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Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)

Shao, Wei, Espenshade, Peter J.·2014·Journal of Biological Chemistry
DOI 10.1074/jbc.m113.545699
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Crossref · 10.1074/jbc.m113.545699

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  • Cleavage by S1P is a prerequisite to release SCAP for COPI-mediated retrograde transport to the ER; pharmacological or genetic inhibition of this process prevents SCAP retrograde trafficking and directs SCAP towards lysosomal degradation.

    “Cleavage by S1P is also a perquisite to release SCAP for COPI-mediated retrograde transport to the ER, as pharmacological or genetic inhibition of this process prevents SCAP retrograde trafficking, and instead directs SCAP towards lysosomal degradation48.”

    From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [48]

    The Discussion states that SREBP cleavage by S1P is required for SCAP to recycle from the Golgi to the ER; without cleavage, SCAP is ultimately degraded in the lysosome. The paper says SCAP “likely” returns in COPI-coated vesicles, so the claim overstates COPI-mediated transport as established. No page numbers are provided in our copy. (LLM, conf=0.87)

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  • The phenotypes of decreased SCAP protein level and SCAP relocation to the Golgi in C12ORF49 knockout are attributable to impairments in C12ORF49-mediated S1P maturation and defective SREBP cleavage.

    “We believe that these phenotypes should be attributable to impairments in C12ORF49-mediated S1P maturation, and defective SREBP cleavage by S1P then prevents Golgi-to-ER transport of SCAP and causes SCAP degradation in lysosomes (Shao and Espenshade, 2014).”

    From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as Shao and Espenshade, 2014

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Metadata

Authors
Shao, W., & Espenshade, P. J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2014-03
Volume
289
Issue
11
Pages
7547-7557
ISSN
0021-9258
DOI
10.1074/jbc.m113.545699
Cited by
88
References
3
Language
en
Licence
Funders
National Institutes of Health (HL077588)

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