The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology
Abstract
We now have a wealth of information about the molecular signals that act on cells in embryos, but how do the control systems based on these signals generate pattern and govern the timing of developmental events? Here, I discuss four examples to show how mathematical modeling and quantitative experimentation can give some useful answers. The examples concern the Bicoid gradient in the early Drosophila embryo, the dorsoventral patterning of a frog embryo by bone morphogenetic protein signals, the auxin-mediated patterning of plant meristems, and the Notch-dependent somite segmentation clock.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Regulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock
Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O. (2006) · Science · doi:10.1126/science.1133141 · Cited by 460
Cited by
Model for the regulation of Arabidopsis thaliana leaf margin development
Bilsborough, G. D., Runions, A., Barkoulas, M., Jenkins, H. W., Hasson, A., Galinha, C., Laufs, P., Hay, A., Prusinkiewicz, P., & Tsiantis, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015162108 · Cited by 467
Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth
Sozzani, R., Cui, H., Moreno-Risueno, M. A., Busch, W., Van Norman, J. M., Vernoux, T., Brady, S. M., Dewitte, W., Murray, J. A. H., & Benfey, P. N. (2010) · Nature · doi:10.1038/nature09143 · Cited by 438
Garcia, H. G., Tikhonov, M., Lin, A., & Gregor, T. (2013) · Current Biology · doi:10.1016/j.cub.2013.08.054 · Cited by 346
Roeder, A. H. K., Chickarmane, V., Cunha, A., Obara, B., Manjunath, B. S., & Meyerowitz, E. M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000367 · Cited by 309
Self-organization of intracellular gradients during mitosis
Fuller, B. G. (2010) · Cell Division · doi:10.1186/1747-1028-5-5 · Cited by 42
Metadata
- Authors
- Lewis, J.
- Venue
- Science
- Published
- 2008-10-17
- Volume
- 322
- Issue
- 5900
- Pages
- 399-403
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089460976
- Cited by
- 174
- References
- 3
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology. https://app.cochat.ai/papers/10.1126/science.1166154
- The paper
- Lewis, J. (2008). From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology. Science. https://doi.org/10.1126/science.1166154
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.