The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Regulation of Homeostatic Chemokine Expression and Cell Trafficking During Immune Responses
Abstract
The chemokines CCL21 and CXCL13 are immune factors that dictate homing and motility of lymphocytes and dendritic cells in lymphoid tissues. However, the means by which these chemokines are regulated and how they influence cell trafficking during immune responses remain unclear. We show that CCL21 and CXCL13 are transiently down-regulated within lymphoid tissues during immune responses by a mechanism controlled by the cytokine interferon-γ. This modulation was found to alter the localization of lymphocytes and dendritic cells within responding lymphoid tissues. As a consequence, priming of T cell responses to a second distinct pathogen after chemokine modulation became impaired. We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues.
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Cites
T-Cell Function and Migration — Two Sides of the Same Coin
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Lymphocyte traffic control by chemokines
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Stromal Cell Networks Regulate Lymphocyte Entry, Migration, and Territoriality in Lymph Nodes
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Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
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Cited by
CCR7 and its ligands: balancing immunity and tolerance
Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Orchestrating the orchestrators: chemokines in control of T cell traffic
Bromley, S. K., Mempel, T. R., & Luster, A. D. (2008) · Nature Immunology · doi:10.1038/ni.f.213 · Cited by 593
Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity
Rodda, L. B., Lu, E., Bennett, M. L., Sokol, C. L., Wang, X., Luther, S. A., Barres, B. A., Luster, A. D., Ye, C. J., & Cyster, J. G. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.006 · Cited by 438
T cell migration, search strategies and mechanisms
Krummel, M. F., Bartumeus, F., & Gérard, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.16 · Cited by 423
Metadata
- Authors
- Mueller, S. N., Hosiawa-Meagher, K. A., Konieczny, B. T., Sullivan, B. M., Bachmann, M. F., Locksley, R. M., Ahmed, R., & Matloubian, M.
- Venue
- Science
- Published
- 2007-08-03
- Volume
- 317
- Issue
- 5838
- Pages
- 670-674
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001911522
- Cited by
- 259
- References
- 18
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mueller, S. N., Hosiawa-Meagher, K. A., Konieczny, B. T., Sullivan, B. M., Bachmann, M. F., Locksley, R. M., Ahmed, R., & Matloubian, M. (2007). Regulation of Homeostatic Chemokine Expression and Cell Trafficking During Immune Responses. Science. https://doi.org/10.1126/science.1144830
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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