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Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment
Open accessAbstract
Leukocyte recruitment to sites of infection or inflammation requires multiple adhesive events. Although numerous players promoting leukocyte-endothelial interactions have been characterized, functionally important endogenous inhibitors of leukocyte adhesion have not been identified. Here we describe the endothelially derived secreted molecule Del-1 (developmental endothelial locus–1) as an anti-adhesive factor that interferes with the integrin LFA-1–dependent leukocyte-endothelial adhesion. Endothelial Del-1 deficiency increased LFA-1–dependent leukocyte adhesion in vitro and in vivo. Del-1 –/– mice displayed significantly higher neutrophil accumulation in lipopolysaccharide-induced lung inflammation in vivo, which was reversed in Del-1/LFA-1 double-deficient mice. Thus, Del-1 is an endogenous inhibitor of inflammatory cell recruitment and could provide a basis for targeting leukocyte-endothelial interactions in disease.
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Self-citationAdhesion mechanisms regulating the migration of monocytes
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Metadata
- Authors
- Choi, E. Y., Chavakis, E., Czabanka, M. A., Langer, H. F., Fraemohs, L., Economopoulou, M., Kundu, R. K., Orlandi, A., Zheng, Y. Y., Prieto, D. A., Ballantyne, C. M., Constant, S. L., Aird, W. C., Papayannopoulou, T., Gahmberg, C. G., Udey, M. C., Vajkoczy, P., Quertermous, T., Dimmeler, S., Weber, C., & Chavakis, T.
- Venue
- Science
- Published
- 2008-11-14
- Volume
- 322
- Issue
- 5904
- Pages
- 1101-1104
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084800734
- Cited by
- 309
- References
- 25
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Choi, E. Y., Chavakis, E., Czabanka, M. A., Langer, H. F., Fraemohs, L., Economopoulou, M., Kundu, R. K., Orlandi, A., Zheng, Y. Y., Prieto, D. A., Ballantyne, C. M., Constant, S. L., Aird, W. C., Papayannopoulou, T., Gahmberg, C. G., Udey, M. C., Vajkoczy, P., Quertermous, T., Dimmeler, S., . . . Chavakis, T. (2008). Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment. Science. https://doi.org/10.1126/science.1165218
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
