The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Open accessAbstract
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several enzymatic and non-enzymatic sources have been identified to contribute to the existing pool of sulfide in circulation and tissues [1][2][3], with a purportedly essential role in blood pressure regulation [4].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070
The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
Zhao, W., Zhang, J., Lu, Y., & Wang, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6008 · Cited by 1,936
Self-citationTwo's company, three's a crowd: can H 2 S be the third endogenous gaseous transmitter?
Wang, R. T. (2002) · The FASEB Journal · doi:10.1096/fj.02-0211hyp · Cited by 1,808
Self-citationBoehning, D. F., & Snyder, S. H. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131047 · Cited by 1,235
Self-citationElevated blood pressures in mice lacking endothelial nitric oxide synthase
Shesely, E. G., Maeda, N., Kim, H.-S., Desai, K. M., Krege, J. H., Laubach, V. E., Sherman, P. A., Sessa, W. C., & Smithies, O. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13176 · Cited by 908
Homocysteine and vascular disease
McCully, K. S. (1996) · Nature Medicine · doi:10.1038/nm0496-386 · Cited by 705
H2S-induced vasorelaxation and underlying cellular and molecular mechanisms
Zhao, W., & Wang, R. T. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00013.2002 · Cited by 505
Self-citationHydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats
Cheng, Y., Ndisang, J. F., Tang, G., Cao, K., & Wang, R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00331.2004 · Cited by 439
Self-citationHydrogen Sulfide as a Neuromodulator
Kimura, H. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:1:013 · Cited by 427
Fiorucci, S., Antonelli, E., Distrutti, E., Rizzo, G., Mencarelli, A., Orlandi, S., Zanardo, R. C. O., Renga, B., Sante, M. D., Morelli, A., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.07.060 · Cited by 409
Flagged first, then by citations
Research works printed but not linked: 2
- S. H. Zlotkin, G. H. Anderson, Pediatr. Res.16, 65 (1982).
- K. D. Lake-Bruseet al., Am. J. Physiol. Heart Circ. Physiol.2, H770 (1999).
Cited by
Sorted by citations
Items 1,001–1,001 of 1,001
Hydrogen sulfide induces nitric oxide release from nitrite
Grossi, L. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.09.030 · Cited by 35
Metadata
- Authors
- Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., Snyder, S. H., & Wang, R.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wu, Lingyun
- Snyder, Solomon H.
- Wang, Rui
- ORCID
- Venue
- Science
- Published
- 2008-10-24
- Volume
- 322
- Issue
- 5901
- Pages
- 587-590
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2749494
- OpenAlex
- W2054064167
- Cited by
- 2,310
- References
- 27
- Citations by year
- 2026: 37 · 2025: 84 · 2024: 89 · 2023: 104 · 2022: 135 · 2021: 148 · 2020: 151 · 2019: 162 · 2018: 145 · 2017: 169 · 2016: 163 · 2015: 188 · 2014: 173 · 2013: 147 · 2012: 134
- FWCI
- 43.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH018501, MH-18501)
- National Institute on Drug Abuse (DA 00074, K05DA000074)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- hydrogen sulfide, cystathionine gamma-lyase, hypertension, vasorelaxation, endothelium-dependent relaxation, calcium/calmodulin signaling, gasotransmitters, blood pressure regulation
- MeSH terms
- Animals, Aorta, Blood Pressure, Calcium, Calmodulin, Cystathionine gamma-Lyase, Cysteine, Endothelium, Vascular, Homocysteine, Hydrogen Sulfide, Hypertension, Mesenteric Arteries, Myocardium, Oxidation-Reduction, Sulfides, Vasodilation, Methacholine Chloride, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
