Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors
Open accessAbstract
The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.
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Endothelium expresses angiocrine factors that affect tumor progression in the metastatic niche.
“Additionally, endothelium is known to express angiocrine factors that affect tumor progression in the metastatic niche6”
From Endothelial Pim3 kinase protects the vascular barrier during lung metastasis (2024) · cites this paper as [6]
The Abstract says endothelial cells secrete or express angiocrine factors in a vascular niche that modulates tumour progression and metastasis. The Inflammatory cell recruitment section discusses angiocrine signals in micrometastatic lesions, but frames their role as a possibility; it does not establish their effect in the metastatic niche as a known fact. (LLM, conf=0.81)
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- Authors
- Butler, J. M., Kobayashi, H., & Rafii, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rafii, Shahin
- Venue
- Nature Reviews Cancer
- Published
- 2010-02
- Volume
- 10
- Issue
- 2
- Pages
- 138-146
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC2944775
- OpenAlex
- W2049016944
- Cited by
- 578
- References
- 120
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 30 · 2023: 38 · 2022: 47 · 2021: 42 · 2020: 46 · 2019: 37 · 2018: 38 · 2017: 45 · 2016: 31 · 2015: 28 · 2014: 48 · 2013: 36 · 2012: 30
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (R21HL083222, R01HL061849, P01HL072942, P01HL059312, R01HL097797, R01HL058707, U01HL066952, P01HL067839, P50HL084936, R01HL075234)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- vascular niche, angiocrine factors, endothelial cells, tumor growth, tissue repair, anti-angiogenic therapy, vascular toxicity, stem cell activity, tumor microenvironment, tumor targeting
- MeSH terms
- Animals, Endothelium, Vascular, Growth Substances, Humans, Neoplasms, Neovascularization, Pathologic, Neoplastic Stem Cells, Disease Progression, Angiogenesis Inhibitors
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