The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
PI4P and PI(4,5)P 2 Are Essential But Independent Lipid Determinants of Membrane Identity
Open accessAbstract
Phosphoinositide Contributions: To study the roles of phosphoinositides in the plasma membrane of mammalian cells, Hammond et al. (p. 727 , published online 21 June; see the Perspective by Fairn and Grinstein ) engineered phosphatase molecules that could be targeted to the membrane on demand, where they would alter the concentrations of the phospholipids phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P 2 ] and phosphatidylinositol 4-phosphate (PI4P). PI4P was thought to provide a major source for the synthesis of PI(4,5)P 2 , but depletion of PI4P did not have much affect on synthesis of PI(4,5)P 2 . Instead, PI4P appears to help to establish the negative charge at the membrane and thus promote electrostatic interactions with positively charged amino acids in membrane-associated proteins and influencing function of ion channels.
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Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome Biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,157
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Phosphoinositides in cell regulation and membrane dynamics
Di Paolo, G., & De Camilli, P. (2006) · Nature · doi:10.1038/nature05185 · Cited by 2,790
A monomeric red fluorescent protein
Campbell, R. E., Tour, O., Palmer, A. E., Steinbach, P. A., Baird, G. S., Zacharias, D. A., & Tsien, R. Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082243699 · Cited by 2,365
Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization
Yeung, T., Gilbert, G. E., Shi, J., Silvius, J., Kapus, A., & Grinstein, S. (2008) · Science · doi:10.1126/science.1152066 · Cited by 1,107
Chaffey, N. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(01)01902-1 · Cited by 1,043
Plasma membrane phosphoinositide organization by protein electrostatics
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Self-citationPI(3,4,5)P 3 and PI(4,5)P 2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane
Heo, W. D., Inoue, T., Park, W. S., Kim, M. L., Park, B. O., Wandless, T. J., & Meyer, T. (2006) · Science · doi:10.1126/science.1134389 · Cited by 775
Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2
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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
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Self-citationPhosphoinositides as membrane organizers
Posor, Y., Jang, W., & Haucke, V. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00490-x · Cited by 469
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
Hammond, G. R. V., Machner, M. P., & Balla, T. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201312072 · Cited by 453
Self-citationPhosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling
Garcia-Gonzalo, F. R., Phua, S. C., Roberson, E. C., Garcia, G., Abedin, M., Schurmans, S., Inoue, T., & Reiter, J. F. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.08.001 · Cited by 330
TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
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Metadata
- Authors
- Hammond, G. R. V., Fischer, M. J., Anderson, K. E., Holdich, J., Koteci, A., Balla, T., & Irvine, R. F.
- Venue
- Science
- Published
- 2012-08-10
- Volume
- 337
- Issue
- 6095
- Pages
- 727-730
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085035388
- Cited by
- 498
- References
- 39
- FWCI
- 17.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Hammond, G. R. V., Fischer, M. J., Anderson, K. E., Holdich, J., Koteci, A., Balla, T., & Irvine, R. F. (2012). PI4P and PI(4,5)P 2 Are Essential But Independent Lipid Determinants of Membrane Identity. Science. https://doi.org/10.1126/science.1222483
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