Human Fatty Liver Disease: Old Questions and New Insights

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092

Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity

Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802

Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121

Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population

Szczepaniak, L. S., Nurenberg, P., Leonard, D. S., Browning, J. D., Reingold, J. S., Grundy, S. M., Hobbs, H. H., & Dobbins, R. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00064.2004 · Cited by 1,573

Prevalence of Fatty Liver in Children and Adolescents

Schwimmer, J. B., Deutsch, R., Kahen, T., Lavine, J. E., Stanley, C. R., & Behling, C. A. (2006) · PEDIATRICS · doi:10.1542/peds.2006-1212 · Cited by 1,477

The role of microbiota in nonalcoholic fatty liver disease

Ciaula, A. D., Bonfrate, L., & Portincasa, P. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13768 · Cited by 44

Sequentially fermented dealcoholized apple juice intervenes fatty liver induced by high-fat diets via modulation of intestinal flora and gene pathways

Li, H., Liang, J., Han, M., Wang, X., Ren, Y., Wang, Y., Huang, J., Li, S., Liu, C., Wang, Z., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111180 · Cited by 47

Role of TFEB in Autophagy and the Pathogenesis of Liver Diseases

Yan, S. (2022) · Biomolecules · doi:10.3390/biom12050672 · Cited by 43

Uridine prevents tamoxifen-induced liver lipid droplet accumulation

Le, T. T., Urasaki, Y., & Pizzorno, G. (2014) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-15-27 · Cited by 44

Krüppel-like factor-10 is directly regulated by carbohydrate response element-binding protein in rat primary hepatocytes

Iizuka, K., Takeda, J., & Horikawa, Y. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.016 · Cited by 44

The effect of a Mediterranean diet vs. a low-fat diet on non-alcoholic fatty liver disease in children: a randomized trial

Akbulut, U. E., Işık, İ. A., Atalay, A., Eraslan, A., Durmus, E., Turkmen, S., & Yurttas, A. S. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1979478 · Cited by 43

Association between smoking cessation and non-alcoholic fatty liver disease using NAFLD liver fat score

Jang, Y. S., Joo, H. J., Park, Y. S., Park, E., & Jang, S. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1015919 · Cited by 43

Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk

Xia, T., Du, M., Li, H., Wang, Y., Zha, J., Wu, T., & Ju, S. (2023) · Radiology · doi:10.1148/radiol.231007 · Cited by 44

The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet

Kuś, E., Zabielski, P., Kochan, K., Kuś, K., Jasztal, A., Sitek, B., Proniewski, B., Wójcik, T., Gula, K., Kij, A., et al. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.004 · Cited by 43

Menhaden Oil Decreases High-Fat Diet–Induced Markers of Hepatic Damage, Steatosis, Inflammation, and Fibrosis in Obese Ldlr−/− Mice

Depner, C. M., Torres‐Gonzalez, M., Tripathy, S., Milne, G. L., & Jump, D. Β. (2012) · Journal of Nutrition · doi:10.3945/jn.112.158865 · Cited by 43

Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs

Yang, S., Xia, J., Zhang, Y., Fan, J., Wang, H., Yuan, J., Zhao, Z.-Z., Pan, Q., Mu, Y., Xin, L., et al. (2015) · Scientific Reports · doi:10.1038/srep13980 · Cited by 43

Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation

de Conti, A., Dreval, K., Tryndyak, V., Orisakwe, O. E., Ross, S. A., Beland, F. A., & Pogribny, I. P. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0109 · Cited by 43

Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis

Ando, W., Yokomori, H., Tsutsui, N., Yamanouchi, E., Suzuki, Y., Oda, M., Inagaki, Y., Otori, K., & Okazaki, I. (2017) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2017.0030 · Cited by 43

The Receptor Interacting Protein Kinases in the Liver

Dara, L. (2018) · Seminars in Liver Disease · doi:10.1055/s-0038-1629924 · Cited by 43

Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis

Nguyen, P., Valanejad, L., Cast, A. E., Wright, M., Garcia, J. M., El‐Serag, H. B., Karns, R. A., & Timchenko, N. A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.014 · Cited by 43

Methods for Lipid Droplet Biophysical Characterization in Flaviviridae Infections

Martins, A. S. D., Martins, I. C., & Santos, N. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01951 · Cited by 43

Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression

Zhou, Y., Zheng, T., Chen, H., Li, Y., Huang, H., Chen, W., Du, Y., He, J., Li, Y., Cao, J., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495830 · Cited by 43

Epigenetic silencing of microRNA-125b-5p promotes liver fibrosis in nonalcoholic fatty liver disease via integrin α8-mediated activation of RhoA signaling pathway

Cai, Q., Chen, F., Xu, F. L., Wang, K., Zhang, K., Li, G., Chen, J., Deng, H. X., & He, Q. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154140 · Cited by 43

Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet

Huang, Z., Deng, J., Li, Q., Cao, Y.-J., Lin, Y., Bai, W., Liu, B., Rao, P., Ni, L., & Lv, X. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08211 · Cited by 46

Sumoylation in liver disease

Min De, Z. E. N. G., Liu, W., Hu, Y., & Fu, N. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.07.044 · Cited by 43

N6-methyladenosine modification and metabolic reprogramming of digestive system malignancies

Cai, X., Liang, C., Zhang, M., Xu, Y., Weng, Y., Li, X., & Yu, W. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215815 · Cited by 43

Insulin Signaling as a Potential Natural Killer Cell Checkpoint in Fatty Liver Disease

Amer, J., Salhab, A., Noureddin, M., Doron, S., Abu‐Tair, L., Ghantous, R., Mahamid, M., & Safadi, R. (2018) · Hepatology Communications · doi:10.1002/hep4.1146 · Cited by 42

An overview of the cholesterol metabolism and its proinflammatory role in the development of MASLD

Zhang, L., Shi, Y., Liang, B., & Li, X. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000434 · Cited by 49

Epidemiology of NAFLD and Type 2 Diabetes: Health Disparities Among Persons of Hispanic Origin

Lazo, M., Bilal, U., & Pérez‐Escamilla, R. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0674-6 · Cited by 42

Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM ‐induced autophagy or BAX

Liu, K., Lou, J., Wen, T., Yin, J., Xu, B., Ding, W., Wang, A., Liu, D., Zhang, C., Chen, D., et al. (2013) · Liver International · doi:10.1111/liv.12238 · Cited by 42

Genetic Variant in PNPLA3 Is Associated With Nonalcoholic Fatty Liver Disease in China

Li, Y., Xing, C., Cohen, J. C., & Hobbs, H. H. (2011) · Hepatology · doi:10.1002/hep.24659 · Cited by 42

Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease

Wheeler, M. C., & Gekakis, N. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m048918 · Cited by 42

I148M variant of PNPLA3 increases the susceptibility to non‐alcoholic fatty liver disease caused by obesity and metabolic disorders

Xia, M., Ling, Y., Bian, H., Lin, H. ‐., Yan, H., Chang, X. ‐., Li, X. ‐., Ma, H., Wang, D., Zhang, L., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13521 · Cited by 45

Caveolin1 protects against diet induced hepatic lipid accumulation in mice

Li, M., Chen, D., Huang, H., Wang, J., Wan, X., Xu, C., Li, C., Ma, H., Yu, C., & Li, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178748 · Cited by 42

A comprehensive bioinformatics analysis on multiple Gene Expression Omnibus datasets of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Huang, S.-Z., Sun, C.-J., Hou, Y., Tang, Y.-H., Zhu, Z., Zhang, Z.-H., Zhang, Y.-X., Wang, L.-H., Zhao, Q., Chen, M.-G., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25658-4 · Cited by 37

Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD

Miyata, M., Matsushita, K., Shindo, R., Shimokawa, Y., Sugiura, Y., & Yamashita, M. (2020) · Nutrients · doi:10.3390/nu12061898 · Cited by 42

Polyphenols in the prevention and treatment of non-alcoholic fatty liver disease: An update of preclinical and clinical studies

Bayram, H. M., Majoo, F. M., & Öztürkcan, A. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.06.026 · Cited by 42

Screening for nonalcoholic fatty liver disease-when, who and how?

Dietrich, C. G., Rau, M., & Geier, A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i35.5803 · Cited by 44

Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents: association with metabolic risk profile

Michaliszyn, S. F., Lee, S., Tfayli, H. M., & Arslanian, S. A. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.015 · Cited by 42

Immune Cells and Metabolism

Chatzigeorgiou, A., & Chavakis, T. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_8 · Cited by 44

Nonalcoholic fatty liver disease

Sotiropoulou, M. G., Katsaros, I., Vailas, M. G., Lidoriki, I., Papatheodoridis, G., Kostomitsopoulos, N. G., Valsami, G. N., Tsaroucha, A. K., & Schizas, D. (2021) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_249_21 · Cited by 43

Remnant cholesterol has a non-linear association with non-alcoholic fatty liver disease

Chen, J., Su, Y., Su, X., & Luo, F. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110733 · Cited by 42

Sex differences in diet-induced MASLD – are female mice naturally protected?

Meyer, J., Teixeira, A. M., Richter, S., Larner, D. P., Syed, A., Klöting, N., Matz‐Soja, M., Gaul, S., Barnikol-Oettler, A., Kiess, W., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1567573 · Cited by 43

Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis

Simon, Y., Kessler, S. M., Gemperlein, K., Bohle, R. M., Müller, R., Haybaeck, J., & Kiemer, A. K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17839 · Cited by 41

Insulin Resistance but Not Visceral Adiposity Index Is Associated with Liver Fibrosis in Nondiabetic Subjects with Nonalcoholic Fatty Liver Disease

Erçin, C. N., Doğru, T., Genç, H., Çelebi, G., Aslan, F., Gürel, H., Kara, M., Sertoğlu, E., Tapan, S., Bağcı, S., et al. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0018 · Cited by 41

Prevalence of Nonalcoholic Steatohepatitis Among Patients with Resectable Intrahepatic Cholangiocarcinoma

Reddy, S. K., Hyder, O. N., Marsh, J. W., Sotiropoulos, G. C., Paul, A., Alexandrescu, S. T., Marques, H. P., Pulitanò, C., Barroso, E., Aldrighetti, L. A., et al. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2149-x · Cited by 41

Nonalcoholic fatty liver disease and alteration in semen quality and reproductive hormones

Li, Y., Liu, L., Wang, B., Chen, D., & Wang, J. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000408 · Cited by 41

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?

Lytle, K. A., & Jump, D. Β. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146942 · Cited by 42

Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease

Zhang, L., Zhang, Z., Li, Y., Liao, S., Wu, X., Chang, Q., & Liang, B. (2015) · Scientific Reports · doi:10.1038/srep15970 · Cited by 41

Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non‐alcoholic fatty liver disease with none‐to‐mild obesity and liver fibrosis

Fujimori, N., Tanaka, N., Shibata, S., Sano, K., Yamazaki, T., Sekiguchi, T., Kitabatake, H., Ichikawa, Y., Kimura, T., Komatsu, M., et al. (2016) · Hepatology Research · doi:10.1111/hepr.12649 · Cited by 41

Natural Products on Nonalcoholic Fatty Liver Disease

Xu, J., Zhang, L. R., Zhongping, L., & Ji, G. (2015) · Current Drug Targets · doi:10.2174/1389450116666150531155711 · Cited by 41

Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

Li, T., Feng, R. M., Zhao, C., Wang, Y., Wang, J., Liu, S., Cao, J., Wang, H., Wang, T., Guo, Y., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6742 · Cited by 41

Glycine protects against high sucrose and high fat-induced non-alcoholic steatohepatitis in rats

Zhou, X., De-wu, H., Xu, R., Wu, H., Qu, C., Wang, F., Wang, X., & Zhao, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.12831 · Cited by 41

Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux

Liu, C., Liu, L., Zhu, H., Sheng, J., Wu, X., He, X., Tian, D., Liao, J., & Li, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-22339-0 · Cited by 41

Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-Induced Hepatic Steatosis in Mice

B'Chir, W., Dufour, C. R., Ouellet, C., Yan, M., Tam, I. S., Andrzejewski, S., Xia, H., Nabata, K. J., St‐Pierre, J., & Giguère, V. (2018) · Endocrinology · doi:10.1210/en.2018-00115 · Cited by 40

Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases

Tiefenbach, J., Magomedova, L., Liu, J., Reunov, A., Tsai, R., Eappen, N. S., Jockusch, R. A., Nislow, C., Cummins, C. L., & Krause, H. M. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.034801 · Cited by 41

Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat

Meng, Y., Liu, Y., Fang, N., & Guo, Y. (2019) · Pharmaceutical Biology · doi:10.1080/13880209.2019.1568509 · Cited by 41

The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease

Zhao, Y., Wu, T., Zhao, M., & Li, C. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.008897 · Cited by 42

Beverages and Non-alcoholic fatty liver disease (NAFLD): Think before you drink

Chhimwal, J., Patial, V., & Padwad, Y. S. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.011 · Cited by 41

Inappropriate Diet Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease via Abdominal Obesity

Xiang, M., Tian, X., Wang, H., Gan, P., & Zhang, Q. (2024) · Nutrients · doi:10.3390/nu16234208 · Cited by 40

Lycium ruthenicum extract alleviates high-fat diet-induced nonalcoholic fatty liver disease via enhancing the AMPK signaling pathway

Lin, J., Zhang, Y., WANG, X., & Wang, W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3840 · Cited by 40

Role of scavenger receptors in the pathophysiology of chronic liver diseases

Armengol, C., Bartolí, R., Sanjurjo, L., Serra, I., Amézaga, N., Sala, M., & Sarrias, M. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013006794 · Cited by 40

Label-free Evaluation of Hepatic Microvesicular Steatosis with Multimodal Coherent Anti-Stokes Raman Scattering Microscopy

Le, T. T., Ziemba, A. J., Urasaki, Y., Brotman, S. J., & Pizzorno, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051092 · Cited by 41

Apolipoprotein B Secretion Is Regulated by Hepatic Triglyceride, and Not Insulin, in a Model of Increased Hepatic Insulin Signaling

Moon, B. C., Hernández‐Ono, A., Stiles, B. L., Wu, H., & Ginsberg, H. N. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241356 · Cited by 41

Tumor Necrosis Factor Receptor 1 Gain-of-Function Mutation Aggravates Nonalcoholic Fatty Liver Disease but Does Not Cause Insulin Resistance in a Murine Model

Aparicio-Vergara, M., Hommelberg, P. P. H., Schreurs, M., Gruben, N., Stienstra, R., Shiri‐Sverdlov, R., Kloosterhuis, N., de Bruin, A., van de Sluis, B., Koonen, D. P. Y., et al. (2012) · Hepatology · doi:10.1002/hep.26046 · Cited by 40

Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease

Heinrich, G., Ghadieh, H. E., Ghanem, S. S., Muturi, H. T., Rezaei, K., Al–Share, Q. Y., Bowman, T. A., Zhang, D., Garofalo, R. S., Yin, L., et al. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00008 · Cited by 42

A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats

Elwahab, A. H. A., Ramadan, B. K., Schaalan, M. F., & Tolba, A. M. A. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480649 · Cited by 40

Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease

Im, A., Yang, W., Park, Y., Kim, S., & Chae, S. (2018) · Nutrients · doi:10.3390/nu10060735 · Cited by 42

Semisynthetic bile acids: a new therapeutic option for metabolic syndrome

Lazarević, S., Đanić, M., Goločorbin-Kon, S., Al‐Salami, H., & Mikov, M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104333 · Cited by 40

Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma

Maceyka, M. W., Rohrbach, T. D., Milstien, S., & Spiegel, S. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_217 · Cited by 40

Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis

Paquette, M., Gauthier, D., Chamberland, A., Prat, A., Rolfe, E. D. L., Rasmussen, J., Kaduka, L. U., Seidah, N. G., Bernard, S., Christensen, D. L., et al. (2020) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2020.01.003 · Cited by 40

Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179/miR-188-3p/GPX4 signaling

Yang, W., Zhao, J., Zhao, Y., Li, W., Zhao, L. Y., Ren, Y., Ou, R., & Xu, Y. (2020) · Aging · doi:10.18632/aging.104081 · Cited by 40

Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels

Du, W. W., Liu, F., Shan, S. W., Cindy, X., Gupta, S., Jin, T., Spaner, D., Krylov, S. N., Zhang, Y., Ling, W., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.64 · Cited by 40

Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo

Bhatia, H., PATTNAIK, B. R., & Datta, M. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.225 · Cited by 41

PEGylated Curcumin Derivative Attenuates Hepatic Steatosis via CREB/PPAR-γ/CD36 Pathway

Liu, Y. X., Cheng, F., Luo, Y., Zhan, Z., Hu, P., Ren, H., Tang, H., & Peng, M. (2017) · BioMed Research International · doi:10.1155/2017/8234507 · Cited by 40

Bile Acid Metabolism in Health and Disease

Li, T., & Chiang, J. Y. L. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch23 · Cited by 40

Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC

Boslem, E., Reibe, S., Carlessi, R., Smeuninx, B., Tegegne, S., Egan, C. L., McLennan, E., Terry, L. V., Nobis, M., Mu, A., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh0831 · Cited by 39

Advances in management of metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics

Jiang, Y., Wu, L., Zhu, X., Bian, H., Gao, X., & Xia, M. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02092-2 · Cited by 46

Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets

Sethi, P., Mishra, A. K., Ghosh, S., Singh, D. K. K., Sharma, S., Stojchevski, R., Avtanski, D. B., & Sinha, J. K. (2025) · Nutrients · doi:10.3390/nu17233699 · Cited by 46

Relationships of body composition and liver fat content with insulin resistance in obesity‐matched adolescents and adults

Linder, K., Springer, L., Machann, J., Schick, F., Fritsche, A., Häring, H., Blumenstock, G., Ranke, M. B., Stefan, N., Binder, G., et al. (2013) · Obesity · doi:10.1002/oby.20685 · Cited by 39

Endoplasmic Reticulum Stress Response in Non-alcoholic Steatohepatitis: The Possible Role of Physical Exercise

Passos, E., Ascensão, A. A. M. R., Martins, M. J., & Magalhães, J. (2015) · Metabolism · doi:10.1016/j.metabol.2015.02.003 · Cited by 40

Developmental Programming of Pediatric Nonalcoholic Fatty Liver Disease

Stewart, M. S., Heerwagen, M. J. R., & Friedman, J. E. (2013) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3182a09760 · Cited by 39

The Amelioration of Hepatic Steatosis by Thyroid Hormone Receptor Agonists Is Insufficient to Restore Insulin Sensitivity in Ob/Ob Mice

Martagón, A. J., Lin, J. Z., Cimini, S. L., Webb, P., & Phillips, K. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122987 · Cited by 41

p38 Mapk signal pathway involved in anti-inflammatory effect of chaihu-shugan-san and shen-ling-bai-zhu-san on hepatocyte in non-alcoholic steatohepatitis rats

Qh, Y., Xu, Y., Feng, G., Hu, C., Zhang, Y., Cheng, S., Wang, Y., & Gong, X. (2013) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v11i1.34 · Cited by 39

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)

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Evolving roles of circadian rhythms in liver homeostasis and pathology

Zhou, D., Wang, Y., Chen, L., Jia, L., Yuan, J., Sun, M., Zhang, W., Wang, P., Zuo, J., Xu, Z., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7065 · Cited by 43

Glycosylation site occupancy in health, congenital disorder of glycosylation and fatty liver disease

Hülsmeier, A. J., Tobler, M., Burda, P., & Hennet, T. (2016) · Scientific Reports · doi:10.1038/srep33927 · Cited by 39

A novel role of astrocyte elevated gene‐1 (AEG‐1) in regulating nonalcoholic steatohepatitis (NASH)

Srivastava, J., Robertson, C. L., Ebeid, K., Dozmorov, M. G., Rajasekaran, D., Mendoza, R. G., Siddiq, A., Akiel, M., Jariwala, N. H., Shen, X., et al. (2017) · Hepatology · doi:10.1002/hep.29230 · Cited by 39

Response of fibroblast growth factor 19 and bile acid synthesis after a body weight-adjusted oral fat tolerance test in overweight and obese NAFLD patients: a non-randomized controlled pilot trial

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Value of homodyned K distribution in ultrasound parametric imaging of hepatic steatosis: An animal study

Zhou, Z., Fang, J., Cristea, A., Lin, Y.-H., Tsai, Y.-W., Wan, Y., Yeow, K., Ho, M., & Tsui, P. (2019) · Ultrasonics · doi:10.1016/j.ultras.2019.106001 · Cited by 39

Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver

Brulport, A., Vaiman, D., Chagnon, M., & Corre, L. L. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125092 · Cited by 39

The Patatin‐Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability

Wang, X., Guo, M., Wang, Q., Wang, Q., Zuo, S.-S., Zhang, X., Tong, H., Chen, J., Wang, H., Chen, X., et al. (2020) · Hepatology · doi:10.1002/hep.31161 · Cited by 42

Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review

Noureddin, M., Sander‐Struckmeier, S., & Mato, J. M. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i2.46 · Cited by 39

Ceramide and Sphingosine 1-Phosphate in Liver Diseases.

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Current and Future Treatments in the Fight against Non-Alcoholic Fatty Liver Disease

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Circulating lipidomic alterations in obese and non‐obese subjects with non‐alcoholic fatty liver disease

Jung, Y., Lee, M. K., Puri, P., Koo, B. K., Joo, S. K., Jang, S. Y., Lee, D. H., Jung, Y. J., Kim, B. G., Lee, K. L., et al. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16066 · Cited by 39

Lipid overload impairs hepatic VLDL secretion via oxidative stress-mediated PKCδ-HNF4α-MTP pathway in large yellow croaker (Larimichthys crocea)

Fang, W., Chen, Q., Cui, K., Chen, Q., Li, X., Xu, N., Mai, K., & Ai, Q. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.001 · Cited by 40

Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease

Moreno‐Vedia, J., Girona, J., Ibarretxe, D., Masana, L., & Rodríguez‐Calvo, R. (2022) · Biomedicines · doi:10.3390/biomedicines10010197 · Cited by 40

Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation

Stocks, B., González-Franquesa, A., Borg, M. L., Björnholm, M., Niu, L., Zierath, J. R., & Deshmukh, A. S. (2022) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2022.100207 · Cited by 37

Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression

Heckmann, B. L., Zhang, X., Saarinen, A. M., Schoiswohl, G., Kershaw, E. E., Zechner, R., & Liu, J. (2017) · JCI Insight · doi:10.1172/jci.insight.88735 · Cited by 36

PNPLA3 I148M variant impairs liver X receptor signaling and cholesterol homeostasis in human hepatic stellate cells

Bruschi, F. V., Claudel, T., Tardelli, M., Starlinger, P., Marra, F., & Trauner, M. (2019) · Hepatology Communications · doi:10.1002/hep4.1395 · Cited by 38

Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis

Ciaula, A. D., Bonfrate, L., Krawczyk, M. J., Frühbeck, G., & Portincasa, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052636 · Cited by 37

Nobiletin mitigates NAFLD via lipophagy and inflammation

Yang, X., Deng, Y., Tu, Y., Feng, D., & Liao, W. (2022) · Food & Function · doi:10.1039/d2fo01682f · Cited by 39

MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives

Karin, M., & Kim, J. Y. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13685 · Cited by 45

Recent insights into the pathogenesis of nonalcoholic fatty liver disease

Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

Tiniakos, D. G., Vos, M. B., & Brunt, E. M. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102132 · Cited by 870

Pathogenesis of Non-alcoholic Steatohepatitis: Human Data

Edmison, J. M., & McCullough, A. J. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.02.011 · Cited by 195

Clinicopathological features of non‐alcoholic fatty liver disease

Sugimoto, K., & Takei, Y. (2011) · Hepatology Research · doi:10.1111/j.1872-034x.2011.00867.x · Cited by 29

Research Advances in Nonalcoholic Fatty Liver Disease

Hai-fen, Z. (2015) · Medical Recapitulate