The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The Science of Resilience: Implications for the Prevention and Treatment of Depression
Abstract
Human responses to stress and trauma vary widely. Some people develop trauma-related psychological disorders, such as posttraumatic stress disorder (PTSD) and depression; others develop mild to moderate psychological symptoms that resolve rapidly; still others report no new psychological symptoms in response to traumatic stress. Individual variability in how animals and humans respond to stress and trauma depends on numerous genetic, developmental, cognitive, psychological, and neurobiological risk and protective factors.
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“Moreover, individuals with low psychological resilience seem to have compromised control of brain circuits involved in emotion and fear [97] and poor cortico-limbic inhibition, representing a dysregulated emotional response to stress that may result in elevated cortisol exposure [98].”
From The prospective association of adolescent loneliness and low resilience with anxiety and depression in young adulthood: The HUNT study (2025) · cites this paper as [97]
In the citing paper
“The prospective association between anxiety and depression is particularly strong and well established. 257”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [257]
Citations
Cites
Neural mechanisms of the cognitive model of depression.
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3027 · Cited by 1,718
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346
Psychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272
Self-citationSocial influences on neuroplasticity: stress and interventions to promote well-being
Davidson, R. J., & McEwen, B. S. (2012) · Nature Neuroscience · doi:10.1038/nn.3093 · Cited by 892
Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., Krystal, J. H., & Gelernter, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.026 · Cited by 692
Southwick, S. M., & Charney, D. S. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139013857 · Cited by 479
Self-citationComprehensive Soldier Fitness: Building resilience in a challenging institutional context.
Cornum, R. L., Matthews, M. D., & Seligman, M. E. P. (2011) · American Psychologist · doi:10.1037/a0021420 · Cited by 466
Psychobiological allostasis: resistance, resilience and vulnerability
Karatsoreos, I. N., & McEwen, B. S. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.005 · Cited by 458
A meta-analytic review of the Penn Resiliency Program’s effect on depressive symptoms.
Brunwasser, S. M., Gillham, J. E., & Kim, E. S. (2009) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0017671 · Cited by 428
Increasing Psychological Well‐Being and Resilience by Psychotherapeutic Methods
Fava, G. A., & Tomba, E. (2009) · Journal of Personality · doi:10.1111/j.1467-6494.2009.00604.x · Cited by 362
Resilience and Mental Health: Challenges Across the Lifespan
(2011) · doi:10.1017/cbo9780511994791 · Cited by 264
Resilience and Mental Health: Challenges Across the Lifespan
Masten, A. S., Monn, A. R., & Supkoff, L. M. (2011) · Cambridge University Press eBooks · Cited by 243
Epigenetic regulation of the neural transcriptome: the meaning of the marks
Meaney, M. J., & Ferguson-Smith, A. C. (2010) · Nature Neuroscience · doi:10.1038/nn1110-1313 · Cited by 216
Resilience: The Science of Mastering Life's Greatest Challenges
Southwick, S. M., & Charney, D. S. (2012) · Cited by 212
Self-citationSerotonin transporter gene, stress and raphe–raphe interactions: a molecular mechanism of depression
Jasinska, A. J., Lowry, C. A., & Burmeister, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.001 · Cited by 95
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.189 · Cited by 87
Beyond depression: Toward a process‐based approach to research, diagnosis, and treatment.
Forgeard, M. J. C., Haigh, E. A. P., Beck, A. T., Davidson, R. J., Henn, F. A., Maier, S. F., Mayberg, H. S., & Seligman, M. E. P. (2011) · Clinical Psychology Science and Practice · doi:10.1111/j.1468-2850.2011.01259.x · Cited by 70
The courage and strategies of hardiness as helpful in growing despite major, disruptive stresses.
Maddi, S. R. (2008) · American Psychologist · doi:10.1037/0003-066x.63.6.563 · Cited by 58
Behavioral resilience in the post-genomic era: emerging models linking genes with environment
Rende, R. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00050 · Cited by 15
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Research works printed but not linked: 3
- 5-HTTLPR www.ncbi.nlm.nih.gov/gene?term=SLC6A4%20solute%20carrier%20family%206.
- Troy A. S. Mauss I. B. in ( 11 ) pp. 30–44.
- Benight C. C. Cieslak R. in ( 11 ) pp. 45–55.
Cited by
Sorted by citations
Resilience definitions, theory, and challenges: interdisciplinary perspectives
Southwick, S. M., Bonanno, G. A., Masten, A. S., Panter-Brick, C., & Yehuda, R. (2014) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v5.25338 · Cited by 2,968
“…and numerous physical conditions, such as inflammatory, cardiovascular, or other medical illnesses (Karatoreos & McEwen, 2013; Russo, Murrough, Han, Charney, & Nestler, 2012; Southwick & Charney, 2012a, 2012b; Southwick, Litz, Charney, & Friedman, 2011; Southwick, Vythilingam, & Charney, 2005).”
Self-citationTime for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842
“Resilience refers to the ability to adapt to and recover from stress (Southwick and Charney, 2012) and is not simply the absence of vulnerability: There is evidence that resilience plays an independent (mitigating) role across the three stages of mood disorder (Davydov et al., 2010; Friedman et…”
BackgroundWu, G., Feder, A., Cohen, H., Kim, J. J., Calderon, S., Charney, D. S., & Mathé, A. A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00010 · Cited by 887
“SUMMARY Resilience is a complex multidimensional construct and the study of its neurobiology is a relatively young area of scientific investigation (Southwick and Charney, 2012).”
BackgroundInfluentialSelf-citationPreventive strategies for mental health
Arango, C., Díaz-Caneja, C. M., McGorry, P. D., Rapoport, J., Sommer, I. E., Vorstman, J. A., McDaid, D., Marín, O., Serrano-Drozdowskyj, E., Freedman, R., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30057-9 · Cited by 1,271
“25 Resilience is a multidimensional construct that can be conceptualized as the ability to adapt well after experiencing adversity, trauma, or other stressors.”
Metadata
- Authors
- Southwick, S. M., & Charney, D. S.
- Affiliations
- United States Department of Veterans Affairs (US)
- Mount Sinai Hospital (US)
- Corresponding author
- Charney, Dennis S.
- Venue
- Science
- Published
- 2012-10-05
- Volume
- 338
- Issue
- 6103
- Pages
- 79-82
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996620918
- Cited by
- 875
- References
- 19
- Citations by year
- 2026: 40 · 2025: 86 · 2024: 90 · 2023: 62 · 2022: 95 · 2021: 78 · 2020: 73 · 2019: 79 · 2018: 57 · 2017: 51 · 2016: 45 · 2015: 45 · 2014: 38 · 2013: 28 · 2012: 2
- FWCI
- 41.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- resilience, depression, depression prevention, depression treatment, stress response, trauma, post-traumatic stress disorder, interindividual variability, risk and protective factors, genetic factors, neurobiology of stress
- MeSH terms
- Animals, Depressive Disorder, Humans, Stress Disorders, Post-Traumatic, Resilience, Psychological
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