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Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

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Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration

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Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy

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AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

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The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

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Latest emerging functions of SPP/SPPL intramembrane proteases

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Spironolactone is an antagonist of NRG1‐ERBB4 signaling and schizophrenia‐relevant endophenotypes in mice

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Initiation and propagation of neurodegeneration

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Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

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Ensemble‐Docking Approach on BACE‐1: Pharmacophore Perception and Guidelines for Drug Design

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β-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins

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Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

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The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1

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Structural Similarities between Neuregulin 1–3 Isoforms Determine Their Subcellular Distribution and Signaling Mode in Central Neurons

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Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

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Rational Design and Synthesis of Potent Dibenzazepine Motifs as β-Secretase Inhibitors

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P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

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Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cellsPreprint

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Activation of α-secretase by curcumin-aminoacid conjugates

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Die Alzheimer‐Demenz: von der Pathologie zu therapeutischen Ansätzen

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MMP-28 as a regulator of myelination

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Amyloid‐beta reduction by memapsin 2 (beta‐secretase) immunization

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Lipids in health and disease

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Neurotrophins Induce Neuregulin Release through Protein Kinase Cδ Activation

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AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

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Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves

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Control of Schwann cell myelination

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Enhanced axonal neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot–Marie–Tooth type 1B mouse model

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Genetic Approaches to Modeling Anxiety in Animals

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Antipsychotic treatment and neuregulin 1–ErbB4 signalling in schizophrenia

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Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer’s disease

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Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.

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The Long Noncoding RNA Landscape in Amygdala Tissues from Schizophrenia Patients

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Linking vascular disorders and Alzheimer's disease: Potential involvement of BACE1

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Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent β-secretase (BACE1) Inhibitors

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Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

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Schwann cell development: From neural crest to myelin sheath

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Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis

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Molecular signaling mechanisms of axon–glia communication in the peripheral nervous system

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New insights in drug development for Alzheimer's disease based on microglia function

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A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles

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Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

Thakker, D. R., Sankaranarayanan, S., Weatherspoon, M. R., Harrison, J., Pierdomenico, M., Heisel, J., Thompson, L. A., Haskell, R. J., Grace, J. E., Taylor, S. J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2262-14.2015 · Cited by 32

Myelin Biology

Bolino, A. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01083-w · Cited by 33

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

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Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease

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Delivery of BACE1 siRNA mediated by TARBP-BTP fusion protein reduces β-amyloid deposits in a transgenic mouse model of Alzheimer’s disease

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SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer’s Disease Mouse Model

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Neuregulin-1 protects against neurotoxicities induced by Swedish amyloid precursor protein via the ErbB4 receptor

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p75 reduces β-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model

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Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus

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β-Secretase Cleavage of the Fly Amyloid Precursor Protein Is Required for Glial Survival

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The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1

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Alzheimer’s Disease: Lessons Learned from Amyloidocentric Clinical Trials

Soejitno, A., Tjan, A., & Purwata, T. E. (2015) · CNS Drugs · doi:10.1007/s40263-015-0257-8 · Cited by 32

The effects of α‐secretase ADAM10 on the proteolysis of neuregulin‐1

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Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes

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Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues

Bäck, M., Nyhlén, J., Kvarnström, I., Appelgren, S., Borkakoti, N., Jansson, K., Lindberg, J., Nyström, S., Hallberg, A., Rosenquist, Å., et al. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.09.041 · Cited by 31

Label‐free quantitative analysis of the membrane proteome of B ace1 protease knock‐out zebrafish brains

Hogl, S., van Bebber, F., Dislich, B., Kuhn, P., Haass, C., Schmid, B., & Lichtenthaler, S. F. (2013) · PROTEOMICS · doi:10.1002/pmic.201200582 · Cited by 31

Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation

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Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy

Wu, H., Lu, M., Wang, W., Zhang, M., Zhu, Q.-Q., Xia, Y., Xu, R., Yang, Y., Chen, L., & Ma, Q. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143162 · Cited by 31

Negative Regulators of Schwann Cell Differentiation—Novel Targets for Peripheral Nerve Therapies?

Heinen, A., Lehmann, H. C., & Küry, P. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9786-9 · Cited by 30

Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies

Hatmal, M. M., Jaber, S., & Taha, M. O. (2016) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-016-9984-2 · Cited by 30

Amyloid precursor protein and amyloid precursor‐like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M. M., Xing, Y. L., Emery, B., & Cappai, R. (2018) · Glia · doi:10.1002/glia.23561 · Cited by 29

Specific paucity of unmyelinated C‐fibers in cutaneous peripheral nerves of the African naked‐mole rat: Comparative analysis using six species of bathyergidae

Smith, E. S. J., Purfürst, B., Grigoryan, T., Park, T. J., Bennett, N. C., & Lewin, G. R. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23133 · Cited by 30

Fluid Biomarkers in Clinical Trials of Alzheimer’s Disease Therapeutics

Ritter, A. R., & Cummings, J. L. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00186 · Cited by 29

Trafficking in neurons: Searching for new targets for Alzheimer's disease future therapies

Musardo, S., Saraceno, C., Pelucchi, S., & Marcello, E. E. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.019 · Cited by 29

Hyccin, the Molecule Mutated in the Leukodystrophy Hypomyelination and Congenital Cataract (HCC), Is a Neuronal Protein

Gazzerro, E., Baldassari, S., Giacomini, C., Musante, V., Fruscione, F., Padula, V. L., Biancheri, R., Scarfı̀, S., Prada, V., Sotgia, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032180 · Cited by 29

Proteomic Substrate Identification for Membrane Proteases in the Brain

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BACE1 partial deletion induces synaptic plasticity deficit in adult mice

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Post-Translational Modifications of BACE1 in Alzheimer's Disease

Wen, W., Li, P., Liu, P., Xu, S., Wang, F., & Huang, J. H. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210121163224 · Cited by 33

Structural Studies Providing Insights into Production and Conformational Behavior of Amyloid-β Peptide Associated with Alzheimer’s Disease Development

Urban, A. S., Pavlov, K. V., Kamynina, A. V., Okhrimenko, I. S., Arseniev, A. S., & Bocharov, E. V. (2021) · Molecules · doi:10.3390/molecules26102897 · Cited by 30

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice

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Molecular Signaling

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Role of APP for dendritic spine formation and stability

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Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1

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A Two Decade Contribution of Molecular Cell Biology to the Centennial of Alzheimer's Disease: Are We Progressing Toward Therapy?

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The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing

Rabe, S., Reichwald, J., Ammaturo, D., Strooper, B. D., Säftig, P., Neumann, U., & Staufenbiel, M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07412.x · Cited by 28

Mossy Fiber Long-Term Potentiation Deficits in BACE1 Knock-Outs Can Be Rescued by Activation of α7 Nicotinic Acetylcholine Receptors

Wang, H., Song, L., Lee, A., Laird, F. M., Wong, P. C., & Lee, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1070-10.2010 · Cited by 28

Post-translational regulation of the β-secretase BACE1

Araki, W. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.009 · Cited by 26

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1

Gerakis, Y., Dunys, J., Bauer, C., & Checler, F. (2016) · Scientific Reports · doi:10.1038/srep37436 · Cited by 30

BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia

Zhang, Z., Huang, J., Shen, Y., & Li, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00302 · Cited by 23

BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice

Chatila, Z. K., Kim, E., Berlé, C., Bylykbashi, E., Rompala, A., Oram, M. K., Gupta, D., Kwak, S. S., Kim, Y. H., Kim, D. Y., et al. (2018) · eNeuro · doi:10.1523/eneuro.0067-18.2018 · Cited by 27

BACE1 inhibitor drugs for the treatment of Alzheimer's disease: Lessons learned, challenges to overcome, and future prospects†

Ghosh, A. K. (2024) · Global Health & Medicine · doi:10.35772/ghm.2024.01033 · Cited by 27

Postsynaptic Target Specific Synaptic Dysfunctions in the CA3 Area of BACE1 Knockout Mice

Wang, H., Megill, A., Wong, P. C., Kirkwood, A., & Lee, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092279 · Cited by 29

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

Rudan Njavro, J., Klotz, J., Dislich, B., Wanngren, J., Shmueli, M. D., Herber, J., Kuhn, P., Kumar, R., Koeglsperger, T., Conrad, M., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902347r · Cited by 28

The Glucose Metabolic Pathway as A Potential Target for Therapeutics: Crucial Role of Glycosylation in Alzheimer’s Disease

Bukke, V. N., Villani, R., Moola, A., Wawrzyniak, A., Balawender, K., Orkisz, S., Ferraro, L., Serviddio, G., & Cassano, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207739 · Cited by 27

Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target

Syeda, T., & Cannon, J. R. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22694 · Cited by 30

Alzheimer's secretases regulate voltage-gated sodium channels

Kovacs, D. M., Gersbacher, M. T., & Kim, D. Y. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.048 · Cited by 27

Amyloid Beta Hypothesis in Alzheimer's Disease: Major Culprits and Recent Therapeutic Strategies

Dileep, K. V., & Chandra, R. (2019) · Current Drug Targets · doi:10.2174/1389450120666190806153206 · Cited by 26

Peripheral Nerve Development and the Pathogenesis of Peripheral Neuropathy: the Sorting Point

Previtali, S. C. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01080-z · Cited by 27

AβPP-Selective BACE Inhibitors (ASBI): Novel Class of Therapeutic Agents for Alzheimer’s Disease

Descamps, O., Spilman, P., Zhang, Q., Libeu, C. P., Poksay, K., Gorostiza, O. F., Campagna, J. J., Jagodzinska, B., Bredesen, D., & John, V. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130578 · Cited by 22

Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer’s Disease

Ghosh, A. K., & Tang, J. J. N. (2015) · ChemMedChem · doi:10.1002/cmdc.201500216 · Cited by 25

Differential effects of γ‐secretase and BACE1 inhibition on brain Aβ levels in vitro and in vivo

Elvang, A. B., Volbracht, C., Pedersen, L. Ø., Jensen, K. G., Karlsson, J.-J., Larsen, S. A., Mørk, A., Stensbøl, T. B., & Bastlund, J. F. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06215.x · Cited by 24

BACE1 regulates the proliferation and cellular functions of Schwann cells

Hu, X., Hou, H., Bastian, C., He, W., Qiu, S., Ge, Y., Yin, X., Kidd, G. J., Brunet, S., Trapp, B. D., et al. (2017) · Glia · doi:10.1002/glia.23122 · Cited by 27

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

Rueeger, H., Lueoend, R. M., Machauer, R., Veenstra, S. J., Jacobson, L. H., Staufenbiel, M., Desrayaud, S., Rondeau, J., Möbitz, H., & Neumann, U. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.07.071 · Cited by 28

β‐Secretase cleavage is not required for generation of the intracellular C‐terminal domain of the amyloid precursor family of proteins

Frigerio, C. S., Fadeeva, J. V., Minogue, A. M., Citron, M., LEUVEN, F. V., Staufenbiel, M., Paganetti, P., Selkoe, D. J., & Walsh, D. M. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07579.x · Cited by 25

Non-coding RNA transcripts: Sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease

Laurent, G. S., Faghihi, M. A., & Wahlestedt, C. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.08.032 · Cited by 25

Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia

Barakat, A., Dean, B., Scarr, E., & Evin, G. M. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.09.001 · Cited by 26

Selective amyloid-β lowering agents

Wolfe, M. S. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s2-s4 · Cited by 27

Alzheimer’s Enzyme and Myelination

Hurtley, S. M. (2006) · Science s STKE · doi:10.1126/stke.3592006tw374

BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination

Velanac, V. (2010) · doi:10.53846/goediss-3279

P1‐032: BACE1 dependent proteolysis of neuregulin in vitro and in vivo

Willem, M., Novak, B., Volbracht, C., Garratt, A. N., Birchmeier, C., & Haass, C. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.617

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

Hu, X., He, W., Diaconu, C., Tang, X., Kidd, G. J., Macklin, W. B., Trapp, B. D., & Yan, R. (2008) · The FASEB Journal · doi:10.1096/fj.08-106666 · Cited by 155

Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves

Hu, X., Hu, J., Dai, L., Trapp, B. D., & Yan, R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5207-14.2015 · Cited by 41