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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

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BRCA1 and BRCA2: 1994 and beyond

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The BRCT Domain Is a Phospho-Protein Binding Domain

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Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

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Ubiquitylation and cell signaling

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BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

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Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

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BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

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RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

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Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

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How the Fanconi Anemia Pathway Guards the Genome

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BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

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PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

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CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

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Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

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Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

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BRCA1 and its toolbox for the maintenance of genome integrity

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BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

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Factors determining DNA double‐strand break repair pathway choice in G2 phase

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The novel functions of ubiquitination in signaling

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CDK targets Sae2 to control DNA-end resection and homologous recombination

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A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

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The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

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Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

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DNA end resection: Many nucleases make light work

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HDACs link the DNA damage response, processing of double-strand breaks and autophagy

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DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

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Mutations in BRIP1 confer high risk of ovarian cancer

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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

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Delivery of ubiquitinated substrates to protein-unfolding machines

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Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

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Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

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E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

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A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

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Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

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PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

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The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

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Cellular functions of the BRCA tumour-suppressor proteins

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BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint

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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

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Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

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BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

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An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

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BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

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BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

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Common variants at 19p13 are associated with susceptibility to ovarian cancer

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BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

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Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains

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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear fociPreprint

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CtIP Links DNA Double-Strand Break Sensing to Resection

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The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

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K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1

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The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

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CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

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MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function

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Mechanisms, biology and inhibitors of deubiquitinating enzymes

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The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

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CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

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Protein partners of deubiquitinating enzymes

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NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

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MERIT40 facilitates BRCA1 localization and DNA damage repairPreprint

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BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

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MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaksPreprint

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BRCA2: a universal recombinase regulator

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Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

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CCDC98 targets BRCA1 to DNA damage sites

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HERC2 Is an E3 Ligase That Targets BRCA1 for Degradation

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BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

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BRCC36 Is Essential for Ionizing Radiation–Induced BRCA1 Phosphorylation and Nuclear Foci Formation

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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

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BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

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BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork

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Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites

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Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates

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RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage

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Abro1 maintains genome stability and limits replication stress by protecting replication fork stabilityPreprint

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Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells

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NAD+ Metabolism in Aging and Cancer

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Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice

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BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites

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BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2–RAD52

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The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations

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The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression

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Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage

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BRCA1 and Metastasis: Outcome of Defective DNA Repair

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Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by CezannePreprint

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BRCA1 the Versatile Defender: Molecular to Environmental Perspectives

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Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex

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BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes

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E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease

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Making Connections: Integrative Signaling Mechanisms Coordinate DNA Break Repair in Chromatin

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DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair

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Transcriptomic insight into salinomycin mechanisms in breast cancer cell lines: synergistic effects with dasatinib and induction of estrogen receptor β

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Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage

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BRCT Domains: Structure, Functions, and Implications in Disease—New Therapeutic Targets for Innovative Drug Discovery against Infections

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BRCA1, LMO4, and CtIP mRNA Expression in Erlotinib-Treated Non–Small-Cell Lung Cancer Patients with EGFR Mutations

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Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1

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The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer

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The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops

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The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination

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The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression

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Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity

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Conserved Overlapping Gene Arrangement, Restricted Expression, and Biochemical Activities of DNA Polymerase ν (POLN)

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Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts

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Systematic investigation of BRCA1-A, -B, and -C complexes and their functions in DNA damage response and DNA repair

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Structural insights into DNA double-strand break signaling

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FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

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ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways—lessons from breast cancer patients

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Functional Analysis of Promoter Variants in Genes Involved in Sex Steroid Action, DNA Repair and Cell Cycle Control

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A special issue on DNA damage response and genome stability

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BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells

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Phospho-Proteomics Analysis of Early Response to X-Ray Irradiation Reveals Molecular Mechanism Potentially Related to U251 Cell Radioresistance

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