The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres
Open accessAbstract
Heterochromatin is defined by distinct posttranslational modifications on histones, such as methylation of histone H3 at lysine 9 (H3K9), which allows heterochromatin protein 1 (HP1)–related chromodomain proteins to bind. Heterochromatin is frequently found near CENP-A chromatin, which is the key determinant of kinetochore assembly. We have discovered that the RNA interference (RNAi)–directed heterochromatin flanking the central kinetochore domain at fission yeast centromeres is required to promote CENP-A Cnp1 and kinetochore assembly over the central domain. The H3K9 methyltransferase Clr4 (Suv39); the ribonuclease Dicer, which cleaves heterochromatic double-stranded RNA to small interfering RNA (siRNA); Chp1, a component of the RNAi effector complex (RNA-induced initiation of transcriptional gene silencing; RITS); and Swi6 (HP1) are required to establish CENP-A Cnp1 chromatin on naïve templates. Once assembled, CENP-A Cnp1 chromatin is propagated by epigenetic means in the absence of heterochromatin. Thus, another, potentially conserved, role for centromeric RNAi-directed heterochromatin has been identified.
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Cites
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
Volpe, T. A., Kidner, C., Hall, I. M., Teng, G., Grewal, S. I. S., & Martienssen, R. A. (2002) · Science · doi:10.1126/science.1074973 · Cited by 2,055
Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
Nakayama, J.-I., Rice, J. C., Strahl, B. D., Allis, C. D., & Grewal, S. I. S. (2001) · Science · doi:10.1126/science.1060118 · Cited by 1,739
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
Verdel, A., Jia, S., Gerber, S., Sugiyama, T., Gygi, S., Grewal, S. I. S., & Moazed, D. (2004) · Science · doi:10.1126/science.1093686 · Cited by 1,221
Cleveland, D. W., Mao, Y., & Sullivan, K. F. (2003) · Cell · doi:10.1016/s0092-8674(03)00115-6 · Cited by 1,003
Requirement of Heterochromatin for Cohesion at Centromeres
Bernard, P., Maure, J.-F., Partridge, J. F., Genier, S., Javerzat, J.-P., & Allshire, R. C. (2001) · Science · doi:10.1126/science.1064027 · Cited by 616
Self-citationSullivan, B. A., & Karpen, G. H. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb845 · Cited by 574
Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast
Nonaka, N., Kitajima, T., Yokobayashi, S., Xiao, G., Yamamoto, M., Grewal, S. I. S., & Watanabe, Y. (2002) · Nature Cell Biology · doi:10.1038/ncb739 · Cited by 455
Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.
Allshire, R. C., Nimmo, E. R., Ekwall, K., Javerzat, J. P., & Cranston, G. (1995) · Genes & Development · doi:10.1101/gad.9.2.218 · Cited by 450
Self-citationNoma, K.-I., Sugiyama, T., Cam, H., Verdel, A., Zofall, M., Jia, S., Moazed, D., & Grewal, S. I. S. (2004) · Nature Genetics · doi:10.1038/ng1452 · Cited by 395
Cited by
Histones: annotating chromatin
Campos, E. I., & Reinberg, D. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.032608.103928 · Cited by 852
The molecular basis for centromere identity and function
McKinley, K. L., & Cheeseman, I. M. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.5 · Cited by 668
Heterochromatin: Guardian of the Genome
Janssen, A., Colmenares, S. U., & Karpen, G. H. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062653 · Cited by 500
Major Evolutionary Transitions in Centromere Complexity
Malik, H. S., & Henikoff, S. (2009) · Cell · doi:10.1016/j.cell.2009.08.036 · Cited by 375
A two-step mechanism for epigenetic specification of centromere identity and function
Fachinetti, D., Diego Folco, H., Nechemia-Arbely, Y., Valente, L. P., Nguyen, K., Wong, A. J., Zhu, Q., Holland, A. J., Desai, A., Jansen, L. E. T., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2805 · Cited by 255
Metadata
- Authors
- Folco, H. D., Pidoux, A. L., Urano, T., & Allshire, R. C.
- Venue
- Science
- Published
- 2008-01-04
- Volume
- 319
- Issue
- 5859
- Pages
- 94-97
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970569685
- Cited by
- 275
- References
- 21
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- green
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