The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity
Open accessAbstract
The properties of breast cancer susceptibility protein required for tumor suppression have been explored.
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“Mice carrying a BRCT mutant of BRCA1 defective in recognition of phosphorylated proteins are prone to tumor development indicating that BRCT phosphoprotein recognition is required for BRCA1 tumor suppression (Shakya et al., 2011).”
From The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression (2014) · cites this paper as Shakya et al., 2011
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Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993
Self-citationBrca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
Self-citationMitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 959
Self-citationXu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743
Self-citationThe tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680
Hashizume, R., Fukuda, M., Maeda, I., Nishikawa, H., Oyake, D., Yabuki, Y., Ogata, H., & Ohta, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000881200 · Cited by 634
Ludwig, T. E., Chapman, D. L., Papaioannou, V. E., & Efstratiadis, A. (1997) · Genes & Development · doi:10.1101/gad.11.10.1226 · Cited by 539
Self-citationBRCA1 and its toolbox for the maintenance of genome integrity
Huen, M. S. Y., Sy, S. M.-H., & Chen, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2831 · Cited by 517
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Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869
Self-citationAccurate classification of BRCA1 variants with saturation genome editing
Findlay, G. M., Daza, R. M., Martin, B., Zhang, M. D., Leith, A. P., Gasperini, M., Janizek, J. D., Huang, X., Starita, L. M., & Shendure, J. (2018) · Nature · doi:10.1038/s41586-018-0461-z · Cited by 843
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
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Metadata
- Authors
- Shakya, R., Reid, L. J., Reczek, C. R., Cole, F., Egli, D., Lin, C.-S., deRooij, D. G., Hirsch, S., Ravi, K., Hicks, J. B., Szabolcs, M., Jasin, M., Baer, R., & Ludwig, T.
- Affiliations
- Columbia University (US)
- Memorial Sloan Kettering Cancer Center (US)
- New York Stem Cell Foundation (US)
- Amsterdam University Medical Centers (NL)
- Cold Spring Harbor Laboratory (US)
- Herbert Irving Comprehensive Cancer Center (US)
- Corresponding author
- Shakya, Reena
- Reid, Latarsha J.
- Baer, Richard
- Ludwig, Thomas
- ORCID
- Venue
- Science
- Published
- 2011-10-28
- Volume
- 334
- Issue
- 6055
- Pages
- 525-528
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3904783
- OpenAlex
- W2000636252
- Cited by
- 244
- References
- 28
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 19 · 2019: 11 · 2018: 17 · 2017: 15 · 2016: 25 · 2015: 20 · 2014: 20 · 2013: 22 · 2012: 35
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Cancer Institute (P01CA097403, R01CA137023, T32CA009503, F31CA132626)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD051392, R01HD040916)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- BRCA1, tumor suppression, BRCT domain, E3 ubiquitin ligase activity, germline mutations, hereditary breast cancer, ovarian cancer, genetically engineered mouse models, ubiquitination
- MeSH terms
- Animals, Cells, Cultured, Disease Models, Animal, Ligands, Mammary Neoplasms, Experimental, Pancreatic Neoplasms, Phosphoproteins, Protein Binding, BRCA1 Protein, Genes, BRCA1, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Mutant Proteins, Basic-Leucine Zipper Transcription Factors, Mice, Embryonic Stem Cells, Protein Interaction Domains and Motifs, RING Finger Domains, Protein Multimerization
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