Behavioral phenotyping strategies for mutant mice
Open accessAbstract
Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the functional roles of many genes in the brain. Over the past 10 years, strategies for mouse behavioral phenotyping have evolved to maximize the scope and replicability of findings from a cohort of mutant mice, minimize the interpretation of procedural artifacts, and provide robust translational tools to test hypotheses and develop treatments. This Primer addresses experimental design issues and offers examples of high-throughput batteries, learning and memory tasks, and anxiety-related tests.
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In mouse behavioral studies, testing paradigms for learning and memory have been widely accepted.
“In mouse behavioral studies, testing paradigms for learning and memory have been widely accepted (Crawley, 2008; Crawley and Paylor, 1997; Morris, 1981).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Crawley, 2008
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- Authors
- Crawley, J. N.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Crawley, Jacqueline N.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 57
- Issue
- 6
- Pages
- 809-818
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2104202813
- Cited by
- 439
- References
- 137
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 12 · 2023: 13 · 2022: 23 · 2021: 17 · 2020: 31 · 2019: 19 · 2018: 28 · 2017: 30 · 2016: 23 · 2015: 32 · 2014: 35 · 2013: 26 · 2012: 32
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- behavioral phenotyping, mouse mutants, knockout mice, transgenic mice, experimental design, anxiety-like behavior, translational neuroscience
- MeSH terms
- Animals, Behavior, Animal, Disease Models, Animal, Female, Male, Mice, Neurologic Mutants, Phenotype, Mice
About these checks
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