The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes
Open accessAbstract
Fat-Burning Fat: In mammals, fat exists in two forms—the well-known white adipose tissue (WAT), which stores energy and is associated with obesity, and the lesser-known brown adipose tissue (BAT), which burns energy to generate heat. BAT's role in human physiology was once thought to be restricted to newborns, but the recent discovery that adults also harbor functional BAT has re-ignited interest in the factors regulating BAT development and their potential as targets for anti-obesity therapies. Vegiopoulos et al. (p. 1158 , published online 6 May; see the Perspective Ishibashi and Seale ) now show that cyclooxygenase-2 (COX-2), an enzyme critical to prostaglandin synthesis, triggers fat progenitor cells in mice to differentiate into BAT rather than WAT. Mice overexpressing COX-2 displayed increased energy expenditure and were protected from diet-induced obesity.
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Cites
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PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
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Cited by
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A.-H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,319
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Brown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Seale, P., Conroe, H. M., Estall, J., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,252
Adipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177
Metadata
- Authors
- Vegiopoulos, A., Müller-Decker, K., Strzoda, D., Schmitt, I., Chichelnitskiy, E., Ostertag, A., Diaz, M. B., Rozman, J., Hrabe de Angelis, M., Nüsing, R. M., Meyer, C. W., Wahli, W., Klingenspor, M., & Herzig, S.
- Venue
- Science
- Published
- 2010-05-28
- Volume
- 328
- Issue
- 5982
- Pages
- 1158-1161
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986098635
- Cited by
- 459
- References
- 8
- FWCI
- 23.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Vegiopoulos, A., Müller-Decker, K., Strzoda, D., Schmitt, I., Chichelnitskiy, E., Ostertag, A., Diaz, M. B., Rozman, J., Hrabe de Angelis, M., Nüsing, R. M., Meyer, C. W., Wahli, W., Klingenspor, M., & Herzig, S. (2010). Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes. Science. https://doi.org/10.1126/science.1186034
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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