Cited by 875Resilience and Mental HealthPosttraumatic Stress Disorder ResearchStress Responses and Cortisol

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The Science of Resilience: Implications for the Prevention and Treatment of Depression

Southwick, Steven M., Charney, Dennis S.·2012·Science

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Abstract

Human responses to stress and trauma vary widely. Some people develop trauma-related psychological disorders, such as posttraumatic stress disorder (PTSD) and depression; others develop mild to moderate psychological symptoms that resolve rapidly; still others report no new psychological symptoms in response to traumatic stress. Individual variability in how animals and humans respond to stress and trauma depends on numerous genetic, developmental, cognitive, psychological, and neurobiological risk and protective factors.

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“(Southwick & Charney, 2012a, 2012b).”
BackgroundInfluential
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Background
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Resilience training that can change the brain.
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“INTRODUCTION Resilience is an individual’s ability to maintain physical and emotional well-being in the face of adversity.(1,2) Although theories conflict about how (or when) to objectively measure it, they consistently suggest that individual resilience enables patients to harness the resources needed to maintain wel…”
Background
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“34 Failing to do so may contribute to the onset and recurrence of mood disorders like depression 35 and anxiety [5,6].”
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Self-citation
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“responses to stressors [4, 41] and protection against depressive symptoms [41, 42].”
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Background
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“…Neuroscience, University of Siena, Siena, Italy psychosocial factors, cognitive profile, and functional neural circuitry, all contributing to Bshield^ mind and brain against pathological conditions (Southwick & Charney, 2012; van der Werff, van den Berg, Pannekoek, Elzinga, & van der Wee, 2013).”
Background
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Background
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“Based on depression risk factors, such as weaknesses in cognitive function, emotional regulation, social interaction skill, circadian and stress responses [36], we used chronic stress to produce depression-like mice in the following principle.”
Method
Multiple traumas and resilience among street children in Haiti: Psychopathology of survival
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“Research on neuroplasticity has shown that living under such conditions can particularly change the brain and ways of understanding and facing the social and environmental adversities (Southwick & Charney, 2012; Ungar et al., 2013).”
Background

Authors: Southwick, S. M., & Charney, D. S.
Affiliations: United States Department of Veterans Affairs (US)
Mount Sinai Hospital (US)
Corresponding author: Charney, Dennis S.
ORCID: Southwick, Steven M.
Charney, Dennis S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-10-05
Volume: 338
Issue: 6103
Pages: 79-82
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1222942
OpenAlex: W1996620918
Cited by: 875
References: 19
Citations by year: 2026: 40 · 2025: 86 · 2024: 90 · 2023: 62 · 2022: 95 · 2021: 78 · 2020: 73 · 2019: 79 · 2018: 57 · 2017: 51 · 2016: 45 · 2015: 45 · 2014: 38 · 2013: 28 · 2012: 2
FWCI: 41.03
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: resilience, depression, depression prevention, depression treatment, stress response, trauma, post-traumatic stress disorder, interindividual variability, risk and protective factors, genetic factors, neurobiology of stress
MeSH terms: Animals, Depressive Disorder, Humans, Stress Disorders, Post-Traumatic, Resilience, Psychological

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The Science of Resilience: Implications for the Prevention and Treatment of Depression

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