Human Fatty Liver Disease: Old Questions and New Insights

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Items 301–400 of 1,007

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  3. Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding
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  4. High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs
    Wencong Dai, Kunyuan Wang, Xinchun Zheng, Xiaohui Chen, Wenqing Zhang, Yiyue Zhang, Jinlin Hou, Li Liu · 2015 · Nutrition & Metabolism
  5. mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion
    William J. Quinn, Min Wan, Swapnil V. Shewale, Rebecca Gelfer, Daniel James Rader, Morris J. Birnbaum, Paul M. Titchenell · 2017 · Journal of Clinical Investigation
  6. Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK–PPAR-γ–CD36 Pathway
    Cheng Zhang, Xiaohe Luo, Jianrong Chen, Baoyong Zhou, Mengliu Yang, Rui Liu, Dongfang Liu, Harvest F. Gu, Zhiming Zhu, Hongting Zheng et al. · 2019 · Diabetes
  7. Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies
    Otilia Elena Frăsinariu, Sara Ceccarelli, Anna Alisi, Evelina Moraru, Valério Nobili · 2012 · Digestive and Liver Disease
  8. Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
    Chandramohan Chitraju, Martin Trötzmüller, Jürgen Hartler, Heimo Wolinski, Gerhard Thallinger, Achim Lass, Rudolf Zechner, Robert Zimmermann, Harald C. Köfeler, Friedrich Spener · 2012 · Journal of Lipid Research
  9. Lycopene Metabolite, Apo-10′-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet–Promoted Hepatic Inflammation and Tumorigenesis in Mice
    Blanche C. Ip, Kang‐Quan Hu, Chun Liu, Donald E. Smith, Martin S. Obin, Lynne M. Ausman, Xiangdong Wang · 2013 · Cancer Prevention Research
  10. Poria cocos polysaccharides rescue pyroptosis-driven gut vascular barrier disruption in order to alleviates non-alcoholic steatohepatitis
    Haixin Ye, Shuoyi Ma, Zhantu Qiu, Sha Huang, Guanghui Deng, Yunjia Li, Shu Xu, Menghan Yang, Hao Shi, Chaofeng Wu et al. · 2022 · Journal of Ethnopharmacology
  11. Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia
    Pooja Jha, Thierry Claudel, Anna Baghdasaryan, Michaela Mueller, Emina Halilbasic, Suman Kumar Das, Achim Lass, Robert Zimmermann, Rudolf Zechner, Gerald Höefler et al. · 2013 · Hepatology
  12. Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells
    Honghui Guo, Guoling Liu, Ruimin Zhong, Yun Wang, Duan Wang, Min Xia · 2012 · Lipids in Health and Disease
  13. Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
    Ross, Trenton T., Crowley, Collin, Kelly, Kenneth L., Rinaldi, Anthony, Beebe, David A., Lech, Matthew P., Martinez, Robert V., Carvajal-Gonzalez, Santos, Boucher, Magalie, Hirenallur-Shanthappa, Dinesh et al. · 2020 · Cellular and Molecular Gastroenterology and Hepatology
  14. MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice
    Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Valentina Mastroiaco, Antonella Vetuschi, Roberta Sferra, Remo Barnabei et al. · 2016 · BMC Cancer
  15. The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
    Julien Bricambert, Marie‐Clotilde Alves‐Guerra, Pauline Estèves, Carina Prip‐Buus, Justine Bertrand‐Michel, Hervé Guillou, Christopher J. Chang, Mark N. Vander Wal, François Canonne‐Hergaux, Philippe Mathurin et al. · 2018 · Nature Communications
  16. Diet‐induced rodent models of obesity‐related metabolic disorders—A guide to a translational perspective
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  17. Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and Cholangiocarcinoma
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  18. Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study
    Jun He, Guangyu Li, Jun Chen, Juan Lin, Cheng Chu Zeng, Jing Chen, Junliang Deng, Ping Xie · 2016 · Archives of Toxicology
  19. IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression
    Daniel A. Giles, Maria E. Moreno‐Fernandez, Senad Divanovic · 2015 · Current Drug Targets
  20. Role of adipose tissue in methionine–choline-deficient model of non-alcoholic steatohepatitis (NASH)
    Pooja Jha, Astrid Knopf, Harald C. Köfeler, Michaela Mueller, Carolin Lackner, Gerald Höefler, Thierry Claudel, Michael Trauner · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  21. PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation
    Qian Gao, Yuzhi Jia, Gongshe Yang, Xiaohong Zhang, Prajwal Chaitanya Boddu, Bryon E. Petersen, Saiprasad Narsingam, Yi-Jun Zhu, Bayar Thimmapaya, Yashpal S. Kanwar et al. · 2015 · American Journal Of Pathology
  22. Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation
    Bing Zhou, Danli Zhou, Xiao‐Hong Wei, Rong-yu Zhong, Jie Xu, Liao Sun · 2017 · Acta Pharmacologica Sinica
  23. Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule
    Yasir Elhassan, Andrew Philp, Gareth Geoffrey Lavery · 2017 · Journal of the Endocrine Society
  24. G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux
    Xiaodong Zhang, Bradlee L. Heckmann, Latoya E. Campbell, Jun Liu · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  25. Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Metabolism: Insights into Health and Disease
    Sébastien Molière, Amélie Jaulin, Catherine Tomasetto, Nassim Dali‐Youcef · 2023 · International Journal of Molecular Sciences
  26. Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems
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  27. Precision medicine in type 2 diabetes
    Rashmi B. Prasad, Leif Groop · 2018 · Journal of Internal Medicine
  28. Bifidobacterium-derived short-chain fatty acids and indole compounds attenuate nonalcoholic fatty liver disease by modulating gut-liver axis
    Sang Jun Yoon, Jeong Seok Yu, Byeong Hyun Min, Haripriya Gupta, Sung‐Min Won, Hyojin Park, Sang Hak Han, Byung‐Yong Kim, Kyung Hwan Kim, Byoung Kook Kim et al. · 2023 · Frontiers in Microbiology
  29. Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways
    Chunxiao Li, Jianguo Gao, Xingyong Wan, Yi Chen, Chengfu Xu, Zemin Feng, Hang Zeng, Yiming Lin, Han Ma, Ping Xu et al. · 2019 · World Journal of Gastroenterology
  30. Liver Physiology: Metabolism and Detoxification
    John Y.L. Chiang · 2014 · Elsevier eBooks
  31. Increased expression of c-Jun in nonalcoholic fatty liver disease
    Christoph Dorn, Julia C. Engelmann, M Saugspier, A. Koch, Arndt Hartmann, Martina Müller, Rainer Spang, Anja‐Katrin Bosserhoff, Claus Hellerbrand · 2014 · Laboratory Investigation
  32. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
    Kento Imajo, Masato Yoneda, Takaomi Kessoku, Yuji Ogawa, Shin Maeda, Yoshio Sumida, Hideyuki Hyogo, Yuichiro Eguchi, Koichiro Wada, Atsushi Nakajima · 2013 · International Journal of Molecular Sciences
  33. Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance
    Pär Steneberg, Alexandros G. Sykaras, Fredrik Backlund, Jurate Straseviçiene, Ingegerd Söderström, Helena Edlund · 2015 · Journal of Biological Chemistry
  34. Aurone Derivative Revealing the Metabolism of Lipid Droplets and Monitoring Oxidative Stress in Living Cells
    Kang‐Nan Wang, Shuyue Ma, Yanyan Ma, Yuping Zhao, Miaomiao Xing, Liyu Zhou, Duxia Cao, Weiying Lin · 2020 · Analytical Chemistry
  35. Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease
    Anping Chen, Youcai Tang, Victoria R. Davis, Fong‐Fu Hsu, Susan Kennedy, Haowei Song, JOHN W. TURK, Elizabeth M. Brunt, Elizabeth P. Newberry, Nicholas O. Davidson · 2013 · Hepatology
  36. Melatonin improves non-alcoholic fatty liver disease via MAPK-JNK/P38 signaling in high-fat-diet-induced obese mice
    Hang Sun, Xingchun Wang, Jiaqi Chen, Kexiu Song, Aaron M. Gusdon, Liang Li, Le Bu, Shen Qu · 2016 · Lipids in Health and Disease
  37. Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
    Elaine Xu, Mafalda M. A. Pereira, Ismene Karakasilioti, Sebastian Theurich, Mona Al-Maarri, Gunter Rappl, Ari Waisman, Frank Thomas Wunderlich, Jens C. Brüning · 2017 · Nature Communications
  38. Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways
    Debra Dorotea, Daisuke Koya, Hunjoo Ha · 2020 · Frontiers in Pharmacology
  39. Yin Yang 1 facilitates hepatocellular carcinoma cell lipid metabolism and tumor progression by inhibiting PGC-1β-induced fatty acid oxidation
    Yanjun Li, Vivi Kasim, Xuesong Yan, Lang Li, Ian Timothy Sembiring Meliala, Can Huang, Zhuolin Li, Ke Lei, Guanbin Song, Xiaodong Zheng et al. · 2019 · Theranostics
  40. The metabolic basis of nonalcoholic steatohepatitis
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  41. Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside
    Feng Zhang, Desong Kong, Yin Lu, Shizhong Zheng · 2012 · Cellular and Molecular Life Sciences
  42. PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis
    Julia Perttilä, Carolina Huaman Samanez, Sandrine Caron, Kimmo Tanhuanpää, Bart Staels, Hannele Yki‐Järvinen, Vesa M. Olkkonen · 2012 · American Journal of Physiology-Endocrinology and Metabolism
  43. Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster
    Viktor Kis, Benjámin Barti, Mónika Lippai, Miklós Sass · 2015 · PLoS ONE
  44. Nonalcoholic Fatty Liver Disease, Nocturnal Hypoxia, and Endothelial Function in Patients With Sleep Apnea
    Caroline Minville, Marie‐Noëlle Hilleret, Renaud Tamisier, Judith Aron‐Wisnewsky, Karine Clément, Candice Trocmé, Jean‐Christian Borel, Patrick A. Levy, Jean‐Pierre Zarski, Jean‐Louis Pépin · 2013 · CHEST Journal
  45. Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis
    Perinur Bozaykut, Ali Şahin, Betul Karademir-Yilmaz, Nesrin Kartal Özer · 2016 · Mechanisms of Ageing and Development
  46. The lipid droplet: A conserved cellular organelle
    Congyan Zhang, Pingsheng Liu · 2017 · Protein & Cell
  47. Berberine alleviates nonalcoholic fatty liver induced by a high‐fat diet in mice by activating SIRT3
    Xi Xu, Xiaopeng Zhu, Jinyun Bai, Pu Xia, Yu Li, Yan Lü, Xiao-Ying Li, Xin Gao · 2019 · The FASEB Journal
  48. C/EBP Homologous Protein-induced Macrophage Apoptosis Protects Mice from Steatohepatitis
    Harmeet Malhi, Erin M. Kropp, Vinna Clavo, Christina R. Kobrossi, JaeSeok Han, Amy S. Mauer, Jing Yong, Randal J. Kaufman · 2013 · Journal of Biological Chemistry
  49. Gut microbiota, fatty liver disease, and hepatocellular carcinoma
    Chu, Huikuan, Williams, Brandon, Schnabl, Bernd · 2018 · Liver Research
  50. Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis
    Shin‐Yu Tsai, Pei-Chin Chung, Eddy Owaga, I-Jong Tsai, Pei-Yuan Wang, Jeng‐I Tsai, Tien-Shun Yeh, Rong‐Hong Hsieh · 2016 · Nutrition & Metabolism
  51. Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy
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  52. Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice
    Bo Xia, Guo He Cai, Hao Yang, Shu Pei Wang, Grant A. Mitchell, Jiang Wei Wu · 2017 · PLoS Genetics
  53. Metabolic profiling of visceral adipose tissue from obese subjects with or without metabolic syndrome
    Eleonora Candi, Manfredi Tesauro, Carmine Cardillo, Anna Maria Lena, Francesca Schinzari, Giuseppe Rodia, Giuseppe Sigismondo Sica, Paolo Gentileschi, Valentina Rovella, Margherita Annicchiarico‐Petruzzelli et al. · 2018 · Biochemical Journal
  54. Systematic Review with Meta-Analysis: The Effects of Probiotics in Nonalcoholic Fatty Liver Disease
    Meng-Wei Xiao, Shixin Lin, Zhaohua Shen, Weiwei Luo, Xiaoyan Wang · 2019 · Gastroenterology Research and Practice
  55. Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation
    Kira L. Diehl, Julia Vorac, Kristina Hofmann, Philippa Meiser, Iris A. Unterweger, Lars Kuerschner, Heike Weighardt, Irmgard Förster, Christoph Thiele · 2020 · Cells
  56. Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice
    Claudia Daniela Fuchs, Thierry Claudel, Pooja Kumari, Guenter Haemmerle, Marion Julia Pollheimer, Tatjana Stojaković, Hubert Scharnagl, Emina Halilbasic, Judith Gumhold, Dagmar Silbert et al. · 2012 · Hepatology
  57. Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis
    Ahmed Lawan, Lei Zhang, Florian Gatzke, Kisuk Min, Michael J. Jurczak, Mashael Al‐Mutairi, Patric Richter, João Paulo Camporez, Anthony D. Couvillon, Dominik Hans Pesta et al. · 2014 · Molecular and Cellular Biology
  58. A Nutrigenomic Approach to Non-Alcoholic Fatty Liver Disease
    Paola Dongiovanni, Luca V. C. Valenti · 2017 · International Journal of Molecular Sciences
  59. Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction
    Manal M. Hassan, Ahmed Omar Kaseb, Carol Jean Etzel, Hashem B. El‐Serag, Margaret R. Spitz, Ping Chang, Katherine Stemke‐Hale, Mei Liu, Asif Rashid, Mohamed Shama et al. · 2013 · Molecular Carcinogenesis
  60. Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD
    Claudia Daniela Fuchs, Thierry Claudel, Michael Trauner · 2014 · Trends in Endocrinology and Metabolism
  61. Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)
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  62. Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
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  63. Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward
    Kevin Jon Williams, Xiangdong Wu · 2016 · Atherosclerosis
  64. The hepatokines fetuin-A and fetuin-B are upregulated in the state of hepatic steatosis and may differently impact on glucose homeostasis in humans
    Andreas Peter, Markéta Kovářová, Harald Staiger, Jürgen Machann, Fritz Schick, Alfred Königsrainer, Ingmar Königsrainer, Erwin D. Schleicher, Andreas Fritsche, Hans‐Ulrich Häring et al. · 2017 · American Journal of Physiology-Endocrinology and Metabolism
  65. Association Between Dietary Fiber Intake and Non-alcoholic Fatty Liver Disease in Adults
    Huimin Zhao, Aihua Yang, Lina Mao, Yaning Quan, Jiajia Cui, Yongye Sun · 2020 · Frontiers in Nutrition
  66. Diet-Sensitive Sources of Reactive Oxygen Species in Liver Mitochondria: Role of Very Long Chain Acyl-CoA Dehydrogenases
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  67. Liver fat reduction with niacin is influenced by DGAT-2 polymorphisms in hypertriglyceridemic patients
    Miao Hu, Chiu‐Wing Winnie Chu, Shizuya Yamashita, David Ka Wai Yeung, Lin Shi, Defeng Wang, Daisaku Masuda, Ya‐Ling Yang, Brian Tomlinson · 2012 · Journal of Lipid Research
  68. Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21
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  69. A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia
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  70. PNPLA3 expression and its impact on the liver: current perspectives
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  73. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease
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  78. Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
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  82. Open Chromatin Profiling in Mice Livers Reveals Unique Chromatin Variations Induced by High Fat Diet
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  83. Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease
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  84. Applications of human organoids in the personalized treatment for digestive diseases
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  85. Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice
    Lipeng Bi, John Y.L. Chiang, Wen‐Xing Ding, Winston Dunn, Benjamin Roberts, Tiangang Li · 2013 · Journal of Lipid Research
  86. TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice
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  87. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease
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  88. Catalase and nonalcoholic fatty liver disease
    Su‐Kyung Shin, Hyun-Woo Cho, Seung-Eun Song, Dae‐Kyu Song · 2018 · Pflügers Archiv - European Journal of Physiology
  89. FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation
    Jun Yao · 2014 · World Journal of Gastroenterology
  90. Maraviroc, a CCR5 antagonist, ameliorates the development of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD)
    Laura Pérez‐Martínez, Patricia Pérez‐Matute, Javier Aguilera‐Lizarraga, Susana Rubio-Mediavilla, Judit Narro-Íñiguez, Emma Recio, Laura Ochoa‐Callejero, José Antonio Oteo, José Ramón Blanco · 2014 · Journal of Antimicrobial Chemotherapy
  91. CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma
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  92. Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity
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  93. Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease
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  94. Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development
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  95. Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients
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  96. Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity
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  97. Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway
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  98. Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish
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  99. Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets
    Youxia Wang, Xiaoling Chen, Zhiqing Huang, Daiwen Chen, Bing Yu, Jie Yu, Hong Chen, Jun He, Yuheng Luo, Ping Zheng · 2020 · Nutrients
  100. Modeling PNPLA3‐Associated NAFLD Using Human‐Induced Pluripotent Stem Cells
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