Cited by 2,089Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health EffectsLiver physiology and pathology

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Human Fatty Liver Disease: Old Questions and New Insights

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Cohen, Jonathan C., Horton, Jay D., Hobbs, Helen H.·2011·Science

DOI 10.1126/science.1204265PMC PMC3229276

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are limited. Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies.

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Authors: Cohen, J. C., Horton, J. D., & Hobbs, H. H.
Affiliations: The University of Texas Southwestern Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Hobbs, Helen H.
ORCID: Cohen, Jonathan C.
Horton, Jay D.
Hobbs, Helen H.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-06-24
Volume: 332
Issue: 6037
Pages: 1519-1523
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1204265
PMC: PMC3229276
OpenAlex: W2065612971
Cited by: 2,089
References: 53
Citations by year: 2026: 38 · 2025: 88 · 2024: 103 · 2023: 118 · 2022: 139 · 2021: 152 · 2020: 168 · 2019: 158 · 2018: 166 · 2017: 170 · 2016: 153 · 2015: 171 · 2014: 143 · 2013: 171 · 2012: 122
FWCI: 17.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (P01 HL-20948, P01HL020948, RL1HL092550)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090066)
National Institute of Dental and Craniofacial Research (UL1DE019584, UL1DE109584)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: non-alcoholic fatty liver disease, hepatic triglyceride accumulation, liver inflammation, liver cirrhosis, hepatocellular carcinoma, obesity, insulin resistance, NAFLD pathogenesis, genetic susceptibility, metabolic mechanisms
MeSH terms: Animals, Dietary Fats, Disease Models, Animal, Fatty Liver, Female, Humans, Insulin Resistance, Liver, Liver Cirrhosis, Liver Neoplasms, Male, Obesity, Triglycerides, Disease Progression, Genetic Predisposition to Disease, Non-alcoholic Fatty Liver Disease

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