Cited by 294Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

Open access

Gerber, Stefan H., Rah, Jong-Cheol, Min, Sang-Won, Liu, Xinran, de Wit, Heidi, Dulubova, Irina, Meyer, Alexander C., Rizo, Josep, Arancillo, Marife, Hammer, Robert E., Verhage, Matthijs, Rosenmund, Christian, Südhof, Thomas C.·2008·Science

DOI 10.1126/science.1163174PMC PMC3235364

Open this paper in CoChat — free account

Abstract

During synaptic vesicle fusion, the soluble N -ethylmaleimide-sensitive factor–attachment protein receptor (SNARE) protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a “closed” conformation outside the SNARE complex and an “open” conformation in the SNARE complex. Although SNARE complexes containing open syntaxin-1 and Munc18-1 are essential for exocytosis, the function of closed syntaxin-1 is unknown. We generated knockin/knockout mice that expressed only open syntaxin-1B. Syntaxin-1B Open mice were viable but succumbed to generalized seizures at 2 to 3 months of age. Binding of Munc18-1 to syntaxin-1 was impaired in syntaxin-1B Open synapses, and the size of the readily releasable vesicle pool was decreased; however, the rate of synaptic vesicle fusion was dramatically enhanced. Thus, the closed conformation of syntaxin-1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE-complex/Munc18-1 assemblies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1163174

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
THE SYNAPTIC VESICLE CYCLE
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
Self-citation
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Synaptic assembly of the brain in the absence of neurotransmitter secretion.
Verhage, M., Maia, A., Plomp, J., Brussaard, A., Heeroma, J., Vermeer, H., Toonen, R., Hammer, R., van den Berg, T. K., Missler, M., et al. (2000) · Science · doi:10.1126/science.287.5454.864 · Cited by 1,387
Self-citation
Definition of the readily releasable pool of vesicles at hippocampal synapses.
Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084
Self-citation
Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex
Misura, K. M. S., Scheller, R. H., & Weis, W. I. (2000) · Nature · doi:10.1038/35006120 · Cited by 790
A conformational switch in syntaxin during exocytosis: role of munc18
Dulubova, I., Sugita, S., Hill, S., Hosaka, M., Fernández, I., Südhof, T., & Rizo, J. (1999) · EMBO Journal · doi:10.1093/emboj/18.16.4372 · Cited by 772
Self-citation
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
Shen, J., Tareste, D. C., Paumet, F., Rothman, J. E., & Melia, T. J. (2007) · Cell · doi:10.1016/j.cell.2006.12.016 · Cited by 487
Functional impact of syntaxin on gating of N-type and Q-type calcium channels
Bezprozvanny, I., Scheller, R., & Tsien, R. (1995) · Nature · doi:10.1038/378623a0 · Cited by 441
An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
Richmond, J. E., Weimer, R. M., & Jorgensen, E. M. (2001) · Nature · doi:10.1038/35085583 · Cited by 437

Show all 23 references

Research works printed but not linked: 1

A. T. Brunger, Q. Rev. Biophys.9, 1 (2005).

Sorted by citations

Items 201–292 of 292

The Molecular Mechanisms Underlying Synaptic Transmission
Ashery, U., Bielopolski, N., Lavi, A., Barak, B., Michaeli, L., Ben‐Simon, Y., Sheinin, A., Bar-On, D., Shapira, Z., & Gottfried, I. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418675-0.00002-x · Cited by 13
Exploring the Landscape of Pre- and Post-Synaptic Pediatric Disorders with Epilepsy: A Narrative Review on Molecular Mechanisms Involved
Scorrano, G., Francesco, L. D., Ludovico, A. D., Chiarelli, F., & Matricardi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211982 · Cited by 13
Rapid Activation of Dormant Presynaptic Terminals by Phorbol Esters
Chang, C. Y., Jiang, X., Moulder, K. L., & Mennerick, S. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1159-10.2010 · Cited by 11
Testing the SNARE/SM protein model of membrane fusion
Bacaj, T., Pang, Z. P., & Südhof, T. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017268108 · Cited by 11
Hybrid Refinement of Heterogeneous Conformational Ensembles Using Spectroscopic Data
Hays, J. M., Cafiso, D. S., & Kasson, P. M. (2019) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.9b01407 · Cited by 9
Membrane‐mediated disorder‐to‐order transition of SNAP25 flexible linker facilitates its interaction with syntaxin‐1 and SNARE‐complex assembly
Jiang, X., Zhang, Z., Cheng, K., Wu, Q. S., Jiang, L., Pielak, G. J., Liu, M., & Li, C. (2019) · The FASEB Journal · doi:10.1096/fj.201802796r · Cited by 9
Reconstruction of destruction – in vitro reconstitution methods in autophagy research
Moparthi, S. B., & Wollert, T. (2018) · Journal of Cell Science · doi:10.1242/jcs.223792 · Cited by 9
Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex
Gong, J., Wang, X., Cui, C., Qin, Y., Jin, Z., Ma, C., & Yang, X. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.785696 · Cited by 7
Exocytosis through the Lens
Graczyk, A., & Rickman, C. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00147 · Cited by 8
Conformational change of Syntaxin-3b in regulating SNARE complex assembly in the ribbon synapses
Gething, C., Ferrar, J., Misra, B., Howells, G., Andrzejewski, A. L., Bowen, M. E., & Choi, U. B. (2022) · Scientific Reports · doi:10.1038/s41598-022-09654-3 · Cited by 9
The Role of Munc18-1 and Its Orthologs in Modulation of Cortical F-Actin in Chromaffin Cells
Kurps, J., & de Wit, H. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9775-8 · Cited by 8
STXBP1 Encephalopathy with Epilepsy
Khaikin, Y., & Mercimek‐Andrews, S. (2016) · Europe PMC (PubMed Central) · Cited by 8
The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly
Rehman, A., Hu, S., Tnimov, Z., Whitten, A. E., King, G. J., Jarrott, R. J., Norwood, S. J., Alexandrov, K. A., Collins, B. M., Christie, M. P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183366 · Cited by 7
Nueva mutación en el gen STXBP1 en un paciente con síndrome de Ohtahara no lesional
Ortega-Moreno, L., Giráldez, B. G., Verdú, A., García‐Campos, Ó., Sánchez‐Martín, G., Serratosa, J. M., & Guerrero, R. (2015) · Neurología · doi:10.1016/j.nrl.2014.10.017 · Cited by 7
Ataxia, tremor, intellectual disability: a case of STXBP1 encephalopathy with a new mutation
Değerli̇yurt, A., Kesen, G. G., & Ceylaner, S. (2019) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2019.05.015 · Cited by 6
Novel mutation in STXBP1 gene in a patient with non-lesional Ohtahara syndrome
Ortega-Moreno, L., Giráldez, B. G., Verdú, A., García‐Campos, Ó., Sánchez‐Martín, G., Serratosa, J. M., & Guerrero, R. (2016) · Neurología (English Edition) · doi:10.1016/j.nrleng.2014.10.004 · Cited by 6
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
Martínez‐Mármol, R., Muhaisen, A., Cotrufo, T., Roselló-Busquets, C., Ros, O., Hernaiz-Llorens, M., Pérez‐Brangulí, F., Andrés, R. M., Parcerisas, A., Pascual, M., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1253954 · Cited by 6
Interactions among the SNARE proteins and complexin analyzed by a yeast four-hybrid assay
Shih, A. M., & Shin, O. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.05.010 · Cited by 5
Sequestration of the exocytic SNARE Psy1 into multiprotein nodes reinforces polarized morphogenesis in fission yeast
Miller, K. E., Magliozzi, J. O., Picard, N. A., & Moseley, J. B. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-05-0277 · Cited by 5
Syntaxin 3B: A SNARE Protein Required for Vision
Dey, H., Perez-Hurtado, M., & Heidelberger, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910665 · Cited by 4
How SNARE proteins generate force to fuse membranes
Butu, I. C., An, D., & O’Shaughnessy, B. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.01.015 · Cited by 4
The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A
Salazar-Lázaro, A., Trimbuch, T., Vardar, G., & Rosenmund, C. (2023) · eLife · doi:10.7554/elife.90775 · Cited by 6
Self-citation
Novel Splice Site Pathogenic Variant in STXBP1 Gene in a Child with Intellectual Disability, Epilepsy, and Autism Spectrum Disorder: A Case Report
Amllal, N., Lyahyai, J., Elalaoui, S. C., Kadiri, Y. E., & Sefiani, A. (2024) · Molecular Syndromology · doi:10.1159/000538115 · Cited by 4
Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction
Szule, J. A. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.798225 · Cited by 4
The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins
Usher, S., Toulmé, E., Florea, R., Yatskevich, S., Jao, C. C., Dijkhof, L. R. H., Colding, J. M., Joshi, P., Zilberleyb, I., Trimbuch, T., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads6004 · Cited by 3
Self-citation
Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis
Xia, T., Tong, J., Rathore, S. S., Gu, X., & Dickerson, J. A. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-19 · Cited by 3
Der molekulare Mechanismus der Neurotransmitterfreisetzung und Nervenzell‐Synapsen (Nobel‐Aufsatz)
Südhof, T. C. (2014) · Angewandte Chemie · doi:10.1002/ange.201406359 · Cited by 3
Inference of Joint Conformational Distributions from Separately Acquired Experimental Measurements
Hays, J. M., Boland, E., & Kasson, P. M. (2021) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.0c03623 · Cited by 3
Network modeling in systems biology
Xia, T. (2010) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-4318 · Cited by 3
Novel role of glial syntaxin‐1B in supporting neuronal survival
Park, S., Bin, N., & Sugita, S. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12723 · Cited by 2
VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular PrimingPreprint
Kasula, R., Blum, A., Salla‐Martret, M., Chai, Y. J., Jiang, A., Wallis, T. P., Gormal, R. S., Brouillet, J. Z., Padmanabhan, P., Weeratunga, S. K., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3362260 · Cited by 3
Investigation of Vesicle Pool Dynamics at Activity Modulated Inner Hair Cell Ribbon Synapses
Chakrabarti, R. (2018) · doi:10.53846/goediss-6685 · Cited by 3
Molecular and Morphological Correlates of Synaptic Vesicle Priming
Imig, C. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4755 · Cited by 3
New Developments in Free Fatty Acids and Lysophospholipids: Decoding the Role of Phospholipases in Exocytosis
Narayana, V. K., Kvaskoff, D., & Meunier, F. A. (2017) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-49343-5_10 · Cited by 2
La machinerie moléculaire de sécrétion des neurotransmetteurs
Südhof, T. C. (2015) · Biologie Aujourd hui · doi:10.1051/jbio/2015012 · Cited by 2
Possible involvement of syntaxin 1A downregulation in the late phase of allodynia induced by peripheral nerve injury
Fukushima, T., Takasusuki, T., Tomitori, H., & Hori, Y. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.049 · Cited by 2
Overview: Presynaptic Terminal Proteins Orchestrate Stepwise Synaptic Vesicle Phases
Mochida, S. (2014) · Springer eBooks · doi:10.1007/978-4-431-55166-9_1 · Cited by 2
Fusion Machinery: SNARE Protein Complex
Milošević, I., & Sørensen, J. B. (2014) · Springer eBooks · doi:10.1007/978-4-431-55166-9_4 · Cited by 2
Synergistic SNARE Modulators of Neurotransmission: Complexins and SNAP-29
Sivakumar, N. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5635 · Cited by 1
VAMP2/Munc18-1 domain 3a interaction controls the nanoscale reorganization underpinning vesicular primingPreprint
Jiang, A., Gormal, R. S., Kasula, R., Blum, A., Salla‐Martret, M., Chai, Y. J., Wallis, T. P., Brouillet, J. Z., Padmanabhan, P., Weeratunga, S. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.10.556776 · Cited by 2
Comparative studies on regulation of SNARE complex formation by the SM protein Sly1p
Demircioglu, F. E. (2012) · doi:10.53846/goediss-3262 · Cited by 2
Accumulation of GSK ‐3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission
Liu, F., Cui, J., Li, X., Zhang, Z., Liang, S., Sun, Y., Li, J., Qu, H., Ye, J., Guo, Q., et al. (2025) · Aging Cell · doi:10.1111/acel.70115 · Cited by 2
Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction
Yu, J., Choi, I. S., Kim, G. H., Bahn, S.-K., Kim, J., Bae, S., Lee, T., Choi, J. H., Kwon, J. S., Kim, M., et al. (2026) · Science Advances · doi:10.1126/sciadv.aee2152 · Cited by 1
Self-citation
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
Nestvogel, D. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6444 · Cited by 1
A novel VPS33A interaction motif is a master-switch controlling the inhibition and promotion of mammalian Stx17 interactions with SNAP29 and VAMP7 during autophagyPreprint
Saleeb, R. S., Kavanagh, D. M., Dun, A. R., Dalgarno, P. A., & Duncan, R. R. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/182626 · Cited by 1
Why are SNAREpins rod-shaped?Preprint
Zeng, J., McDargh, Z. A., An, D., & O’Shaughnessy, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.23.449668 · Cited by 1
The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1APreprint
Salazar-Lázaro, A., Trimbuch, T., Vardar, G., & Rosenmund, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.06.547909 · Cited by 1
Self-citation
Investigation of SNARE-mediated exocytosis controlled by synaptic regulatory proteins
Shin, J. (2014) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-434
A role for the endosomal SNARE complex and tethers in autophagy
Cowan, M. (2014) · Enlighten: Theses (The University of Glasgow)
The timing of the final assembly of the SNARE complex in exocytosis
Walter, A. M. (2010) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3650
THE FUNCTIONAL ORGANIZATION OF SYNAPTIC VESICLE POOLS IN A RETINAL BIPOLAR NEURON
Datta, P. (2012) · Digital Commons-TMC (Texas Medical Center)
Rim1α and Neurexin3 Regulate Synaptosomal Dopamine Release
Lee, S. K. (2009) · Journal of Life Science · doi:10.5352/jls.2009.19.9.1232
MISSISSIPPI SOYBEAN PROMOTION BOARD PROJECT NO. 18-2013 (YEAR 4) 2013 FINAL REPORT Title: Development of a rapid genetic field race test for soybean cyst nematode (SCN) and generation of SCN resistance through gene inactivation
Klink, V. P. (2014)
Struktur und Funktion der afferenten Synapse innerer Haarzellen der Cochlea
Meyer, A. C. (2010) · doi:10.53846/goediss-779
Self-citation
Non-Canonical Amino Acids as Minimal Tags for Investigating Protein Organization and Turnover
Gebura-Vreja, I.-C. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5450
Role of Munc13 Isoforms in Regulating Large Dense Core Vesicle Exocytosis in Chromaffin Cells
Man, K. N. M. (2015) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5351
and Syntaxinl N-peptide and C-terminal anchor in SNARE complex formation
Hua, S.-H., Christie, M. P., Saez, N. J., Latham, C. F., Jarrott, R. J., Luac, L. H. L., Collins, B. M., & Martin, J. L. (2016)
Structure and Function Relationship of Syntaxin-1 in Neurotransmitter Release
Park, S. (2015) · TSpace (University of Toronto)
Molecular physiology of signal transmission along the auditory pathway
Butola, T. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6529
Charakterisierung des Targetingverhaltens präsynaptischer Proteine
Riemann, D. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6846
Study of SNARE-mediated membrane fusion with a novel single vesicle fusion assay
Witkowska, A. (2018) · doi:10.53846/goediss-6921
Unraveling the Molecular Mechanisms of Munc18 and Munc13 in Mast Cell Exocytosis
Bin, N. (2017) · TSpace (University of Toronto)
Cellular Role Of The Drosophila EFR3, Rolling Blackout (RBO) In Synaptic Transmission.
Vijayakrishnan, N. (2010)
Ανάλυση γενετικών και βιολογικών δεικτών σε ασθενείς με νόσο Alzheimer
Σταμάτη, Π. (2020) · doi:10.12681/eadd/48041
Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsionPreprint
Martínez‐Mármol, R., Muhaisen, A., Cotrufo, T., Roselló-Busquets, C., Hernaiz-Llorens, M., Pérez‐Brangulí, F., Andrés, R. M., Ros, O., Pascual, M., Ulloa, F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.20.444954
SNAREs and Synaptotagmin cooperatively determine the Ca 2+ sensitivity of neurotransmitter release in fixed stoichiometry modulesPreprint
McDargh, Z. A., & O’Shaughnessy, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.22.449527
Conformational Change of Syntaxin-3b in Regulating SNARE Complex Assembly in the Ribbon SynapsesPreprint
Gething, C., Ferrar, J., Misra, B., Howells, G., & Choi, U. B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.07.459295
Faculty Opinions recommendation of Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ.
Chen, L., & Fan, J. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718027115.793482861
Faculty Opinions recommendation of Clinical spectrum of STX1B-related epileptic disorders.
Lasko, P. F. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735057908.793581708
Faculty Opinions recommendation of Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.
Rizo, J. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.7138956.12282054
Self-citation
Faculty Opinions recommendation of Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography.
Lappalainen, P., & Serlachius, M. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1688956.1918054
Reconstitution of SNARE Mediated Membrane Fusion
Kreutzberger, A. J. B. (2017) · doi:10.18130/v3qh1c
Excitation-Secretion Coupling of Dense-Core Vesicle Release
Cirkovic, V. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10009
Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behaviorPreprint
Huang, M., Wang, Y., Chow, C. H., Stepien, K. P., Indrawinata, K., Xu, J., Argiropoulos, P., Xie, X., Sugita, K., Tien, C.-W., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.18.553709
Self-citation
Reviewer #2 (Public Review): The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1A
Salazar-Lázaro, A., Trimbuch, T., Vardar, G., et al. (2023) · eLife · doi:10.7554/elife.90775.1.sa1
eLife Assessment: The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1A
Yang, X. (2023) · eLife · doi:10.7554/elife.90775.1.sa3
Reviewer #1 (Public Review): The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1A
Salazar-Lázaro, A., Trimbuch, T., Vardar, G., et al. (2023) · eLife · doi:10.7554/elife.90775.1.sa2
The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1APreprint
Salazar-Lázaro, A., Trimbuch, T., Vardar, G., & Rosenmund, C. (2023) · eLife · doi:10.7554/elife.90775.1
Self-citation
Reviewer #3 (Public Review): The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1A
Salazar-Lázaro, A., Trimbuch, T., Vardar, G., et al. (2023) · eLife · doi:10.7554/elife.90775.1.sa0
The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1APreprint
Salazar-Lázaro, A., Trimbuch, T., Vardar, G., & Rosenmund, C. (2024) · eLife · doi:10.7554/elife.90775.2
Self-citation
Readily Releasable Pool
Zobel, S., & Rosenmund, C. (2024) · Neuromethods · doi:10.1007/978-1-0716-4019-7_14
Self-citation
Temporal Expression Prediction by Integrating Genome Dynamics via Spatio-temporal GNNsPreprint
Kaya, B., & Sefer, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.07.678022
DYNAMIQUE DE L'ASSEMBLAGE MOLÉCULAIRE SYNAPTIQUE : ÉTUDE DE LA DIFFUSION LATÉRALE DE LA SYNTAXIN 1A
Ribrault, C. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
A Rare Case Report of STXBP1 Gene Mutation Causing Intractable Epilepsy
Barua, P., Fatema, K., & Paul, B. C. (2025) · Paediatric Nephrology Journal of Bangladesh · doi:10.4103/pnjb.pnjb_3_25
Presynaptic mechanisms of short-term plasticity at hippocampal mossy fibersynapses
Llinares, B. G. I. (2014) · theses.fr (ABES) · doi:10.70675/260d23d6z0385z420bz9500z71856e7257bd
Pathophysiological consequences of a Fragile X missense mutation
Garcia, M. P. (2020) · theses.fr (ABES) · doi:10.70675/b8e86263z5926z4a83zbaf6z0f61bf2d15f9
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
Role of SNAREs in membrane fusion : reconstitution in bacteria
Singh, N. P. (2023) · theses.fr (ABES) · doi:10.70675/4f3ecddczf7d3z4948z90cczd2bc6b205d54
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
Chattopadhyay, M., Xu, J., & Rizo, J. (2026) · FEBS Open Bio · doi:10.1002/2211-5463.70272 · Cited by 1
Self-citation
Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signalingPreprint
Parekh, P. K., Rocks, D., Kenwood, M. M., Roshgadol, J., Munguba, H., & Liston, C. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.11.737837
A pooled CRISPR-based neuronal activity screen links TMEM50A-dependent MVB function to synaptic integrity and remote memory
Wang, J., Liu, M., Chen, Y., Chen, J., Zhong, X., Wang, Z., Jiang, X., & Tian, R. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117756
Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a comparative approach
Iraheta, R. E. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3160

Authors: Gerber, S. H., Rah, J.-C., Min, S.-W., Liu, X., de Wit, H., Dulubova, I., Meyer, A. C., Rizo, J., Arancillo, M., Hammer, R. E., Verhage, M., Rosenmund, C., & Südhof, T. C.
Affiliations: Baylor College of Medicine (US)
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390–9111, USA.
Corresponding author: Gerber, Stefan H.
Rah, Jong-Cheol
Min, Sang-Won
Rosenmund, Christian
ORCID: Rah, Jong-Cheol
Liu, Xinran
Meyer, Alexander C.
Rizo, Josep
Arancillo, Marife
Verhage, Matthijs
Rosenmund, Christian
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2008-09-12
Volume: 321
Issue: 5895
Pages: 1507-1510
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1163174
PMC: PMC3235364
OpenAlex: W2006897184
Cited by: 294
References: 23
Citations by year: 2026: 4 · 2025: 6 · 2024: 7 · 2023: 15 · 2022: 9 · 2021: 13 · 2020: 16 · 2019: 12 · 2018: 15 · 2017: 15 · 2016: 15 · 2015: 18 · 2014: 28 · 2013: 22 · 2012: 24
FWCI: 10.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Pure Amsterdam UMC (submittedVersion)
VU Research Portal (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Neurological Disorders and Stroke (NS 37200, R01NS037200, R01NS051262, NS051262)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: syntaxin-1, Munc18-1, SNARE complex, synaptic vesicle fusion, conformational switching, exocytosis, seizures, synaptic transmission
MeSH terms: Animals, Calcium, Epilepsy, Membrane Fusion, Mutation, Protein Conformation, Sucrose, Synapses, Synaptic Vesicles, Protein Structure, Tertiary, Mice, Knockout, Excitatory Postsynaptic Potentials, SNARE Proteins, Syntaxin 1, Mice, Munc18 Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks