The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Abstract
Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.
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“Piwi-interacting RNAs (piRNAs) associate with a germlineexpressed clade of argonaute proteins, known as Piwis 26 , and have a role in transposon silencing and genome methylation 26 .”
From Genome analysis of the platypus reveals unique signatures of evolution (2008) · cites this paper as [26]
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Metadata
- Authors
- Aravin, A. A., Hannon, G. J., & Brennecke, J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Aravin, Alexei A.
- Hannon, Gregory J.
- Brennecke, Julius
- Venue
- Science
- Published
- 2007-11-02
- Volume
- 318
- Issue
- 5851
- Pages
- 761-764
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046318418
- Cited by
- 1,096
- References
- 38
- Citations by year
- 2026: 28 · 2025: 43 · 2024: 37 · 2023: 32 · 2022: 41 · 2021: 45 · 2020: 42 · 2019: 56 · 2018: 62 · 2017: 46 · 2016: 53 · 2015: 78 · 2014: 76 · 2013: 68 · 2012: 74
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- RNA interference, transposable elements, small RNA, Argonaute proteins, genome defense, selfish genetic elements, gene silencing
- MeSH terms
- Adaptation, Biological, Animals, Base Sequence, DNA Transposable Elements, Molecular Sequence Data, Proteins, RNA-Binding Proteins, Evolution, Molecular, Gene Silencing, Drosophila Proteins, RNA, Small Interfering, RNA-Induced Silencing Complex, Argonaute Proteins
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