The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses
Open accessAbstract
Patten recognition receptors, which recognize pathogens or components of injured cells (danger), trigger activation of the innate immune system. Whether and how the host distinguishes between danger- versus pathogen-associated molecular patterns remains unresolved. We report that CD24-deficient mice exhibit increased susceptibility to danger- but not pathogen-associated molecular patterns. CD24 associates with high mobility group box 1, heat shock protein 70, and heat shock protein 90; negatively regulates their stimulatory activity; and inhibits nuclear factor kappaB (NF-kappaB) activation. This occurs at least in part through CD24 association with Siglec-10 in humans or Siglec-G in mice. Our results reveal that the CD24-Siglec G pathway protects the host against a lethal response to pathological cell death and discriminates danger- versus pathogen-associated molecular patterns.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“A clear example of glycan-based SAMPs has been reported in the form of inhibitory Siglec recognition of cell surface sialoglycans (962 -964), which may also provide a mechanism for the host to discriminate between infectious nonself and noninfectious self (965).”
From Biological roles of glycans (2017) · cites this paper as [963]
In the citing paper
“CD24-mediated inhibition was associated with increased pro-inflammatory cytokine production by HMGb1 and decreased survival following acetaminophen-induced liver injury106.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [106]
In the citing paper
“Specifically, CD24, which can bind to both HMGb1 and HSPs, negatively regulates sterile inflammatory responses.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [106]
In the citing paper
“It has also been shown that DAMP-specific receptors can negatively regulate inflammatory responses.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [106]
In the citing paper
“Specifically, CD24, which can bind to both HMGb1 and HSPs, negatively regulates sterile inflammatory responses.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,263
Self-citationApetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056
Siglecs and their roles in the immune system
Crocker, P. R., Paulson, J. C., & Varki, A. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2056 · Cited by 2,032
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 790
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
Miles, L. A., Hermans, S. J., Crespi, G. A. N., Gooi, J. H., Doughty, L., Nero, T. L., Markulić, J., Ebneth, A., Wroblowski, B., Oehlrich, D., et al. (2019) · iScience · doi:10.1016/j.isci.2019.07.023 · Cited by 81
After cell death: the molecular machinery of efferocytosis
Moon, B., Yang, S., Moon, H., Lee, J., & Park, D. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01070-5 · Cited by 78
Wang, X., Xiang, L., Li, H., Chen, P., Feng, Y., Zhang, J., Yang, N., Li, F., Wang, Y., Zhang, Q., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922527 · Cited by 76
“, heparin sulfate [40]), CD24 [41], the T-cell immunoglobulin domain and mucin domain-3 (TIM-3) [42], the member of the G protein-coupled receptors CXCR4 [43], N-methyl-D-aspartate”
BackgroundInteraction between uric acid and HMGB1 translocation and release from endothelial cells
Rabadi, M. M., Kuo, M., Ghaly, T., Rabadi, S. M., Weber, M., Goligorsky, M. S., & Ratliff, B. B. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00520.2011 · Cited by 78
In Situ trans Ligands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics
Ramya, T. N. C., Weerapana, E., Liao, L., Zeng, Y., Tateno, H., Liao, L., Yates, J. R., Cravatt, B. F., & Paulson, J. C. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900461-mcp200 · Cited by 77
“ably via an alternative binding site(s) (56, 71, 72).”
BackgroundShoda, L. K. M., Woodhead, J. L., Siler, S. Q., Watkins, P. B., & Howell, B. A. (2014) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.1878 · Cited by 75
Modulatory Effects of Antidepressant Classes on the Innate and Adaptive Immune System in Depression
Eyre, H. A., Lavretsky, H., Kartika, J., Qassim, A., & Baune, B. T. (2016) · Pharmacopsychiatry · doi:10.1055/s-0042-103159 · Cited by 77
SOX2‐mediated upregulation of CD24 promotes adaptive resistance toward targeted therapy in melanoma
Hüser, L., Sachindra, S., Granados, K., Federico, A., Larribère, L., Novak, D., Umansky, V., Altevogt, P., & Utikal, J. S. (2018) · International Journal of Cancer · doi:10.1002/ijc.31609 · Cited by 75
“interact with siglecs, a class of sialic acid binding receptors on immune cells.(15,20) CD24 expression can regulate tumor”
BackgroundImmunotherapeutic approaches to curtail COVID-19
Owji, H., Negahdaripour, M., & Hajighahramani, N. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106924 · Cited by 79
Gruber, S., Hendrikx, T., Tsiantoulas, D., Ozsvár-Kozma, M., Göderle, L., Mallat, Z., Witztum, J. L., Shiri‐Sverdlov, R., Nitschke, L., & Binder, C. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.027 · Cited by 75
“A suppressive role of Siglec-G in non-B cells has been suggested in drug-induced liver damage, as Siglec-G deficiency results in increased production of pro-inflammatory cytokines, including IL-6, TNF-a, and MCP-1, following stimulation with DAMPs that are released in this setting (Chen et al., 2009).”
BackgroundHDAC Inhibition and Graft Versus Host Disease
Choi, S. W., & Reddy, P. R. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00007 · Cited by 75
Zhang, P., Lu, X., Tao, K., Shi, L., Li, W., Wang, G., & Wu, K. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.09.035 · Cited by 74
CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder
Wang, X., Liu, M., Zhang, J., Brown, N. K., Zhang, P., Zhang, Y., Liu, H., Du, X., Wu, W., Devenport, M., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.07.005 · Cited by 74
Self-citationKristiansen, G., Machado, E., Bretz, N. P., Rupp, C., Winzer, K., König, A.-K., Moldenhauer, G., Marmé, F., Costa, J., & Altevogt, P. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.70 · Cited by 73
“13 A recent study has shown that mouse CD24 can bind to Siglec-10”
BackgroundAbdominal drains: a brief historical review.
Memon, M. A., Memon, M. A., & Donohue, J. H. (2001) · PubMed · Cited by 72
Life after death: targeting high mobility group box 1 in emergent cancer therapies.
Guo, Z. S., Liu, Z., Bartlett, D. L., Tang, D., & Lotze, M. T. (2013) · Europe PMC (PubMed Central) · Cited by 72
DAMPs and Innate Immune Training
Jentho, E., & Weis, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.699563 · Cited by 73
Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation
Andersson, J., Tracey, K. J., & Yang, H. (2021) · Cells · doi:10.3390/cells10123323 · Cited by 75
“HMGB1-CD24 forms a trimolecular complex on dendritic cells with the signaling receptor Siglec-10, which subsequently associates with the tyrosine phosphatase SHP-1, a negative regulator of nuclear factor-kB (NF-κB) activation [78] (Figure 6).”
BackgroundInfluentialLi, W., Li, J., Sama, A. E., & Wang, H. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00064 · Cited by 72
Sterile post‐traumatic immunosuppression
Islam, M. N., BRADLEY, B. A., & Ceredig, R. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.13 · Cited by 73
High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation
Kim, S. Y., Son, M., Lee, S. E., Park, I. H., Kwak, M. S., Han, M., Lee, H. S., Kim, E. S., Kim, J., Lee, J. E., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00705 · Cited by 72
“HMGB1 released from damaged hepatocytes promotes inflammatory processes, and the neutralization of HMGB1 can attenuate liver injury (52).”
BackgroundCellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development
Ignat, S.-R., Dinescu, S., Hermenean, A. O., & Costache, M. (2020) · Cells · doi:10.3390/cells9020461 · Cited by 75
“Such is the case for HMGB1 and HSPs when binding to CD24 or sialic acid-binding Ig-like lectin 10 (SIGLEC10) [66].”
BackgroundBeatson, R., Graham, R. A., Freile, F. G., Cozzetto, D., Kannambath, S., Pfeifer, E., Woodman, N. L., Owen, J., Nuamah, R. A., Mandel, U., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01359-5 · Cited by 71
Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors
Iborra, S., & Sancho, D. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.09.013 · Cited by 74
“, 2007), and mouse Siglec-G deletion results in overreactive responses to DAMPs and PAMPs (Chen et al., 2009).”
BackgroundInfluentialHigh-mobility group box 1 serves as an inflammation driver of cardiovascular disease
Wahid, A., Chen, W., Wang, X., & Tang, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111555 · Cited by 71
High Mobility Group Box-1 (HMGB1): A Potential Target in Therapeutics
Vijayakumar, E. C., Bhatt, L. K., & Prabhavalkar, K. S. (2019) · Current Drug Targets · doi:10.2174/1389450120666190618125100 · Cited by 67
Damage-mediated macrophage polarization in sterile inflammation
Koncz, G., Jenei, V., Tóth, M., Váradi, E., Kardos, B., Bácsi, A., & Mázló, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1169560 · Cited by 74
Insight into the mechanisms regulating immune homeostasis in health and disease.
Sirisinha, S. (2011) · PubMed · Cited by 68
Zhang, L., Gao, S., White, Z., Dai, Y. D., Malik, A. B., & Rehman, J. (2022) · JCI Insight · doi:10.1172/jci.insight.158079 · Cited by 72
CD22 and Siglec-G in B cell function and tolerance
Poe, J. C., & Tedder, T. F. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.04.010 · Cited by 66
“Siglec-G and Siglec-10 have also been shown to play a role in the suppression of immune responses to danger-associated molecular patterns (DAMPs) through their interactions with CD24, a process that appears to prevent tissue damage by distinguishing DAMPs from pathogen-associated molecular patterns (PAMPs) [69].”
BackgroundEthyl pyruvate administration inhibits hepatic tumor growth
Liang, X., Chavez, A. R. D. V., Schapiro, N. E., Loughran, P., Thorne, S. H., Amoscato, A. A., Zeh, H. J., Beer–Stolz, D., Lotze, M. T., & de Vera, M. E. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908578 · Cited by 66
“HMGB1 signals through receptors such as the RAGE or TLR2, TLR4, and TLR9, as well as most recently, CD25/Siglec 10 [9].”
BackgroundNucleic acid-associated autoantigens: Pathogenic involvement and therapeutic potential
Hoffmann, M. H., Trembleau, S., Muller, S., & Steiner, G. E. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.013 · Cited by 66
Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases
Pilzweger, C., & Holdenrieder, S. (2015) · Diagnostics · doi:10.3390/diagnostics5020219 · Cited by 67
“Such host-protecting functions can be seen in improved discrimination between DAMPs and pathogen associated molecular patterns (PAMPs) via HMGB1-dependent activation of CD24-Siglec G pathway [110].”
BackgroundSiglec receptors impact mammalian lifespan by modulating oxidative stress
Schwarz, F., Pearce, O. M. T., Wang, X., Samraj, A. N., Laubli, H. P., Garcia, J. O., Lin, H., Fu, X., Garcia-Bingman, A., Secrest, P., et al. (2015) · eLife · doi:10.7554/elife.06184 · Cited by 67
“Their primary function is to recognize self-associated molecular patterns and modulate host immune responses by regulating cellular reactions, survival, and production of cytokine mediators (Crocker et al., 2007; Chen et al., 2009; Cao and Crocker, 2011; Varki, 2011).”
BackgroundThe role of high mobility group box chromosomal protein 1 in rheumatoid arthritis
Chen, Y., Sun, W., Gao, R., Su, Y., Umehara, H., Dong, L., & Gong, F. (2013) · Rheumatology · doi:10.1093/rheumatology/ket134 · Cited by 66
Lectin Receptors Expressed on Myeloid Cells
Brown, G. D., & Crocker, P. R. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0036-2016 · Cited by 70
“This is thought to be due to a dampening effect of cis-interactions between Siglec-G and the heavily sialylated DAMP receptor, CD24 (130).”
BackgroundWang, L., Liu, R., Ye, P., Wong, C.-S., Chen, G., Zhou, P., Sakabe, K., Zheng, X., Wu, W., Zhang, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms6909 · Cited by 63
Self-citationRobinson, A. P., Caldis, M. W., Harp, C. T., Goings, G. E., & Miller, S. D. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.02.005 · Cited by 64
“HMGB1 is enhanced following paracetamol-induced liver damage [26], ischemia-reperfusion damage of the heart [27], acute lung and kidney injury [28,29], hemorrhage [30], and burns [31].”
Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer
Su, N., Peng, L., Xia, B., Zhao, Y., Xu, A., Wang, J., Wang, X., & Jiang, B. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-43 · Cited by 64
“Several ligands of CD24, including P-selectin [10] and Siglec-10 [11], have been identified and are found to be crucial for tumor development.”
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond
Shapira, S., Shimon, M. B., Hay-Levy, M., Shenberg, G., Choshen, G., Bannon, L., Tepper, M., Kazanov, D., Seni, J., Lev‐Ari, S., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202215997 · Cited by 64
“CD24 binds both DAMPs and Siglec-10 resulting in activation of the Siglec-10 signaling pathway (Chen et al , 2009; Barkal et al , 2019).”
Li, X., Tian, W., Jiang, Z., Song, Y., Leng, X., & Yu, J. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-023-03606-0 · Cited by 65
Nitschke, L. (2014) · Glycobiology · doi:10.1093/glycob/cwu066 · Cited by 63
“It should be noted that Siglec-G is also expressed on the surface of dendritic cells and a loss of Siglec-G on these cells has been implicated to increase severity in a hepatocyte inflammation model and in bacterial sepsis (Chen et al. 2009; Chen et al. 2011).”
BackgroundHan, Y., Chen, R., Lin, Q., Liu, Y., Ge, W., Cao, H., & Li, J. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16855 · Cited by 64
Self-citationInnate-Like B Cells and Their Rules of Engagement
Baumgarth, N. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6217-0_7 · Cited by 62
The CD24 surface antigen in neural development and disease
Gilliam, D. T., Menon, V., Bretz, N. P., & Pruszak, J. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.011 · Cited by 62
Shi, X., Yu, L., Zhang, Y., Liu, Z., Zhang, H., Zhang, Y., Liu, P., & Du, P. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106578 · Cited by 61
“TLR4 signaling has been reported to contribute to tissue damage in both pathogenic hepatic injury and sterile inflammatory hepatitis [31] [32] [33] .”
Hargadon, K. M. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.37 · Cited by 63
Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers
Lin, C.-H., Yeh, Y.-C., & Yang, K. D. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2019.10.019 · Cited by 62
Cai, C., Huang, H., Whelan, S., Liu, L., Kautza, B. C., Luciano, J. A., Wang, G., Chen, G., Stratimirovic, S., Tsung, A., et al. (2014) · Hepatology · doi:10.1002/hep.27201 · Cited by 61
“Among the DAMPs in liver injury, HMGB1 has been shown to play a vital role, including in APAPtreated mice.(34) HMGB1 release itself or as a complex with DNA can activate TLR2, 4, and 9.”
BackgroundSelf-citationMensah, F., Armstrong, C. W., Reddy, V. R., Bansal, A. S., Berkovitz, S., Leandro, M. J., & Cambridge, G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02421 · Cited by 61
Gianchecchi, E., Arena, A., & Fierabracci, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115774 · Cited by 62
“In more detail, they show sialoglycan-SAMP-like structures on their surface that dampen host immune responses via inhibitory Siglec engagement [23].”
BackgroundPerspective of Immunopathogenesis and Immunotherapies for Kawasaki Disease
Chang, L., Yang, H., Lin, T.-Y., & Yang, K. D. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.697632 · Cited by 60
Microbe- and danger-induced inflammation
Broggi, A., & Granucci, F. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.037 · Cited by 60
Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications · doi:10.1038/s41467-023-40393-9 · Cited by 57
The role of HMGB1 in inflammation-mediated organ injury
Asavarut, P., Zhao, H., Gu, J., & Ma, D. (2013) · Acta anaesthesiologica Taiwanica · doi:10.1016/j.aat.2013.03.007 · Cited by 60
Sammar, M., Siwetz, M., Meiri, H., Fleming, V., Altevogt, P., & Huppertz, B. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1531-7 · Cited by 59
Sialic Acids in the Immune Response during Sepsis
Liu, Y., Yu, M., Chai, Y., & Shou, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01601 · Cited by 58
“In sepsis, CD24 associates with DAMPs, such as highmobility group box 1, Hsp70, and Hsp90, negatively regulates their stimulatory activity and inhibits NF-κB activation through association with Siglec-G (62).”
BackgroundSelf-citationTargeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy
Xu, S., Wang, C., Yang, L., Wu, J., Li, M., Xiao, P., Xu, Z., Xu, Y., & Wang, K. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1199631 · Cited by 59
CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer
Deng, X., Apple, S. K., Zhao, H., Song, J.-Y., Lee, M., Luo, W. Y., Wu, X., Chung, D. U., Pietras, R. J., & Chang, H. R. (2017) · Oncotarget · doi:10.18632/oncotarget.16203 · Cited by 58
“These observation may be related to our finding of high recurrence rates in patients with CD24+ TNBC who are treated with taxane-based regimens, but further investigation is needed to clarify the involvement of CD24 in metastasis as well as regulation of the host immune response [23, 41].”
BackgroundMarkovics, A., Rosenthal, K. S., Mikecz, K., Carambula, R. E., Ciemielewski, J. C., & Zimmerman, D. H. (2021) · Biomedicines · doi:10.3390/biomedicines10010044 · Cited by 59
“CD24 ↓ TNF-α, IL-6, MCP-1(CCL2), IL-1β [59] NF-κβ [60] [59,61,62]”
Zhu, S., Li, W., Ward, M. F., Sama, A. E., & Wang, H. (2010) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152810791292872 · Cited by 57
Kuhn, A., Wenzel, J., & Bijl, M. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0550-0 · Cited by 58
Westman, J., Papareddy, P., Dahlgren, M. W., Chakrakodi, B., Norrby‐Teglund, A., Smeds, E., Linder, A., Mörgelin, M., Johansson‐Lindbom, B., Egesten, A., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005319 · Cited by 57
Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · doi:10.1101/2023.01.12.523760 · Cited by 57
Turning enemies into allies—reprogramming tumor-associated macrophages for cancer therapy
Molgora, M., & Colonna, M. (2021) · Med · doi:10.1016/j.medj.2021.05.001 · Cited by 56
Wu, H., Steenstra, R., de Boer, E. C. S., Zhao, C. Y., Ma, J., van der Stelt, J., & Chadban, S. J. (2013) · Kidney International · doi:10.1038/ki.2013.475 · Cited by 56
HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells
Gougeon, M.-L., Melki, M.-T., & Saïdi, H. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.134 · Cited by 58
Soto, P. C., Stein, L. L., Hurtado‐Ziola, N., Hedrick, S. Μ., & Varki, A. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903420 · Cited by 56
“(26), and Siglec-H has been shown to affect signaling in plasmacytoid dendritic cells (34).”
BackgroundBerga-Bolaños, R., Drews‐Elger, K., Aramburu, J. F., & López‐Rodríguez, C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001232 · Cited by 55
“In another scenario, Liu’s group has recently identified a novel role for CD24 in dendritic cells, in which it attenuates inflammatory signals delivered by tissue damage (63).”
BackgroundParlato, M., Souza-Fonseca-Guimarães, F., Philippart, F., Misset, B., Captain Study Group, Jacqmin, S., Journois, D., Lagrange, A., de Villechenon, G. P., Aïssaoui, N., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301055 · Cited by 55
“CD24 also plays a role in inflammation because it was recently shown to bind a variety of danger-associated molecular patterns, such as high mobility group box protein 1, members of the heat shock protein (HSP) family, and nucleolins (17), and to repress the host response to tissue injury through its interaction with…”
BackgroundImmunosurveillance as a regulator of tissue homeostasis
Senovilla, L., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.06.005 · Cited by 57
Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry
Büll, C., Heise, T., van Hilten, N., Pijnenborg, J. F. A., Bloemendal, V. R. L. J., Gerrits, L., Kers‐Rebel, E. D., Ritschel, T., den Brok, M. H., Adema, G. J., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201612193 · Cited by 55
Damage‐associated molecular patterns and immune activation in bipolar disorder
Stertz, L., Fries, G. R., Rosa, A. R., Kauer‐Sant'anna, M., Ferrari, P., Paz, A. V. C., Green, C., Cunha, Â. B. M., Dal‐Pizzol, F., Gottfried, C., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12417 · Cited by 53
“On the other hand, HSP90 can also engage inhibitory receptors like CD24 and block their proinflammatory effects (34).”
BackgroundFunctional Diversity of Non-Histone Chromosomal Protein HmgB1
Chikhirzhina, E. V., Starkova, T. Y., Beljajev, A., Polyanichko, A. M., & Tomilin, A. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217948 · Cited by 60
Tan, Y., Zhao, M., Xiang, B., Chang, C., & Lu, Q. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8470-2 · Cited by 54
“It has been shown that CD24 expressed by DCs binds to Siglec-G/10 and HMGB1, an intracellular DNA-binding protein released by necrotic cells.”
BackgroundInfluentialDipotassium Glycyrrhizate Inhibits HMGB1-Dependent Inflammation and Ameliorates Colitis in Mice
Vitali, R., Palone, F., Cucchiara, S., Negroni, A., Cavone, L., Costanzo, M., Aloi, M., Dilillo, A., & Stronati, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066527 · Cited by 55
Berthelot, F., Fattoum, L., Casulli, S., Gozlan, J., Maréchal, V., & Elbim, C. (2011) · Journal of Innate Immunity · doi:10.1159/000328798 · Cited by 53
Tecle, E., Reynoso, H., Wang, R., & Gagneux, P. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008729 · Cited by 53
“We also report that a subset of sperm bears CD24, a sialic acid containing glycoprotein that is an established activator of Siglec-10 signaling (39).”
BackgroundBispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
Sun, F., Cheng, Y., Wanchai, V., Guo, W., Mery, D. E., Xu, H., Gai, D., Siegel, E. R., Bailey, C., Ashby, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44873-4 · Cited by 55
“CD24 on tumor cells binds to sialic-acid-binding Ig-like lectin 10 (Siglec-10) on macrophages causing immune-cell inhibition, which is mediated by Src homology 2 domain-containing protein tyrosine phosphatase 1/2 (SHP-1/2) 25,26 .”
BackgroundThe roles of leptin and adiponectin at the fetal-maternal interface in humans
Dos Santos, E., Duval, F., Vialard, F., & Dieudonné, M.-N. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0031 · Cited by 52
Role of Siglec-7 in Apoptosis in Human Platelets
Nguyen, K., Hamzeh‐Cognasse, H., Palle, S., Anselme‐Bertrand, I., Arthaud, C., Chavarin, P., Pozzetto, B., Garraud, O., & Cognasse, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106239 · Cited by 52
“Furthermore, Siglec(s) form a complex with CD24, a glycosyl-phosphatidyl-inositol–anchored molecule expressed by immature hematopoietic cells, that recognizes DAMPs and reduces immune system-mediated damage [44].”
BackgroundPedrazzi, M., Averna, M., Sparatore, B., Patrone, M., Salamino, F., Marcoli, M., Maura, G., Cervetto, C., Frattaroli, D., Pontremoli, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044518 · Cited by 51
“like receptors (TLRs) 2 and 4 [1,2].”
Inhibitory pattern recognition receptors
Rumpret, M., von Richthofen, H. J., Peperzak, V., & Meyaard, L. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211463 · Cited by 51
Siglec Receptors Modulate Dendritic Cell Activation and Antigen Presentation to T Cells in Cancer
Wang, J., Manni, M., Bärenwaldt, A., Wieboldt, R., Kirchhammer, N., Ivánek, R., Stanczak, M. A., Zippelius, A., König, D., Mantuano, N. R., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.828916 · Cited by 50
“In particular, EKO Sp37A3 cells showed stronger upregulation of type I and II interferon (IFN-α and IFN-γ)related responses, tumor necrosis factor alpha (TNF-α) response, and general inflammatory response (Figure 4B).”
BackgroundResultInfluentialHMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
Yuan, J., Guo, L., Ma, J., Zhang, H., Xiao, M., Li, N., Gong, H., & Yan, M. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09893-2 · Cited by 53
“HMGB1, CD24 as well as Siglec-10 form trimeric complexes, which can inhibit inflammation induced by acetaminophen (AAP) via the NF-κB signaling pathway (Chen et al. 2009).”
BackgroundTargeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis
Wree, A., Mehal, W. Z., & Feldstein, A. E. (2016) · Seminars in Liver Disease · doi:10.1055/s-0035-1571272 · Cited by 52
“[74] [75] [76] [77] The consequence of HMGB1-receptor binding is also dependent on the oxidation state of one of three cysteine residues.”
BackgroundSiglecs as Therapeutic Targets in Cancer
Lim, J., Sari, D., & Bagga, T. (2021) · Biology · doi:10.3390/biology10111178 · Cited by 54
Alarming Dendritic Cells for Allergic Sensitization
Willart, M. A. M., & Hammad, H. (2010) · Allergology International · doi:10.2332/allergolint.09-rai-0162 · Cited by 49
Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake
Zhang, Y., Li, W., Zhu, S., Jundoria, A., Li, J., Yang, H., Fan, S., Wang, P., Tracey, K. J., Sama, A. E., et al. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.09.015 · Cited by 50
“Notably, HMGB1 can bind to many other cell surface proteins including thrombomodulin [46], CD24/Siglec-10 [44], Mac-1 [45], as well as single transmembrane domain proteins (e.g., syndecans) [47].”
BackgroundWang, X., Zhang, Y., Zhao, Y., Liang, Y., Xiang, C., Zhou, H., Zhang, H., Zhang, Q., Qing, H., Jiang, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10971 · Cited by 51
RETRACTED: Exploring the therapeutic promise of targeting HMGB1 in rheumatoid arthritis
Kaur, I., Behl, T., BUNGAU, S. G., Kumar, A., Mehta, V., Setia, D., Uddin, M. S., Zengin, G., Aleya, L., & Arora, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118164 · Cited by 50
RetractedThe impact of DAMP-mediated inflammation in severe COVID-19 and related disorders
Parthasarathy, U., Martinelli, R., Vollmann, E. H., Best, K., & Therien, A. G. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114847 · Cited by 51
“For example, CD24 has been shown to associate with Siglec-10 and downregulate HMGB1-mediated NF-κB inhibition, while soluble CD52 binding to Siglec-10 inhibits T cell receptor-associated kinase phosphorylation and T cell activation [109,110].”
Pillai, S., Cariappa, A., & Pirnie, S. P. (2009) · Trends in immunology · doi:10.1016/j.it.2009.07.006 · Cited by 49
Ryan, P. M., Bourdi, M., Korrapati, M. C., Proctor, W. R., Vasquez, R. A., Yee, S. B., Quinn, T. D., Chakraborty, M., & Pohl, L. R. (2011) · Chemical Research in Toxicology · doi:10.1021/tx2003992 · Cited by 49
“In contrast, other factors reduce susceptibility to AILI, including glycoproteins (13), antioxidants (14, 15) and hepatoprotective cytokines and chemokines (8).”
BackgroundChaiworapongsa, T., Romero, R. J., Whitten, A. E., Tarca, A. L., Bhatti, G., Drăghici, S., Chaemsaithong, P., Miranda, J., & Hassan, S. S. (2013) · Journal of Perinatal Medicine · doi:10.1515/jpm-2013-0082 · Cited by 49
“Furthermore, a recent study reported that cytotrophoblasts and the syncytiotrophoblasts expressed CD24, and treating placental explants with adiponectin (an adipokine that has been reported to be elevated in circulation of patients with PE [123]) increased expression of Siglec10 (both mRNA and protein) [112], suggesti…”
Ishida, A., Akita, K., Mori, Y., Tanida, S., Toda, M., Inoue, M., & Nakada, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.523480 · Cited by 49
“Although the precise role of Siglec-10 in the down-regulation of the signaling has not been elucidated yet, a similar type of complex, CD14/CD33 and CD24/Siglec10, may play an important role in the down-regulation of TLRmediated signaling after ligation with LPS and HMGB1, respectively.”
BackgroundInfluentialBeyond the grave: When is cell death critical for immunity to infection?
Stephenson, H. N., Herzig, A., & Zychlinsky, A. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.11.004 · Cited by 53
Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation
Büll, C., Camps, E. C., Kers‐Rebel, E. D., Heise, T., Søndergaard, J. N., den Brok, M. H., Schulte, B. M., Boltje, T. J., & Adema, G. J. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.105 · Cited by 49
Unveiling Molecular Recognition of Sialoglycans by Human Siglec-10
Forgione, R. E., Carluccio, C. D., Guzmán-Caldentey, J., Gaglione, R., Battista, F., Chiodo, F., Manabe, Y., Arciello, A., Vecchio, P. D., Fukase, K., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101231 · Cited by 48
Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology
Song, N., Allen, C., Vilgelm, A. E., Riesenberg, B., Weller, K. P., Reynolds, K., Chakravarthy, K. B., Kumar, A., Khatiwada, A., Sun, Z., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01222-y · Cited by 46
“CD24 is an important checkpoint molecule for controlling the innate immune response [16]; it binds to extracellular high-mobility group box 1 (HMGB1) and heat shock proteins, as well as the downstream Siglec10-SHP1 pathway to blunt NF-κB activation [15].”
BackgroundSelf-citation
Metadata
- Authors
- Chen, G.-Y., Tang, J., Zheng, P., & Liu, Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zheng, Pan
- Liu, Yang
- Venue
- Science
- Published
- 2009-03-27
- Volume
- 323
- Issue
- 5922
- Pages
- 1722-1725
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2765686
- OpenAlex
- W2158924104
- Cited by
- 786
- References
- 29
- Citations by year
- 2026: 36 · 2025: 51 · 2024: 43 · 2023: 46 · 2022: 55 · 2021: 64 · 2020: 45 · 2019: 23 · 2018: 28 · 2017: 34 · 2016: 47 · 2015: 44 · 2014: 53 · 2013: 58 · 2012: 37
- FWCI
- 22.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ai064350-15)
- National Cancer Institute (R01CA112001, CA-58033, R01CA058033, CA112001)
- National Institute of Allergy and Infectious Diseases (R01-AI064350, AI064350)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Keywords
- CD24, Siglec-10, Siglec-G, pattern recognition receptors, damage-associated molecular patterns, pathogen-associated molecular patterns, innate immune regulation, high mobility group box 1, HSP70, HSP90, NF-κB activation, tissue damage
- MeSH terms
- Acetaminophen, Animals, Dendritic Cells, Humans, Immunity, Innate, Inflammation, Lipopolysaccharides, Liver, Necrosis, Receptors, Antigen, B-Cell, Receptors, Cell Surface, Signal Transduction, Cytokines, Protein Structure, Tertiary, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, HMGB1 Protein, Lectins, Immunoprecipitation, Mutant Proteins, Receptors, Pattern Recognition, Mice, CD24 Antigen, Transcription Factor RelA, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Sialic Acid Binding Immunoglobulin-like Lectins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
