( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Losman, Julie-Aurore, Looper, Ryan E., Koivunen, Peppi, Lee, Sungwoo, Schneider, Rebekka K., McMahon, Christine, Cowley, Glenn S., Root, David E., Ebert, Benjamin L., Kaelin, William G.·2013·Science

DOI 10.1126/science.1231677

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Chan‐Wang Jerry Lio, Hiroshi Yuita, Anjana Rao · 2019 · Blood
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Ochocki, Joshua D., Simon, M. Celeste · 2013 · Journal of Cell Biology
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Xiaolan Deng, Rui Jun Su, Savanna Stanford, Jianjun Chen · 2018 · Frontiers in Endocrinology
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Jorge Andrade, Chenyue Shi, Ana S.H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann et al. · 2021 · Nature Cell Biology
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Stéphane de Botton, Pierre Fenaux, Karen W L Yee, Christian Récher, Andrew H. Wei, Pau Montesinos, David Christopher Taussig, Arnaud Pigneux, Thorsten Braun, Antonio Curti et al. · 2023 · Blood Advances
Mitochondrial metabolites: undercover signalling molecules
Frezza, Christian · 2017 · Interface Focus
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Lucille Stuani, Marie Sabatier, Feng Wang, Nathalie Poupin, Claudie Bosc, Estelle Saland, Florence Anne Castelli, Lara Gales, Camille Montersino, Emeline Boët et al. · 2021 · The Journal of Experimental Medicine
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Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael Scott Regan, Yu‐Fen Lin et al. · 2022 · Cancer Cell
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Steven M. Chan, Ravindra Majeti · 2013 · International Journal of Hematology
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Sriram Venneti, Craig B. Thompson · 2017 · Annual Review of Pathology Mechanisms of Disease
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Ning Yi Jin, Tiffany L. George, Gregory A. Otterson, Claire F. Verschraegen, Haitao Wen, David Paul Carbone, James Gordon Herman, Erin Marie Bertino, Kai He · 2021 · Clinical Epigenetics
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Ježek, Petr · 2020 · Antioxidants & Redox Signaling
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Chunzhi Zhang, Lynette M. Moore, Xia Li, W. K. Alfred Yung, Wei Zhang · 2013 · Neuro-Oncology
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Feng Wang, Kiyomi Morita, Courtney Denton Dinardo, Ken Furudate, Tomoyuki N. Tanaka, Yuanqing Yan, Keyur Pravinchandra Patel, Kyle J. MacBeth, Bin Wu, Guowen Liu et al. · 2021 · Nature Communications
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Bo Wang, Yingjiang Ye, Xin Ping Yang, Boya Liu, Zhe Wang, Shuaiyi Chen, Kewei Jiang, Wei Zhang, Hongpeng Jiang, Harri K. Mustonen et al. · 2020 · EMBO Reports
Origins of aberrant DNA methylation in acute myeloid leukemia
Till Schoofs, Wolfgang E. Berdel, Carsten Müller‐Tidow · 2013 · Leukemia
Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
Hamoud Al‐Khallaf · 2017 · Cell & Bioscience
D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization
Böttcher, Martin, Renner, Kathrin, Berger, Raffaela, Mentz, Kristin, Thomas, Simone, Cardenas-Conejo, Zugey Elizabeth, Dettmer, Katja, Oefner, Peter J., Mackensen, Andreas, Kreutz, Marina et al. · 2018 · OncoImmunology
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Zhen Xing, Xiefeng Yang, Dejun She, Yu Lin, Yuyang Zhang, Dairong Cao · 2017 · American Journal of Neuroradiology
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Serena Pellegatta, Lorella Valletta, Cristina Corbetta, Monica Patanè, Ileana Zucca, Federico Riccardi Sirtori, Maria Grazia Bruzzone, Gianpaolo Fogliatto, Antonella Isacchi, Bianca Pollo et al. · 2015 · Acta Neuropathologica Communications
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Anuhar Chaturvedi, Lena Herbst, Stefan Pusch, Lara C. Klett, Ramya Goparaju, Damian Stichel, Silke Kaulfuß, Olaf Panknin, Katja C. Zimmermann, Luisella Toschi et al. · 2017 · Leukemia
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Miguel Reina‐Campos, Maria Teresa Díaz-Meco, Jorge Moscat · 2019 · The Journal of Cell Biology
Olutasidenib alone or with azacitidine in IDH1-mutated acute myeloid leukaemia and myelodysplastic syndrome: phase 1 results of a phase 1/2 trial
Justin M. Watts, Maria R. Baer, Jay Yang, Thomas Prébet, Sang‐Min Lee, Gary John Schiller, Shira Naomi Dinner, Arnaud Pigneux, Pau Montesinos, Eunice S. Wang et al. · 2022 · The Lancet Haematology
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Maxime Janin, Elena Mylonas, Véronique Saada, Jean‐Baptiste Micol, Aline Renneville, Cyril Quivoron, Serge Koscielny, Laurianne Scourzic, Sébastien Forget, Cécile Pautas et al. · 2013 · Journal of Clinical Oncology
Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR
Pan Deng, Cole M. Haynes · 2017 · Seminars in Cancer Biology
Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
Anja Karlstaedt, Javid J. Moslehi, Rudolf A. de Boer · 2022 · Nature Reviews Cardiology
Metabolic regulation of the hallmarks of stem cell biology
Benjamin T. Jackson, Lydia W.S. Finley · 2024 · Cell stem cell
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Lee Chong, Taylor, Ahearn, Emily L., Cimmino, Luisa · 2019 · Frontiers in Cell and Developmental Biology
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Fan Xing, Yizhao Luan, Jing Cai, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao et al. · 2017 · Cell Reports
Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets
Sushanta Kumar Mishra, Scott E. Millman, Lingbo Zhang · 2022 · Blood
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Michelle M. Kim, Abhijit Parolia, Mark P. Dunphy, Sriram Venneti · 2016 · Nature Reviews Clinical Oncology
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Aparna Vasanthakumar, Lucy A. Godley · 2015 · Cancer Genetics
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Beatrice Philip, Diana Xuan Yu, Mark R. Silvis, Clifford Shin, James P. Robinson, Gemma L. Robinson, Adam Welker, Stephanie N. Angel, Sheryl R. Tripp, Joshua Aaron Sonnen et al. · 2018 · Cell Reports
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Isabel Puig, Stephan P. Tenbaum, Irene Chicote, Oriol Arqués, Jordi Martínez‐Quintanilla, Estefania Cuesta-Borràs, Lorena Ramírez, Pilar Gonzalo, Atenea Soto, Susana Aguilar et al. · 2018 · Journal of Clinical Investigation
Oxidative stress and hypoxia in normal and leukemic stem cells
Ugo Testa, Catherine Labbaye, Germana Castelli, Elvira Pelosi · 2016 · Experimental Hematology
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
Hugh Shunsuke Colvin, Naohiro Nishida, Masamitsu Konno, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, Taishi Hata, Koichi Kawamoto, Ayumu Asai, Kenta Tsunekuni et al. · 2016 · Scientific Reports
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Xiaoyan Liu, Yuping Gong · 2019 · Biomarker Research
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Marco Sciacovelli, Edoardo Gaude, Mika Hilvo, Christian Frezza · 2014 · Methods in enzymology on CD-ROM/Methods in enzymology
New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma
Lilia Dimitrov, Christopher S. Hong, Chunzhang Yang, Zhengping Zhuang, John D. Heiss · 2015 · International Journal of Medical Sciences
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Namgyu Lee, Dohoon Kim · 2016 · Molecules and Cells
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Tor-Christian Aase Johannessen, Joydeep Mukherjee, Pavithra Viswanath, Shigeo Ohba, Sabrina M. Ronen, Rolf Bjerkvig, Russell O. Pieper · 2016 · Molecular Cancer Research
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Aurélie Morin, Judith Goncalves, Sophie Moog, Luis Jaime Castro‐Vega, Sylvie Job, Alexandre Buffet, Marie‐Joséphine Fontenille, Justine Woszczyk, Anne‐Paule Gimenez‐Roqueplo, Éric Letouzé et al. · 2020 · Cell Reports
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Petros A. Tyrakis, Marie E. Yurkovich, Marco Sciacovelli, Evangelia K. Papachristou, Hannah R. Bridges, Edoardo Gaude, Alexander Schreiner, Clive S. D’Santos, Judy Hirst, Juan Ramon Hernandez-Fernaud et al. · 2017 · Cell Reports
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Remco Jurriaan Molenaar, Swapna Thota, Yasunobu Nagata, Bhumika J. Patel, Michael J. Clemente, Bartlomiej P. Przychodzen, Cassandra M. Hirsch, Aaron D. Viny, N Hosano, Fonnet E. Bleeker et al. · 2015 · Leukemia
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Mingay, M, Chaturvedi, A, Bilenky, M, Cao, Q, Jackson, L, Hui, T, Moksa, M, Heravi-Moussavi, A, Humphries, R K, Heuser, M et al. · 2018 · Leukemia
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Tapan Mahendra Kadia, Farhad Ravandi, Jörge E. Cortes, Hagop M. Kantarjian · 2016 · Annals of Oncology
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Mindy I. Davis, Stefan Größ, Min Shen, Kimberly S. Straley, Rajan Pragani, Wendy Lea, Janeta V. Popovici-Müller, Byron DeLaBarre, Erin Artin, Natasha Thorne et al. · 2014 · Journal of Biological Chemistry
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Jacopo Di Gregorio, Sabrina Petricca, Roberto Iorio, Elena Toniato, Vincenzo Flati · 2022 · European Journal of Cell Biology
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Bing Yao, Peng Jin · 2014 · Genes & Development
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James M. Cleary, Betty Rouaisnel, Antoine Daina, Srivatsan Raghavan, Lauren A. Roller, Brandon M. Huffman, Harshabad Singh, Patrick Yung Wen, Nabeel M. Bardeesy, Vincent Zoete et al. · 2022 · npj Precision Oncology
Epigenetics of myelodysplastic syndromes
Raphaël Itzykson, Pierre Fenaux · 2013 · Leukemia
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Sandeep Balu Shelar, Eun‐Hee Shim, Garrett J. Brinkley, Anirban Kundu, Francesca Carobbio, Tyler L. Poston, Jubilee C. Tan, Vishwas Parekh, Daniel G. Benson, David K. Crossman et al. · 2018 · Clinical Cancer Research
Driver mutations in acute myeloid leukemia
Ashwin Kishtagari, Ross L. Levine, Aaron D. Viny · 2020 · Current Opinion in Hematology
ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming
Prachi Mishra, Wei Tang, Vasanta Putluri, Tiffany H. Dorsey, Feng Jin, Fang Wang, Donewei Zhu, Lauren Amable, Tao Deng, Shaofei Zhang et al. · 2017 · Journal of Clinical Investigation
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Vikas Bhardwaj, Jun He · 2020 · International Journal of Molecular Sciences
Rare insights into cancer biology
Julie Adam, Mingming Yang, Tomoyoshi Soga, Patrick J. Pollard · 2013 · Oncogene
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Esra A. Akbay, Javid J. Moslehi, Camilla Laulund Christensen, Supriya K. Saha, Jeremy H. Tchaicha, Shakti H Ramkissoon, Kelly M. Stewart, Julián Carretero, Eiki Kikuchi, Haikuo Zhang et al. · 2014 · Genes & Development
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Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarína Kľučková, Mark Jeeves et al. · 2018 · Cell Reports
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
An‐Ping Lin, Saman Abbas, Sang‐Woo Kim, Manoela Marques Ortega, Hakim Bouamar, Yissela Analy Escobedo, Prakash Varadarajan, Yuejuan Qin, Jessica Sudderth, Eduard Schulz et al. · 2015 · Nature Communications
Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
Héléna Boutzen, Estelle Saland, Clément Larrue, Fabienne de Toni, Lara Gales, Florence Anne Castelli, Mathilde Cathebas, Sonia Zaghdoudi, Lucille Stuani, Tony Kaoma et al. · 2016 · The Journal of Experimental Medicine
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Jan Philipp Bewersdorf, Rory Michael Shallis, Maximilian F. Stahl, Amer Methqal Zeidan · 2019 · Therapeutic Advances in Hematology
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Luana Schito, Sergio Rey · 2017 · Trends in Cell Biology
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Dan Ye, Shenghong Ma, Yue Xiong, Kun‐Liang Guan · 2013 · Cancer Cell
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
Tarhonskaya, Hanna, Rydzik, Anna M., Leung, Ivanhoe K. H., Loik, Nikita D., Chan, Mun Chiang, Kawamura, Akane, McCullagh, James S. O., Claridge, Timothy D. W., Flashman, Emily, Schofield, Christopher J. · 2014 · Nature Communications
Autophagy and oxidative stress in gliomas with IDH1 mutations
Misty R. Gilbert, Yinxing Liu, Janna H. Neltner, Hong Pu, Andrew J. Morris, Manjula Sunkara, Thomas A. Pittman, Natasha Kyprianou, Craig Horbinski · 2013 · Acta Neuropathologica
Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo
Yusuke Tarumoto, Shan Lin, Jinhua Wang, Joseph P. Milazzo, Yali Xu, Bin Lu, Zhaolin Yang, Yiliang Wei, Sofya A. Polyanskaya, Mark Wunderlich et al. · 2019 · Blood
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Yang, Zhentao, Jiang, Bin, Wang, Yan, Ni, Hengxiao, Zhang, Jia, Xia, Jinmei, Shi, Minggang, Hung, Li-Man, Ruan, Jingsong, Mak, Tak Wah et al. · 2017 · Cell Reports
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Nathan P. Coussens, John C. Braisted, Tyler Peryea, Gurusingham Sitta Sittampalam, Anton M. Simeonov, Matthew D. Hall · 2017 · Pharmacological Reviews
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Anna Sophia McKenney, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, Barbara G. Spitzer, Andrew M. Intlekofer, Jihae Ahn, KAITLYN R. SHANK, Franck T. Rapaport, Minal A. Patel, Efthymia Papalexi et al. · 2018 · Journal of Clinical Investigation
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity
Xiang Sun, Yu Cui, Haiyun Feng, Haifeng Liu, Xiaolong Liu · 2019 · The Journal of Experimental Medicine
Metabolic regulation of stem cell function
Rob Burgess, Michalis Agathocleous, Sean J. Morrison · 2014 · Journal of Internal Medicine
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Elhammali, Adnan, Ippolito, Joseph E., Collins, Lynne, Crowley, Jan, Marasa, Jayne, Piwnica-Worms, David · 2014 · Cancer Discovery
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Judit Gil‐Zamorano, Roberto Martín‐Hernández, Lidia Daimiel, Kris Richardson, Elena Giordano, Nathalie Marie Nicod, Belén García-Carrasco, Sara Malaguti Andrade Soares, Eduardo Iglesias‐Gutiérrez, Miguel Angel Lasunción et al. · 2014 · Journal of Nutrition
Portraits of TET-mediated DNA hydroxymethylation in cancer
Jana Jeschke, Évelyne Collignon, François Fuks · 2016 · Current Opinion in Genetics & Development
Isocitrate Dehydrogenase 1 (IDH1) Mutation in Breast Adenocarcinoma Is Associated With Elevated Levels of Serum and Urine 2-Hydroxyglutarate
Amir Tahmasb Fathi, Hossein Sadrzadeh, Amy H. Comander, Michaela Jane Higgins, Aditya Bardia, Ashley Marie Perry, Meghan E. Burke, Regina M. Silver, Christina R. Matulis, Kimberly S. Straley et al. · 2014 · The Oncologist
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Behrouz Zand, Rebecca A. Previs, Niki Marie Zacharias, Rajesha Rupaimoole, Takashi Mitamura, Archana Sidalaghatta Nagaraja, Michele Guindani, Heather J. Dalton, Lifeng Yang, Joelle Baddour et al. · 2016 · JNCI Journal of the National Cancer Institute