H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

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The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

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Two's company, three's a crowd: can H 2 S be the third endogenous gaseous transmitter?

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N OVEL N EURAL M ODULATORS

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Elevated blood pressures in mice lacking endothelial nitric oxide synthase

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Homocysteine and vascular disease

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H2S-induced vasorelaxation and underlying cellular and molecular mechanisms

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Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats

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Hydrogen Sulfide as a Neuromodulator

Kimura, H. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:1:013 · Cited by 427

Inhibition of Hydrogen Sulfide Generation Contributes to Gastric Injury Caused by Anti-Inflammatory Nonsteroidal Drugs

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The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

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Pyridinium substituted BODIPY as NIR fluorescent probe for simultaneous sensing of hydrogen sulphide/glutathione and cysteine/homocysteine

Zhang, J., Ji, X., Zhou, J., Chen, Z., Dong, X., & Zhao, W. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.10.133 · Cited by 116

A red to near-infrared fluorescent probe featuring a super large Stokes shift for light-up detection of endogenous H2S

Hong, J., Zhou, E., Gong, S., & Feng, G. (2018) · Dyes and Pigments · doi:10.1016/j.dyepig.2018.09.001 · Cited by 116

Sensitive Fluorescent Sensor for Hydrogen Sulfide in Rat Brain Microdialysis via CsPbBr 3 Quantum Dots

Chen, C., Cai, Q., Luo, F., Dong, N., Guo, L., Qiu, B., & Lin, Z. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04387 · Cited by 116

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is inactivated by S-sulfuration in vitro

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Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Szabó, C. (2021) · Cells · doi:10.3390/cells10020220 · Cited by 115

Highly Stable and Selective Sensing of Hydrogen Sulfide in Living Mouse Brain with NiN 4 Single-Atom Catalyst-Based Galvanic Redox Potentiometry

Pan, C., Wu, F., Mao, J., Wu, W., Zhao, G., Ji, W., Ma, W., Yu, P., & Mao, L. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c04695 · Cited by 115

On the chemical biology of the nitrite/sulfide interaction

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The era of nitric oxide in plant biology: Twenty years tying up loose ends

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Reactive Sulfur Species

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Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract

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Metal complexes as fluorescent probes for sensing biologically relevant gas molecules

Strianese, M., & Pellecchia, C. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.04.006 · Cited by 113

The Role of Hydrogen Sulfide in Renal System

Cao, X., & Bian, J. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00385 · Cited by 113

The Role of Hydrogen Sulfide on Cardiovascular Homeostasis: An Overview with Update on Immunomodulation

Pan, L., Qin, M., Liu, X., & Zhu, Y. Z. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00686 · Cited by 113

Preeclampsia link to gestational hypoxia

Tong, W., & Giussani, D. A. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s204017441900014x · Cited by 121

A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria

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Induction of MicroRNA-21 With Exogenous Hydrogen Sulfide Attenuates Myocardial Ischemic and Inflammatory Injury in Mice

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Protein kinase G–regulated production of H 2 S governs oxygen sensing

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Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca 2+ -activated K + channels and smooth muscle Ca 2+ sparks

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Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Ding, H., Chang, J., He, F., Gai, S., & Yang, P. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101984 · Cited by 113

Molecular Regulation of Tumor Angiogenesis and Perfusion via Redox Signaling

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A FRET–ICT dual-quenching fluorescent probe with large off–on response for H 2 S: synthesis, spectra and bioimaging

Zhang, C., Wei, L., Wei, C., Zhang, J., Wang, R., Xi, Z., & Yi, L. (2015) · Chemical Communications · doi:10.1039/c5cc01184a · Cited by 111

Hydropersulfides: H-Atom Transfer Agents Par Excellence

Chauvin, J. R., Grießer, M., & Pratt, D. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b02571 · Cited by 113

Working with “H2S”: Facts and apparent artifacts

Wedmann, R., Bertlein, S., Mačinković, I., Boeltz, S., Miljković, J. L., Munoz, L. E., i, M. H., & Filipović, M. R. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.06.003 · Cited by 110

H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects

Huang, C. W., & Moore, P. K. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-18144-8_1 · Cited by 110

NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide

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Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

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Distribution of hydrogen sulfide (H2S)-producing enzymes and the roles of the H2S donor sodium hydrosulfide in diabetic nephropathy

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Gaseous mediators in resolution of inflammation

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Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation

Miller, T. W., Kaur, S., Ivins-O'Keefe, K., & Roberts, D. D. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.02.009 · Cited by 109

Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines

Yin, P., Zhao, C., Li, Z., Mei, C., Yao, W., Liu, Y., Li, N., Qi, J., Wang, L., Shi, Y., et al. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.02.003 · Cited by 109

Hydrogen Sulfide Attenuates sFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor

Holwerda, K. M., Burke, S. D., Faas, M. M., Zsengellér, Z. K., Stillman, I. E., Kang, P. M., van Goor, H., McCurley, A., Jaffe, I. Z., Karumanchi, S. A., et al. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013030291 · Cited by 110

Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential

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New drugs for exacerbations of chronic obstructive pulmonary disease

Hansel, T. T., & Barnes, P. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61342-8 · Cited by 112

Biochemical insight into physiological effects of H2S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite

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Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia

Marutani, E., Yamada, M., Ida, T., Tokuda, K., Ikeda, K., Kai, S., Shirozu, K., Hayashida, K., Kosugi, S., Hanaoka, K., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002125 · Cited by 109

Hydrogen Sulfide in Renal Physiology and Disease

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Beyond a Gasotransmitter: Hydrogen Sulfide and Polysulfide in Cardiovascular Health and Immune Response

Yuan, S. S., Shen, X., & Kevil, C. G. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7096 · Cited by 109

Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases

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Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage

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Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency

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Hydrogen Sulfide (H2S)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases

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Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via K+ATP Channel Activation

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Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition

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Probing the Intracellular Dynamics of Nitric Oxide and Hydrogen Sulfide Using an Activatable NIR II Fluorescence Reporter

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A Nitro‐Functionalized Metal–Organic Framework as a Reaction‐Based Fluorescence Turn‐On Probe for Rapid and Selective H2S Detection

Nagarkar, S. S., Desai, A. V., & Ghosh, S. K. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201501043 · Cited by 106

Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

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Chromogenic and fluorogenic chemosensors for hydrogen sulfide: review of detection mechanisms since the year 2009

Li, J., Yin, C., & Huo, F. (2014) · RSC Advances · doi:10.1039/c4ra11870g · Cited by 106

Immunomodulatory Effects of Glutathione, Garlic Derivatives, and Hydrogen Sulfide

Rodrigues, C., & Percival, S. S. (2019) · Nutrients · doi:10.3390/nu11020295 · Cited by 106

Endogenous H2S‑Activated Orthogonal Second Near-Infrared Emissive Nanoprobe for In Situ Ratiometric Fluorescence Imaging of Metformin-Induced Liver Injury

Deng, Z., Bi, S., Jiang, M., & Zeng, S. (2021) · ACS Nano · doi:10.1021/acsnano.0c09799 · Cited by 106

Endogenous Production of H 2 S in the Gastrointestinal Tract: Still in Search of a Physiologic Function

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Ischemia-reperfusion reduces cystathionine-β-synthase-mediated hydrogen sulfide generation in the kidney

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A highly selective and sensitive fluorescent thiol probe through dual-reactive and dual-quenching groups

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Electroactive Au@Ag nanoparticles driven electrochemical sensor for endogenous H2S detection

Zhao, Y., Yang, Y., Cui, L., Zheng, F., & Song, Q. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.05.047 · Cited by 105

Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

Benchoam, D., Cuevasanta, E., Möller, M. N., & Álvarez, B. (2019) · Antioxidants · doi:10.3390/antiox8020048 · Cited by 105

Nitrobenzoxadiazole Ether-Based Near-Infrared Fluorescent Probe with Unexpected High Selectivity for H 2 S Imaging in Living Cells and Mice

Gong, S., Zhou, E., Hong, J., & Feng, G. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03383 · Cited by 105

Capture and Visualization of Hydrogen Sulfide by a Fluorescent Probe

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Production of H2S by 3-mercaptopyruvate sulphurtransferase

Tanizawa, K. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr018 · Cited by 104

Protein Kinase G Iα Oxidation Paradoxically Underlies Blood Pressure Lowering by the Reductant Hydrogen Sulfide

Stubbert, D., Prysyazhna, O. D., Rudyk, O., Scotcher, J., Burgoyne, J. R., & Eaton, P. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04281 · Cited by 104

Pharmacological characterization of the vascular effects of aryl isothiocyanates: Is hydrogen sulfide the real player?

Martelli, A., Testai, L., Citi, V., Marino, A., Bellagambi, F. G., Ghimenti, S., Breschi, M. C., & Calderone, V. (2013) · Vascular Pharmacology · doi:10.1016/j.vph.2013.11.003 · Cited by 104

Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides

Bruce King, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.005 · Cited by 103

Designing reaction-based fluorescent probes for selective hydrogen sulfide detection

Lippert, A. R. (2013) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2013.10.010 · Cited by 103

Novel Fluorescein-Based Fluorescent Probe for Detecting H2S and Its Real Applications in Blood Plasma and Biological Imaging

Jin, X., Wu, S., She, M., Jia, Y., Hao, L., Yin, B. Z., Wang, L., Obst, M., Shen, Y., Zhang, Y., et al. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04087 · Cited by 103

Enhancing and Extending Biological Performance and Resilience

Leak, R. K., Calabrese, E. J., Kozumbo, W. J., Gidday, J. M., Johnson, T. E., Mitchell, J. R., Ozaki, C. K., Wetzker, R., Bast, A., Belz, R. G., et al. (2018) · Dose-Response · doi:10.1177/1559325818784501 · Cited by 107

Chemical and Biochemical Mechanisms Underlying the Cardioprotective Roles of Dietary Organopolysulfides

Tocmo, R., Liang, D., Lin, Y., & Huang, D. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00001 · Cited by 102

Fluorescence chemosensors for hydrogen sulfide detection in biological systems

Guo, Z. H., Chen, G., Zeng, G., Li, Z., Chen, A., Wang, J., & Jiang, L. (2014) · The Analyst · doi:10.1039/c4an01909a · Cited by 102

Cerium-based azide- and nitro-functionalized UiO-66 frameworks as turn-on fluorescent probes for the sensing of hydrogen sulphide

Buragohain, A., & Biswas, S. (2016) · CrystEngComm · doi:10.1039/c6ce00032k · Cited by 102

Responsive Lanthanide Coordination Polymer for Hydrogen Sulfide

Liu, B., & Chen, Y. (2013) · Analytical Chemistry · doi:10.1021/ac402651y · Cited by 102

Metabolism of Amino Acids in the Brain and Their Roles in Regulating Food Intake

He, W., & Wu, G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-45328-2_10 · Cited by 112

Production of Hydrogen Sulfide from D-Cysteine and Its Therapeutic Potential

Shibuya, N., & Kimura, H. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00087 · Cited by 103

Inorganic–Organic Hybrid Nanoprobe for NIR‐Excited Imaging of Hydrogen Sulfide in Cell Cultures and Inflammation in a Mouse Model

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Hydrogen Sulfide and l-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)/Serine/Threonine Protein Kinase (AKT)/Protein Kinase Cζ/λ (PKCζ/λ) in 3T3l1 Adipocytes

Manna, P., & Jain, S. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.270884 · Cited by 102

Hydrogen sulfide donors in research and drug development

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Toward Direct Protein S-Persulfidation: A Prodrug Approach That Directly Delivers Hydrogen Persulfide

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The Torpid State: Recent Advances in Metabolic Adaptations and Protective Mechanisms†

Giroud, S., Habold, C., Nespolo, R. F., Mejías, C., Terrien, J., Logan, S. M., Henning, R. H., & Storey, K. B. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.623665 · Cited by 100

A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS

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An Update on Hydrogen Sulfide and Nitric Oxide Interactions in the Cardiovascular System

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Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II ‐induced hypertensive heart disease in rats

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Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels

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Dysregulation of cystathionine γ‐lyase promotes prostate cancer progression and metastasis

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Physiological Roles of Hydrogen Sulfide and Polysulfides

Kimura, H. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-18144-8_3 · Cited by 99

Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence

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Bio-inspired Track-Etched Polymeric Nanochannels: Steady-State Biosensors for Detection of Analytes

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Hydrogen Sulfide Attenuates Hyperhomocysteinemia-Induced Cardiomyocytic Endoplasmic Reticulum Stress in Rats

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