Human Fatty Liver Disease: Old Questions and New Insights

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092

Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity

Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802

Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121

Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population

Szczepaniak, L. S., Nurenberg, P., Leonard, D. S., Browning, J. D., Reingold, J. S., Grundy, S. M., Hobbs, H. H., & Dobbins, R. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00064.2004 · Cited by 1,573

Prevalence of Fatty Liver in Children and Adolescents

Schwimmer, J. B., Deutsch, R., Kahen, T., Lavine, J. E., Stanley, C. R., & Behling, C. A. (2006) · PEDIATRICS · doi:10.1542/peds.2006-1212 · Cited by 1,477

Targeting of the Arf-GEF GBF1 to lipid droplets and Golgi membranes

Bouvet, S., Golinelli‐Cohen, M., Contremoulins, V., & Jackson, C. L. (2013) · Journal of Cell Science · doi:10.1242/jcs.134254 · Cited by 75

Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice

Guo, F., Ma, Y., Kadegowda, A. K. G., Betters, J. L., Xie, P., Liu, C., Liu, X., Miao, H., Ou, J., Su, X., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m035519 · Cited by 74

Accumulation of Advanced Glycation End-Products and Activation of the SCAP/SREBP Lipogenetic Pathway Occur in Diet-Induced Obese Mouse Skeletal Muscle

Mastrocola, R., Collino, M., Nigro, D., Chiazza, F., D’Antona, G., Aragno, M., & Minetto, M. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119587 · Cited by 77

Evaluation of short-term safety and efficacy of HMG-CoA reductase inhibitors in hypercholesterolemic patients with elevated serum alanine transaminase concentrations: PITCH study (PITavastatin versus atorvastatin to evaluate the effect on patients with hypercholesterolemia and mild to moderate hepatic damage)

Han, K. H., Rha, S., Kang, H., Bae, J., Choi, B., Choi, S., Gwon, H., Bae, J., Hong, B., Choi, D., et al. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.01.009 · Cited by 75

Opuntia ficus indica (Nopal) Attenuates Hepatic Steatosis and Oxidative Stress in Obese Zucker (fa/fa) Rats3

Morán‐Ramos, S., Ávila-Nava, A., Tovar, A. R., Pedraza‐Chaverrí, J., López‐Romero, P., & Torres, N. (2012) · Journal of Nutrition · doi:10.3945/jn.112.165563 · Cited by 77

Optimal cutoff points for HOMA-IR and QUICKI in the diagnosis of metabolic syndrome and non-alcoholic fatty liver disease: A population based study

Motamed, N., Hajimiresmaiel, S. J., Rabiee, B., Keyvani, H., Farahani, B., Maadi, M., & Zamani, F. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.11.019 · Cited by 78

miR‐212 downregulation contributes to the protective effect of exercise against non‐alcoholic fatty liver via targeting FGF ‐21

Xiao, J., Bei, Y., Liu, J., Dimitrova‐Shumkovska, J., Kuang, D., Zhou, Q., Li, J., Yang, Y., Xiang, Y., Wang, F., et al. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12733 · Cited by 75

PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery

Krawczyk, M. J., Jiménez-Agüero, R., Alústiza, J. M., Emparanza, J. I., Perugorria, M. J., Bujanda, L., Lammert, F., & Bañales, J. M. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.06.004 · Cited by 75

LiverSex Computational Model: Sexual Aspects in Hepatic Metabolism and Abnormalities

Tomaš, T. C., Urlep, Ž., Moškon, M., Mraz, M., & Rozman, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00360 · Cited by 73

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice

Matsuzaka, T., Kuba, M., Koyasu, S., Yamamoto, Y., Motomura, K., Arulmozhiraja, S., Ohno, H., Sharma, R., Shimura, T., Okajima, Y., et al. (2019) · Hepatology · doi:10.1002/hep.30953 · Cited by 74

Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice

Wang, S., Sheng, H., Bai, Y., Weng, Y., Fan, X., Lou, L.-J., & Zhang, F. (2020) · Nutrition and Diabetes · doi:10.1038/s41387-020-00130-3 · Cited by 75

Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans

Ceuninck, F. D., Kargar, C., Ilic, C., Caliez, A., Rolin, J., Umbdenstock, T., Vinson, C., Combettes, M., Fanti, B. A. D., Harley, E. A., et al. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02184.x · Cited by 74

ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway

Mao, Z., Feng, M., Li, Z., Zhou, M., Xu, L., Pan, K., Wang, S., Su, W., & Zhang, W. (2020) · Diabetes · doi:10.2337/db20-0619 · Cited by 73

Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance

Gallardo-Montejano, V. I., Yang, C., Hahner, L., McAfee, J. L., Johnson, J. A., Holland, W. L., Fernandez‐Valdivia, R., & Bickel, P. E. (2021) · Nature Communications · doi:10.1038/s41467-021-23601-2 · Cited by 75

PNPLA3(148M) is a gain-of-function mutation that promotes hepatic steatosis by inhibiting ATGL-mediated triglyceride hydrolysis

Wang, Y., Hong, S., Hudson, H., Kory, N., Kinch, L. N., Kozlitina, J., Cohen, J. C., & Hobbs, H. H. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.10.048 · Cited by 75

Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis

Jin, J., Iakova, P. A., Breaux, M., Sullivan, E. M., Jawanmardi, N., Chen, D., Jiang, Y., Medrano, E. M., & Timchenko, N. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.009 · Cited by 73

Nonhuman Primates and Translational Research—Cardiovascular Disease

Cox, L. A., Olivier, M., Spradling‐Reeves, K. D., Karere, G. M., Comuzzie, A. G., & VandeBerg, J. L. (2017) · ILAR Journal · doi:10.1093/ilar/ilx025 · Cited by 75

Geranylgeranyl diphosphate synthase (GGPPS) regulates non‐alcoholic fatty liver disease (NAFLD)–fibrosis progression by determining hepatic glucose/fatty acid preference under high‐fat diet conditions

Liu, J., Jiang, S., Zhao, Y., Sun, Q., Zhang, J., Shen, D., Wu, J., Shen, N., Fu, X., Sun, X., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5131 · Cited by 72

Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis

Jiang, X., Fulte, S., Deng, F., Chen, S., Xie, Y., Chao, X., He, X. C., Zhang, Y., Li, T., Li, F., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.04.010 · Cited by 76

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs

Casanova, J., & Anderson, M. S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci166283 · Cited by 72

Molecular Interactions between NAFLD and Xenobiotic Metabolism

Naik, A., Belič, A., Zanger, U. M., & Rozman, D. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00002 · Cited by 79

Mapping lipid and collagen by multispectral photoacoustic imaging of chemical bond vibration

Wang, P., Wang, P., Wang, H., & Cheng, J. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.9.096010 · Cited by 72

Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice

Wang, K., Cao, P., Wang, H., Tang, Z., Wang, N., Wang, J., & Zhang, Y. (2016) · Scientific Reports · doi:10.1038/srep26229 · Cited by 74

Pediatric Non-Alcoholic Fatty Liver Disease

Bush, H., Golabi, P., & Younossi, Z. M. (2017) · Children · doi:10.3390/children4060048 · Cited by 73

Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway

Chu, Q., Zhang, S., Chen, M., Han, W., Jia, R., Chen, W., & Zheng, X. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4825949 · Cited by 72

Myricetin modulates macrophage polarization and mitigates liver inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis

Yao, Q., Li, S., Li, X., Wang, F., & Tu, C. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00071 · Cited by 71

Dual role for inositol‐requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet‐induced obesity in mice

Wu, Y., Shan, B., Dai, J., Xia, Z., Cai, J., Chen, T., Lv, S., Feng, Y., Zheng, L., Wang, Y., et al. (2018) · Hepatology · doi:10.1002/hep.29871 · Cited by 75

miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder

Fan, L., Lai, R., Ma, N., Dong, Y., Li, Y., Wu, Q., Qiao, J., Lu, H., Gong, L., Tao, Z., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.07.048 · Cited by 70

Hepatic Macrophage as a Key Player in Fatty Liver Disease

Xu, L., Liu, W., Bai, F., Xu, Y., Liang, X., Ma, C., & Gao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708978 · Cited by 73

Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation

Cao, Y., Xue, Y., Xue, L., Jiang, X., Wang, X., Zhang, Z., Yang, J., Lu, J., Zhang, C. X., Wang, W., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.011 · Cited by 71

DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity

Xie, L., Wang, P., Zhang, P., Zhang, X., Zhao, G., Wang, A., Guo, J., Zhu, X., Zhang, Q., & Li, H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.03.008 · Cited by 71

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis

Park, J., Xu, X., Cho, S., Hur, K. Y., Lee, M., Kersten, S., & Lee, A. (2016) · Scientific Reports · doi:10.1038/srep27938 · Cited by 71

FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy

Zhu, S., Wu, Y., Ye, X., Ma, L., Qi, J., Yu, D., Wei, Y., Lin, G., Ren, G., & Li, D. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2774-2 · Cited by 71

Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP 72 as an upstream target

Zeng, X., Wang, H., Bai, F., Zhou, X., Li, S., Ren, L., Sun, R., Xue, C. C., Jiang, H., Hu, L., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13209 · Cited by 70

Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

Wang, C., Cui, Y., Li, C., Zhang, Y., Xu, S. Z., Li, X., Li, H., & Zhang, X. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-165 · Cited by 71

Dietary (−)-Epigallocatechin-3-gallate Supplementation Counteracts Aging-Associated Skeletal Muscle Insulin Resistance and Fatty Liver in Senescence-Accelerated Mouse

Liu, H., Chan, Y., Wang, M.-F., Wei, C.-C., & Chang, S.-J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02501 · Cited by 71

Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice

Ni, Y., Zhuge, F., Nagashimada, M., Nagata, N., Xu, L., Yamamoto, S., Fuke, N., Ushida, Y., Suganuma, H., Kaneko, S., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.036 · Cited by 72

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

Armour, S. M., Remsberg, J. R., Damle, M., Sidoli, S., Ho, W. Y., Li, Z., Garcia, B. A., & Lazar, M. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00772-5 · Cited by 69

Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer

Rajesh, Y., & Sarkar, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042163 · Cited by 75

Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration

Ryu, J., Hadley, J. T., Li, Z., Dong, F., Xu, H. Y., Xin, X., Zhang, Y., Chen, C., Li, S., Guo, X., et al. (2021) · Diabetes · doi:10.2337/db20-1073 · Cited by 73

Association between anxiety and depression and nonalcoholic fatty liver disease

Choi, J. M., Chung, G. E., Kang, S. J., Kwak, M.-S., Yang, J. I., Park, B., & Yim, J. Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.585618 · Cited by 68

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

Suzuki‐Kemuriyama, N., Matsuzaka, T., Kuba, M., Ohno, H., Han, S., Takeuchi, Y., Isaka, M., Kobayashi, K., IWASAKI, H. O., Yatoh, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157580 · Cited by 69

Non‐alcoholic fatty liver diseases and risk of colorectal neoplasia

Ahn, J., Sinn, D. H., Min, Y. W., Hong, S. N., Kim, H. S., Jung, S., Gu, S., Rhee, P., Paik, S. W., Son, H. J., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13866 · Cited by 68

Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet

Tanaka, N., Takahashi, S., Fang, Z., Matsubara, T., Krausz, K. W., Qu, A., & Gonzalez, F. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.015 · Cited by 68

High Fat Diet Subverts Hepatocellular Iron Uptake Determining Dysmetabolic Iron Overload

Dongiovanni, P., Lanti, C., Gatti, S., Rametta, R., Recalcati, S., Maggioni, M., Fracanzani, A. L., Riso, P., Cairo, G., Fargion, S. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116855 · Cited by 72

Nonalcoholic Fatty Liver Disease

Paredes, A. H., Torres, D. M., & Harrison, S. A. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.03.005 · Cited by 72

Peroxisome proliferator-activated receptor-α activation and excess energy burning in hepatocarcinogenesis

Misra, P., & Reddy, J. K. (2013) · Biochimie · doi:10.1016/j.biochi.2013.11.011 · Cited by 70

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease

Arndt, S., Wacker, E., Dorn, C., Koch, A., Saugspier, M., Thasler, W. E., Hartmann, A., Bosserhoff, A., & Hellerbrand, C. (2014) · Gut · doi:10.1136/gutjnl-2014-306968 · Cited by 66

Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging

Ghosh, P., Shu, Z.-J., Zhu, B., Lu, Z., Ikeno, Y., Barnes, J. L., Yeh, C., Zhang, B.-X., Katz, M. S., & Kamat, A. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0406 · Cited by 74

High fat diet‐induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice

Yu, D., Chen, G., Pan, M., Zhang, J., He, W., Liu, Y., Nian, X., Sheng, L., & Xu, B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26270 · Cited by 69

Role of HSD17B13 in the liver physiology and pathophysiology

Su, W., Mao, Z., Liu, Y., Zhang, X., Zhang, W., Gustafsson, J.-Α., & Guan, Y. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.10.014 · Cited by 69

Dual Role of MicroRNAs in NAFLD

Ceccarelli, S., Panera, N., Gnani, D., & Nobili, V. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14048437 · Cited by 66

XBP1s Is an Anti-lipogenic Protein

Herrema, H., Zhou, Y., Zhang, D., Lee, J., Hernández, M. A. S., Shulman, G. I., & Özcan, U. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.728949 · Cited by 67

Anthocyanin‐Biofortified Colored Wheat Prevents High Fat Diet–Induced Alterations in Mice: Nutrigenomics Studies

Sharma, S., Khare, P., Kumar, A., Chunduri, V., Kumar, A., Kapoor, P., Mangal, P., Kondepudi, K. K., Bishnoi, M., & Garg, M. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900999 · Cited by 66

The role of pyroptosis in inflammatory diseases

Chai, R., Li, Y., Shui, L., Ni, L., & Zhang, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1173235 · Cited by 68

Liver Defatting: An Alternative Approach to Enable Steatotic Liver Transplantation

Nativ, N. I., Maguire, T. J., Yarmush, G., Brasaemle, D., Henry, S. D., Guarrera, J. V., Francois Berthiaume, B., & Yarmush, M. L. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04288.x · Cited by 67

Effects of different diets on intestinal microbiota and nonalcoholic fatty liver disease development

Liu, J., Zou, W., Chen, S.-J., Wei, H., Yin, Y., Zou, Y.-Y., & Lu, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7353 · Cited by 67

CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice

Liu, Y., Qi, X., Zeng, Z., Wang, L., Wang, J., Zhang, T., Xu, Q., Shen, C., Zhou, G., Yang, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03070-8 · Cited by 67

Improving Metabolic Health Through Precision Dietetics in Mice

Barrington, W. T., Wulfridge, P., Wells, A., Rojas, C. M., Howe, S., Perry, A. L., Hua, K., Pellizzon, M., Hansen, K. D., Voy, B. H., et al. (2017) · Genetics · doi:10.1534/genetics.117.300536 · Cited by 64

Multifunctional pyrazoline based AIEgens: real-time tracking and specific protein “fishing” of lipid droplets

Zhao, N., Li, Y., Yang, W., Zhuang, J., Li, Y., & Li, N. (2019) · Chemical Science · doi:10.1039/c9sc03111a · Cited by 67

Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a

Wang, S., Song, K., Srivastava, R., Dong, C., Go, G., Li, N., Iwakiri, Y., & Mani, A. (2015) · The FASEB Journal · doi:10.1096/fj.15-271171 · Cited by 66

Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression

Imai, Y., Boyle, S., Varela, G. M., Caron, É., Yin, X., Dhir, R., Dhir, R. N., Graham, M. J., & Ahima, R. S. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00045.2012 · Cited by 66

Sonographic assessment of fatty liver: intraobserver and interobserver variability.

Cengiz, M., Sentürk, S., Çetin, B., Bayrak, A. H., & Bilek, S. U. (2014) · PubMed Central · Cited by 66

Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study

Suomela, E., Oikonen, M., Pitkänen, N., Ahola‐Olli, A., Virtanen, J. M., Parkkola, R. K., Jokinen, E. V., Laitinen, T. P., Hutri‐Kähönen, N., Kähönen, M. A. P., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.020 · Cited by 66

Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress

Ge, C., Xu, M., Qin, Y., Gu, T.-T., Feng, J., Jinxiao, L., Sujun, W., Ma, Y., Deshuai, L., Qiang, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.034 · Cited by 63

A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling

van der Veen, J. N., Lingrell, S., McCloskey, N. S., LeBlond, N. D., Galleguillos, D., Zhao, Y., Curtis, J. M., Sipione, S., Fullerton, M. D., Vance, D. E., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802117r · Cited by 65

Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression

El-Haleim, E. A. A., Bahgat, A. K., & Saleh, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i10.2931 · Cited by 68

Genome‐wide analysis of long noncoding RNA expression profiles in patients with non‐alcoholic fatty liver disease

Sun, C., Liu, X., Yi, Z., Xiao, X., Yang, M., Hu, G. M., Liu, H., Liao, L., & Huang, F. (2015) · IUBMB Life · doi:10.1002/iub.1442 · Cited by 65

Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis

Komiya, C., Tanaka, M., Tsuchiya, K., Shimazu, N., Mori, K., Furuke, S., Miyachi, Y., Shiba, K., Yamaguchi, S., Ikeda, K., et al. (2017) · Scientific Reports · doi:10.1038/srep44754 · Cited by 65

Chronic exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces an obesogenic effect in C57BL/6J mice fed a high fat diet

Brulport, A., Corre, L. L., & Chagnon, M. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.017 · Cited by 66

Epigenetics, DNA Organization, and Inflammatory Bowel Disease

Ray, G., & Longworth, M. S. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy330 · Cited by 64

Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis

Zhou, C., Zhen, M., Yu, M., Li, X., Yu, T., Liu, J., Jia, W., Liu, S., Li, L., Li, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc1586 · Cited by 64

Sirtuin 1 Deacetylase

Kemper, J. K., Choi, S.-E., & Kim, D.-H. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-407766-9.00016-x · Cited by 65

Mechanistic link between nonalcoholic fatty liver disease and cardiometabolic disorders

Lim, S. K., Oh, T. J., & Koh, K. K. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.107 · Cited by 64

Cafeteria diet induces obesity and insulin resistance associated with oxidative stress but not with inflammation: improvement by dietary supplementation with a melon superoxide dismutase

Carillon, J., Romain, C., Bardy, G., Fouret, G., Feillet‐Coudray, C., Gaillet, S., Lacan, D., Cristol, J., & Rouanet, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.022 · Cited by 67

Applications of coherent Raman scattering microscopies to clinical and biological studies

Schie, I. W., Krafft, C., & Popp, J. (2015) · The Analyst · doi:10.1039/c5an00178a · Cited by 64

MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury

Kato, H., Kuriyama, N., Duarte, S. M., Clavien, P., Busuttil, R. W., & Coito, A. J. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.022 · Cited by 63

IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling

Kessler, S. M., Pokorny, J., Zimmer, V., Laggai, S., Lammert, F., Bohle, R. M., & Kiemer, A. K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00005.2012 · Cited by 64

CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice

Bian, Z., Peng, Y., You, Z., Wang, Q., Miao, Q., Liu, Y., Han, X., Qiu, D., Li, Z., & Ma, X. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m026013 · Cited by 64

Fatty liver and FGF21 physiology

Maratos–Flier, E. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.006 · Cited by 66

Symposium review: Milk fat globule size: Practical implications and metabolic regulation

Argov-Argaman, N. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-15240 · Cited by 64

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

Petta, S., Valenti, L. V. C., Bugianesi, E., Targher, G., Bellentani, S., Bonino, F., Ferrannini, E., Loguercio, C., Lonardo, A., Marra, F., et al. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.10.027 · Cited by 66

Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Non-alcoholic Fatty Liver Disease

Jia, X., & Zhai, T. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00599 · Cited by 63

Sirtuin 3‐mediated deacetylation of acyl‐ CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease

Sun, R., Kang, X., Zhao, Y., Wang, Z., Wang, R., Fu, R., Li, Y., Hu, Y. W., Wang, Z., Shan, W., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15159 · Cited by 62

Malvidin-3-O-Glucoside from Blueberry Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Transcription Factor EB-Mediated Lysosomal Function and Activating the Nrf2/ARE Signaling Pathway

Xu, Y., Ke, H., Li, Y., Xie, L., Su, H., Xie, J., Mo, J., & Chen, W. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06695 · Cited by 63

Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1‐13C]pyruvate

Josan, S., Billingsley, K. L., Orduna, J. M., Park, J. M., Luong, R. H., Yu, L., Hurd, R. E., Pfefferbaum, A., Spielman, D. M., & Mayer, D. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3431 · Cited by 63

Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters

Chang, Y., Yang, D., Chiu, C., Lin, Y., Chen, J., & Chen, Y. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.08.002 · Cited by 63

Choline Supplementation Protects against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet

Rajabi, A. A., de Castro, G. S., da Silva, R. P., Nelson, R. C., Thiesen, A., Vannucchi, H., Vine, D. F., Proctor, S. D., Field, C. J., Curtis, J. M., et al. (2013) · Journal of Nutrition · doi:10.3945/jn.113.185389 · Cited by 62

Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD

Allison, M., Griffin, J. L., Vacca, M., & Vidal‐Puig, A. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1562945 · Cited by 67

NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation

Neumann, K., Schiller, B., & Tiegs, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092732 · Cited by 64

Chitosan Oligosaccharide Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Mice

Qian, M., Lyu, Q., Liu, Y., Hu, H., Wang, S., Pan, C., Duan, X., Gao, Y., Qi, L., Liu, W., et al. (2019) · Marine Drugs · doi:10.3390/md17070391 · Cited by 63

LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway

Chen, X., Cai, C., Yu, M., Feng, Z., Zhang, Y.-W., Liu, P., Zeng, H., & Yu, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i45.6607 · Cited by 61

Aging‐induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation

Wan, J., Wu, X., Chen, H., Xia, X., Song, X., Chen, S., Lu, X., Jin, J., Su, Q., Cai, D., et al. (2020) · Aging Cell · doi:10.1111/acel.13238 · Cited by 62

Ginseng Saponin Enriched in Rh1 and Rg2 Ameliorates Nonalcoholic Fatty Liver Disease by Inhibiting Inflammasome Activation

Wang, F., Park, J.-S., Ma, Y., Ma, H., Lee, Y.-J., Lee, G., Yoo, H., Hong, J. T., & Roh, Y. (2021) · Nutrients · doi:10.3390/nu13030856 · Cited by 67

Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology

Schlegel, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1037-y · Cited by 64

Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?

Finelli, C. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i46.6790 · Cited by 63

Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico

Ramos-López, O. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11552 · Cited by 65

The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease

Zhu, X., Bian, H., & Gao, X. (2016) · Molecules · doi:10.3390/molecules21101336 · Cited by 63

Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice

Lytle, K. A., Wong, C. P., & Jump, D. Β. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173376 · Cited by 62

Ubiquitin‐Specific Protease 4 Is an Endogenous Negative Regulator of Metabolic Dysfunctions in Nonalcoholic Fatty Liver Disease in Mice

Zhao, Y., Wang, F., Gao, L., Xu, L., Tong, R., Lin, N., Su, Y., Yang, Y., Gao, Y., He, J., et al. (2018) · Hepatology · doi:10.1002/hep.29889 · Cited by 62

Recent insights into the pathogenesis of nonalcoholic fatty liver disease

Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

Tiniakos, D. G., Vos, M. B., & Brunt, E. M. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102132 · Cited by 870

Pathogenesis of Non-alcoholic Steatohepatitis: Human Data

Edmison, J. M., & McCullough, A. J. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.02.011 · Cited by 195

Clinicopathological features of non‐alcoholic fatty liver disease

Sugimoto, K., & Takei, Y. (2011) · Hepatology Research · doi:10.1111/j.1872-034x.2011.00867.x · Cited by 29

Research Advances in Nonalcoholic Fatty Liver Disease

Hai-fen, Z. (2015) · Medical Recapitulate