Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

Alzheimer's Disease Is a Synaptic Failure

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

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Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

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Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

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Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

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Neuregulin-1 Type III Determines the Ensheathment Fate of Axons

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Semagacestat's fall: where next for AD therapies?

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β -Secretases, Alzheimer’s Disease, and Down Syndrome

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Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives

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Exploring the landscape of ectodomain shedding by quantitative protein terminomics

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Evaluation of putative CSF biomarkers in paediatric spinal muscular atrophy (SMA) patients before and during treatment with nusinersen

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The Pursuit of the “Inside” of the Amyloid Hypothesis—Is C99 a Promising Therapeutic Target for Alzheimer’s Disease?

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Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons.

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Research status of the regulation of miRNA on BACE1

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Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases

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Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings

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From Alpha to Omega with Aβ: Targeting the Multiple Molecular Appearances of the Pathogenic Peptide in Alzheimers Disease

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Neuregulin 1 Expression and Electrophysiological Abnormalities in the Neuregulin 1 Transmembrane Domain Heterozygous Mutant Mouse

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BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs)

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Protein structures in Alzheimer's disease: The basis for rationale therapeutic design

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Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo

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Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies

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Sheddases and intramembrane‐cleaving proteases: RIPpers of the membrane

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Evidence for dimeric BACE-mediated APP processing

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β‐Amyloid 1‐42 induces physiological transcriptional regulation of BACE1

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The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve

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Transcriptional activation with Cas9 activator nanocomplexes rescues Alzheimer's disease pathology

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Regulation of beta‐amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds

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Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production

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BACE1 in central nervous system myelination revisited

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β-Secretase BACE1 Is Required for Normal Cochlear Function

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Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo

Kim, W., Watanabe, H., Lomoio, S., & Tesco, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100372 · Cited by 21

Alzheimer's Disease

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BACE Inhibitor Clinical Trials for Alzheimer’s Disease

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A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

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Non-conventional compounds with potential therapeutic effects against Alzheimer’s disease

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Neurodegenerative and Hepatorenal Disorders Induced Via Aluminum Chloride in Murine System: Impact of β-Secretase, MAPK, and KIM

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Cellular basis of Alzheimer′s disease

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Effect of Schwann cell transplantation combined with electroacupuncture on axonal regeneration and remyelination in rats with spinal cord injury

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Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease

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Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.

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BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex

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8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

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BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

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Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat ( MK ‐8931) in Healthy Elderly Male and Female Subjects

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Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

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Recent Understanding of the Molecular Mechanisms of Alzheimer?s Disease

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BACE1 Expression and Activity: Relevance in Alzheimer’s Disease

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Literature-Related Discovery (LRD)

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Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors.

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Increased BACE1 activity inhibits peripheral nerve regeneration after injury

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Reversing hypomyelination in BACE1‐null mice with Akt‐DD overexpression

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Recent advances in Alzheimer’s disease therapy: clinical trials and literature review of novel enzyme inhibitors targeting amyloid precursor protein

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Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360

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Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing

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PMP2 regulates myelin thickening and ATP production during remyelination

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Population pharmacokinetic and pharmacodynamic analysis of plasma Aβ40and Aβ42following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers

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Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells

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β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses

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Model Peptides Uncover the Role of the β-Secretase Transmembrane Sequence in Metal Ion Mediated Oligomerization

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O1‐02‐06: The Alzheimer's beta‐secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

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Therapeutic Antibodies for Brain Disorders

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Analyzing the Behavior of Neuronal Pathways in Alzheimer's Disease Using Petri Net Modeling Approach

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A target safety assessment of the potential toxicological risks of targeting plasmepsin IX/X for the treatment of malaria

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Expression changes of the neuregulin 1 isoforms in neuropathic pain model rats

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Beta secretase activity in peripheral nerve regeneration

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Chapter 3 Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease

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Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

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Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

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Additive dominant effect of a SOX10 mutation underlies a complex phenotype of PCWH

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Identifying the key residues instrumental in imparting stability to amyloid beta protofibrils – a comparative study using MD simulations of 17–42 residues

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Inhibition of amyloid β‐peptide production by blockage of β‐secretase cleavage site of amyloid precursor protein

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Embryonic Corneal Schwann Cells Express Some Schwann Cell Marker mRNAs, but No Mature Schwann Cell Marker Proteins

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Efficient four‐drug cocktail therapy targeting amyloid‐β peptide for Alzheimer's disease

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Performance evaluation of molecular docking and free energy calculations protocols using the D3R Grand Challenge 4 dataset

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Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia

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BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

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BACE1 Translation: At the Crossroads Between Alzheimer’s Disease Neurodegeneration and Memory Consolidation

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The three sisters of fate: Genetics, pathophysiology and outcomes of animal models of neurodegenerative diseases

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Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3

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Predicting memapsin 2 (β‐secretase) hydrolytic activity

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pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo

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