The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
Abstract
From Wnt Signals to Telomerase Activity: Telomerase activity is associated with stem cell renewal and cancers, whereas a decrease in telomerase activity is seen during cell differentiation and senescence. Wnt/β-catenin signaling is also a critical regulator of stem cells, and deregulation of the pathway is associated with cancer. Now, Hoffmeyer et al. (p. 1549 ; see the Perspective by Greider ) have found a link between these two pathways. In embryonic stem cells, β-catenin was able to regulate telomerase expression and activity directly. Similar observations were obtained in adult stem cells, a model of intestinal tumors, and human cancer cells.
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Cited by
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Clevers, H., Loh, K. M., & Nusse, R. (2014) · Science · doi:10.1126/science.1248012 · Cited by 1,364
The intestinal crypt, a prototype stem cell compartment
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Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma
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Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Totoki, Y., Tatsuno, K., Covington, K. R., Ueda, H., Creighton, C. J., Kato, M., Tsuji, S., Donehower, L. A., Slagle, B. L., Nakamura, H., et al. (2014) · Nature Genetics · doi:10.1038/ng.3126 · Cited by 781
Epigenetic reprogramming in cancer
Suvà, M. L., Riggi, N., & Bernstein, B. E. (2013) · Science · doi:10.1126/science.1230184 · Cited by 706
Metadata
- Authors
- Hoffmeyer, K., Raggioli, A., Rudloff, S., Anton, R., Hierholzer, A., Del Valle, I., Hein, K., Vogt, R., & Kemler, R.
- Venue
- Science
- Published
- 2012-06-22
- Volume
- 336
- Issue
- 6088
- Pages
- 1549-1554
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094831008
- Cited by
- 526
- References
- 24
- FWCI
- 32.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells. https://app.cochat.ai/papers/10.1126/science.1218370
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- Hoffmeyer, K., Raggioli, A., Rudloff, S., Anton, R., Hierholzer, A., Del Valle, I., Hein, K., Vogt, R., & Kemler, R. (2012). Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells. Science. https://doi.org/10.1126/science.1218370
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