H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

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The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

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Two's company, three's a crowd: can H 2 S be the third endogenous gaseous transmitter?

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N OVEL N EURAL M ODULATORS

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Elevated blood pressures in mice lacking endothelial nitric oxide synthase

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Homocysteine and vascular disease

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H2S-induced vasorelaxation and underlying cellular and molecular mechanisms

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Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats

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Hydrogen Sulfide as a Neuromodulator

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Inhibition of Hydrogen Sulfide Generation Contributes to Gastric Injury Caused by Anti-Inflammatory Nonsteroidal Drugs

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The Liver as a Central Regulator of Hydrogen Sulfide

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Differential effects of statins on endogenous H2S formation in perivascular adipose tissue

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Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells

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Characterization of Hydrogen Sulfide and Its Synthases, Cystathionine β-Synthase and Cystathionine γ-Lyase, in Human Prostatic Tissue and Cells

Guo, H. J., Gai, J., Wang, Y., Jin, H., Du, J., & Jin, J. (2012) · Urology · doi:10.1016/j.urology.2011.10.013 · Cited by 95

Hydroxocobalamin for the Treatment of Vasoplegia: A Review of Current Literature and Considerations for Use

Shapeton, A. D., Mahmood, F. U., & Ortoleva, J. P. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2018.08.017 · Cited by 95

The Inhibitory Role of Hydrogen Sulfide in Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

Zhang, G., Wang, P., Yang, G., Cao, Q., & Wang, R. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.008 · Cited by 94

Redox signaling, Nox5 and vascular remodeling in hypertension

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An NBD fluorophore-based colorimetric and fluorescent chemosensor for hydrogen sulfide and its application for bioimaging

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A TICT-based fluorescent probe for rapid and specific detection of hydrogen sulfide and its bio-imaging applications

Ren, M., Deng, B., Kong, X., Zhou, K., Liu, K., Xu, G., & Lin, W. (2016) · Chemical Communications · doi:10.1039/c6cc00966b · Cited by 93

Impaired Hydrogen Sulfide–Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults

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The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease

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Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration

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Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes

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Hydrogen Sulfide Impairs Glucose Utilization and Increases Gluconeogenesis in Hepatocytes

Zhang, L., Yang, G., Untereiner, A. A., Ju, Y., Wu, L., & Wang, R. (2012) · Endocrinology · doi:10.1210/en.2012-1658 · Cited by 93

Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners

Papapetropoulos, A., Whiteman, M., & Cirino, G. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12806 · Cited by 92

A colorimetric and ratiometric fluorescent probe for the imaging of endogenous hydrogen sulphide in living cells and sulphide determination in mouse hippocampus

Zhang, L., Li, S., Hong, M., Xu, Y., Wang, S., Liu, Y., Qian, Y., & Zhao, J. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00285g · Cited by 92

Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway

Hine, C., & Mitchell, J. R. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.12.010 · Cited by 91

Cystathionine γ-Lyase Deficiency Protects Mice from Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure

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S-sulfhydration as a cellular redox regulation

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Glyceraldehyde 3-Phosphate Dehydrogenase is Unlikely to Mediate Hydrogen Peroxide Signaling: Studies with a Novel Anti-Dimedone Sulfenic Acid Antibody

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Modulation of Ion Channels by Hydrogen Sulfide

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Differential Effects of Cystathionine-γ-lyase–Dependent Vasodilatory H2S in Periadventitial Vasoregulation of Rat and Mouse Aortas

Köhn, C., Schleifenbaum, J., Szijártó, I. A., Markó, L., Dubrovska, G., Huang, Y., & Gollasch, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041951 · Cited by 91

A critical life-supporting role for cystathionine γ-lyase in the absence of dietary cysteine supply

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Biological signaling by small inorganic molecules

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Intermittent Hypoxia in Rats Increases Myogenic Tone Through Loss of Hydrogen Sulfide Activation of Large-Conductance Ca 2+ -Activated Potassium Channels

Jackson‐Weaver, O., Paredes, D. A., Bosc, L. V. G., Walker, B. R., & Kanagy, N. L. (2011) · Circulation Research · doi:10.1161/circresaha.110.228999 · Cited by 90

Intracolonic hydrogen sulfide lowers blood pressure in rats

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The role of hydrogen sulfide in aging and age-related pathologies

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FXR an emerging therapeutic target for the treatment of atherosclerosis

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Hypoxia in the Renal Medulla: Implications for Hydrogen Sulfide Signaling

Bełtowski, J. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.166637 · Cited by 90

Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent Mechanisms

Chatzianastasiou, A., Bibli, S.-I., Andreadou, I., Efentakis, P., Kaludercic, N., Wood, M. E., Whiteman, M., Lisa, F. D., Daiber, A., Manolopoulos, V. G., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.235119 · Cited by 89

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

Hine, C., Kim, H.-J., Zhu, Y., Harputlugil, E., Longchamp, A., Matos, M. S., Ramadoss, P., Bauerle, K. T., Brace, L. E., Asara, J. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.003 · Cited by 89

PdCu alloy nanosheets-constructed 3D flowers: New highly sensitive materials for H2S detection

Shang, H., Xu, H. J., Liu, Q., & Du, Y. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.03.101 · Cited by 89

Gas and the Microbiome

Pimentel, M., Mathur, R., & Chang, C. C.-C. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0356-y · Cited by 91

Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells

Pupo, E., Fiorio, A., Avanzato, D., Moccia, F. D., Avelino-Cruz, J. E., Tanzi, F., Merlino, A., Mancardi, D., & Munaron, L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.007 · Cited by 89

Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels

Naik, J. S., Osmond, J. M., Walker, B. R., & Kanagy, N. L. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00465.2016 · Cited by 89

Chasing Cysteine Oxidative Modifications

Murray, C. I., & Eyk, J. E. V. (2012) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.961425 · Cited by 90

A direct and selective electrochemical hydrogen sulfide sensor

Brown, M. D., Hall, J. R., & Schoenfisch, M. H. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.08.054 · Cited by 88

Advances and Opportunities in H2S Measurement in Chemical Biology

Smith, H. M., & Pluth, M. D. (2023) · JACS Au · doi:10.1021/jacsau.3c00427 · Cited by 88

Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery

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Hydrogen Sulfide Represses Androgen Receptor Transactivation by Targeting at the Second Zinc Finger Module

Zhao, K., Li, S., Wu, L., Lai, C., & Yang, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559518 · Cited by 88

Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9

Kundu, S., Pushpakumar, S. B., Tyagi, A. C., Coley, D. M., & Sen, U. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00604.2012 · Cited by 88

Protective Actions of H 2 S in Acute Myocardial Infarction and Heart Failure

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Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide

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Down-regulated CBS/H2S pathway is involved in high-salt-induced hypertension in Dahl rats

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Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes

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Microplate-Based Colorimetric Detection of Free Hydrogen Sulfide

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Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

Holwerda, K. M., Bos, E. M., Rajakumar, A., Ris-Stalpers, C., van Pampus, M. G., Timmer, A., Erwich, J. J. H. M., Faas, M. M., van Goor, H., & Lely, A. T. (2012) · Placenta · doi:10.1016/j.placenta.2012.02.014 · Cited by 86

Sodium thiosulfate attenuates angiotensin II-induced hypertension, proteinuria and renal damage11These authors contributed equally to this manuscript.

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Development of a Highly Selective, Sensitive, and Fast Response Upconversion Luminescent Platform for Hydrogen Sulfide Detection

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Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism

Kohl, J. B., Mellis, A., & Schwarz, G. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14464 · Cited by 89

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Song, Z., Zhao, L., Ma, T., Osama, A., Shen, T., He, Y., & Fang, J. (2022) · Medicinal Research Reviews · doi:10.1002/med.21913 · Cited by 87

Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction

Jung, K.-J., Jang, H., Kim, J. I., Han, S. J., Park, J., & Park, K. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.06.015 · Cited by 89

Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases

Nagpure, B. V., & Bian, J. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-18144-8_10 · Cited by 86

Recent advances in the chemical biology of nitroxyl (HNO) detection and generation

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A dinitro-functionalized Zr(IV)-based metal-organic framework as colorimetric and fluorogenic probe for highly selective detection of hydrogen sulphide

Dalapati, R., Balaji, S., Trivedi, V., Khamari, L., & Biswas, S. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.02.005 · Cited by 86

Dynamic change of hydrogen sulfide during global cerebral ischemia–reperfusion and its effect in rats

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Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells

Pei, Y., Wu, B., Cao, Q., Wu, L., & Yang, G. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.09.026 · Cited by 85

Butyrate-stimulated H 2 S Production in Colon Cancer Cells

Cao, Q., Zhang, L., Yang, G., Xu, C., & Wang, R. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2915 · Cited by 85

Reduction of Ammineruthenium(III) by Sulfide Enables In Vivo Electrochemical Monitoring of Free Endogenous Hydrogen Sulfide

Wang, S., Liu, X., & Zhang, M. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00069 · Cited by 85

Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors

Steiger, A. K., Marcatti, M., Szabó, C., Szczęsny, B., & Pluth, M. D. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00279 · Cited by 85

Effects of hydrogen sulphide on quality and antioxidant capacity of mulberry fruit

Hu, H., Shen, W., & Li, P. (2013) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12313 · Cited by 84

L-cysteine and hydrogen sulfide increase PIP3 and AMPK/PPARγ expression and decrease ROS and vascular inflammation markers in high glucose treated human U937 monocytes

Manna, P., & Jain, S. K. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24578 · Cited by 86

H2S: A “Double face” molecule in health and disease

di Masi, A., & Ascenzi, P. (2012) · BioFactors · doi:10.1002/biof.1061 · Cited by 83

Hydrogen sulfide in hypertension

van Goor, H., van den Born, J. C., Hillebrands, J., & Joles, J. A. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000206 · Cited by 84

Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis

Xu, S., Liu, Z., & Liu, P. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.01.068 · Cited by 85

Hydrogen sulfide protects H9c2 cells against doxorubicin-induced cardiotoxicity through inhibition of endoplasmic reticulum stress

Wang, X.-Y., Yang, C., Zheng, D., Mo, L., Lan, A., Yang, Z., Hu, F., Chen, P., Liao, X., & Feng, J. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1194-6 · Cited by 83

Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis

Rahman, M. A., Cumming, B. M., Addicott, K. W., Pacl, H. T., Russell, S., Nargan, K., Naidoo, T., Ramdial, P. K., Adamson, J., Wang, R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919211117 · Cited by 83

Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM

Li, S., & Yang, G. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6186 · Cited by 83

Hydrogen sulfide and cerebral microvascular tone in newborn pigs

Leffler, C. W., Parfenova, H., Basuroy, S., Jaggar, J. H., Umstot, E. S., & Fedinec, A. L. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00722.2010 · Cited by 83

Hydrogen sulfide increases nitric oxide production with calcium-dependent activation of endothelial nitric oxide synthase in endothelial cells

Kida, M., Sugiyama, T., Yoshimoto, T., & Ogawa, Y. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.11.001 · Cited by 83

Gasotransmitter Heterocellular Signaling

Kolluru, G. K., Shen, X., Yuan, S. S., & Kevil, C. G. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6909 · Cited by 83

Does Perthionitrite (SSNO–) Account for Sustained Bioactivity of NO? A (Bio)chemical Characterization

Wedmann, R., Zahl, A., Shubina, T. E., Dürr, M., Heinemann, F. W., Bugenhagen, B., Burger, P., Ivanović‐Burmazović, I., & Filipović, M. R. (2015) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.5b00831 · Cited by 83

Potential role of hydrogen sulfide in diabetes-impaired angiogenesis and ischemic tissue repair

Cheng, Z. A., & Kishore, R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101704 · Cited by 81

Biosynthesis of a Central Intermediate in Hydrogen Sulfide Metabolism by a Novel Human Sulfurtransferase and Its Yeast Ortholog

Melideo, S. L., Jackson, M. R. C., & Jörns, M. S. (2014) · Biochemistry · doi:10.1021/bi500650h · Cited by 83

Transcriptional control of amino acid homeostasis is disrupted in Huntington’s disease

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Inflammasomes: Pandora’s box for sepsis

Kumar, V. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s178084 · Cited by 88

An ICT-based fluorescent switch-on probe for hydrogen sulfide in living cells

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CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome

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Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System

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Estrogen Receptors and Estrogen-Induced Uterine Vasodilation in Pregnancy

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Role of Exogenous and Endogenous Hydrogen Sulfide (H2S) on Functional Traits of Plants Under Heavy Metal Stresses: A Recent Perspective

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Specificity Protein-1 as a Critical Regulator of Human Cystathionine γ-Lyase in Smooth Muscle Cells

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A two-photon “turn-on” fluorescent probe based on carbon nanodots for imaging and selective biosensing of hydrogen sulfide in live cells and tissues

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Hydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection

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A bioorthogonal fluorescent probe for mitochondrial hydrogen sulfide: new strategy for cancer cell labeling

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