sukanto Sinha · 2010
  18. Pharmacological Models for Preclinical Testing: From Mouse to Dog to Nonhuman Primates
    Jason L. Eriksen, Michael Paul Murphy, Elizabeth Head · 2010 · Wiley eBooks
  19. Neural crest in development and repair
    Jorge Benjamin Aquino · 2007 · Figshare
  20. Regulation of gene expression by non-protein-coding RNAs
    Mohammad Ali Faghihi · 2009 · Figshare
  21. Safety in semi-urban schools of limpopo Province :A case of Mankweng Circuit
    Tesfanesh Kassa Debusho · 2017
  22. Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord
    Donghang Zhang, Yali Chen, Yiyong Wei, Hongjun Chen, Yujie Wu, Lin Wu, Jin Li, Qiyang Ren, Changhong Miao, Tao Zhu et al. · 2023 · eLife
  23. Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model
    Anna Lord · 2009 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  24. Schwann Cell–Axon Interactions: The Molecular and Metabolic Link Between Schwann Cells and Axons
    Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, Shinichi Ohno · 2014 · Springer eBooks
  25. α-Secretase processing of the Alzheimer amyloid-β precursor protein and its homolog APLP2
    Kristin T. Jacobsen · 2013 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  26. Cdk5 and Neuregulin-1 Signaling
    Yi Wen, Wai Haung Yu, Karen Duff · 2008 · Springer eBooks
  27. Roles Of Neuregulin1 In Neuromuscular Junction Development
    Jiajing Wang · 2013 · Human Biology
  28. Die Amyloidablagerung in einem Mausmodell der Alzheimer Demenz und die Modulation der β-Amyloid-Peptidentstehung durch membranverankerte Inhibitoren
    Heinke Schieb · 2011 · DuEPublico (University of Duisburg-Essen)
  29. Approaches to Amyloid Therapies for the Treatment of Alzheimer's Disease
    Albert J. Robichaud, Ji‐In Kim, J. Steven Jacobsen · 2010 · Wiley eBooks
  30. Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
    Maria Bjerke · 2011 · Gothenburg University Publications Electronic Archive (Gothenburg University)
  31. Characterization of proteins involved in the production of β-Amyloid peptides and tau hyperphosphorlation in Familial Alzheimer’s Disease
    Barrera Ocampo, Álvaro Andrés · 2012
  32. Pathogenic mechanisms of the Arctic Alzheimer mutation.
    Charlotte Sahlin · 2007 · Uppsala University Publications (Uppsala University)
  33. Glial cell reactivity in mouse models reflecting different aspects of Alzheimer's disease
    Mona Gwendolyn Behrendt · 2012 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
  34. A TAG-1/APP signalling pathway through FE65 negatively modulates neurogenesis in Mus musculus (Linnaeus, 1758)
    Quanhong Ma · 2009
  35. Alzheimer – Mechanismen und therapeutische Ansätze. Warum wir im Alter dement werden
    Christian Haass · 2009 · Biologie in unserer Zeit
  36. Therapeutic strategy by manipulating some protease activities for Alzheimer's disease
    Nobuhisa Iwata, Makoto Higuchi, Takaomi C. Saido · 2008 · Folia Pharmacologica Japonica
  37. Lead-Induced Developmental Neurotoxicity and Modulated Gene Expression
    Yanjun Qian, Evelyn Tiffany‐Castiglioni · 2014 · Elsevier eBooks
  38. The Alzheimer s disease related gamma-secretase complex : Localization and novel interacting proteins
    Ji‐Yeun Hur · 2010 · Figshare
  39. Modulation of BACE1 by a novel sorting nexin in Alzheimer's disease
    Hirokazu Okada · ProQuest Demo Repository
  40. 2007 PNS PLENARY LECTURE AND REVIEW Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation
    Rhona Mirsky, Ashwin Woodhoo, David B. Parkinson, Peter Arthur‐Farraj, Ambily Bhaskaran · 2008
  41. BACE1 Inhibitors: Attractive Therapeutics for Alzheimer’s Disease
    Boris Decourt, MiMi P. Macias, Marwan Noel Sabbagh, Abdu Adem · 2014 · Elsevier eBooks
  42. Identification of ADAM10 5`UTR binding proteins - The RNA-binding protein Unr is involved in ADAM10 mRNA stability
    Christian Haass · 2014
  43. ReducedBACE1ActivityEnhancesClearanceofMyelin DebrisandRegenerationofAxonsintheInjuredPeripheral NervousSystem
    PaulN . Hoffman, PhilipC . Wong · 2011
  44. with oral administration of a BACE1 inhibitor in nonhuman primates
    Sethu Sankaranarayanan, Marie A. Holahan, Dennis J. Colussi, Ming‐Chih Crouthamel, Viswanath Devanarayan, Joan D. Ellis, Amy S. Espeseth, Adam T. Gates, Daria J. Hazuda, Jerome H. Hochman et al. · 2008
  45. Synapse- and cell-specific plasticity in the mature hippocampus
    Bridget N. Queenan · 2014 · DigitalGeorgetown (Georgetown University Library)
  46. Regulatory Crosstalk Analysis of Biochemical Networks in the Hippocampus and Nucleus Accumbens
    Shinichi Kikuchi, Eberhard O. Voit · 2013 · Springer eBooks
  47. L’approche biologique de la maladie d’Alzheimer: succès, surprises et incertitudes
    Yves Christen · 2008 · PSN
  48. Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease
    Ann‐Sofi Johansson · 2007 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  49. Alzheimer's disease
    Donald L. Price, Alena V. Savonenko, Tong Li, Philip C. Wong · 2012 · Cambridge University Press eBooks
  50. Potential Animal Models of Alzheimer Disease and Their Importance in Investigating the Pathogenesis of Alzheimer Disease
    A. A. Farooqui · 2016 · Springer eBooks
  51. ADAM19/Meltrin Beta
    Atsuko Sehara‐Fujisawa · 2012 · Handbook of Proteolytic Enzymes
  52. ErbB Membrane Tyrosine Kinase Receptors: Analyzing Migration in a Highly Complex Signaling System
    Nicole Marie Brossier, Stephanie J. Byer, Lafe T. Peavler, Steven Lewis Carroll · 2012 · Neuromethods
  53. Myelin changes in Alzheimer's disease and its mechanism
    Xiang Tang, Di Wu, Zhijun Zhang · 2014
  54. Nitrate Chimeras: A New Class of Disease Modifying Agents for the Treatment of Alzheimer's Disease
    Lawren A. VandeVrede · 2014 · Figshare
  55. The effect of the combination of erythromycin with new beta-lactam antibiotics against gram-negative aerobic respiratory pathogens.
    Masao Nakatomi, Harold C. Neu · 1986 · PubMed
  56. Therapeutic strategies for neurodegenerative disorders
    Yun Dong · 2017 · University of Groningen research database (University of Groningen / Centre for Information Technology)
  57. de dans la maladie d'Alzheimer
    Jean Sévalle · 2009
  58. Choice cuts?
    Charlotte Harrison · 2006 · Nature Reviews Drug Discovery
  59. Modelling schizophrenia endophenotypes by overexpression of Neuregulin-1 isoforms in transgenic mice
    Maria Clara Soto‐Bernardini · 2017 · eDiss (Georg-August-Universität Göttingen)
  60. Choice cuts?
    Charlotte Harrison · 2006 · Nature reviews. Neuroscience
  61. Loss of Ataxin-1 Elevates BACE1 Expression and Impairs Axonal Targeting in the Cerebrum
    Jaehong Suh, Donna Romano, Scott P. Herrick, Basavaraj V. Hooli, Mary K. Oram, Kristina Mullin, Wilma Wasco, Jeremy Dan Schmahmann, Mark W. Albers, Rudolph E. Tanzi · 2018 · SSRN Electronic Journal
  62. Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy
    Sophie Belin, Francesca Ornaghi, Ghjuvan’Ghjacumu Shackleford, Jie Wang, Cristina Scapin, Camila Lopez‐Anido, Nicholas J. Silvestri, Neil Robertson, Courtney Williamson, Akihiro Ishii et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Enhanced axonal Neuregulin-1 type-III signaling ameliorates disease severity in a CMT1B mouse model
    Cristina Scapin, Cinzia Ferri, Emanuela Pettinato, Desirée Zambroni, Francesca Bianchi, Ubaldo Del Carro, Sophie Belin, Donatella Caruso, Nico Mitro, Marta Pellegatta et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Co-imobilização das enzimas acetilcolinesterase e B-secretase1: estudo de condições para triagem de ligantes
    Adriana Ferreira Lopes Vilela · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  65. Investigating the role of normal and abnormal beta-amyloid processing in cognition
    Thomas J. Freeman · 2019 · ORCA Online Research @Cardiff (Cardiff University)
  66. Disruption of the K-Cl Cotransporter-3 Leads to Severe Peripheral Neuropathy
    Nellie E. Byun · 2008
  67. Genetic and functional studies of genes involved in the pathogenesis of Alzheimer's disease
    Teemu Natunen · 2014 · UEF eRepo (University of Eastern Finland)
  68. Longitudinal quantitative whole-brain microscopy reveals distinct temporal and spatial efficacies of anti-Aβ therapies
    Daniel Kirschenbaum, Ehsan Dadgar‐Kiani, Francesca Catto, Fabian F. Voigt, Chiara Trevisan, Oliver Bichsel, Hamid Shirani, K. Peter R. Nilsson, Karl Frontzek, Paolo Paganetti et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  69. Pattern recognition for non-coding RNA promoters
    Georgios K. Georgakilas · 2015
  70. Memapsin 2
    Antje Chang · 2009 · Springer eBooks
  71. Tau and beta-amyloid in Alzheimer’s Disease: Theories, treatments strategies, and future directions
    Jake Colautti, Kien Nagales · 2021 · The Meducator
  72. Aspartic Proteases of Alzheimer's Disease: β- and γ--Secretases
    Michael S. Wolfe · 2016 · Elsevier eBooks
  73. Eta-secretase-like processing of the amyloid precursor protein (APP) by RHBDL4
    Ylauna Christine Mégane Penalva, Sandra Paschkowsky, Sherilyn Junelle Recinto, Anthony Duchesne, Clémence Levet, François M. Charron, Matthew Freeman, Rebecca Anne McKinney, Jean‐François Trempe, Lisa Marie Munter · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  74. Tryptamine Derivatives of Sesquiterpene Lactones as Effective β-Secretase 1 Inhibitors
    Yulia R. Aleksandrova, А. В. Семаков, E. Yu. Vinyukova, S. V. Afanasyeva, S. A. Pukhov, Konstantin V. Balakin, Маргарита Е. Неганова · 2023 · Russian Journal of General Chemistry
  75. ADAMTS1 i TFPI-2: Estudi de la seva interacció funcional i les implicacions en la plasticitat tumoral.
    Torres Collado, A.E. Xavier · 2007 · TDX (Tesis Doctorals en Xarxa)
  76. Detection of the Alzheimer's disease soluble amyloid precursor protein and modulation of its proteolytic processing
    Taverna, Mara · 2014 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
  77. Validation préclinique de l'efficacité de l'ANAVEX2-73 dans des modèles transgénique et non transgénique de la maladie d'Alzheimer
    Valentine Lahmy · 2014 · theses.fr (ABES)
  78. Etude du complexe récepteur 5-HT4/ADAM10/APP et recherche de protéines associées à l’ADAM10 : de nouveaux acteurs favorisant la voie non-amyloïdogénique dans le contexte de la maladie d'Alzheimer
    Romain Donneger · 2014 · theses.fr (ABES)
  79. The involvement of AHR in peripehral myelination and nerve sheath tumorigenesis
    Nirmal Kumar Sampathkumar · 2018 · theses.fr (ABES)
  80. Drug Discovery for Alzheimer’s Disease: Current Status
    Michael S. Wolfe · 2026 · Topics in medicinal chemistry
  81. The role of the nicotinic receptors in prefrontal cortex spontaneous neuronal activity in the normal and diseased brain
    Fani Koukouli · 2016 · theses.fr (ABES)
  82. Gene therapy approach on Charcot-Marie-Tooth type 1A rats
    Hélène Hajjar · 2018 · theses.fr (ABES)
  83. Molecular mechanisms of action of MT-MMPs involved in the pathogenesis of Alzheimer’s disease
    Laura García‐González · 2020 · theses.fr (ABES)
  84. Métalloprotéases matricielles et maladie d'Alzheimer : étude des rôles de MT1- et MT5-MMP dans l'amyloïdogenèse et la neuro-inflammation
    Jean‐Michel Paumier · 2018 · theses.fr (ABES)
  85. Etude des mécanismes physiopathologiques des neuropathies périphériques dues à des mutations dans FRABIN (CMT4H) et VRK1
    Lara El-Bazzal · 2018 · theses.fr (ABES)
  86. Towards in silico prediction of mutations related to antibiotic resistance
    Eddy Elisée · 2019 · theses.fr (ABES)
  87. Heterogeneity and clinical potential of boundary cap cells and their derivatives
    Gaspard Gerschenfeld · 2019 · theses.fr (ABES)
  88. MT5-MMP promotes neuroinflammation, pathogenic processing of amyloid precursor protein and synaptic dysfunction at early stages in an Alzheimer's disease model
    Dominika Piłat · 2021 · theses.fr (ABES)
  89. Physiological and pathological roles of the amyloid precursor protein at the presynapse
    Tomás Jordá-Siquier · 2021 · theses.fr (ABES)
  90. Unraveling the physiopathological actions of the newly discovered Aη peptides in the brain
    Maria Mensch · 2020 · theses.fr (ABES)
  91. Histoire évolutive du plus ancien gène d’enveloppe rétrovirale endogène HEMO encore codant chez l’homme, exprimé dans le placenta et les tumeurs : acquisition récente d’une interaction avec une protéase transmembranaire chez les primates
    Anthony Béguin · 2024 · theses.fr (ABES)
  92. Beta-Secretase Inhibitors
    Justyna A. Dobrowolska Zakaria, Robert J. Vassar · 2026 · Topics in medicinal chemistry
  93. BACE1 Inhibitors: Design, Synthesis, Structure–Activity Relationships, and Therapeutic Applications in Alzheimer’s Disease and Beyond – An Updated Review
    Amine BAYEN, Mohamed Yafout, Mohamed El Bouamri, Amal Ait Haj Said, Adnane Benmoussa · 2026 · Journal of the Turkish Chemical Society Section A Chemistry
  94. Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System
    Kathleen Margaret Hagen, Shalina Sheryl Ousman · 2026 · Journal of the Peripheral Nervous System
  95. Chemical probes for Alzheimer’s disease targets
    Sheenagh Aiken, Tryfon Zarganes‐Tzitzikas, Paul E. Brennan · 2026 · Essays in Biochemistry
  96. Age-dependent biphasic alterations and protein-activity decoupling of plasma BACE1 in major depressive disorder
    Xiang Gao, Hang Li, Zuoli Sun, Min Liu, Yuhong Li, Weiwei Zhang, Jianping Chen, Rena Li · 2026 · Frontiers in Psychiatry
  97. Quest for specific plant BACE1 inhibitors by in silico methods
    Jarmila Nahálková · 2026 · SSRN Electronic Journal
  98. Mechanisms and therapeutic strategies for central and peripheral remyelination
    Jiangshan Zhan, Juyeon Jo, Carlo D. Cristobal, Da Jeong Jeong, Hwan Tae Park, Hyun Kyoung Lee · 2026 · Progress in Neurobiology
  99. BindingDB Entry 50039933: Discovery of cyclic sulfone hydroxyethylamines as potent and selectiveß-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloidß-peptides.
    BindingDB · 2013 · UC San Diego
  100. BindingDB Entry 50043934: Discovery of 7-tetrahydropyran-2-yl chromans:ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloidß-protein (Aß) in the central nervous system.
    BindingDB · 2014 · UC San Diego