Cited by 536Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsAnimal Behavior and Reproduction

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Emergence of Individuality in Genetically Identical Mice

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Freund, Julia, Brandmaier, Andreas M., Lewejohann, Lars, Kirste, Imke, Kritzler, Mareike, Krüger, Antonio, Sachser, Norbert, Lindenberger, Ulman, Kempermann, Gerd·2013·Science

DOI 10.1126/science.1235294

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Abstract

Identical and Still Different: Even in monozygotic twins reared together, there are always observable differences reflecting the influence of individual responses. Freund et al. (p. 756 ; see the Perspective by Bergmann and Frisén ) developed an inbred mouse model for studying the environmental influences on genetically identical animals and examined their effects on behavioral and neural development.

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Episodic Memory Across the Lifespan
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Automated tracking reveals the social network of beach mice and their burrowsPreprint
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“Animal individuality has been described for numerous species and behaviors, including: mouse exploration behavior ( Freund et al., 2013 ), great tit feeding preferences ( Partridge, 1976 ), octopus threat responses and feeding behavior ( Mather and Anderson, 1993 ), pea aphid threat responses (…”

Authors: Freund, J., Brandmaier, A. M., Lewejohann, L., Kirste, I., Kritzler, M., Krüger, A., Sachser, N., Lindenberger, U., & Kempermann, G.
Affiliations: Center for Regenerative Therapies Dresden (DE)
Max Planck Institute for Human Development (DE)
University of Münster (DE)
Corresponding author: Freund, Julia
Brandmaier, Andreas M.
Kempermann, Gerd
ORCID: Brandmaier, Andreas M.
Lewejohann, Lars
Krüger, Antonio
Sachser, Norbert
Lindenberger, Ulman
Kempermann, Gerd
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-05-10
Volume: 340
Issue: 6133
Pages: 756-759
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1235294
OpenAlex: W2053065690
Cited by: 536
References: 0
Citations by year: 2026: 32 · 2025: 51 · 2024: 52 · 2023: 44 · 2022: 42 · 2021: 41 · 2020: 40 · 2019: 48 · 2018: 34 · 2017: 28 · 2016: 28 · 2015: 41 · 2014: 36 · 2013: 18
FWCI: 15.22
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Science (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Max Planck Institute for Plasma Physics (submittedVersion)
Max Planck Digital Library (submittedVersion, other-oa)
DZNE Pub (submittedVersion)
Funders: International Max Planck Research School for Environmental, Cellular and Molecular Microbiology
Deutsche Forschungsgemeinschaft
National Institutes of Health (AI51794, U19 AI51794)
National Institute of Allergy and Infectious Diseases (U19 AI 51794, AI 51794)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: individual differences, neuroplasticity, inbred mouse strains, exploratory activity, hippocampal neurogenesis, environmental enrichment, aging, nonshared environment, behavioral genetics
MeSH terms: Animals, Behavior, Animal, Body Weight, Brain, Female, Hippocampus, Individuality, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Neuronal Plasticity, Organ Size, Models, Animal, Mice, Neurogenesis

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Emergence of Individuality in Genetically Identical Mice

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