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Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase

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Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease

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Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

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Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling

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Bace1 and Neuregulin‐1 cooperate to control formation and maintenance of muscle spindles

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Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

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Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination

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BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

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Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides.

Rueeger, H., Lueoend, R., Rogel, O., Rondeau, J., Mobitz, H., Machauer, R., Jacobson, L., Staufenbiel, M., Desrayaud, S., & Neumann, U. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300069y · Cited by 98

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Stamford, A. W., Scott, J. D., Li, S. W., Babu, S., Tadesse, D., Hunter, R., Wu, Y., Misiaszek, J., Cumming, J. N., Gilbert, E. J., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml3001165 · Cited by 100

Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs

Yan, R. (2016) · Translational Neurodegeneration · doi:10.1186/s40035-016-0061-5 · Cited by 104

The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimers Disease

Vassar, R. J., & Cole, S. (2007) · Current Genomics · doi:10.2174/138920207783769512 · Cited by 108

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice

Ou-Yang, M.-H., Kurz, J. E., Nomura, T., Popovic, J., Rajapaksha, T. W., Dong, H., Contractor, A., Chetkovich, D. M., Tourtellotte, W. G., & Vassar, R. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao5620 · Cited by 94

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Rajapaksha, T. W., Eimer, W. A., Bozza, T. C., & Vassar, R. J. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-88 · Cited by 98

Animal models of amyloid‐β‐related pathologies in Alzheimer’s disease

Philipson, O., Lord, A., Gumucio, A., O'Callaghan, P. W., Lannfelt, L., & Nilsson, L. N. G. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07564.x · Cited by 101

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond

Dislich, B., & Lichtenthaler, S. F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00008 · Cited by 102

Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury

Bartus, K., Galino, J., James, N. D., Hernandez-Miranda, L. R., Dawes, J. M., Fricker, F. R., Garratt, A. N., McMahon, S. B., Ramer, M. S., Birchmeier, C., et al. (2016) · Brain · doi:10.1093/brain/aww039 · Cited by 96

Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system

Ohno, M., Hiraoka, Y., Matsuoka, T., Tomimoto, H., Takao, K., Miyakawa, T., Oshima, N., Kiyonari, H., Kimura, T., Kita, T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2438 · Cited by 93

BACE inhibitors in clinical development for the treatment of Alzheimer’s disease

Panza, F., Lozupone, M., Solfrizzi, V., Sardone, R., Piccininni, C., Dibello, V., Stallone, R., Giannelli, G., Bellomo, A., Greco, A., et al. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1531706 · Cited by 92

Resveratrol and Amyloid-Beta: Mechanistic Insights

Jia, Y., Wang, N., & Liu, X. (2017) · Nutrients · doi:10.3390/nu9101122 · Cited by 93

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

Chakroborty, S., & Stutzmann, G. E. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.012 · Cited by 91

Targeting Aβ and tau in Alzheimer's disease, an early interim report

Golde, T. E., Petrucelli, L., & Lewis, J. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.035 · Cited by 89

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination

Fricker, F. R., Antunes‐Martins, A., Galino, J., Paramsothy, R., Russa, F. L., Perkins, J. R., Goldberg, R., Brelstaff, J., Zhu, N., McMahon, S. B., et al. (2013) · Brain · doi:10.1093/brain/awt148 · Cited by 89

Bace1 processing of NRG1 type III produces a myelin‐inducing signal but is not essential for the stimulation of myelination

Velanac, V., Unterbarnscheidt, T., Hinrichs, W., Gummert, M. N., Fischer, T. M., Rossner, M. J., Trimarco, A., Brivio, V., Taveggia, C., Willem, M., et al. (2011) · Glia · doi:10.1002/glia.21255 · Cited by 88

β‐Site APP‐cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis

Tan, J., & Evin, G. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07623.x · Cited by 90

BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway

Hu, X., He, W., Luo, X., Tsubota, K. E., & Yan, R. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.005 · Cited by 81

Disease-Modifying Approach to the Treatment of Alzheimerʼs Disease

Panza, F., Solfrizzi, V., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Vendemiale, G., Capurso, A., & Imbimbo, B. P. (2009) · Drugs & Aging · doi:10.2165/11315770-000000000-00000 · Cited by 87

Reduced Sodium Channel Nav1.1 Levels in BACE1-null Mice

Kim, D. Y., Gersbacher, M. T., Inquimbert, P., & Kovacs, D. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.134692 · Cited by 84

Function, regulation and therapeutic properties of β-secretase (BACE1)

Willem, M., Lammich, S., & Haass, C. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.01.003 · Cited by 87

Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology

Cai, W., Li, L., Sang, S., Pan, X., & Zhong, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-00985-9 · Cited by 83

Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic

Hook, G., Yu, J., Toneff, T., Kindy, M. S., & HOOK, V. Y. H. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131370 · Cited by 87

Alzheimer’s Enzyme and Myelination

Hurtley, S. M. (2006) · Science s STKE · doi:10.1126/stke.3592006tw374

BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination

Velanac, V. (2010) · doi:10.53846/goediss-3279

P1‐032: BACE1 dependent proteolysis of neuregulin in vitro and in vivo

Willem, M., Novak, B., Volbracht, C., Garratt, A. N., Birchmeier, C., & Haass, C. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.617

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

Hu, X., He, W., Diaconu, C., Tang, X., Kidd, G. J., Macklin, W. B., Trapp, B. D., & Yan, R. (2008) · The FASEB Journal · doi:10.1096/fj.08-106666 · Cited by 155

Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves

Hu, X., Hu, J., Dai, L., Trapp, B. D., & Yan, R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5207-14.2015 · Cited by 41