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Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

Taelman, Vincent F., Dobrowolski, Radoslaw, Plouhinec, Jean-Louis, Fuentealba, Luis C., Vorwald, Peggy P., Gumper, Iwona, Sabatini, David D., De Robertis, Edward M.·2010·Cell
DOI 10.1016/j.cell.2010.11.034PMC PMC3022472
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  • Neurodegeneration is linked to impaired autophagy and trafficking.

    “Neurodegeneration is linked to impaired autophagy and trafficking (Dobrowolski and De Robertis 2011), (Sorkin and von Zastrow 2009), (Taelman et al. 2010), (Killisch et al. 1991), (Lipinski et al. 2010), (Nixon 2013).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Taelman et al. 2010

    The Discussion section, “A Positive Role for Endocytosis in Signal Transduction” (page unavailable), describes endosomal trafficking in Wnt signaling and mentions possible implications for human disease, including cancer. Our copy does not link impaired trafficking or autophagy to neurodegeneration; searches for “autophagy” and “neurodegeneration” found no passage making that link. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 59

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Metadata

Authors
Taelman, V. F., Dobrowolski, R., Plouhinec, J.-L., Fuentealba, L. C., Vorwald, P. P., Gumper, I., Sabatini, D. D., & De Robertis, E. M.
Venue
Cell
Publisher
Elsevier BV
Published
2010-12
Volume
143
Issue
7
Pages
1136-1148
ISSN
0092-8674
DOI
10.1016/j.cell.2010.11.034
PMC
PMC3022472
Cited by
676
References
6
Language
en
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