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A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Open accessAbstract
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen ( HLA )– B*5701 , whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
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Metadata
- Authors
- Fellay, J., Shianna, K. V., Ge, D., Colombo, S., Ledergerber, B., Weale, M., Zhang, K., Gumbs, C., Castagna, A., Cossarizza, A., Cozzi-Lepri, A., De Luca, A., Easterbrook, P., Francioli, P., Mallal, S., Martinez-Picado, J., Miro, J. M., Obel, N., Smith, J. P., Wyniger, J., Descombes, P., Antonarakis, S. E., Letvin, N. L., McMichael, A. J., Haynes, B. F., Telenti, A., & Goldstein, D. B.
- Venue
- Science
- Published
- 2007-08-17
- Volume
- 317
- Issue
- 5840
- Pages
- 944-947
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2123584222
- Cited by
- 1,235
- References
- 2
- FWCI
- 40.55
- Type
- journal article
- Language
- en
- Open access
- green
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