Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience
Open accessAbstract
Resilient Hyperpolarization: Despite constant exposure to all sorts of stressors, most people are resilient and do not develop depression, but we do not understand the neurophysiological underpinnings of stress resilience. Friedman et al. (p. 313 ) studied this phenomenon in a mouse model of social-defeat stress depression. In the mice they found that, despite apparently pathological levels of hyperpolarization and elevated potassium channel currents in the ventral tegmental area (a structure known to be involved in depression), resilient mice showed normal activity in dopaminergic neurons. Thus, if “depressed” mice were experimentally provoked into hyperpolarization—unexpectedly, they completely reversed depression-related behaviors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic optogenetic activation of VTA-DA neurons in susceptible mice can restore their firing rate to normal levels, reverse social avoidance, and shift them from susceptibility to resilience.
“Chronic optogenetic activation of VTA-DA neurons in susceptible mice can restore their firing rate to normal levels, reverse social avoidance, and shift them from susceptibility to resilience”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Friedman et al., 2014
Repeated ventral tegmental area optogenetic stimulation dampens phasic firing of ventral tegmental area neurons through alterations in Ih potassium conductance and promotes resilience in chronic social defeat stress mice.
“For instance, repeated VTA optogenetic stimulation is sufficient to dampen phasic firing of VTA neurons through alterations in Ih potassium conductance (54), promoting resilience in CSDS mice, and providing a potential parallel in mechanism.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [54]
Phasic, but not tonic, optogenetic stimulation of ventral tegmental area to nucleus accumbens projecting neurons promotes susceptibility to chronic social defeat stress.
“The effect of chronic stress on VTA DA neuron firing is lasting (37, 65, 66), is driven by activity of intrinsic potassium channels (54), and phasic but not tonic optogenetic stimulation of VTA-NAc projecting neurons promotes susceptibility to CSDS (54, 66–68).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [54]
Ventral tegmental area dopamine neuron firing is driven by activity of intrinsic potassium channels.
“The effect of chronic stress on VTA DA neuron firing is lasting (37, 65, 66), is driven by activity of intrinsic potassium channels (54), and phasic but not tonic optogenetic stimulation of VTA-NAc projecting neurons promotes susceptibility to CSDS (54, 66–68).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [54]
BDNF is responsible for stress susceptibility.
“Rather, BDNF was responsible for stress susceptibility and antagonism of the BDNF receptor TrkB, prevented susceptibility (37, 38, 54, 65, 67, 68).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [54]
Antagonism of the BDNF receptor TrkB prevents stress susceptibility.
“Rather, BDNF was responsible for stress susceptibility and antagonism of the BDNF receptor TrkB, prevented susceptibility (37, 38, 54, 65, 67, 68).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [54]
Optogenetic stimulation of ventral tegmental area dopamine neurons recapitulates stress susceptibility in previously resilient animals.
“optogenetic stimulation of VTA dopamine neurons recapitulates stress susceptibility in previously resilient animals [23, 24, 30].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [30]
Ih and intrinsic excitability are upregulated in chronic social defeat stress-susceptible mice, but Ih is upregulated to a greater extent in resilient mice.
“Ih and intrinsic excitability are upregulated in CSDS-susceptible mice [30], but somewhat paradoxically, Ih is upregulated to a greater extent in resilient mice.”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [30]
Increased Ih currents occur specifically in nucleus accumbens, but not medial prefrontal cortex, projecting ventral tegmental area dopamine neurons.
“Increased Ih currents occur specifically in NAc, but not mPFC projecting VTA dopamine neurons [30]”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [30]
Through homeostatic adaptations, resilient mice upregulate K+ channels to reduce excitability as a consequence of enhanced Ih.
“Through homeostatic adaptations, resilient mice upregulate K+ channels to reduce excitability as a consequence of the enhanced Ih [13, 30].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [30]
Both chronic social defeat stress and chronic unpredictable stress-induced firing changes are reversed by Ih current normalization after HCN2 overexpression.
“both CSDS and CUS-induced firing changes are reversed by Ih current normalization after HCN2 overexpression [30, 61].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 6× · see citing works
“In a well-established chronic social defeat model of depression, susceptible and resilient phenotypes have been successfully segregated after a 10-day social defeat paradigm (1, 9, 12, 13).”
BackgroundMethodInfluentialSelf-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300 · see citing works
Psychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272 · see citing works
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266 · see citing works
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
Self-citationRapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Self-citationDopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073 · see citing works
Hyperpolarization-Activated Cation Channels: From Genes to Function
Biel, M., Wahl‐Schott, C., Michalakis, S., & Zong, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00029.2008 · Cited by 1,005 · see citing works
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976 · see citing works
The science of resilience: implications for the prevention and treatment of depression
Southwick, S. M., & Charney, D. S. (2012) · Science · doi:10.1126/science.1222942 · Cited by 875 · see citing works
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement
Turrigiano, G. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153238 · Cited by 671 · see citing works
Responses to Positive Affect: A Self-Report Measure of Rumination and Dampening
Feldman, G. C., Joormann, J., & Johnson, S. L. (2007) · Cognitive Therapy and Research · doi:10.1007/s10608-006-9083-0 · Cited by 549 · see citing works
Activity-Dependent Changes in the Intrinsic Properties of Cultured Neurons
Turrigiano, G. G., Abbott, L. F., & Marder, E. E. (1994) · Science · doi:10.1126/science.8178157 · Cited by 484 · see citing works
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Self-citationPharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites
Poolos, N. P., Migliore, M., & Johnston, D. (2002) · Nature Neuroscience · doi:10.1038/nn891 · Cited by 454 · see citing works
Cao, J.-L., Covington, H. E., Friedman, A. K., Wilkinson, M. B., Walsh, J. J., Cooper, D. C., Nestler, E. J., & Han, M.-H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3177-10.2010 · Cited by 402 · see citing works
Self-citationNeuhoff, H., Neu, A. D., Liss, B., & Roeper, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01290.2002 · Cited by 400 · see citing works
Potentiation of cortical inhibition by visual deprivation
Maffei, A., Nataraj, K., Nelson, S. B., & Turrigiano, G. G. (2006) · Nature · doi:10.1038/nature05079 · Cited by 383 · see citing works
Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works
Self-citationPlasticity in single neuron and circuit computations
Alain Destexhe, A., & Marder, E. E. (2004) · Nature · doi:10.1038/nature03011 · Cited by 271 · see citing works
Wanat, M. J., Hopf, F. W., Stuber, G. D., Phillips, P. E. M., & Bonci, A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.150078 · Cited by 256 · see citing works
Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 232 · see citing works
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3591 · Cited by 210 · see citing works
Self-citationChanges in mindfulness and emotion regulation in an exposure-based cognitive therapy for depression
Kumar, S., Feldman, G., & Hayes, A. (2008) · Cognitive Therapy and Research · doi:10.1007/s10608-008-9190-1 · Cited by 206 · cited 2× · see citing works
“Fortunately, however, large EM data sets that allow analysis of myelin are beginning to be available (3, 4).”
BackgroundThe Schizophrenia Susceptibility Gene dysbindin Controls Synaptic Homeostasis
Dickman, D. K., & Davis, G. W. (2009) · Science · doi:10.1126/science.1179685 · Cited by 206 · see citing works
BDNF is a negative modulator of morphine action
Koo, J. W., Mazei-Robison, M. S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D., et al. (2012) · Science · doi:10.1126/science.1222265 · Cited by 189 · see citing works
Self-citationWilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., Russo, S., Neve, R., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0039-11.2011 · Cited by 170 · see citing works
Self-citationBipolar Disorder — A Focus on Depression
Frye, M. A. (2011) · New England Journal of Medicine · doi:10.1056/nejmcp1000402 · Cited by 167 · see citing works
Exposure and reorganization: The what and how of effective psychotherapy
Carey, T. A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.004 · Cited by 112 · see citing works
Zhang, J., & Shapiro, M. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.019 · Cited by 81 · see citing works
The Effect of Lamotrigine on Nav1.4 Voltage-Gated Sodium Channels
Nakatani, Y., Masuko, H., & Amano, T. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13116sc · Cited by 34 · see citing works
Balancing firing rates in vivo
Whalley, K. M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3637 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [4]Kumar S Feldman G Hayes A Cognitive Therapy and Research 32 734 2008 PMC2847784 20360998
Cited by
Sorted by citations
Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression
Grace, A. A. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.57 · Cited by 1,166 · see citing works
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842 · see citing works
The resilience framework as a strategy to combat stress-related disorders
Kalisch, R., Baker, D. G., Basten, U., Boks, M. P., Bonanno, G. A., Brummelman, E., Chmitorz, A., Fernàndez, G., Fiebach, C. J., Galatzer-Levy, I., et al. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0200-8 · Cited by 782 · see citing works
Animal models of major depression: drawbacks and challenges
Planchez, B., Surget, A., & Belzung, C. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02084-y · Cited by 480 · see citing works
Hare, B. D., & Duman, R. S. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0685-9 · Cited by 366 · see citing works
Bagot, R. C., Cates, H. M., Purushothaman, I., Lorsch, Z. S., Walker, D. M., Wang, J., Huang, X., Schlüter, O. M., Maze, I., Peña, C. J., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.015 · Cited by 333 · see citing works
Self-citationChronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297 · see citing works
Neurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296 · see citing works
“Interestingly, resilient mice display control-level firing activity in both of the aforementioned circuits (51) (52).”
BackgroundInfluentialSelf-citationWang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · see citing works
Self-citationDistinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression
Knowland, D., Lilascharoen, V., Pacia, C. P., Shin, S., Wang, E. H.-J., & Lim, B. K. (2017) · Cell · doi:10.1016/j.cell.2017.06.015 · Cited by 273 · see citing works
The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span
Feder, A., Fred-Torres, S., Southwick, S. M., & Charney, D. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.012 · Cited by 269 · see citing works
Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression
Francis, T. C., & Lobo, M. K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.007 · Cited by 230 · see citing works
Reinforcement learning in depression: a review of computational research
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197 · see citing works
Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons
Isingrini, E., Perret, L., Rainer, Q., Amilhon, B., Guma, E., Tanti, A., Martin, G., Robinson, J., Moquin, L., Marti, F., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4245 · Cited by 177 · see citing works
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Friedman, A. K., Juarez, B., Ku, S. M., Zhang, H., Calizo, R. C., Walsh, J. J., Chaudhury, D., Zhang, S., Hawkins, A., Dietz, D. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms11671 · Cited by 172 · see citing works
Self-citationSartiani, L., Mannaioni, G., Masi, A., Novella Romanelli, M., & Cerbai, E. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014035 · Cited by 143 · see citing works
A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia
Qu, N., He, Y., Wang, C., Xu, P., Yang, Y., Cai, X., Liu, H., Yu, K., Pei, Z., Hyseni, I., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0506-1 · Cited by 122 · see citing works
Lüscher, B., & Möhler, H. (2019) · F1000Research · doi:10.12688/f1000research.18758.1 · Cited by 105 · see citing works
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112 · see citing works
Self-citationSantoro, B., & Shah, M. M. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023356 · Cited by 108 · see citing works
HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors
Cheng, J., Umschweif, G., Leung, J., Sagi, Y., & Greengard, P. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.018 · Cited by 110 · see citing works
HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress
Zhong, P., Vickstrom, C. R., Liu, X., Hu, Y., Yu, L., Yu, H.-G., & Liu, Q.-S. (2018) · eLife · doi:10.7554/elife.32420 · Cited by 99 · see citing works
Moreines, J. L., Owrutsky, Z. L., & Grace, A. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.249 · Cited by 93 · see citing works
Illuminating circuitry relevant to psychiatric disorders with optogenetics
Steinberg, E. E., Christoffel, D. J., Deisseroth, K., & Malenka, R. C. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.004 · Cited by 92 · see citing works
Zhang, H., Chaudhury, D., Nectow, A. R., Friedman, A. K., Zhang, S., Juarez, B., Liu, H., Pfau, M. L., Aleyasin, H., Jiang, C., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.08.020 · Cited by 88 · see citing works
Self-citationFernandez, S. P., Broussot, L., Marti, F., Contesse, T., Mouska, X., Soiza-Reilly, M., Marie, H., Faure, P., & Barik, J. (2018) · Nature Communications · doi:10.1038/s41467-018-06809-7 · Cited by 75 · see citing works
HCN Channels Modulators: The Need for Selectivity
Novella Romanelli, M., Sartiani, L., Masi, A., Mannaioni, G., Manetti, D., Mugelli, A., & Cerbai, E. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616999160315130832 · Cited by 73 · see citing works
A thalamic-primary auditory cortex circuit mediates resilience to stress
Li, H.-Y., Zhu, M.-Z., Yuan, X.-R., Guo, Z.-X., Pan, Y.-D., Li, Y.-Q., & Zhu, X.-H. (2023) · Cell · doi:10.1016/j.cell.2023.02.036 · Cited by 64 · see citing works
The Formation and Function of the VTA Dopamine System
Hou, G., Hao, M., Duan, J., & Han, M.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073875 · Cited by 65 · see citing works
Self-citationPPARα modulation of mesolimbic dopamine transmission rescues depression-related behaviors
Scheggi, S., Melis, M., De Felice, M., Aroni, S., Muntoni, A. L., Pelliccia, T., Gambarana, C., De Montis, M. G., & Pistis, M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.024 · Cited by 56 · see citing works
HCN Channel Targets for Novel Antidepressant Treatment
Ku, S. M., & Han, M.-H. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0538-7 · Cited by 54 · see citing works
Self-citationLi, L., Sun, H., Ding, J., Niu, C., Su, M., Zhang, L., Li, Y., Wang, C., Gamper, N., Du, X., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14026 · Cited by 51 · see citing works
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51 · see citing works
“Chronic optogenetic activation of VTA-DA neurons in susceptible mice can restore their firing rate to normal levels, reverse social avoidance, and shift them from susceptibility to resilience, underscoring the intricate role of VTA-DA neurons in social defeat outcomes (Friedman et al., 2014).”
BackgroundSmall, K. M., Nunes, E., Hughley, S., & Addy, N. A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.01.057 · Cited by 43 · see citing works
Neural Circuit Reprogramming: A New Paradigm for Treating Neuropsychiatric Disease?
Tye, K. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.022 · Cited by 21 · see citing works
Pérez de la Mora, M., Borroto-Escuela, D. O., Crespo-Ramírez, M., Rejón-Orantes, J. D. C., Palacios-Lagunas, D. A., Martínez-Mata, M. K., Sánchez-Luna, D., Tesoro-Cruz, E., & Fuxe, K. (2022) · Cells · doi:10.3390/cells11111826 · Cited by 21 · see citing works
Feng, M., Crowley, N. A., Patel, A., Guo, Y., Bugni, S. E., & Luscher, B. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.03.003 · Cited by 20 · see citing works
Cai, M., Zhu, Y., Shanley, M. R., Morel, C., Ku, S. M., Zhang, H., Shen, Y., Friedman, A. K., & Han, M.-H. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100565 · Cited by 18 · see citing works
Self-citationLyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4580 · Cited by 17 · see citing works
Pulcrano, S., De Gregorio, R., De Sanctis, C., Volpicelli, F., Piscitelli, R. M., Speranza, L., Perrone-Capano, C., di Porzio, U., Caiazzo, M., Martini, A., et al. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.0431-23.2023 · Cited by 12 · see citing works
Teichman, E. M., Hu, J., Lin, H.-Y., Fisher-Foye, R. L., Blando, A., Hu, X., Kaniskan, H. Ü., Montgomery, S. E., Cai, M., Parise, L. F., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02972-8 · Cited by 5 · see citing works
Self-citationLayer-specific input to medial prefrontal cortex is linked to stress susceptibility
Solakoğlu, S. T., Erdener, Ş. E., Gliko, O., Can, A., Sümbül, U., & Eren-Koçak, E. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03258-x · Cited by 5 · see citing works
- Authors
- Friedman, A. K., Walsh, J. J., Juarez, B., Ku, S. M., Chaudhury, D., Wang, J., Li, X., Dietz, D. M., Pan, N., Vialou, V. F., Neve, R. L., Yue, Z., & Han, M.-H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Han, Ming-Hu
- ORCID
- Venue
- Science
- Published
- 2014-04-18
- Volume
- 344
- Issue
- 6181
- Pages
- 313-319
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4334447
- OpenAlex
- W2058867280
- Cited by
- 484
- References
- 35
- Citations by year
- 2026: 26 · 2025: 29 · 2024: 51 · 2023: 36 · 2022: 45 · 2021: 41 · 2020: 46 · 2019: 51 · 2018: 35 · 2017: 43 · 2016: 36 · 2015: 27 · 2014: 16 · 2012: 1
- FWCI
- 18.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA022445)
- National Institute of Mental Health (F31MH108326, P50MH096890, R01MH092306, F31MH095425, T32MH096678, F32MH096464, T32MH087004, T32MH020016)
- National Institute of Neurological Disorders and Stroke (R01NS060123)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- depression, ventral tegmental area, dopaminergic neurons, social defeat stress, potassium currents, neuronal hyperactivity, homeostatic plasticity, optogenetics, antidepressant mechanism, depression vulnerability
- MeSH terms
- Lamotrigine, Animals, Behavior, Animal, Depression, Homeostasis, Male, Membrane Potentials, Mice, Inbred C57BL, Mice, Transgenic, Social Behavior, Stress, Psychological, Triazines, Potassium Channels, Ventral Tegmental Area, Patch-Clamp Techniques, Mice, Resilience, Psychological, Electrophysiological Phenomena, Dopaminergic Neurons, Optogenetics, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
