Cited by 578Angiogenesis and VEGF in CancerCancer Cells and MetastasisLymphatic System and Diseases

Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors

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Butler, Jason M., Kobayashi, Hideki, Rafii, Shahin·2010·Nature Reviews Cancer

Abstract

The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.

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  • Endothelium expresses angiocrine factors that affect tumor progression in the metastatic niche.

    “Additionally, endothelium is known to express angiocrine factors that affect tumor progression in the metastatic niche6”

    From Endothelial Pim3 kinase protects the vascular barrier during lung metastasis (2024) · cites this paper as [6]

    The Abstract says endothelial cells secrete or express angiocrine factors in a vascular niche that modulates tumour progression and metastasis. The Inflammatory cell recruitment section discusses angiocrine signals in micrometastatic lesions, but frames their role as a possibility; it does not establish their effect in the metastatic niche as a known fact. (LLM, conf=0.81)

    Experimental — accuracy not yet measured

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Authors
Butler, J. M., Kobayashi, H., & Rafii, S.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Rafii, Shahin
Venue
Nature Reviews Cancer
Published
2010-02
Volume
10
Issue
2
Pages
138-146
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2049016944
Cited by
578
References
120
Citations by year
2026: 10 · 2025: 21 · 2024: 30 · 2023: 38 · 2022: 47 · 2021: 42 · 2020: 46 · 2019: 37 · 2018: 38 · 2017: 45 · 2016: 31 · 2015: 28 · 2014: 48 · 2013: 36 · 2012: 30
FWCI
3.23
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Heart, Lung, and Blood Institute (R21HL083222, R01HL061849, P01HL072942, P01HL059312, R01HL097797, R01HL058707, U01HL066952, P01HL067839, P50HL084936, R01HL075234)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords
vascular niche, angiocrine factors, endothelial cells, tumor growth, tissue repair, anti-angiogenic therapy, vascular toxicity, stem cell activity, tumor microenvironment, tumor targeting
MeSH terms
Animals, Endothelium, Vascular, Growth Substances, Humans, Neoplasms, Neovascularization, Pathologic, Neoplastic Stem Cells, Disease Progression, Angiogenesis Inhibitors

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