Cited by 439Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Behavioral phenotyping strategies for mutant mice

Open access
Crawley, Jacqueline N.·2008·Neuron

Abstract

Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the functional roles of many genes in the brain. Over the past 10 years, strategies for mouse behavioral phenotyping have evolved to maximize the scope and replicability of findings from a cohort of mutant mice, minimize the interpretation of procedural artifacts, and provide robust translational tools to test hypotheses and develop treatments. This Primer addresses experimental design issues and offers examples of high-throughput batteries, learning and memory tasks, and anxiety-related tests.

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Crossref · 10.1016/j.neuron.2008.03.001

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  • In mouse behavioral studies, testing paradigms for learning and memory have been widely accepted.

    “In mouse behavioral studies, testing paradigms for learning and memory have been widely accepted (Crawley, 2008; Crawley and Paylor, 1997; Morris, 1981).”

    From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Crawley, 2008

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Authors
Crawley, J. N.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Crawley, Jacqueline N.
Venue
Neuron
Publisher
Elsevier BV
Published
2008-03
Volume
57
Issue
6
Pages
809-818
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2104202813
Cited by
439
References
137
Citations by year
2026: 13 · 2025: 21 · 2024: 12 · 2023: 13 · 2022: 23 · 2021: 17 · 2020: 31 · 2019: 19 · 2018: 28 · 2017: 30 · 2016: 23 · 2015: 32 · 2014: 35 · 2013: 26 · 2012: 32
FWCI
2.01
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
behavioral phenotyping, mouse mutants, knockout mice, transgenic mice, experimental design, anxiety-like behavior, translational neuroscience
MeSH terms
Animals, Behavior, Animal, Disease Models, Animal, Female, Male, Mice, Neurologic Mutants, Phenotype, Mice

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