The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Abstract
Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.
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“Piwi-interacting RNAs (piRNAs) associate with a germlineexpressed clade of argonaute proteins, known as Piwis 26 , and have a role in transposon silencing and genome methylation 26 .”
From Genome analysis of the platypus reveals unique signatures of evolution (2008) · cites this paper as [26]
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Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., & Hannon, G. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.043 · Cited by 2,524
Self-citationTransposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
A germline-specific class of small RNAs binds mammalian Piwi proteins
Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762
Self-citationA novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
Self-citationA Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vagin, V. V., Sigova, A. A., Li, C., Seitz, H., Gvozdev, V. A., & Zamore, P. D. (2006) · Science · doi:10.1126/science.1129333 · Cited by 1,385
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
Bourc’his, D., & Bestor, T. H. (2004) · Nature · doi:10.1038/nature02886 · Cited by 1,279
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
Gunawardane, L. S., Saito, K., Nishida, K. M., Miyoshi, K., Kawamura, Y., Nagami, T., Siomi, H., & Siomi, M. C. (2007) · Science · doi:10.1126/science.1140494 · Cited by 1,173
MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline
Carmell, M. A., Girard, A., van de Kant, H. J. G., Bourc’his, D., Bestor, T. H., de Rooij, D. G., & Hannon, G. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.001 · Cited by 1,170
Self-citationA Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Houwing, S., Kamminga, L. M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D. V., Blaser, H., Raz, E., Moens, C. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.026 · Cited by 1,132
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MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Establishing, maintaining and modifying DNA methylation patterns in plants and animals
Law, J. A., & Jacobsen, S. E. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2719 · Cited by 3,925
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
Long noncoding RNAs: functional surprises from the RNA worldPreprint
Wilusz, J. E., Sunwoo, H., & Spector, D. L. (2009) · Genes & Development · doi:10.1101/gad.1800909 · Cited by 2,322
Origin, Biogenesis, and Activity of Plant MicroRNAs
Voinnet, O. (2009) · Cell · doi:10.1016/j.cell.2009.01.046 · Cited by 2,251
Metadata
- Authors
- Aravin, A. A., Hannon, G. J., & Brennecke, J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Aravin, Alexei A.
- Hannon, Gregory J.
- Brennecke, Julius
- Venue
- Science
- Published
- 2007-11-02
- Volume
- 318
- Issue
- 5851
- Pages
- 761-764
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046318418
- Cited by
- 1,096
- References
- 38
- Citations by year
- 2026: 28 · 2025: 43 · 2024: 37 · 2023: 32 · 2022: 41 · 2021: 45 · 2020: 42 · 2019: 56 · 2018: 62 · 2017: 46 · 2016: 53 · 2015: 78 · 2014: 76 · 2013: 68 · 2012: 74
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- RNA interference, transposable elements, small RNA, Argonaute proteins, genome defense, selfish genetic elements, gene silencing
- MeSH terms
- Adaptation, Biological, Animals, Base Sequence, DNA Transposable Elements, Molecular Sequence Data, Proteins, RNA-Binding Proteins, Evolution, Molecular, Gene Silencing, Drosophila Proteins, RNA, Small Interfering, RNA-Induced Silencing Complex, Argonaute Proteins
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