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H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Open accessAbstract
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.
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“Several enzymatic and non-enzymatic sources have been identified to contribute to the existing pool of sulfide in circulation and tissues [1][2][3], with a purportedly essential role in blood pressure regulation [4].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [4]
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Cites
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070
The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
Zhao, W., Zhang, J., Lu, Y., & Wang, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6008 · Cited by 1,936
Self-citationTwo's company, three's a crowd: can H 2 S be the third endogenous gaseous transmitter?
Wang, R. T. (2002) · The FASEB Journal · doi:10.1096/fj.02-0211hyp · Cited by 1,808
Self-citationBoehning, D. F., & Snyder, S. H. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131047 · Cited by 1,235
Self-citationElevated blood pressures in mice lacking endothelial nitric oxide synthase
Shesely, E. G., Maeda, N., Kim, H.-S., Desai, K. M., Krege, J. H., Laubach, V. E., Sherman, P. A., Sessa, W. C., & Smithies, O. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13176 · Cited by 908
Homocysteine and vascular disease
McCully, K. S. (1996) · Nature Medicine · doi:10.1038/nm0496-386 · Cited by 705
H2S-induced vasorelaxation and underlying cellular and molecular mechanisms
Zhao, W., & Wang, R. T. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00013.2002 · Cited by 505
Self-citationHydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats
Cheng, Y., Ndisang, J. F., Tang, G., Cao, K., & Wang, R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00331.2004 · Cited by 439
Self-citationHydrogen Sulfide as a Neuromodulator
Kimura, H. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:1:013 · Cited by 427
Fiorucci, S., Antonelli, E., Distrutti, E., Rizzo, G., Mencarelli, A., Orlandi, S., Zanardo, R. C. O., Renga, B., Sante, M. D., Morelli, A., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.07.060 · Cited by 409
Research works printed but not linked: 2
- S. H. Zlotkin, G. H. Anderson, Pediatr. Res.16, 65 (1982).
- K. D. Lake-Bruseet al., Am. J. Physiol. Heart Circ. Physiol.2, H770 (1999).
Cited by
Sorted by citations
Items 501–600 of 1,001
Predictions of thermodynamic properties for hydrogen sulfide
Jia, C., Li, J., Liu, Y., Peng, X., Xu, J., Zhang, L., Jiang, R., Li, X., Liu, J., & Zhao, Y. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.113751 · Cited by 77
A New Hope for Neurodegeneration: Possible Role of Hydrogen Sulfide
Gong, Q., Shi, X., Hong, Z., Pan, L., Liu, X.-H., & Zhu, Y. Z. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110128 · Cited by 77
Zhang, D., & Jin, W. (2012) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2012.01.013 · Cited by 77
Yang, G.-D., Tang, G., Zhang, L., Wu, L.-Y., & Wang, R. (2011) · American Journal of Pathology · doi:10.1016/j.ajpath.2011.04.028 · Cited by 83
Self-citationHydrogen Sulfide Regulates Homocysteine-Mediated Glomerulosclerosis
Sen, U., Munjal, C., Qipshidze, N., Abe, O. A., Gargoum, R., & Tyagi, S. C. (2010) · American Journal of Nephrology · doi:10.1159/000296717 · Cited by 78
A mitochondrial-targeted ratiometric probe for detecting intracellular H2S with high photostability
Bu, D., Wang, Y., Wu, N., Feng, W., Wei, D., Li, Z., & Yu, M. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.12.044 · Cited by 76
Haris, U., Kagalwala, H. N., Kim, Y. L., & Lippert, A. R. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00185 · Cited by 76
Chen, Z., Ouyang, C., Zhang, H., Gu, Y., Deng, Y., Du, C., Cui, C., Li, S., Wang, W., Kong, W., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2026097 · Cited by 75
H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells
Ju, Y., Untereiner, A. A., Wu, L., & Yang, G. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.08.003 · Cited by 76
Self-citationHydrosulfide (HS−) Coordination in Iron Porphyrinates
Pavlik, J. W., Noll, B. C., Oliver, A. G., Schulz, C. E., & Scheidt, W. R. (2009) · Inorganic Chemistry · doi:10.1021/ic901853p · Cited by 76
Modes of Physiologic H 2 S Signaling in the Brain and Peripheral Tissues
Paul, B. D., & Snyder, S. H. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5917 · Cited by 76
Self-citationThe enzymes of the transsulfuration pathways: Active-site characterizations
Aitken, S. M., Lodha, P. H., & Morneau, D. J. K. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.03.006 · Cited by 76
Yang, G., Pei, Y., Cao, Q., & Wang, R. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.24006 · Cited by 74
Self-citationMechanism of vasorelaxation and role of endogenous hydrogen sulfide production in mouse aorta
Al-Magableh, M., & Hart, J. L. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0608-z · Cited by 76
Ivanciuc, T., Sbrana, E., Ansar, M., Bazhanov, N., Szabó, C., Casola, A., & Garofalo, R. P. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0385oc · Cited by 76
Weber, G. J., Pushpakumar, S. B., Tyagi, S. C., & Sen, U. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.09.002 · Cited by 76
Sun, L., Wu, Y., Chen, J., Zhong, J., Zeng, F., & Wu, S. (2018) · Theranostics · doi:10.7150/thno.30080 · Cited by 78
Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases
Corvino, A., Frecentese, F., Magli, E., Perissutti, E., Santagada, V., Scognamiglio, A., Caliendo, G., Fiorino, F., & Severino, B. (2021) · Antioxidants · doi:10.3390/antiox10030429 · Cited by 74
Hydrogen sulfide inhibits the translational expression of hypoxia‐inducible factor‐1α
Wu, B., Teng, H., Yang, G., Wu, L., & Wang, R. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02113.x · Cited by 74
Self-citationOzone: A New Therapeutic Agent in Vascular Diseases
Bocci, V. A., Zanardi, I., & Travagli, V. (2011) · American Journal of Cardiovascular Drugs · doi:10.2165/11539890-000000000-00000 · Cited by 77
Peng, Y., Makarenko, V. V., Nanduri, J., Vasavda, C., Raghuraman, G., Yuan, G., Gadalla, M. M., Kumar, G. K., Snyder, S. H., & Prabhakar, N. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322172111 · Cited by 75
Self-citationvan den Berg, E., Pasch, A., Westendorp, W. H., Navis, G. J., Brink, E. J., Gans, R. O. B., van Goor, H., & Bakker, S. J. L. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013050497 · Cited by 76
H2S Increases Survival during Sepsis: Protective Effect of CHOP Inhibition
Ferlito, M., Wang, Q., Fulton, W. B., Colombani, P. M., Marchionni, L., Fox-Talbot, K., Paolocci, N., & Steenbergen, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300835 · Cited by 75
Ratiometric Time-Gated Luminescence Probe for Hydrogen Sulfide Based on Lanthanide Complexes
Dai, Z., Tian, L., Song, B., Ye, Z., Liu, X., & Yuan, J. (2014) · Analytical Chemistry · doi:10.1021/ac503611f · Cited by 75
Chen, S., Li, H., & Hou, P. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.10.052 · Cited by 74
Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease
Wu, D., Wang, D., Li, H., Guo, J., Duan, S., & Ji, X. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3831713 · Cited by 75
Organic Isothiocyanates as Hydrogen Sulfide Donors
Martelli, A., Citi, V., Testai, L., Brogi, S., & Calderone, V. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7888 · Cited by 74
The Role of Protein Persulfidation in Brain Aging and Neurodegeneration
Petrovic, D., Kouroussis, E., Vignane, T., & Filipović, M. R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.674135 · Cited by 75
Unravelling the theories of pre‐eclampsia: are the protective pathways the new paradigm?
Ahmed, A., & Ramma, W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12977 · Cited by 74
Yang, G., Li, H., Tang, G., Wu, L., Zhao, K., Cao, Q., Xu, C., & Wang, R. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.12.004 · Cited by 74
Self-citationAgrawal, N., & Banerjee, R. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004032 · Cited by 74
Pan, L., Liu, X., Shen, Y., Wang, N.-Z., Xu, J., Wu, D., Xiong, Q., Deng, H., Huang, G.-Y., & Zhu, Y. Z. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.06.007 · Cited by 74
Yamada, H., Akahoshi, N., Kamata, S., Hagiya, Y., Hishiki, T., Nagahata, Y., Matsuura, T., Takano, N., Mori, M., Ishizaki, Y., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.033 · Cited by 74
Wei, L., Zhu, Z., Li, Y., Yi, L., & Xi, Z. (2015) · Chemical Communications · doi:10.1039/c5cc03707g · Cited by 73
Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway
Ziosi, M., Meo, I. D., Kleiner, G., Gao, X., Barca, E., Sanchez‐Quintero, M. J., Tadesse, S., Jiang, H., Qiao, C., Rodenburg, R. J., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606356 · Cited by 73
TLRs-JNK/ NF-κB Pathway Underlies the Protective Effect of the Sulfide Salt Against Liver Toxicity
Abdellatif, R., Heeba, G. H., Hassanin, S. O., Waz, S., & Amin, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.850066 · Cited by 73
Flannigan, K. L., Ferraz, J. G., Wang, R., & Wallace, J. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071962 · Cited by 73
Self-citationParsanathan, R., & Jain, S. K. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1431626 · Cited by 73
Yang, G., Ju, Y., Fu, M., Zhang, Y., Pei, Y., Racine, M., Baath, S., Merritt, T. J. S., Wang, R., & Wu, L. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.11.008 · Cited by 72
Self-citationImpact of Hydrogen Sulfide on Mitochondrial and Bacterial Bioenergetics
Borisov, V. B., & Forte, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312688 · Cited by 73
Role of hydrogen sulphide in physiological and pathological angiogenesis
Zhang, Y., Jing, M., Cai, C., Zhu, S., Zhang, C.-J., Wang, Q., Zhai, Y., Ji, X., & Wu, D. (2022) · Cell Proliferation · doi:10.1111/cpr.13374 · Cited by 73
Hydrogen sulphide improves adaptation of Zea mays seedlings to iron deficiency
Chen, J., Wu, F.-H., Shang, Y., Wang, W., Hu, W., Simon, M., Liu, X., Shangguan, Z., & Zheng, H. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/erv368 · Cited by 74
Hydrogen sulfide as a potent cardiovascular protective agent
Yu, X., Cui, L.-B., Wu, K. H., Zheng, X., Cayabyab, F. S., Chen, Z., & Tang, C. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.07.012 · Cited by 77
Roy, A., Khan, A. H., Islam, M. T., Prieto, M. C., & Majid, D. S. A. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.149 · Cited by 72
Nandi, S., Reinsch, H., Banesh, S., Stock, N., Trivedi, V., & Biswas, S. (2017) · Dalton Transactions · doi:10.1039/c7dt02293j · Cited by 72
Hu, X., Liu, Y., Wang, W., Zhang, H., Qin, Y., Guo, S., Zhang, X., Fu, L., & Huang, W. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03324 · Cited by 72
Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation
Wang, Y., Yu, R., Wu, L., & Yang, G. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109870 · Cited by 70
Self-citationLinden, D., Furne, J. K., Stoltz, G. J., Abdel-Rehim, M. S., Levitt, M., & Szurszewski, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01681.x · Cited by 71
Hydrogen sulfide as a regulator of calcium channels
Munaron, L., Avanzato, D., Moccia, F. D., & Mancardi, D. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.07.001 · Cited by 71
Liu, S., Zhang, L., Yang, T., Yang, H., Zhang, K. Y., Zhao, X., Lv, W. Y., Yu, Q., Zhang, X., Zhao, Q., et al. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5035158 · Cited by 71
Wu, P., Zhang, J., Wang, S., Zhu, A., & Hou, X. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201303753 · Cited by 70
Erucin exhibits vasorelaxing effects and antihypertensive activity by H2S‐releasing properties
Martelli, A., Piragine, E., Citi, V., Testai, L., Pagnotta, E., Ugolini, L., Lazzeri, L., Mannelli, L. D. C., Manzo, O. L., Bucci, M., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14645 · Cited by 70
Jia, H., Wang, X., Shi, C., Guo, J., Ma, P., Ren, X., Wei, T., Liu, H., & Li, J. (2020) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2020.08.033 · Cited by 70
Kabil, Ö., Yadav, V., & Banerjee, R. V. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.c116.742213 · Cited by 73
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Hou, C., Wang, M.-J., Sun, C., Huang, Y., Jin, S., Mu, X.-P., Chen, Y., & Zhu, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7570489 · Cited by 70
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Shefa, U., Yeo, S. G., Kim, M., Song, I. O., Jung, J., Jeong, N. Y., & Huh, Y. (2017) · BioMed Research International · doi:10.1155/2017/1689341 · Cited by 73
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Lee, H. J., Féliers, D., Barnes, J. L., Oh, S. B., Choudhury, G. G., Diaz, V., Galván, V., Strong, R., Nelson, J. F., Salmon, A. B., et al. (2018) · GeroScience · doi:10.1007/s11357-018-0018-y · Cited by 69
Li, J., Teng, X., Jin, S., Dong, J., Guo, Q., Tian, D., & Wu, Y. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002101 · Cited by 69
Role of Hydrogen Sulfide in Inflammatory Bowel Disease
Stummer, N., Feichtinger, R. G., Weghuber, D., Kofler, B., & Schneider, A.-M. (2023) · Antioxidants · doi:10.3390/antiox12081570 · Cited by 72
A regeneratable and highly selective fluorescent probe for sulfide detection in aqueous solution
Wu, X., Li, H., Kan, Y., & Yin, B. (2013) · Dalton Transactions · doi:10.1039/c3dt51953h · Cited by 69
Zhao, Y., Xiaohe, Z., Kan, H., Wang, W., Zhu, B., Du, B., & Zhang, X. (2012) · The Analyst · doi:10.1039/c2an36106j · Cited by 69
Manna, P., Gungor, N., McVie, R., & Jain, S. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.524645 · Cited by 69
Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation
Zhao, H., Lu, S., Jiachao, C., Zhang, Y., Ma, X., Chen, J., Guan, Q., Wan, M., & Liu, Y. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.06.011 · Cited by 69
Szijártó, I. A., Markó, L., Filipović, M. R., Miljković, J. L., Tabeling, C., Tsvetkov, D., Wang, N., Rabelo, L. A., Witzenrath, M., Diedrich, A., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10562 · Cited by 69
Strianese, M., Pappalardo, D., Mazzeo, M., Lamberti, M., & Pellecchia, C. (2020) · Dalton Transactions · doi:10.1039/d0dt02639e · Cited by 68
Liang, Z., Tsoi, T., Chan, C., Dai, L., Wu, Y., Du, G., Zhu, L., Lee, C., Wong, W., Law, G., et al. (2015) · Chemical Science · doi:10.1039/c5sc04091d · Cited by 68
Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity
Oliveira, C. S., Piccoli, B. C., Aschner, M., & da Rocha, J. B. T. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-60189-2_4 · Cited by 70
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase
Peleli, M., Bibli, S., Li, Z., Chatzianastasiou, A., Varela, A., Katsouda, A., Zukunft, S., Bucci, M., Vellecco, V., Davos, C. H., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113833 · Cited by 68
Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness
Llarena, N. C., & Hine, C. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa204 · Cited by 68
Bithi, N., Link, C., Henderson, Y. O., Kim, S., Yang, J., Li, L., Wang, R., Willard, B. B., & Hine, C. (2021) · Nature Communications · doi:10.1038/s41467-021-22001-w · Cited by 68
Self-citationTherapeutic applications of organosulfur compounds as novel hydrogen sulfide donors and/or mediators
Gu, X., & Zhu, Y. Z. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.129 · Cited by 68
Pan, Y., Ye, S., Yuan, D., Zhang, J., Bai, Y., & Shao, C. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.03.002 · Cited by 68
Cystathionine γ-lyase: Clinical, metabolic, genetic, and structural studies
Kraus, J. P., Hašek, J., Kožich, V., Collard, R., Venezia, S., Janošı́ková, B., Wang, J., Stabler, S. P., Allen, R. H., Jakobs, C., et al. (2009) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2009.04.001 · Cited by 68
Roman, H. B., Hirschberger, L. L., Krijt, J., Valli, A., Kožich, V., & Stipanuk, M. H. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5010 · Cited by 68
Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/ H2S Pathway
Talaei, F., Bouma, H. R., van der Graaf, A. C., Strijkstra, A. M., Schmidt, M., & Henning, R. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022568 · Cited by 68
Chen, X., Chen, Q., Zhang, X., Li, R., Jia, Y., Ef, A. A., Jia, A., Hu, L., & Hu, X. (2016) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2016.02.033 · Cited by 68
Zhang, Y., Shen, H., Hai, X., Chen, X., & Wang, J. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04407 · Cited by 68
Yang, C., Chen, L., Xu, S. J., Day, J. J., Li, X., & Xian, M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00664 · Cited by 68
Thiosulfate sulfurtransferase-like domain–containing 1 protein interacts with thioredoxin
Libiad, M., Motl, N., Akey, D. L., Sakamoto, N., Fearon, E. R., Smith, J. L., & Banerjee, R. V. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000826 · Cited by 68
Narne, P., Pandey, V., & Phanithi, P. B. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1141-6 · Cited by 71
Zhou, L., Wang, Q., Tan, Y., Lang, M. J., Sun, H., & Liu, X. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201701365 · Cited by 67
Ji, Y., Xia, L.-J., Chen, L., Guo, X., Wang, H., & Zhang, H. (2017) · Talanta · doi:10.1016/j.talanta.2017.12.067 · Cited by 67
Recent achievements of bioluminescence imaging based on firefly luciferin-luciferase system
Li, S., Ruan, Z., Zhang, H., & Xu, H. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.113111 · Cited by 68
Sun, Y. K., Huang, Y., Zhang, R., Chen, Q., Chen, J., Zong, Y., Liu, J., Feng, S., Liu, A. D., Holmberg, L., et al. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1227-1 · Cited by 68
Gu, X., Liu, C., Zhu, Y., & Zhu, Y. Z. (2011) · Tetrahedron Letters · doi:10.1016/j.tetlet.2011.07.004 · Cited by 67
Lu, C., Kavalier, A. R., Lukyanov, E., & Gross, S. S. (2013) · Methods · doi:10.1016/j.ymeth.2013.05.020 · Cited by 67
Tian, X., Li, Z., Lau, C., & Lu, J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b03712 · Cited by 67
Mikami, Y., Shibuya, N., Ogasawara, Y., & Kimura, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.01.010 · Cited by 66
Tang, G., Zhang, L., Yang, G., Wu, L., & Wang, R. (2012) · Diabetologia · doi:10.1007/s00125-012-2806-8 · Cited by 66
Self-citationHydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure
Givvimani, S., Munjal, C., Gargoum, R., Sen, U., Tyagi, N., Vacek, J. C., & Tyagi, S. C. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01064.2010 · Cited by 66
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Metadata
- Authors
- Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., Snyder, S. H., & Wang, R.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wu, Lingyun
- Snyder, Solomon H.
- Wang, Rui
- ORCID
- Venue
- Science
- Published
- 2008-10-24
- Volume
- 322
- Issue
- 5901
- Pages
- 587-590
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2749494
- OpenAlex
- W2054064167
- Cited by
- 2,310
- References
- 27
- Citations by year
- 2026: 37 · 2025: 84 · 2024: 89 · 2023: 104 · 2022: 135 · 2021: 148 · 2020: 151 · 2019: 162 · 2018: 145 · 2017: 169 · 2016: 163 · 2015: 188 · 2014: 173 · 2013: 147 · 2012: 134
- FWCI
- 43.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH018501, MH-18501)
- National Institute on Drug Abuse (DA 00074, K05DA000074)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- hydrogen sulfide, cystathionine gamma-lyase, hypertension, vasorelaxation, endothelium-dependent relaxation, calcium/calmodulin signaling, gasotransmitters, blood pressure regulation
- MeSH terms
- Animals, Aorta, Blood Pressure, Calcium, Calmodulin, Cystathionine gamma-Lyase, Cysteine, Endothelium, Vascular, Homocysteine, Hydrogen Sulfide, Hypertension, Mesenteric Arteries, Myocardium, Oxidation-Reduction, Sulfides, Vasodilation, Methacholine Chloride, Mice, Knockout, Mice
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