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Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

Harker, James A., Lewis, Gavin M., Mack, Lauren, Zuniga, Elina I.·2011·Science

DOI 10.1126/science.1208421PMC PMC3388900

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A persisting wave of the cytokine interleukin-6 allows control of chronic viral infections.

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T cell exhaustion
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Impaired immune and acute-phase responses in interleukin-6-deficient mice
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Bcl6 mediates the development of T follicular helper cells
Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506

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Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591
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T follicular helper cell-dependent clearance of a persistent virus infection requires T cell expression of the histone demethylase UTX
Cook, K. D., Shpargel, K. B., Starmer, J., Whitfield-Larry, F., Conley, B., Allard, D. E., Rager, J. E., Fry, R. C., Davenport, M. L., Magnuson, T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.002 · Cited by 83
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Lin, W. W., Yi, Z., Stunz, L. L., Maine, C. J., Sherman, L. A., & Bishop, G. A. (2015) · Science Signaling · doi:10.1126/scisignal.aaa5157 · Cited by 50
Excessive Innate Immunity Steers Pathogenic Adaptive Immunity in the Development of Theiler’s Virus-Induced Demyelinating Disease
Kim, B. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105254 · Cited by 8

Authors: Harker, J. A., Lewis, G. M., Mack, L., & Zuniga, E. I.
Affiliations: Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-11-11
Volume: 334
Issue: 6057
Pages: 825-829
ISSN: 0036-8075
1095-9203
DOI: 10.1126/science.1208421
PMC: PMC3388900
Cited by: 311
References: 3
Language: en

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Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

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